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PHARMACOLOGYPHARMACOLOGYThe Journal of
And Experimental Therapeutics
A Publication of the American Society for
Pharmacology and Experimental Therapeutics
Edited for the Society by Rick G. Schnellmann
Volume 325 ■ Number 1 ■ April 2008 ■ ISSN 0022-3565
DrugPredicted Effect
Unexpected Effect
A
Adaptations (Network Architecture) Can
Create Unpredicted Therapeutic Actions
Predicted
Drug TargetEffect
Complexity Creates Unpredicted Targets
Unpredicted Target
B
zpt0040800SPC1.qxd 3/11/08 10:55 AM Page 1
PERSPECTIVES IN PHARMACOLOGYExploiting Complexity and the Robustness of NetworkArchitecture for Drug Discovery
Marc K. Hellerstein 1
BEHAVIORAL PHARMACOLOGYEarly Postnatal Stress Alters Place Conditioning to Both �- and�-Opioid Agonists
Clifford C. Michaels and Stephen G. Holtzman 313
CARDIOVASCULAR□S Design of Mutant �2 Subunits as Decoy Molecules to Reduce the
Expression of Functional Ca2� Channels in Cardiac CellsSabine Telemaque, Swapnil Sonkusare,Terrie Grain, Sung W. Rhee, Joseph R. Stimers,Nancy J. Rusch, and James D. Marsh
37
Sphingosine 1-Phosphate Inhibits Nitric Oxide ProductionInduced by Interleukin-1� in Rat Vascular Smooth Muscle Cells
Takuji Machida, Yukihiro Hamaya,Sachiko Izumi, Yumika Hamaya, Kenji Iizuka,Yasuyuki Igarashi, Masaru Minami,Roberto Levi, and Masahiko Hirafuji
200
Andrographolide Up-Regulates Cellular-Reduced GlutathioneLevel and Protects Cardiomyocytes againstHypoxia/Reoxygenation Injury
Anthony Y. H. Woo, Mary M. Y. Waye,Stephen K. W. Tsui, Sandy T. W. Yeung, andChristopher H. K. Cheng
226
Orally Available Levosimendan Dose-Related Positive Inotropicand Lusitropic Effect in Conscious Chronically InstrumentedNormal and Heart Failure Dogs
Satoshi Masutani, Heng-Jie Cheng,Minja Hyttila-Hopponen, Jouko Levijoki,Aira Heikkila, Arja Vuorela, William C. Little,and Che-Ping Cheng
236
Evoked Changes in Cardiovascular Function in Rats by Infusion ofLevosimendan, OR-1896 [(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one],Dobutamine, and Milrinone: Comparative Effects on PeripheralResistance, Cardiac Output, dP/dt, Pulse Rate, and Blood Pressure
Jason A. Segreti, Kennan C. Marsh,James S. Polakowski, and Ryan M. Fryer
331
CELLULAR AND MOLECULARActivation and Inhibition of Adenylyl Cyclase Isoforms byForskolin Analogs
Cibele Pinto, Dan Papa, Melanie Hubner,Tung-Chung Mou, Gerald H. Lushington, andRoland Seifert
27
Phosphorylation Increases Affinity of the Phosphodiesterase-5Catalytic Site for Tadalafil
Emmanuel P. Bessay, Mitsi A. Blount,Roya Zoraghi, Alfreda Beasley,Kennard A. Grimes, Sharron H. Francis, andJackie D. Corbin
62
Proteasome-Dependent Pharmacological Rescue of Cystic FibrosisTransmembrane Conductance Regulator Revealed by Mutation ofGlycine 622
Caroline Norez, Frederic Bilan, Alain Kitzis,Yvette Mettey, and Frederic Becq
89
The Journal of
PHARMACOLOGYAnd Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
April 2008 Vol. 325, No. 1
Contents
The Journal of Pharmacology and Experimental Therapeutics (ISSN0022-3565) is published monthly by the American Society for Pharma-cology and Experimental Therapeutics, 9650 Rockville Pike,Bethesda, MD 20814-3995; email: info@aspet.org; web site:www.aspet.org. Periodicals postage paid at Bethesda, MD, and at addi-tional mailing offices. POSTMASTER: Send address changes to The Jour-nal of Pharmacology and Experimental Therapeutics, 9650 RockvillePike, Bethesda, MD 20814-3995. Subscription rates: U.S.: $893.00 forinstitutions and $389.00 for non-ASPET members. Outside the U.S.:$1,049.00 for institutions and $545.00 for non-ASPET members.
