Chapter 1. Applications of Synthetic Receptors for Biomolecules Evan M. Peck and Bradley D. Smith*...

Post on 11-Jan-2016

223 views 6 download

Tags:

transcript

Chapter 1. Applications of Synthetic Receptors for Biomolecules

Evan M. Peck and Bradley D. Smith*

Department of Chemistry and Biochemistry,

236 Nieuwland Science Hall,

University of Notre Dame, Notre Dame, 46556 IN, USA

*Email: smith.115@nd.edu

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.1 Receptor biomolecule association with 1:1 stoichiometry.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.2 Work flow diagram for supramolecular chemistry research.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.3 Major categories of synthetic receptors.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.4 Common scaffolds for organic molecular receptors.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.5 Receptor scaffolds that incorporate Lewis acids.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.6 X-ray structure of RNA aptamer complex with 5’-adenosine monophosphate (AMP) guest.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.7 Molecular imprinted polymer created by non-covalent imprinting.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.8 Guest encapsulation within the internal cavities of a dendrimer or hyperbranched polymer.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.9 Nanoparticle with core shell architecture.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.10 Major applications of receptors for biomolecules.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.11 Affinity chromatography involves three major steps.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.12 Synthetic receptors for separations.

Scheme 1.13 Liquid membrane transport.

Scheme 1.14 Supramolecular systems for imaging and sensing.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.15 Synthetic receptors used for imaging and sensing.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.16 Supramolecular catalysis of ligation or cleavage reactions.

Scheme 1.17 Synthetic pyridoxamine dendrimer as transaminase mimic.

Scheme 1.18 Synthetic receptors for catalysis.

Scheme 1.19 Pharmaceutically relevant protein biomolecule association systems.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.20 Synthetic receptors with pharmaceutical activity.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015

Scheme 1.21 Channel and carrier mechanisms for membrane transport.

Supplementary information for Synthetic Receptors for Biomolecules: Design Principles and Applications© The Royal Society of Chemistry 2015