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GGNNIIPPSSTT UULLLL TTIINN 22 1144
13th
June , 2014 Volume No.: 34 Issue No.: 03
Vision
O REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIOF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASE
LEARNING AND PRACTICE
ontentsMessage from
PRINCIPAL
Editorial board
Historical article
News Update
Knowledge based Article
Disease Related
Breaking News
Upcoming Events
Drugs Update Campus News
Student’s Section
Editor’s Note
Archive
GNIPST Photo Gallery
or your comments/contribution
For ack-Issues,
ailto:gnipstbulletin@gmail.com
GURU NANAK INSTITUTE OF PHARMACEUTICAL
SCIENCE AND TECHNOLOGY
Website: http://gnipst.ac.in
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MESSAGE FROM PRINCIPAL
" It can happen. It does happen.
But it can't happen if you quit ." Lauren Dane.
‘We are what we repeatedly do.
Excellence then is not an act, but a habit .’ Aristotle
It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the
last year’s editors and congratulate the newly selected editors for the current year.
Our first consideration is always in the best interest of the students. Our goal is to promote academicexcellence and continuous improvement.
I believe that excellence in education is aided by creating a learning environment in which all learners are
supported in maximizing their potential and talents. Education needs to focus on personalized learning
and instruction, while promoting an education system that is impartial, universally accessible, and meeting
the needs of all students.
It is of paramount importance that our learners have sufficient motivation and encouragement in order to
achieve their aims. We are all very proud of you, our students, and your accomplishments and look
forward to watching as you put your mark on the profession in the years ahead.
The call of the time is to progress, not merely to move ahead. Our progressive Management is looking
forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in
this direction and fruits of these efforts will be received by our students in the near future. Our Teachers
are committed and dedicated for the development of the institution by imparting their knowledge and play
the role of facilitator as well as role model to our students.
The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive
challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic
needs of our students.
I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the
opportunities and meet the challenges with purpose and determination.
Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on
this path.
My best wishes to all.
Dr. A. Sengupta
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EDITORIAL BOARD CHIEF EDITOR DR. ABHIJIT SENGUPTA
EDITOR MS. JEENATARA BEGUM
ASSOCIATE EDITOR MR. DIPANJAN MANDAL
HISTORICAL ARTICLE
HISTORICAL NOTES ON PHARMACY:The beginnings of pharmacy are ancient. When the first person
expressed juice from a succulent leaf to apply to a wound, this art
was being practiced. In the Greek legend, Asclepius, the god of thehealing art, delegated to Hygieia the duty of compounding his
remedies. She was his apothecaryor pharmacist. The physician-
priests of Egypt were divided into two classes: those who visited
the sick and those who remained in the temple and prepared
remedies for the patients.
In ancient Greece and Rome and during the Middle Ages in
Europe, the art of healing recognized a separation between the
duties of the physician and those of the herbalist, who suppliedthe physician with the raw materials from which to make
medicines. The Arabian influence in Europe during the 8th
century AD, however, brought about the practice of separate duties
for the pharmacist and physician. The trend toward specialization
was later reinforced by a law enacted by the city council of Bruges
in 1683, forbidding physicians to prepare medications for their
patients. In America, Benjamin Franklin took a pivotal step inkeeping the two professions separate when he appointed an
apothecary to the Pennsylvania Hospital. The development of
the pharmaceutical industry since World War II led to the
discovery and use of new and effective drug substances. It also
changed the role of the pharmacist. The scope for extemporaneous
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compounding of medicines was much diminished and with it the
need for the manipulative skills that were previously applied by
the pharmacist to the preparation of bougies, cachets, pills,
plasters, and potions. The pharmacist continues, however, to fulfillthe prescriber’s intentions by providing advice and information; by
formulating, storing, and providing correct dosage forms; and by
assuring the efficacy and quality of the dispensed or supplied
medicinal product.
The first college of pharmacy was founded in the United States in
1821 and is now known as the Philadelphia College of Pharmacy
and Science. Other institutes and colleges were established soon
after in the United States, Great Britain, and continental Europe.Colleges of pharmacy as independent organizations or as schools
of universities now operate in most developed countries of the
world.
