Bellingham + Stanley Refractometers Latest Applications · 2017-05-24 · Bellingham + Stanley A...

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Bellingham + Stanley

Refractometers Latest Applications

A World Leader in

the Manufacture

and Sales of High

Quality

Refractometers

and Polarimeters

ISO 9001-2008

Bellingham + Stanley Ltd. operates a Quality Management System

complying with ISO 9001:2008 (Certificate Number LRQ 0963791)

Past and Present…..

Company Locations and Representation

Head Office and Factory, Tunbridge Wells, UK

Bellingham + Stanley USA

Sales & Service for USA, Atlanta, USA

Bellingham + Stanley Authorised Dealers and

Distributors in over 90 Countries

Xylem Sales & Support Centres in every

continent

Markets & Applications

Industry Sectors

Industrial

Research, Education

& Government

Beverages

& Sugars

Market Split

Food 31%

Beverage 29%

Pharma 22%

Industrial 7%

Education 11%

Research, Education & Government

Research Laboratories – commercial & government

Education – Schools, Colleges & Universities

Industrial

• Pharmaceutical (USP781/831)

• Chemical

• Petrochemical

• Aviation (fuel, ice inhibitors)

• Hydraulic fluids

• Fire fighting foam

• Surfactants, detergents

• Shampoo

• Starches (paper/textiles)

• Flavours, fragrances

• Essences, oil

• Cosmetics

• Resins & adhesives

• Petrochemicals, waxes

• Lubricants, quenchants

• Biofuels, ethanol, oils

• DEF/AdBlue®, antifreeze

• Seawater

• Fruit Ripeness

• Canned Fruits

• Jams, Jellies, Gelatine

• Stabilisers (gum acacia etc.)

• Liquid egg

• Yeast cultures

• Honey

• Edible oils

• Dairy (Yoghurt/milk/butter)

• Ketchup & salsas

• Mustards

• Cooking sauces & soups

• Edible starches

• Confectionary (fondants,)

• Toffee, Taffy

• Cocoa & chocolate

• Brine

Beverages & Sugars

• Carbonated Drinks

• Diet Drinks

• Soft Drinks Syrups

• Orange Juice

• Juices General

• Fruit Concentrates

• Lactic Acid Beverages

• Energy Drinks

• Milkshakes

• Flavoured Waters

• Beer Malts

• Ciders

• Wine Alcohol

• Alcopops

• Sugar

• Fructose

• Glucose

• Molasses

• Cane Juice

• Beet Juice

• Corn Syrup

• Coffee

• Sweet Tea

12 © all trademarks recognized

Global Customers

Latest Application

Precise Control

Model RFM330-T RFM340-T

Scale Brix, RI & user Brix, RI & user

Range 0 – 100 Brix

1.32 – 1.58 RI

0 – 100 Brix

1.32 – 1.58 RI

Resolution 0.1 / 0.0001 0.001 / 0.000001 (Selectable to 6 d.p.)

Accuracy 0.1 / 0.0001 0-30 Brix: 0.01 / 0.00002 (1.32-1.38 RI)

30-100 Brix: 0.03 / 0.00004 (1.38-1.58 RI)

Precision

(Reproducibility*)

0.05 / 0.00005 0.004 Brix / 0.000006 RI)

Reading time 4 seconds minimum (dependant on precision required)

Working Temp Range 0°C or 10°C below ambient whichever is greater to 80°C

Automatic Temp Comp Brix, User (to any C)

User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose SG (3),

PHR-MEAN, Urea and more; plus customer programmable user scales via PC.

Interface 3 x USB (A) 1 x USB (B)

1 x Ethernet 1 x Serial (RS232)

Using a traceable homogenous sample under laboratory conditions at 20°C

RFM300-T & RFM300-M Measurement Specification

Production Line Effeciency

RFM300-Flow for Tare House

Also great for fruit juice and carbonated beverage producers as a funnel

flowcell reduces the need to clean the prism between each sample!

Making Measurement Easy

It’s not that simple!

RI also depends on temperature

20 N is the symbol for RI

D = sodium D line (589 nm)

20 = 1.00000

20 = 1.33299

For air,

For water,

When defining RI, the wavelength and temperature are specified:

RI depends on the wavelength of light

Natural light is made up of light of

different colour or wavelength (energy)

Control = Profitability (Case Study)

Refractometers ‘The Models’

Eclipse Professional Handheld Refractometers

NEW - Easy Read Scales

NEW - Higher resolution

Bright Field of View

Sealed construction

Unique Dribble Feed

Zero adjust (lock)

Ergonomic Design

Anti-roll supports

Push on prism flap

Serial Numbered

Certificate

OPTi Refractometer - Features

Single & Dual (Duo) Scale Models

Full & High Range

Robust sealed design

Silicon rubber keypad (not plastic!)

