Biology 151 lecture 1 2012 2013

transcript

Monday, June 18, 2012

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BIOLOGY 151 (INTRODUCTION TO IMMUNOLOGY)

1. Orientation2. Overview of Immunology a. History of Immunology & Famous Personalities b. General Properties & Components of the Immune System

ORIENTATION

COURSE DESCRIPTION: Structure and Function of the Immune System; Antigen-Antibody Reactions; Genetic Control of the Immune System and Basic Immunological Techniques

COURSE CREDIT: 3 units (2 units lecture and 1 unit laboratory)

PREREQUISITES: Biology 10, 21, 22; Chemistry 40 and 40.1

ORIENTATION

COURSE OBJECTIVES

ORIENTATION

COURSE OBJECTIVES

Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;

ORIENTATION

COURSE OBJECTIVES

Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge;

ORIENTATION

COURSE OBJECTIVES

Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies;

ORIENTATION

COURSE OBJECTIVES

Be familiar with the mechanisms of the different immunodeficiencies;

ORIENTATION

COURSE OBJECTIVES

Define and differentiate the types of vaccines and their uses; and

ORIENTATION

COURSE OBJECTIVES

Define and differentiate the types of vaccines and their uses; and

Determine the ethical considerations in the study and applications of Immunology in research

CALENDAR OF ACTIVITIESDATE ACTIVITY

June 19 (2 hours) ORIENTATION & OVERVIEW OF IMMUNOLOGY

History of Immunology and Famous Personalities

General properties and components: the cells and their function

June 26 (2 hours) ANTIGENS AND ANTIBODIES

July 3-10 (4 hours) INNATE & ADAPTIVE IMMUNITY

July 17-24 (4 hours) HUMORAL & CELLULAR IMMUNITY

July 31 EXAMINATION 1

August 7 (2 hours) PATHOGENESIS OF BACTERIAL INFECTIONSa. Immunity to bacteriab. Important bacterial infectionsc. Serological diagnosis to detect antigens and antibodies

August 14 (2 hours) PATHOGENESIS OF VIRAL INFECTIONSa. Immunity to virusesb. Important viral infectionsc. Serological diagnosis to detect antigens and antibodies

August 21-24 BIOWEEK CELEBRATION: CLASS POSTER PRESENTATION

August 28 (2 hours) PATHOGENESIS OF FUNGAL INFECTIONSa. Immunity to fungib. Important fungal infectionsc. Serological diagnosis to detect antigens and antibodies

September 4 (2 hours) PATHOGENESIS OF PARASITIC INFECTIONSa. Immunity to parasitesb. Important parasitic infectionsc. Serological diagnosis to detect antigens and antibodies

September 11 EXAMINATION 2

September 18 ( 2hours) IMMUNODEFICIENCIESa. Immunologic tolerance and hypersensitivitiesb. Selected immunodeficiencies (e.g. HIV, etc)

VACCINES a. types of vaccines and their designb. Philippine laws on vaccinationc. vaccine challenges

September 25 CLASS PLENARY REPORT: VACCINE CHALLENGES (HIV, pandemics, vector-borne or zoonotic diseases)

October 2 EXAMINATION 3

EXAM 1: JULY 31, 2012

EXAM 2: SEPT 11, 2012

EXAM 3: OCT 2, 2012

COURSE REQUIREMENTA. Lecture (60%)

Lecture exams (3)! ! 60%

Quizzes! ! ! 20%

Plenary Report!! 20%

B. Laboratory (40%)

Laboratory exams (2)!! 50%

Laboratory reports! ! 10%

Journal report! ! ! 10%

Quizzes! ! ! 10%

Laboratory performance! 10%

EXAMS & QUIZZES

sit-down, written exam; class hours

objective and critical thinking type

QUIZZES

individual, pair, group, class quizzes

written, oral or take-home

no make-up for missed quizzes!

