3D Printing for MicroFluidics Manufacturing

Innovative Manufacturing of Microfluidics

Jan Eite Bullema, Wijnand Germs, Marc van Kleef, Jelle Rohlfs

OUTLINE

• Introduction 3D Printing of Micro Fluidics

• 3D Printing for Microfuidics

• 3D Printing as a Manufacturing Technology

• MFManufacturing Project

• Conclusion

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

2

3D Printing for MicroFluidics Manufacturing

Introduction 3D Printing of Micro Fluidics

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

3

Source Scopus, December 1, 2015

Introduction 3D Printing of Micro Fluidics

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

4

F.P.W. Mechels, Additive Manufacturing of Tissue and Organs, Progress in Polymer Science 37 (2012) 1079-1104

Introduction 3D Printing of Micro Fluidics

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

5

Principle of VAT polymerisation

Glass

(blue) light curable resin

Release layer

Cured

Resin Layers

Product carrier Electronic semi-product

DLP Projector

Introduction 3D Printing of Micro Fluidics

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

6

Principle of VAT polymerisation

Glass

(blue) light curable resin

Release layer

Cured

Resin Layers

Product carrier Electronic semi-product

DLP Projector

3D Printing for Microfuidics: Printed Stenosis

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

7

Stenosis for Thrombosis on a Chip, BIOC material, Printed By TNO, 2015

3D Printing for Microfuidics: Printed micro Villi

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

8

3D Printed microVilli for Gut on a Chip in R11 Material, Printed By TNO, 2015

3D Printing for Microfuidics: Printed micro Villi

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

9

3D Printed microVilli for Gut on a Chip with Coca2 cells , BIOC material, Printed By TNO, 2015

3D Printing for Microfuidics: Vascular System

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

10

Vascular System for Alzheimer on a Chip, BIOC material, Printed By TNO, 2015

3D Printing for Microfuidics: Organ on a Chip

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

11

Cancer on a Chip Well Plate, First Prototype, BIOC material, Printed By TNO, 2015

3D Printing for Microfuidics: Organ on a Chip

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

12

Cancer on a Chip Well Plate, Current Device, BIOC material, Printed By TNO, 2015

3D Printing for Microfuidics: Serpentine Mixer

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

13

Serpentine Mixer, Printed By TNO, 2015

1

1 ~ 270 micron

2 ~ 450 micron

3 ~ 360 micron

4 ~ 470 micron

3D Printing for Microfuidics: Serpentine Mixer

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

14

Serpentine Mixer, BIOC material, Printed By TNO, 2015

1

1 ~ 570 micron

2 ~ 450 micron

3 ~ 450 micron

4 ~ 515 micron

4 ~ 415 micron

3D Printing for Microfuidics: Serpentine Mixer

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

15

Serpentine Mixer, CFD modelling, 2015

1

3D Printing for Microfuidics: Multiple Functions

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

16

Integrated Serpentine Mixer and Tesla Valve, BIOC material, Printed By TNO, 2015

3D Printing for Microfuidics: Multiple Functions

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

17

Serpentine Mixer and Tesla Valve as Modular Building Block, BIOC material, Printed By TNO, 2015

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

18

After: P. Neil, Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications, 2015

Company XY (mm) Z (mm) Biocomp. Price($)

EnvisonTEC 16 15 Yes 100.000

Digital Wax - 10 Yes 100.000

FormLabs 300 25 No 2.000

B9 Creator 50 6.35 No 2.400

Rapid Shape 25 25 Yes 25.000

Lepus Next Gen 20 20 Yes Development

VAT Equipment Developed by TNO

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

19

TNO Printvaley Machine , 2012

Printvaley Machine: Third Industrial Revolution

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

20

TNO Hyproline 3D Printing Machine, 2015

Hyproline: Hybrid AM production, Integrated Assembly, cyle time < 60 s

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

21

Carbon 3D: Continuous Liquid Interface Production , 2015

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

22

Carbon 3D: Continuous Liquid Interface Production , 2015

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

23

Nexa3D develops fast LSPc resin NX1 3D printer – prints up to a centimeter per minute, 2015

Nexa 3D: 25 mm in height per 3 minutes

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

24

TNO Lepus Next Gen printer, 2014

Lepus Next Gen: Fast, High Resolution and Large build platform (A4)

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

25

TNO Lepus Next Gen printer, 2015

3D Printing as a Manufacturing Technology

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

26

Euromold, Launch of the TNO Lepus Next Gen printer, 2014

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

27

MFManufacturing Project

Build microfluidic demonstrators based upon technology building

blocks that can be supplied by different technology providers

MFManufacturing Project, 2014-2017

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

28

MFManufacturing Project

To make microfluidic successful, printed or otherwise, we need microfluidic standards !

MFManufacturing Project, 2014

Dimensions and port positions

of the serpentine mixer building

block at standardized positions

CONCLUSION

• Introduction 3D Printing of Micro Fluidics

• 3D Printing for Microfuidics

• 3D Printing as a Manufacturing Technology

• MFManufacturing Project

• Conclusion

December 08, 2015

Jan Eite Bullema

MicroFluidics Manufacturing

29

3D Printing for MicroFluidics Manufacturing

MicroFluidicManufacturing