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Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
The Pharmacy TechnicianFOUNDATIONS AND PRACTICES
Chapter 10Introduction to Compounding
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Figure 10.1A pharmacy technician compounding a prescription.
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Rationale for Compounding
•Certain valuable drugs have been discontinued by their manufacturers
•The FDA has removed some drugs from the market
•Drugs may not be available in a strength or dosage form appropriate for a specific patient
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Rationale for Compounding (cont.)
•Patients may have sensitivities or allergies to preservatives or other substances
•A combination therapy may not be commercially available
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Basic Procedures in Compounding
•Obtaining the recipe or formula•Writing a worksheet based on the formula•Collecting all ingredients and equipment
necessary to prepare the compound•Weighing each ingredient and having
measurements verified by the pharmacist•Following the directions of the formula to
prepare the compounded medication
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Basic Procedures in Compounding (cont.)
•Packaging and labeling the compounded medication in an appropriate container
•Having the pharmacist provide a final check of the compound
•Cleaning the workstation and equipment used
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Table 10.1Examples of Compounding Equipment
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Table 10.1 (continued)Examples of Compounding Equipment
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Table 10.1 (continued)Examples of Compounding Equipment
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Figure 10.5A technician prepares tablets using a mold.
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Solid Dosage Forms
•Capsule—a solid dosage form in which the active ingredient and any excipients are enclosed in a soluble gelatin shell that will dissolve in the stomach
•Tablet—a solid dosage form that may be administered orally, sublingually, vaginally, or as a pellet under the skin
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Solid Dosage Forms (cont.)
•Powder—a solid dosage form made from blended active ingredients and excipients
•Lozenge—a solid dosage form administered orally to be dissolved in the mouth
•Troche—interchangeable term for lozenge, but sometimes prepared in soft form
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Solid Dosage Forms (cont.)
•Stick—used in topical application of local anesthetics, sunscreens, antivirals, and antibiotics
•Suppository—a solid dosage form used to administer medication by way of the rectum, vagina, or urethral tract
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Figure 10.4Capsule size chart.
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Liquid Dosage Forms
•Solution—a water-soluble chemical dissolved in water
•Suspension—liquids containing ingredients that are not soluble in the vehicle
•Emulsion—a suspension consisting of two immiscible liquids and an emulsifying agent to hold them together
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Semisolid or Soft Solid Dosage Forms
•Ointment—a semisolid topical preparation that is applied to the skin or mucous membranes
•Cream—soft solid that is opaque and usually applied externally
•Paste—stiff, or very viscous, ointment that does not melt or soften at body temperature
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Semisolid or Soft Solid Dosage Forms (cont.)
•Gel—semisolid system consisting of suspension made up of small inorganic particles or of large organic molecules interpenetrated by a liquid
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Other Dosage Forms
•Ophthalmic—preparations for the eye•Otic—preparations for the ear•Nasal—preparations for the nose or
sinuses
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Psychological Impact of Medication Flavoring
•Medication with an appealing color/taste is perceived as more effective by patients
•Successful flavoring helps ensure medication compliance
•Sight and sound play an important role in flavor experience
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Sensory Roles in Flavoring
•Influenced by taste, smell, sight, touch, and sound
•Smell makes a stronger impression on a person than actual taste– Females are more sensitive to smell than
males•Elderly patients may require extra flavoring•Certain diseases alter a patient’s ability to
taste and smell
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Flavoring Considerations
•Focus on the individual patient– Be aware of allergies or sensitivities—
chocolate, peanuts, particular preservative or dye
– What does this patient like?
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Flavoring Considerations (cont.)
•Pediatric flavoring– Children have more taste buds and are more
sensitive to taste– Prefer sweet tastes; dislike bitter flavors– Newborns/babies with less taste “experience”
require less flavor– Some appropriate flavor choices include
raspberry, bubblegum, marshmallow, berry, citrus, vanilla
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Flavoring Considerations (cont.)
•Adult Flavoring– More tolerant of bitter flavors– Use flavoring agents like coffee, chocolate,
cherry, anise, grapefruit, or mint with extremely bitter drugs to cut bitterness
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Flavoring’s Impact on Stability, Solubility, and Ph
•Some flavors may raise or lower pH of compounded medication and cause instability– Aqueous solutions should be flavored with
water-miscible flavors– Oil preparations require an oil-based flavor
•Some flavoring agents/preservatives in the flavor may affect the active ingredient in the compound and cause degradation of the drug
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Flavoring’s Impact on Stability, Solubility, and Ph (cont.)
•Use a flavoring agent that will not affect pH for compounded medications that are stable only at a certain pH– Obtain exact pH from the company that
produces the flavoring agent; most provide a list of flavors and relative pH values
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Four Taste Types
•Sour, sweet, bitter, and salty•“Fifth” sense is called umami—tastes
glutamates and cannot be duplicated by the combination of any of the other four tastes
•Taste buds contain taste receptors for all tastes
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Figure 10.20The four basic taste experiences are sour, sweet, bitter, and salty.
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Five Basic Flavoring Techniques
•I. Blending uses a flavor that will blend with the drug taste– Example: Citrus flavors blend with sour
tastes; bitter tastes can be blended with salty, sweet, and sour tastes; salt reduces bitterness and sourness and increases sweetness
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Five Basic Flavoring Techniques (cont.)
•II. Overshadowing or overpowering uses a flavor with a stronger intensity than the original product– Examples: Wintergreen, methyl salicylate,
glycyrrhiza (licorice), and oleoresins
•III. Physical methods include formation of insoluble ingredients into a suspension and emulsification of oils
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
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The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Five Basic Flavoring Techniques (cont.)
•IV. Chemical methods include absorption of the drug with an ingredient that eliminates the taste of the offensive drug
•V. Physiological methods include use of an additive, such as peppermint, to anesthetize taste buds and thus reduce their sensitivity
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Coloring
•Should be appealing and appropriate for dosage form– Not always necessary– Use minimal amount to keep color “light”
•Coloring agent should match flavor of the product– Example: Cherry should be red, grape should
be purple, and so on
Copyright ©2009 by Pearson Education, Inc.Upper Saddle River, New Jersey 07458
All rights reserved.
The Pharmacy Technician: Foundations and PracticesMike Johnston, Karen Davis, and Jeff Gricar
Coloring (cont.)
•Be aware of patient sensitivities or allergies to certain dyes– Dye-free flavoring agents available