Single copy: $79.00. GST Tax Number for Canadian subscribers: BN:13489 2330 RT. Indexed or abstracted by Biochemistry & BiophysicsCitation Index®, Biological Abstracts, BIOSIS Previews Database, Bio-Sciences Information Services, Current Awareness in Biological Sci-ences, Current Contents®/Life Sciences, EMBASE/Excerpta Medica,Index Medicus, Medical Documentation Service®, PsycINFO, Refer-ence Update®, Research Alert®, Science Citation Index®, SciSearch®,and SIIC Data Bases. Copyright © 2008 by the American Society forPharmacology and Experimental Therapeutics. All rights reserved.Printed in the U.S.A.
Paradoxical Behavior of Neuromedin U in Isolated SmoothMuscle Cells and Intact Tissue
Paul J. Brighton, Alan Wise, Narinder B. Dass,and Gary B. Willars
154
G Protein Coupling and Ligand Selectivity of the D2L and D3Dopamine Receptors
J. Robert Lane, Ben Powney, Alan Wise,Stephen Rees, and Graeme Milligan
319
Mapping the Structural Requirements in the CB1 CannabinoidReceptor Transmembrane Helix II for Signal Transduction
Ankur Kapur, Patrick Samaniego,Ganesh A. Thakur, Alexandros Makriyannis, andMary E. Abood
341
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPYDesign and Evaluation of S-Nitrosylated Human Serum Albuminas a Novel Anticancer Drug
Naohisa Katayama, Keisuke Nakajou,Hisakazu Komori, Kunitoshi Uchida,Jun-ichi Yokoe, Norikiyo Yasui,Hisashi Yamamoto, Toshiya Kai, Makoto Sato,Takenobu Nakagawa, Motohiro Takeya,Toru Maruyama, and Masaki Otagiri
69
ENDOCRINE AND DIABETES□S (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-
quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), aNovel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has aSuperior Potency and Longer Duration of Action Compared withOther Dipeptidyl Peptidase-4 Inhibitors
Leo Thomas, Matthias Eckhardt,Elke Langkopf, Moh Tadayyon,Frank Himmelsbach, and Michael Mark
175
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL□S Discovery and Characterization of Novel Tryptophan Hydroxylase
Inhibitors That Selectively Inhibit Serotonin Synthesis in theGastrointestinal Tract
Qingyun Liu, Qi Yang, Weimei Sun,Pete Vogel, William Heydorn, Xiang-Qing Yu,Zhixiang Hu, Wangsheng Yu, Brandie Jonas,Randy Pineda, Valerie Calderon-Gay,Michael Germann, Emily O’Neill,Robert Brommage, Emily Cullinan, Ken Platt,Alan Wilson, Dave Powell, Arthur Sands,Brian Zambrowicz, and Zhi-cai Shi
47
Pharmacological Properties of N-(3,5-Diamino-6-chloropyrazine-2-carbonyl)-N�-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidineMethanesulfonate (552-02), a Novel Epithelial Sodium ChannelBlocker with Potential Clinical Efficacy for Cystic Fibrosis LungDisease
Andrew J. Hirsh, Jim Zhang, Andra Zamurs,Jacquelyn Fleegle, William R. Thelin,Ray A. Caldwell, Juan R. Sabater,William M. Abraham, Mark Donowitz,Boyoung Cha, Kevin B. Johnson,Judith A. St. George, M. Ross Johnson, andRichard C. Boucher
77
Inhibitory Phosphorylation of Soluble Guanylyl Cyclase byMuscarinic m2 Receptors via G��-Dependent Activation of c-SrcKinase
Karnam S. Murthy 183
5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-�]pyridine-8-carboxamide (CJ-033,466), aNovel and Selective 5-Hydroxytryptamine4 Receptor PartialAgonist: Pharmacological Profile in Vitro and GastroprokineticEffect in Conscious Dogs
Tadayoshi Mikami, Yasuo Ochi, Keiko Suzuki,Toshiyuki Saito, Yutaka Sugie, andMinoru Sakakibara
190
Regulation of Renal Ectophosphodiesterase by Protein Kinase Cand Sodium Diet
Edwin K. Jackson and Zaichuan Mi 210
Rutaecarpine Induces Chloride Secretion across Rat IsolatedDistal Colon