CLASS plenary

CONFERENCE-TYPE OF PAPER PRESENTATIONS

3 PAPERS: VACCINE CHALLENGES (HIV, pandemics, vector-borne or zoonotic diseases)

TASKS: Speakers, Master of Ceremonies, Moderator, Reactors, Technical Group, Logistics Group, Refreshments Group, Press Group, etc

CLASS GRADE: Absent during the presentation is given a ZERO (0) mark

your grade

PFG = lecture (60%) + laboratory (40%) rating

NOTE: This will be the final grade when exempted to take the final exams.

If the student will take the finals the rating will be computed as follows, which should be no lower than 60% or 3.0:

RATING = PFG (80%) + Score in Finals Exam (20%)

OUR TEXTBOOK

Abbas, Abul K. and Andrew H. Lichtman. 2004. Basic Immunology: Function and Disorders of the Immune System. 2nd ed.

POLICIESThe student should be able to pass (PFG = 3.0) both lecture and laboratory component to pass the course

There will be no make-up exams, missed exams will qualify students to take the final examination. The score in the final exam may replace the missed exam. However, in the case of two missed exams, the other exam will have a score of zero (0)

The student should be able to incur a PFG of 2.0 or better to be exempted to take the written final exam

Should the student fail the final exam, an oral removal exam to satisfy the course competencies will be given to pass the course. The grade to be given here shall only be a “pass” (3.0) or “fail” (5.0)

QUESTIONS???Monday, June 18, 2012

RECALL from BIOLOGY 120THE WAR WITH

MICROBES...

HOW WE FIGHT INFECTIONS...

www.youtube.com/watch?v=T_4TrNRa3v8Monday, June 18, 2012

TODAY....Looking back.........

famous personalities

how it all started

Who’s who of our immune system...

general functions

International Journal of Infectious DiseasesVolume 3, Issue 1, July-September 1998, Pages 54-60

!▪! 2001 – Discovery of FOXP3 – the gene directing regulatory T cell development!▪! 2005 – Development of human papillomavirus vaccine (Ian Frazer)

CELLS & ORGANS OF THE IMMUNE SYSTEM

INNATE

HUMORAL

complement system

CELLULAR

monocytes (macrophages, dendritic cells)

NKC (natural killer cells)

granulocytes (mast cells and , basophils, eosinophils, neutrophils)

ADAPTIVE

HUMORAL

antibodies

complement system

CELLULAR

B cells

T cells

organs of the immune system

MUST KNOW...ANTIGEN

ANTIBODIES

OJT: IMMUNE CELLS

OUR IMMUNE SYSTEMPhysiologic function of the immune system:

prevent infections

eradicate established infections

vaccines: stimulation of our Immune System

OUR IMMUNE SYSTEM

INNATE: immunity which mediates the initial protection against infections

always present in health individuals

block the entry of microbes and rapidly eliminate microbes that do succeed in entering host tissues

ADAPTIVE: immunity which!develop more slowly and mediates innate immunity

more effective defense against infections

specific or acquired

stimulated by microbes that invade tissues

adapts to the presence of microbial invaders

overview: host defense mechanisms

OVERVIEW: HUMORAL & CELL-MEDIATED IMMUNITY

NOTE: ADAPTIVE RESPONSE

Immunity may be induced in an individual by infection or vaccination (active immunity) or conferred on an individual by transfer of antibodies or lymphocytes from an actively immunized individual (passive immunity)

SPECIFICITY & MEMORY

OVERVIEW: PHASES OF ADAPTIVE IMMUNITY

MAJOR CHARACTERS OF THE IMMUNE SYSTEM

THE EFFECTOR FUNCTIONS

When naive lymphocytes recognize microbial antigens and also receive additional ("second) signals induced by microbes, the antigen-specific lymphocytes proliferate and differentiate into effector cells and memory cells

Naive lymphocytes express receptors for antigens but do not perform the functions that are required to eliminate antigens

Differentiation into effector cells and memory cells is initiated by antigen recognition, thus ensuring that the immune response that develops is specific for the antigen

END OF LECTURE 1

Biology 151 lecture 1 2012 2013

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