2-second read time

Zero calibration (all models!)

AG Test Mode (unique!)

-HAL- “High Ambient Light” Detection

Temperature Display

Temperature in °C or °F

Simple operation

No operator errors = PRECISION

Portable or laboratory (back-up!)

Certificate by B+S (UKAS/NIST traceable)

OPTi Refractometer – ONE to FOUR

Scale: 0-54 Brix

Code: 38-02

• Covers 80% of applications

Scale: 40-95 Brix

Code: 38-33

• Covers syrups and jams at a low price

OPTi THREE

Scale: 0-95 Brix

Code: 38-A1

• Covers Full Brix scale incl. syrups for confectionary

Scale: 0-83 Brix

Code: 38-34

• Best price covering commonly used Brix scale

Digital Refractometers

RFM700-M Series Refractometers

Food, beverage, sugar &

other applications with ATC.

Launch: January 2017

RFM700-M Series - Technical Specification

Model RFM712 RFM732 RFM742

Scale % Sugar (Brix)

Range 0 – 50 0 – 100 0 – 100

Resolution 0.1 0.1 0.01

Accuracy 0.1 0.1 0.04

Reading time 4.5 4.5 seconds (delay option)

Working Temp Range

5 – 80 C

Automatic Temp Comp

to 20 C

Interface USB A,B Ethernet & RS232

RFM300 Series Refractometers

•RFM300-M Series keypad for industrial applications

•RFM300-T Series touchscreen for lab & factory

Instrument Key Feature

Flat Prism Dish with sapphire prism Easy application and cleaning

RFM300-M Important Features

• Choice of RI accuracy – RFM330-M and RFM340-M

• Intelligent thermal control – 6 sensors

• Peltier temperature control to 70°C

• Rapid temperature response/Stability

• SMART temperature stability checks – sample & calibration

• Measurement Range up to 1.58 RI

• Super flat prism dish for easy cleaning

• Wide measurement beam – non-homogenous samples

• Keypad – membrane for safe factory use

RFM300-Flow Refractometers

• Macro flowcell

• Funnel flowcell

• Same spec as RFM300+s

RFM-T Series Refractometers

•RFM300-T Series for industrial applications

•RFM900-T Series for high precision applications covering 1.30-1.70 RI

RFM-T Series – New & common features

7 “ Touchscreen full colour HD display

USB (A), USA (B), Ethernet & RS232 connectivity

Single low noise, low maintenance, inter-changeable fan

6 decimal place precision – Refractive Index

3 decimal place precision – Brix

Remote diagnostics via Ethernet

Simple USB Back-up & Clone for multi-instr. configuration

Print to Secure PDF

RFM300-T Series for industrial applications with easy-clean prism and

wide beam optics for measuring non-homogenous samples

RFM900-T Series for high precision applications covering a wide RI

range and fully confirming to Pharmacopeia and FDA reg. 21 Part 11

RFM-T Series Common Features

Peltier + Air Flow Temperature Control

Intelligent and accurate thermal sensing

Controlled Sample Containment

Network connection via ethernet for

remote lab monitoring

Chemical-Resistant ABS Construction

Strict Password Control

RFID User Identification & Clearance

8000 stored results for tabular display or o/p

Flat prism dish – especially RFM300-T Series

Materials of Construction

ABS Housing

Sapphire Prism

316 Stainless Steel Sample Dish

PEEK* Insulation and Spill Barrier

Kalrez* Seals (RFM900-T)

* Chemically-Resistant Plastics

Controlling Sample Temperature to Target Value

System of Powerful Peltier Devices

Pumped Air Flow (with single dust filter)

Single low-noise, easy maintenance fan

Configurable on-screen filter change prompt

Rapid Heating/Cooling of Sample

Wide Operating Temperature Range: 10 below ambient to 80 °C

Software Features

4 levels of security – NONE-LOW-MEDIUM-HIGH

SMART & other temp. stability checks settings”

“Methods” system for one-touch configuration

Readings Limits Check

Installation Wizards

At least 4 menu ‘languages’

Software - Methods

Measuring mode and measuring

specifications can be stored against a

product code/name

Scale and Temperature Compensation

Reading limits/tolerances

Result verification feature

‘Wizard’ to facilitate set-up of methods

Target temperature for readings

Analytical Methods – coffee / D 2140 / pharma

Insert an image to help users navigate!