NEWS UPDATE
'Tomato pill' improves function of blood vesselsin patients with cardiovascular disease:
(9th June, 2014)A daily supplement of an extract found in tomatoes may improvethe function of blood vessels in patients with cardiovasculardisease, according to new research. The incidence ofcardiovascular is notably where a 'Mediterranean diet' consistingof a larger consumption of fruit, vegetables and olive oil
predominates. Recent dietary studies suggest that this dietreduces the incidence of events related to the disease, includingheart attack and stroke, in patients at high cardiovascular risk, orthose who have previously had the disease. One component of theMediterranean diet thought to play a role in reducing this risk islycopene, a powerful antioxidant which is ten times more potent
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than vitamin E. Lycopene is found in tomatoes and other fruits,and its potency appears to be enhanced when it is consumedpureed, in ketchup or in the presence of olive oil. Whilst there isstrong epidemiological evidence to support the role of lycopene in
reducing cardiovascular risk, the mechanism by which it does so isunclear.
Human stem cells used to create light-sensitive
retina:(10th June,2014)
Like many processes in the body, vision depends on many different
types of cells working in concert, in this case to turn light intosomething that can be recognized by the brain as an image.
Photoreceptors are only part of the story in the complex eye-brain
process of vision. Using a type of human stem cell, researchers say
they have created a three-dimensional complement of human
retinal tissue in the laboratory, which notably includes
functioning photoreceptor cells capable of responding to light, the
first step in the process of converting it into visual images.
'Onion' vesicles for drug deliver developed:
(10th June, 2014)One of the defining features of cells is their membranes. Each cell'srepository of DNA and protein-making machinery must be keptstable and secure from invaders and toxins. Scientists haveattempted to replicate these properties, but, despite decades of
research, even the most basic membrane structures, known asvesicles, still face many problems when made in the lab. They aredifficult to make at consistent sizes and lack the stability of theirbiological counterparts.A certain kind of dendrimer, a moleculethat features tree-like branches, offers a simple way of creatingvesicles and tailoring their diameter and thickness, researchers
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report. Moreover, these dendrimer-based vesicles self-assemblewith concentric layers of membranes, much like an onion.
Malaria-carrying mosquitoes wiped out in lab
with genetic method that creates male-only
offspring: (10th June, 2014)Since 2000, increased prevention and control measures havereduced global malaria mortality rates by 42 per cent, but thedisease remains a prevalent killer especially in vulnerable sub-Saharan African regions. Malaria control has also been threatenedby the spread of insecticide resistant mosquitoes and malaria
parasites resistant to drugs. Scientists have modified mosquitoesto produce sperm that will only create males, pioneering a freshapproach to eradicating malaria. Since 2000, increased preventionand control measures have reduced global malaria mortality ratesby 42 per cent, but the disease remains a prevalent killer especiallyin vulnerable sub-Saharan African regions. Malaria control hasalso been threatened by the spread of insecticide resistantmosquitoes and malaria parasites resistant to drugs.
Limiting carbohydrates could reduce breastcancer recurrence in women with positive IGF1
receptor:(10th June, 2014)Receptors for IGF1 have been found in breast tumor tissue, andexpression of those receptors may contribute to treatmentresistance among breast cancer survivors. Since diet can influenceinsulin activation, the researchers wondered whether diet couldimpact breast cancer prognosis based on expression of the IGF1
receptor in the primary breast tumor tissue. Using an unusualapproach, this study assessed the combined association of twofactors implicated in tumor growth -- carbohydrate intake andIGF1 receptor status -- to test whether activating theinsulin/insulin-like growth-factor axis can impact breast cancer.Since carbohydrates stimulate the biological pathway that can
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increase concentrations of IGF1, the researchers focused oncarbohydrate intake.
'All systems go' for a paralyzed person to kick
off the World Cup: (10th June, 2014)All systems are go for a bold demonstration of neuroscience andcognitive technology in action: on June 12, during the opening ofthe FIFA 2014 World Cup in Brazil, a paralyzed person wearing abrain-controlled robotic exoskeleton is expected to make the firstkick. The system records electrical activity in the patient's brainand translates that to action. It also gives the patient tactilefeedback using sensitive artificial skin.
MRI shows brain abnormalities in late preterm
infants: (10th June, 2014)Babies born 32 to 36 weeks into gestation may have smaller brainsand other brain abnormalities that could lead to long-termdevelopmental problems, according to a new study. Researchersfocused on moderate and late preterm (MLPT) babies -- those
born between 32 weeks, zero days, and 36 weeks, six days, intogestation. MLPT babies account for approximately 80 percent ofall preterm births and are responsible for much of the rise in therates of preterm birth over the last 20 years.
