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Tissues of the Immune Response

Tissues of the Immune Response

Hugh B. FackrellHugh B. Fackrell

Filename:tissuesv7Filename:tissuesv7

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Structure and Function of the Lymphatic SystemStructure and Function

of the Lymphatic System Lymphatic systemLymphatic system Primary Lymphoid tissuesPrimary Lymphoid tissues Secondary Lymphoid TissuesSecondary Lymphoid Tissues

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Lymphatic System: FunctionLymphatic System: Function

Generate lymphocytesGenerate lymphocytes committed to a committed to a particular antigenic specificityparticular antigenic specificity

Create an environment to Create an environment to trap antigenstrap antigens from from various tissues, spaces or fluidsvarious tissues, spaces or fluids

Provide sites where the committed Provide sites where the committed lymphocytes interact with the trapped lymphocytes interact with the trapped antigensantigens

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Committed LymphocytesCommitted Lymphocytes

Immature lymphocytesImmature lymphocytes generated by hematopoiesis of pleuripotent stem generated by hematopoiesis of pleuripotent stem

cells within the bone marrow.cells within the bone marrow. Lymphocytes mature in the primary lymphoid Lymphocytes mature in the primary lymphoid

organsorgans Bone Marrow, Thymus, Bursa (in birds)Bone Marrow, Thymus, Bursa (in birds)

Mature lymphocytes migrate to the secondary Mature lymphocytes migrate to the secondary lymphoid organslymphoid organs Lymph nodes, spleen, mucosal associated lymphoid Lymph nodes, spleen, mucosal associated lymphoid

tissuestissues

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Primary Lymphoid TissuesPrimary Lymphoid Tissues

B cellsB cells BirdsBirds

Bursa of FabriciusBursa of Fabricius MammalsMammals

Fetal LiverFetal LiverBone MarrowBone Marrow

T CellsT Cells ThymusThymus

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BursaBursa

LocationLocation StructureStructure FunctionFunction

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Avian Lymphoid SystemAvian Lymphoid System

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Bursa of Fabricius:FolliclesBursa of Fabricius:Follicles

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Bursa of Fabricius: X-SectionBursa of Fabricius: X-Section

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Bursa: B cell germinal centersBursa: B cell germinal centers

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B cell OriginsB cell Origins

Hemopoietic stem cells develop in the fetal Hemopoietic stem cells develop in the fetal liverliver

Later they are produced in the Bone Later they are produced in the Bone MarrowMarrow

““Bursal equivalent”Bursal equivalent” NextNext

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Fetal liver: HematopoiesisFetal liver: Hematopoiesis

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Bone Marrow Scanning EMBone Marrow Scanning EM

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Bone Marrow DifferentiationBone Marrow Differentiation

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ThymusThymus

LocationLocation StructureStructure CirculationCirculation FunctionFunction Summary DiagramSummary Diagram

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Thymus: LocationThymus: Location

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Thymus: LobulesThymus: Lobules

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Thymus: X sectionThymus: X section

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Thymus: DevelopmentThymus: Development

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Thymus: EmbrogenisisThymus: Embrogenisis

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Thymus: Summary DiagramThymus: Summary Diagram

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Athymic MouseAthymic Mouse

““Nude” mouse - lacks hair folliclesNude” mouse - lacks hair follicles Lacks developed thymusLacks developed thymus few circulating T cellsfew circulating T cells No cell mediated immunityNo cell mediated immunity

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“Nude Mouse”“Nude Mouse”

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Lymph NodesLymph Nodes

DistributionDistribution StructureStructure CirculationCirculation FunctionFunction Summary DiagramSummary Diagram

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Lymphatic SystemLymphatic System

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Node: CirculationNode: Circulation

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Node: TD & TI areasNode: TD & TI areas

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Node: X sectionNode: X sectionCapsule

Cortex

MedullaParacortex

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Node: Diagram 2Node: Diagram 2

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CortexCortex

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Node: DiagramNode: Diagram

Efferent lymphatic

Afferent lymphatic

Primary Follicle

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Node: B cells in cortexNode: B cells in cortex

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Node: Germinal CenterNode: Germinal Center

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Node: Reticular networkNode: Reticular network

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Node Follicle: Mantle of lymphocytesNode Follicle: Mantle of lymphocytes

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ParacortexParacortex

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Node T Cells Diffuse cortexNode T Cells Diffuse cortex

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Node: T Cells in ParacortexNode: T Cells in Paracortex

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Node: T cell depletionNode: T cell depletion

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MedullaMedulla

Thymic Dependent areaThymic Dependent area

T cells localizeT cells localize

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Lymph Node: MedullaLymph Node: Medulla

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Node: LM MedullaNode: LM Medulla

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Node: Medullary SinusNode: Medullary Sinus

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Node: Subcapsular SinusNode: Subcapsular Sinus

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Node: EM of MedullaNode: EM of Medulla

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Node: Primary FollicleNode: Primary Follicle

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Node: Diffuse CortexNode: Diffuse Cortex

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Node: HEVNode: HEV

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Node: Diagram summaryNode: Diagram summary

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SpleenSpleen

LocationLocation StructureStructure CirculationCirculation Immunological functionImmunological function Summary DiagramSummary Diagram

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Spleen: Connective TissueSpleen: Connective Tissue

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Spleen: X section low magSpleen: X section low mag

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Spleen : X section higher magSpleen : X section higher mag

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Spleen: circulationSpleen: circulation

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Spleen EM: Marginal zoneSpleen EM: Marginal zone

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Marginal zone B cellsMarginal zone B cells

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Antigen localization in SpleenAntigen localization in Spleen

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Spleen: Summary DiagramSpleen: Summary Diagram

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The EndThe End