Software - Quality Management

Meeting the requirements of FDA 21 CFR Part 11, GLP, HACCP

• Date and Time Recording

• Product and Operator Identifiers:

(Audit Trail*)

• Reading Log:

(not available to highest level of security)

• Calibration Log: (Audit Trail*)

• Calibration Check and Report

• PIN Password Control:

(in accordance with CFR21 Part 11)

Interfaces

-Ethernet connection for LAN

-USB (A) x 3

-USB B connection x 1

-RS232 serial x 1

cables not supplied – generally available

The RS232 is used for GLP printers (dot-matrix

Back Plate

RFM300-T Refractometer Series

• 1.32-1.58 RI

• Flattest prism

• Wide beam optics

1.32 – 1.58 RI

0 – 100 Brix

1.32 – 1.58 RI

Accuracy 0.1 / 0.0001 0-30 Brix: 0.01 / 0.00002 (1.32-1.38 RI)

30-100 Brix: 0.03 / 0.00004 (1.38-1.58 RI)

Precision

(Reproducibility*)

0.05 / 0.00005 0.004 Brix / 0.000006 RI)

User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose SG (3),

PHR-MEAN, Urea and more; plus customer programmable user scales via PC.

RFM300-T & RFM300-M Measurement Specification

RFM300-T Features

RFM300-T Series – New Opportunities!

-High resolution capacitive touchscreen

-Wide beam optics range – 1.32 to 1.58 RI

-Peltier Temperature Control

-Enhanced Brix performance 0-30 ±0.01 Brix

- Flattest Easy Clean prism

-SMART temperature control

-Dual Display function for Brix & equivalent SG for beverages

RFM300-T & RFM300-M - Application Scope

RFM300-M/T – wide beam optics and flat prism

• Beverage

• Industrial surfactants & emulsions

• Edible Oils

• Sauces & soups

• Sugar syrups & concentrates

Suitable for harsh industrial applications

• Confectionery

RFM900-T Refractometer Series

• 1.30-1.70 RI

• Kalrez® gasket

• Pharma & Petro

RFM900-T Features

RFM900-T Series – New Opportunities!

-High resolution capacitive touchscreen

-Wide range – 1.30 to 1.70 RI

-Up to 6 decimal places RI

-Easy clean prism

-SMART temperature control

1.30 – 1.70 RI

0 – 100 Brix

1.30 – 1.70 RI

Accuracy 0.1 / 0.0001 0.02 / 0.00002

Precision

(Reproducibility*)

0.05 Brix

0.00005 RI

0.005 Brix

0.000005 RI (6 d.p. RI)

User Scale Library 20+ pre-programmed scales including HFCS (3), sugar (4), sucrose

SG (3), PHR-MEAN, Urea and more; plus customer programmable

user scales via PC.

RFM900-T Measurement Specification

RFM900-T - Application Scope

RFM900-T - very wide measuring range - RI and Temperature

• Research Institutes & academia

• Flavours, Fragrance & Essences

• Chemicals & Industrial

• Pharmaceuticals incl. veterinarian

• Petroleum & derivatives

Suitable for high end laboratory applications

• Healthcare & Cosmetics

Why buy an RFM-T/ M Series Refractometer?

• Capable of six decimal place precision RI (3 d.p. Brix)

• Peltier temperature control

• Ergonomically designed so that any spills are dealt with by its

sloping shape or by the PEEK spill barrier.

• High definition full colour capacitive touchscreen

• RFID user clearance on all models

• USB & Ethernet connectivity

• Almost noise free, maintainable fan

• RFM300-T Series with wide beam optics and flattest easy-clean

prism for “difficult” samples within food, beverage and other

harsh industrial applications. Keypad version available (2017)

• RFM900-T Series wide measuring range 1.30-1.70 RI with

Kalrez® gasket for use in the chemical, petrochemical,

pharmaceutical, flavours & fragrance industries

QUALITY

MEASUREMENT

Sample

Preparation

Experimental

Protocol

Instrument

Capability Instrument

Interaction

(Care)

Interpretation

What makes a good reading?

Certified Reference Materials

Product Training

Jan 2017

A UKAS accredited calibration

laboratory

No. 0834

A UKAS accredited testing

laboratory

No. 2798

CRM – Verification & Calibration

CRM - ILAC-MRA Statement

http://www.bellinghamandstanley.com/ltd/newcalibration/ilac_signatorysearch.html

• The United Kingdom Accreditation Service (UKAS) is

one of the signatories to the International Laboratory

Accreditation Co-operation (ILAC) Arrangement for

the mutual recognition of calibration certificates.

• This means your local accreditation body accepts

UKAS certification as if it were it’s own!

• This is very powerful in terms of persuasion!

Water – 1.33299 & 0.00 Brix

Oils – Range 60 - 90 Brix (1.46 to 1.56RI)

Sugars – Range 5 - 60 Brix

AG Fluids – 2.5 - 40 Brix (1.334 to 1.40RI)

Solid Materials* – glass, silica

*Not recommended for digital instruments

CRM – Commercially Available Samples

CRM – Example Certificate of Calibration (AG40)

Thank you for your attention Any questions?….

Coffee Break……

Polarimeters

Polarimeters - Past and Present…..