Infection prevention implanted directly into
bones: (11th June,2014)
Hospital germs can be fatal, since they are resistant to antibiotics.As a result, alternative methods of defense against bacteria are in
demand. A research team has been able to develop bone implants
that keep the germs at bay. At first glance, the fine-grained
implant looks like flour. Only under the microscope can one see
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what is inside: The individual grains of the granules consist of
apatite crystals. These are similar in composition and structure to
natural bone material, which is formed of the same chemical
elements-calcium and phosphorus. The granules make it an ideal
material for implants. To prevent complications, some
manufacturers coat their bone substitute material with
antibiotics.
Mechanism explains complex brain wiring:
(11th June, 2014)It is estimated that a person has 100 billion neurons, or nerve cells.
These neurons have thin, elongated, highly branched offshootscalled dendrites and axons. They are the body's information andsignal processors. The dendrites receive electrical impulses fromthe other neurons and conduct these to the cell body. The cellbody then decides whether stimuli will or will not be transferredto other cells via the axon. A researcher unravels a part of themystery by describing a mechanism that explains novel aspects ofhow the wiring of highly branched neurons in the brain works.
These new insights into how complex neural networks are formedare very important for understanding and treating neurologicaldiseases.
For detail mail to editor
KNOWLEDGE BASED ARTICLE
PHARMACEUTICAL WATER:
Water is the most widely used substance, raw material or startingmaterial in the production, processing and formulation ofpharmaceutical products. It has unique chemical properties due toits polarity and hydrogen bonds. This means it is able to dissolve,
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absorb, adsorb or suspend many different compounds. Theseinclude contaminants that may represent hazards in themselves orthat may be able to react with intended product substances,resulting in hazards to health. Control of the quality of water
throughout the production, storage and distribution processes,including microbiological and chemical quality, is a major concern.Unlike other product and process ingredients, water is usuallydrawn from a system on demand, and is not subject to testing andbatch or lot release before use. Assurance of quality to meet theon-demand expectation is, therefore, essential. Additionally,certain microbiological tests may require periods of incubationand, therefore, the results are likely to lag behind the water use.
Different grades of water quality are required depending on theroute of administration of the pharmaceutical products. Othersources of guidance about different grades of water can be found inpharmacopoeias and related documents.
Drinking water:
Drinking-water should be supplied under continuous positivepressure in a plumbing system free of any defects that could lead
to contamination of any product. If drinking-water is used directlyin certain stages of pharmaceutical manufacture or is the feed-water for the production of higher qualities of WPU, then testingshould be carried out periodically by the water user’s site to con-firm that the quality meets the standards required for drinking-water.
Bulk Purified water:
Bulk purified water (BPW) should be prepared from a drinking-water source as a minimum-quality feed-water. It should meet therelevant pharmacopoeial specifications for chemical andmicrobiological purity with appropriate action and alert limits. Itshould also be protected from recontamination and microbial
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proliferation. BPW may be prepared by a combination of reverseosmosis (RO) RO/electro-deionization (EDI) and vapourcompression (VC). Alert levels for the water system should bedetermined from knowledge of the system and are not specified in
the pharmacopoeias.
Bulk Highly Purified water:Bulk highly purified water (BHPW) should be prepared fromdrinking water as a minimum-quality feed-water. BHPW is aunique specification for water found only in the EuropeanPharmacopoeia. This grade of water must meet the same qualitystandard as water for injections (WFI), including the limit for
endotoxins, but the water-treatment process used may bedifferent. Current production methods include, for example,double-pass RO coupled with othersuitable techniques such as ultrafiltration and deionization.BHPW may be prepared by a combination of different methodssuch as RO, ultrafiltration and deionization.
Bulk water for Injections:Bulk water for injections (BWFI) should be prepared from
drinking-water (usually with further treatment) or purified wateras a minimum-quality feedwater. BWFI is not sterile water and isnot a final dosage form. It is an intermediate bulk product andsuitable to be used as an ingredient during formulation. BWFI isthe highest quality of pharmacopoeial WPU. Certainpharmacopoeias place constraints upon the permitted puri-fication techniques as part of the specification of the BWFI. TheInternational Pharmacopoeia and the European Pharmacopoeia,
for example, allow only distillation as the final purification step.BWFI should meet the relevant pharmacopoeial specifications forchemical and microbiological purity (including endotoxin) withappropriate action andalert limits. BWFI should also be protected from recontaminationand microbial proliferation.
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Other Grades of water:When a specific process requires a special non-pharmacopoeialgrade of water, its specification must be documented within thecompany quality system. As a minimum it must meet the
pharmacopoeial requirements relating to the grade of WPUrequired for the type of dosage form or process step.