DaZheng Wu and ZhiBi Hu 256
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMAAnti-Inflammatory and Analgesic Potency ofCarboxyamidotriazole, a Tumorostatic Agent
Lei Guo, Caiying Ye, Wenying Chen, Hua Ye,Ru Zheng, Juan Li, Huifen Yang, Xiaoli Yu,and Dechang Zhang
10
□S Treatment of Sepsis-Induced Acquired Protein C DeficiencyReverses Angiotensin-Converting Enzyme-2 Inhibition andDecreases Pulmonary Inflammatory Response
Mark A. Richardson, Akanksha Gupta,Lee A. O’Brien, David T. Berg, Bruce Gerlitz,Samreen Syed, Ganesh R. Sharma,Martin S. Cramer, Josef G. Heuer,Elizabeth J. Galbreath, and Brian W. Grinnell
17
The Carbon Monoxide-Releasing MoleculeTricarbonyldichlororuthenium(II) Dimer Protects HumanOsteoarthritic Chondrocytes and Cartilage from the CatabolicActions of Interleukin-1�
Javier Megıas, Marıa Isabel Guillen,Antonio Bru, Francisco Gomar, andMarıa Jose Alcaraz
56
Evidence for the Role of Mitogen-Activated Protein KinaseSignaling Pathways in the Development of Spinal Cord Injury
Tiziana Genovese, Emanuela Esposito,Emanuela Mazzon, Carmelo Muia,Rosanna Di Paola, Rosaria Meli,Placido Bramanti, and Salvatore Cuzzocrea
100
□S Differential High-Affinity Interaction of Dectin-1 with Natural orSynthetic Glucans Is Dependent upon Primary Structure and IsInfluenced by Polymer Chain Length and Side-Chain Branching
Elizabeth L. Adams, Peter J. Rice,Bridget Graves, Harry E. Ensley, Hai Yu,Gordon D. Brown, Siamon Gordon,Mario A. Monteiro, Erzsebet Papp-Szabo,Douglas W. Lowman, Trevor D. Power,Michael F. Wempe, and David L. Williams
115
Thiopental Protects Human T Lymphocytes from Apoptosis inVitro via the Expression of Heat Shock Protein 70
Martin Roesslein, David Schibilsky,Laurent Muller, Ulrich Goebel,Christian Schwer, Matjaz Humar,Rene Schmidt, Klaus K. Geiger, Heike L. Pahl,Benedikt H. J. Pannen, and Torsten Loop
217
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS□S Aberrant Splicing Caused by Single Nucleotide Polymorphism
c.516G>T [Q172H], a Marker of CYP2B6*6, Is Responsible forDecreased Expression and Activity of CYP2B6 in Liver
Marco H. Hofmann, Julia K. Blievernicht,Kathrin Klein, Tanja Saussele,Elke Schaeffeler, Matthias Schwab, andUlrich M. Zanger
284
NEUROPHARMACOLOGYDevelopment and Preclinical Testing of a High-Affinity Single-Chain Antibody against (�)-Methamphetamine
Eric C. Peterson, Elizabeth M. Laurenzana,William T. Atchley, Howard P. Hendrickson,and S. Michael Owens
124
Correlating Efficacy in Rodent Cognition Models with in Vivo5-Hydroxytryptamine1A Receptor Occupancy by a NovelAntagonist, (R)-N-(2-Methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane Carboxamide (WAY-101405)
Warren D. Hirst, Terrance H. Andree,Suzan Aschmies, Wayne E. Childers,Thomas A. Comery, Lee A. Dawson,Mark Day, Irene B. Feingold,Steven M. Grauer, Boyd L. Harrison,Zoe A. Hughes, John Kao, Michael G. Kelly,Heidi van der Lee, Sharon Rosenzweig-Lipson,Annmarie L. Saab, Deborah L. Smith,Kelly Sullivan, Stacey J. Sukoff Rizzo,Cesario Tio, Mei-Yi Zhang, andLee E. Schechter
134
A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, ReducesTau Pathology and Enhances Cognitive Function in a MouseModel of Alzheimer’s Disease
Yasuji Matsuoka, Yan Jouroukhin,Audrey J. Gray, Li Ma, Chiho Hirata-Fukae,Hui-Fang Li, Li Feng, Laurent Lecanu,Benjamin R. Walker, Emmanuel Planel,Ottavio Arancio, Illana Gozes, andPaul S. Aisen
146
Nanomolar Propofol Stimulates Glutamate Transmission toDopamine Neurons: A Possible Mechanism of Abuse Potential?