Polarimeter Principle

Light source

Polariser

Analyser Eye

Tube (sample)

= angle of rotation

D = dextrorotatory (right hand or

clockwise)

L = Laevorotatory (left hand or

counter clockwise).

Polarimeter Scales

Chemical and Pharmaceutical Industries -

°Angular Scale (°A)

% Concentration

Sugar and Food Industries -

International Sugar Scale (°Z)

Purity

% Inversion

% Invert Sugar

% Concentration

Temperature

Optical Rotation is affected by temperature

Typically 20 °C is used when measuring

optical rotation in Europe (25 °C USP)

Normally samples are stabilised at the

required temperature of measurement

before analysis

Or special ‘temperature controlled

tubes’ are used

ADP 430 - High Resolution / Security Polarimeter

ADP450- Patented XPC Technology

XPC Technology - Xylem’s patented

on-board Peltier temperature control system

ADP430 / 450 Accuracy

Angular (°A)

Sugar (°Z)

Resolution

±0.001

Accuracy

±0.01

±0.03

Reproducibility

±0.002

±0.006

Validation Documentation (IQ/OQ/PQ)

Software – Quality Management

Meeting the requirements of FDA (21 CFR Part 11)*, GLP, ISO...

Date and Time Recording

Product and Operator Identifiers – (Audit Trail*)

Reading Log – (not available to highest level of security)

Calibration Log – (Audit Trail*)

Calibration Check and Report

PIN Password Control (in accordance with 21 CFR Part 11*)

ADP 430 / 450 Methods

Similar to RFM900 Series

Specific Rotation & Concentration Methods

Pharmaceutical MEAN Method

Rapid configuration

RFID User Clearance & Tabular navigation thru audit

% Invert Sugar & % Inversion (start – finish) Methods

Standard Display

A METHOD system is available in place of the standard MODE

function by internal software switch!

Specific Rotation

Reading mode options

ADP 430 / 450 Advantages

HIGHEST SPEC POLARIMETER – competes with …….

ADP450- Patented XPC Technology

CONFORMS to technical requirements 21 CFR Part 11

CONFORMS to minimum requirements of EP/USP/BP/JP

HIGH SALES POTENTIAL

CONFORMS to technical requirements of ICUMSA

LOWEST price 3-decimal polarimeter in market

Why buy the ADP430 / 450

• ADP450- Patented XPC Technology. Peltier temperature control

with easy to fit tubes.

• New Single or Continuous Read Mode Quick identification of

drift, bubbles or erroneous results

• Specific / Concentration Calculation – reduces risk of user error

– faster than manual calculation

• Connection capabilities ensure instrument is ready for future lab

• Storing results / batch / User ID – improving results + traceability

• Above 5 °A it matches performance of many high end

competitors!

ADP 600 Series Polarimeter

Our Models…..

ADP600 Series – New Opportunities!

-High Resolution – 4 decimals

-High Accuracy – 3 decimals

-Multiple Wavelength – 6 options (UV/Vis)

-HD Touch-screen display

-Latest Technology Communications

ADP600 – USP Nomograms NOT at 589nm

Nomogram Wavelength Acceptance

(Specific Rotation)

Metyrosine 546nm 185 195

Iopamidol 436nm -4.6 -5.2

Saquinavir Mesylate 436nm -66.8 -69.6

Finasteride 405nm -56 -60

Lisinopril 405nm -115.3 -122.5

Metaraminol Bitartrate 405nm -31.5 -33.5

Methydopate Hydrochloride 405nm -13.5 -14.9

Timolol Maletate 405nm -11.7 -12.5

Indinavir Sulfate 365nm 122 129

Physostigmine 365nm -236 -246

Ropivacaine Hydrochloride 365nm -210 -255

Vidarabine 365nm -56 -65

Dextromethorphan Hydrobromide 325nm 1%* 1%*

Polarimeter Selection Guide

TEMP Accuracy °A @

Wavelength

Model Peltier ±0.02 ±0.01 ±0.003 325nm 365nm 405nm 436nm 546nm 589nm

ADP430 √ √

ADP450 √ √

ADP610 √ √ √

ADP620 √ √ √ √

ADP622 √ √ √ √

ADP640 √ √ √ √ √ √

ADP650 √ √ √ √ √ √ √

ADP660 √ √ √ √ √ √ √ √

ADP600 Peltier Performance

Sample Temp Set Temp Stabilisation Time

35°C 20°C 4 minutes

5°C 20°C 5 minutes

22°C (ambient) 20°C 2 minutes

The speed and efficiency of the Peltier system enables the set point

temperature to be reached in the quickest time possible, typically within two

minutes for a 10ml sample in a glass tube at or around ambient temperature.

Above are the extremes!

Bellingham + Stanley Refractometers Latest Applications · 2017-05-24 · Bellingham + Stanley A...

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