Maintenance of water systems:Water for Pharmaceutical Use or WPU systems should bemaintained in accordance with a controlled,documented maintenance programme that takes into account thefollowing:
– de"ned frequency for system elements;– the calibration programme;– SOPs for speci"c tasks;– control of approved spares;– issue of a clear maintenance plan and instructions;– review and approval of systems for use upon completion of work;– record and review of problems and faults during maintenance.Inspection of water system:WPU (BPW, BHPW and BWFI) systems are likely to be the
subject of regulatory inspection from time to time. Users shouldconsider conducting routine audit and self-inspection ofestablished water systems.This GMP guidance can be used as the basis of inspection. A tourof the water generation plant and visible pipework (including userpoints) should be performed to ensure that the system isappropriately designed, installed and maintained (e.g. that thereare no leaks and that the system matches the piping and
instrumentation diagram or drawing (P&ID).The following list identifies items and a logical sequence for aWPUsystem inspection or audit:– a current drawing of the water system showing all equipment inthe system from the inlet to the points of use along with sampling
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points and their designations;– approved piping drawings (e.g. orthographic and/or isometric);– a sampling and monitoring plan with a drawing of all samplepoints;
– training programme for sample collection and testing;– the setting of monitoring alert and action levels;– monitoring results and evaluation of trends;– inspection of the last annual system review;– review of any changes made to the system since the last auditanda check that the change control has been implemented;– review of deviations recorded and their investigation;
– general inspection of system for status and condition;– review of maintenance, failure and repair logs;– checking calibration and standardization of critical instruments.
DISEASE RELATED BREAKING NEWS
Middle East respiratory syndrome
coronavirus (11th
June, 2014)WHO encourages all Member States to continue theirsurveillance for acute respiratory infections. Infectionprevention and control measures are critical to prevent thepossible spread of MERS-CoV in health care facilities. It is notalways possible to identify patients with MERS-CoV earlybecause like other respiratory infections, the early symptoms ofMERS-CoV are non-specific. Therefore, health-care workers
should always apply standard precautions consistently with allpatients, regardless of their diagnosis. Droplet precautionsshould be added to the standard precautions when providingcare to patients with symptoms of acute respiratory infection;contact precautions and eye protection should be added whencaring for probable or confirmed cases of MERS-CoV infection;
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airborne precautions should be applied when performingaerosol generating procedures.Read more
UPCOMING EVENTS5th International Conference on Stem Cells and Cancer 2014, JNU
Convention Centre, New Delhi,India from 8-10 November.2014
DRUGS UPDATES
FDA Approves Bunavail Buccal Film for the
Maintenance Treatment of Opioid Dependence: (9th
June, 2014)
BUNAVAIL is the first and only formulation of buprenorphine andnaloxone for buccal (inside of the cheek) administration. Theability of BUNAVAIL to stick on the inside of the cheek, unlikesublingual products that need to be kept in place under the tongueuntil they dissolve, allows patients to talk, swallow and go about
normal daily activities while the medication is being consistentlyabsorbed. BioDelivery Sciences International, Inc. (BDSI)(NASDAQ: BDSI) received approval of the New Drug Application(NDA) for BUNAVAIL™ (buprenorphine and naloxone) buccalfilm (CIII) from the U.S. Food and Drug Administration (FDA).BUNAVAIL is indicated for the maintenance treatment of opioiddependence and should be used as part of a complete treatmentplan to include counseling and psychosocial support. BDSI
expects to launch BUNAVAIL late in the third quarter of 2014. Read more
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CAMPUS NEWS
Reminiscence, 2014(GNIPST Reunion) was held in College
campus on 2
nd
February,2014.
1st Annual Sports of GNIPST was held on 3rd February,2014 in
College campus ground.
An industrial tour and biodiversity tour was conducted in Sikkim
for B.Pharm and B.Sc. students under the supervision of Mr. Asis
Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.
B.Pharm 3rd year won the GNIPST Football Champions trophy,
2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd
year. Deep Chakraborty was the only scorer of the final.
Students of GNIPST organized pre puja celebration programme,
‘Saaranya’ on 7th October, 2013 in college Auditorium.
GNIPST organized a garment distribution programme on 28th
September, 2013 at Dakshineswar Kali Temple and Adyapith,
Kolkata. On this remarkable event about hundred people have
received garments. More than hundred students and most of the
faculties participated on that day with lot of enthusiasm.
