… Rejection

Transplantation Biology:

Kidney rejection:

Allograft rejection: specificity and memmory.

Adoptive transfer of skin allograft rejection.

MHC-matching: microcytotoxicity assay

Microcytotoxicity test.

Mixed Lymphocyte Reaction.

Luminex Cross-matching Assay:Checks for the presence of pre-existing anti-HLA antibodies in recipient serum to assess the risk of hyperacute rejection.

Organ Rejection:

1. Hyperacute (immediate) : hoursPre-existing antibodies.

2. Acute: (weeks)Cell-mediated – MHC-mismatch.

3. Chronic (months, years)minor histocompatibility antigens.

Transplantation of blood: blood transfusion.

Hyperacute rejection of kidney graft.

Allo-antibodies and chronic rejection.

Black: Azathioprine + corticosteroids

Blue: Cyclosporin A + corticosteroids

Fraternal twins cattle

“Transfusion of a goat’s blood” (1892) Jules Andler (1865-1952).