Post on 20-Dec-2015
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B-Cell Epitopes
Chapter 10
Antibodies
Antibody - Antigen interaction
Fab
Antigen
Epitope
Paratope
Antibody
Antibody Effect
Virus or Toxin
Neutralizing Antibodies
B-Cells
B-lymphocytes each displaying a unique B-cell receptor
Stem Cell
Precurser B-lymphocytes
Gene rearrangements
Gene Shuffling
José Saldanha © 2000. Birkbeck College, London WC1E 7HX.
B-Cell ActivationNo Affinity
Low Affinity
No Affinity
High Affinity
Somatic Hypermutations
Memory B-cells
Plasma cells
B-Cell Activation
B Cell
T Helper Cell
Class II MHC
Bound Peptide
TCR
Cartoon by Eric Reits
Structural Epitopes
Discontinuous Epitopes
Variable regionsAlpha-carbon trace of the structure of the heavy chain and light chain variable regions of a typical antibody. The framework regions of both chains are shown in grey whilst the complementarity determining regions (CDRs) are coloured individually, i.e.
Heavy chainCDR 1 = Light blueCDR 2 = CeriseCDR 3 = Yellow Light ChainCDR 1 = RedCDR 2 = GreenCDR 3 = Blue
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CDR Regions
CDR = complementarity determining region
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