Ke-Yong Li, Cheng Xiao, Ming Xiong,Ellise Delphin, and Jiang-Hong Ye
165
Calcitonin Gene-Related Peptide8-37 Antagonizes Capsaicin-Induced Vasodilation in the Skin: Evaluation of a Human in VivoPharmacodynamic Model
B. J. Van der Schueren, A. Rogiers,F. H. Vanmolkot, A. Van Hecken, M. Depre,S. A. Kane, I. De Lepeleire, S. R. Sinclair, andJ. N. de Hoon
248
Reversal of Chronic Inflammatory Pain by Acute Inhibition ofCa2�/Calmodulin-Dependent Protein Kinase II
Fang Luo, Cheng Yang, Yan Chen,Pradeep Shukla, Lei Tang, Lili X. Wang, andZaijie Jim Wang
267
Haloperidol and Clozapine Differentially Affect the Expression ofArrestins, Receptor Kinases, and Extracellular Signal-RegulatedKinase Activation
Mohamed Rafiuddin Ahmed,Vsevolod V. Gurevich, Kevin N. Dalby,Jeffrey L. Benovic, and Eugenia V. Gurevich
276
Dysregulation of Dopamine Transporter Trafficking and Functionafter Abstinence from Cocaine Self-Administration in Rats:Evidence for Differential Regulation in Caudate Putamen andNucleus Accumbens
Devadoss J. Samuvel, Lankupalle D. Jayanthi,Senthilvelan Manohar,Kolanjiappan Kaliyaperumal, Ronald E. See,and Sammanda Ramamoorthy
293
Differential Role of Nicotinic Acetylcholine Receptor Subunits inPhysical and Affective Nicotine Withdrawal Signs
K. J. Jackson, B. R. Martin, J. P. Changeux,and M. I. Damaj
302
□S Supplemental material is available online at http://jpet.aspetjournals.org.
About the cover: Fundamental reason for high attrition of drug candidates: outputs of complex biochemicalnetworks are unpredictable and are the true therapeutic targets. See the article by Hellerstein on page 1of this issue.
Rick G. Schnellmann, EditorCraig C. Beeson, Assistant Editor
ASSOCIATE EDITORSDarrell R. AbernethyIan AdcockJerry J. BuccafuscoPhilip S. BurtonDavid B. BylundPaul Ernsberger
Mitchell P. FinkAlan R. GintzlerRonald N. HinesMyron K. JacobsonMichael F. Jarvis
Norbert E. KaminskiRaouf A. KhalilDaniel R. KnappLawrence H. LashRoberto Levi
Louis M. LuttrellDavid S. MillerRichard A. MorrisettA. Leslie MorrowMichael J. O’Neill
Bryan L. RothRobert A. RothRoland SeifertKenneth D. TewStephanie W. WattsAlice M. Young
EDITORIAL ADVISORY BOARDGeoffrey W. AbbottThomas J. AbbruscatoPeter AbelEdson X. AlbuquerqueThomas M. ArgentieriBork BalkanWilliam A. BanksReina BendayanJack BergmanDaniel C. BertrandItalo BiaggioniFloyd E. BloomJean-Marie BoeynaemsFranco BorsiniMarco BrottoNancy BrownJohn CharpieLucio G. CostaBrian M. CoxBryan F. CoxBrian CummingsSalvatore CuzzocreaM. Imad DamajWilliam C. deGroatRussell Delude
Patrick DoughertyFrederick J. EhlertJohn L. EvendenSteven J. FeinmarkGiora Z. FeuersteinStephen F. FlaimAnthony W. FoxGert FrickerRyan FryerBernard W. FutscherJames J. GalliganVadivel GanapathyPatricia E. GaneyKathy GauthierGary GintantJohn R. GlowaSteven M. GrasslGarrett J. GrossPerry V. HalushkaGyorgy HaskoYuichi HattoriJ. Paul HiebleK. Roger HornbrookSusanna HouraniLeonard L. HowellDale G. Hoyt
John ImigHarry IschiropoulosEdwin K. JacksonDouglas JohnsKenneth M. JohnsonWilliam J. JuskoPeter W. KalivasLaurence S. KaminskyJonathan L. KatzMark R. KelleyLewis B. KinterThomas KocarekGeorge F. KoobSuk-Hee LeeRichard LockBenedict R. LucchesiJoseph J. LynchRosalinde MasereeuwPhilip R. MayeuxDonald E. McMillanMark J. MillanGary W. MillerVirginia MillerHitoshi MorikawaHasan MukhtarStanley Nattel
