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SURVEY OF BIOCHEMISTRYLipids & Biological Membranes

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CETL Course Survey(s)

• Course-Instructor Opinion Survey (CIOS)– http://www.coursesurvey.gatech.edu– Also on T-Square Home Page

• Pilot Survey– Go to T-Square: Announcements for link to

survey– Focus groups to learn more about student

opinions – Deadline: August 3, 2008– IRB Approval requested: minimal risk

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PRS Update

• Scores on T-Square this weekend

• Next week– Mon: Fatty Acid Oxidation– Wed and Fri: Course Review via PRS – Point Summary

• 75-100% of total points = 10 PRS POINTS• 50-74% of total points = 5 PRS POINTS• 1-49% of total points = 1 PRS POINT• 0% = 0 PRS POINTS

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Types of Lipids

• Fatty Acids • Triacylglycerols• Glycerophospholipids• Sphingolipids• Steroids• Isoprenoids• Eicosanoids

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Fatty Acids

Carboxylic acids with nonpolar hydrocarbon

chain

Fatty acids can be saturated with H’s or unsaturated with H’s

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Fatty Acids

Double bonds can be cis or trans - usually see cis form

Cis form causesmolecule to kink

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Common Fatty Acids

Know C12 - C20 names and structures!

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Triacylglycerols

• R1, R2 and R3 are fatty acid chains• Most abundant!• Energy reservoirs

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Glycerophospholipids

• R1 and R2 are fatty acid chains• X = functional group• Abundant in bio membranes

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Classes of Glycerophospholipids

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Phospholipases

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Sphingolipids

Sphingolipids are also found in membranes.

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SphingolipidsSphingomyelin

Compose 10-20% of plasma membrane

Head group couldalso be a

phosphoethanolamine group

-O3P-CH2CH2NH3+

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SphingolipidsCerebrosides

Sugar head group and no phosphate

From Avantilipids.com

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SphingolipdsGangliosides

• Most complex, found in brain tissue

Be familiar with

structure but do not memorize for Final

Exam

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Steroids:Structure of Cholesterol

Know this!

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Steroids

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Steroids

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Arachidonic Acid Breakdown

Involved in pain and fever,

blood pressure, blood

coagulation, reproduction

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Micelles

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Lipid Bilayer and Glycophorin A

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Biological Membranes