Bone developmentand

skeletal growth

Przemko Tylzanowski

przemko@kuleuven.be

http://tolweb.org/tree/

http://www.hps.cam.ac.uk/people/hopwood/haeckel.pdf

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6

7

9

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Collagen type II reporter

Weismann et al. Genetics 2015

http://www.scientificamerican.com/slideshow/neurology-neural-cells-brain-in-psychedelic-relief/#9

Livet et al., Nature 2007

Histology

http://www.eurogrow.net/eug/Project+Information/Objectives

Li et al., eLife 2017

Li et al., FASEB J 2017

http://pixgood.com/lateral-plate-mesoderm.html

wt heterozygote

Human heterozygote

Human mutations in RUNX2 lead to cleidocranial dysplasia (CCD)

Otto et al. Cell, 1997 Mundlos et al. Cell, 1997

27Ingo Arndt

Spielman et al. HMG 2016

30

Lupianez et al, Cell 2015

Petit et al., NatRevGen 2017

Spielman et al. AJHG 2012

Liebenberg Syndrome

Ospelt et al, NatRevRheuma. 2017

Thank you