S. Stevens Negus IIIKim A. NeveYasuyuki NomuraJames S. NorrisGrazyna NowakJames M. O’DonnellPatricio O’DonnellMichael F. O’NeillMark OsinskiAchilles J. PappanoB. Kevin ParkSandra PfisterRussell O. PieperJohn B. PritchardRussell A. ProughRaymond M. QuockFabio RecchiaJ. Larry RenfroRichard RothmanMichael C. SanguinettiJonathan G. ScammellMichal Laniado
SchwartzmanFederico SestiDavid R. SibleyTheodore A. Slotkin
Mark SmithPhilip C. SmithNikolai M. SoldatovEdward E. SoltisPatricia K. SonsallaMichael D. SouthallRoger D. SpealmanFrancis G. SpinaleJohn L. SutkoDouglas SweetIstvan SzelenyiMilt TeitlerPaul F. TerranovaAlvin V. TerryMyron L. ToewsGeorge J. TrachteHiroshi UedaSandra P. WelchDaniel WierdaMichael WilliamsRaymond J. WinquistJeffrey M. WitkinBryan K. Yamamoto
BOARD OF PUBLICATIONS TRUSTEESJames E. Barrett, Chair; P. Jeffrey Conn, Ross Feldman, Lorraine J. Gudas, Eric F. Johnson, John S. Lazo, Edward T. Morgan,
Richard R. Neubig, Rick G. Schnellmann, Darryle D. Schoepp, and Mary VoreASPET EXECUTIVE OFFICER: Christine K. Carrico
Journals Director: Richard Dodenhoff Managing Editor: Jill Filler Senior Editorial Coordinator: David D. Williams
Journal and ASPET office: 9650 Rockville Pike, Bethesda, MD 20814-3995; telephone: 301-634-7060; fax: 301-634-7061; email: info@aspet.org; website: www.aspet.org; journal web site: jpet.aspetjournals.org.Editorial matters should be addressed to Dr. Rick Schnellmann, Editor, TheJournal of Pharmacology and Experimental Therapeutics, at the above ad-dress.Official version: The online version of The Journal of Pharmacology andExperimental Therapeutics contains all of the information and material con-tained in the print version plus additional material that may not appear inprint such as videos and large data sets. The online version may be morecurrent than the print version. Where noted, the online version has beencorrected in departure from the print version. The online version of TheJournal of Pharmacology and Experimental Therapeutics officially publishedby the American Society for Pharmacology and Experimental Therapeutics isthe definitive version and, to the extent any difference exists, will prevail overthe print version.Instructions to Authors: See jpet.aspetjournals.org for the Instructions toAuthors and the ASPET Authorship Responsibility, Financial Disclosure, andCopyright Transfer form.Subscriptions: Contact the ASPET Subscriptions Dept., 9650 RockvillePike, Bethesda, MD 20814-3995; telephone: 301-634-7782; fax: 301-634-7061;email: subscriptions@aspet.org. For multi-site and consortia sales in Europe,contact: David Charles, eLicensing, 92 avenue du General de Gaulle, 78600,Maisons-Laffitte, France; telephone: �33-1-39-12-29-29; fax: �33-1-39-12-47-45; email: dc.elicensing@organge.fr.Change of address: ASPET must be notified 60 days in advance. Copiesundeliverable because of incorrect address will be destroyed. Duplicate copiesmay be obtained, if available, from ASPET at the single copy price. Sendaddress changes to the ASPET office.Issue replacement policy: Domestic subscribers—Claims for nondelivery ofissues must be made within three (3) months of issue mail date. Foreignsubscribers—Claims for nondelivery of issues must be made within six (6)
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The Journal of Pharmacology and Experimental TherapeuticsA Publication of the American Society for Pharmacology and Experimental Therapeutics
Founded by John J. Abel - 1908