GNIPST celebrated World Heart Day (29
th
September) andPharmacist’s Day (25th September) on 25th and 26th September,
2013 in GNIPST Auditorium. A seminar on ‘Violence against
woman’ and ‘female foeticide’ was held on GNIPST Auditorium on
25th September organized by JABALA Action Research
Organization. On 26th September an intra-college Oral and Poster
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presentation competition related to World Pharmacist’s day and
Heart day was held in GNIPST. Ms. Purbali Chakraborty of
B.Pharm 4th year won the first prize in Oral Presentation. The
winner of Poster presentation was the group of Ms. Utsa Sinha,Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year).
A good number of students have participated in both the
competition with their valuable views.
STUDENTS’ SECTION
WHO CAN ANSWER FIRST????
Who is the CEO of Dr Reddy’s Laboratories? Which pharmaceutical company recently
acquired a UK-based firm called CP
Pharmaceuticals? Answer of Previous Issue’s Questions
A) Fuleco B)Armadillo Identify the lady
Answer of Previous Issue’s Image
Sunderlal Bahuguna
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Congrts Mr. Subhadeep Sengupta for the correct
answers
Send your thoughts/
Quiz/Puzzles/games/write-ups or any other
contributions for Studen ts ’ Section answ ers
of this Section at gnipstbulletin@gmail.com
EDITOR’S NOTE
I am proud to publish the 3rd
issue of 34th
Volume of GNIPST
BULLETIN. GNIPST BULLETIN now connected globally
through facebook account ‘GNIPST bulletin’
I want to convey my thanks to all the GNIPST members and the
readers for their valuable comments, encouragement and supports.
I am thankful to Dr. Abhijit Sengupta, Director of GNIPST forhis valuable advice and encouragement. Special thanks to Dr.
Prerona Saha, Mr. Debabrata Ghosh Dastidar for their kind co-
operation and technical supports. An important part of the
improvement of the bulletin is the contribution of the readers. You
are invited to send in your write ups, notes, critiques or any kind of
contribution for the forthcoming special and regular issue.
ARCHIVE
Teacher’s day was celebrated on 5th September, 2013 by the
students of GNIPST in GNIPST Auditorium.
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A zalea exotic flower ) , the fresher welcome programme for
newcomers of GNIPST in the session 2013-14 was held on 8th
August in GNIPST Auditorium.
One day seminar cum teachers’ development programme forschool teachers on the theme of “Recent Trends of Life Sciences
in Higher Education” organized by GNIPST held on 29th June,
2013 at GNIPST auditorium. The programme was inaugurated by
Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy
Director of JIS Group and Dr. Abhijit Sengupta, Director cum
Principal of GNIPST with lamp lighting. The programme started
with an opening song performed by the B.Pharm students of this
institute. The seminar consists of a series of lectures, video
presentations and poster session. On the pre lunch session 4
lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata
Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty
respectively. On their presentation the speakers enlighten the
recent development of Pharmacy, Genetics and Microbiology and
their correlation with Life Sciences. On the post lunch session, Ms.
Saini Setua and Ms. Sanchari Bhattacharjee explained the recentdevelopment and career opportunities in Biotechnology and
Hospital Management. The programme was concluded with
valedictory session and certificate distribution.
About 50 Higher secondary school teachers from different
schools of Kolkata and North& South 24 Parganas district of
West Bengal participated in this programme. A good interactive
session between participants and speakers was observed in theseminar. The seminar was a great success with the effort of
faculties, staffs and students of our Institute. It was a unique
discussion platform for school teachers and professional of the
emerging and newer branches of Life Science.
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The general body meeting of APTI, Bengal Branch has been
conducted at GNIPST on 15th June, 2012. The program started
with a nice presentation by Dr. Pulok Kr. Mukherjee, School ofNatural Products, JU on the skill to write a good manuscript for
publication in impact journals. It was followed by nearly two hour
long discussion among more than thirty participants on different
aspects of pharmacy education. Five nonmember participants
applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years’ post graduate course (M.Pharm) inP H A R M A C O L O G Y . The approved number of seat is 18.
The number of seats in B.Pharm. has been increased from 60 to
120.
AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-13to
GNIPST as per the details below:a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical
Science & Technology.
b. Principal Investigator: Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d. Approved duration: 3 years
e. Title of the project: Screening and identification of potential
medicinal plant of Purulia & Bankura districts of West Bengalwith respect to diseases such as diabetes, rheumatism, Jaundice,
hypertension and developing biotechnological tools for enhancing
bioactive molecules in these plants.