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ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Supercores – Genomics & Metabolomics/Proteomics
Indiana CTSI – Purdue Retreat
MONDAY, April 21, 2014
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Objectives
• Review how CTSI facilitates core use today
• Propose how “Supercores” can enhance research at CTSI member institutions
• Discuss challenges
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Access Technology Program
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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ATP and Cores
• Be a resource for investigators requiring core services– Help Desk and Liaisons– HUB
• Improve quality of core services
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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ATP People
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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70+ Cores and Resources
https://www.indianactsi.org/servicecores
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Comparative Options
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ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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• 46 CTSI Approved Cores– Initial Review– Annual reassessment
• Establish Policies• User satisfaction• Oversight committee• Approved prices by the University
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Supercore Concept
Investigators identifies Need
Need assessed:•Equipment•Expertise•Turnaround
Purdue
Notre Dame
IUB
IUSM
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Supercore Advantages• Core
– Provide more consistency of activity/ ? More activity– Collaboration / sharing of knowledge– Access to new technologies
• Investigator– Access to different technologies– More timely results
• Institution– Resource allocation savings– Integration with other cores– Negotiating vendor costs
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Challenges
• A21 Circular
• Regulation applies to billing for core services on federally funded grants
• Requirement related to accepting indirects on grant
• Charge must not exceed true cost of delivering service
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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A21 Challenge to Cores
• Don’t meet quota you run at a loss
• Exceed quota have to decrease prices
• No mark-up = no reserves
• No funds for development
• No funds to replace equipment
Cores can’t survive on this model
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Maintaining Core in the Black
• Institutional support– Provide base funding to allow development– Replace equipment and handle unexpected costs– Allow to subsidize costs so price to investigator may be less than actual cost of
service
• Find non-federal sources of support– Commercial work
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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CTSI Challenges to Supercores
• Prices differ among the 4 campuses for similar services
• Difference reflects level of institutional support for a core
• Inter-institutional prices need to balance investment by home institution and ease of use
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Next-Gen Sequencing Cores in the CTSI
• IUSM– SOLID 5500xl; Ion Torrent, Ion PGM
• Notre Dame– Illumina MiSeq
• IUB– Illumina MiSeq
• Purdue– Illumina HiSeq2500
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Sequencing Questionnaire
Workload Too variable, not enough
Too variableToo busy
* Not enough
Bioinformatics Outside core 50:50 core and outside
Both inside and outside core
Outside core
Sample prep Core Core Core and investigators
Core
Outsource of samples
0% 0% 65% 0%
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Sequencing Questionnaire Users
Own University 75% 80% 85% 84%
Other CTSI 25% 10% 10% 1.5%
Other Academic 0% 10% 5% 14%
Experience of Users
Very 10% 20% 50% 25%
Moderate 15% 30% 25% 45%
Inexperienced 75% 50% 25% 30%
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Today’s Workshop
• Hearing from the research community
• Broader discussion of – Advantages– Challenges
• Expand on the discussion