CHROMOSOMES, CHROMATIN & CELLULAR CYCLE

Kamila Geraldinne Varón RincónMedicine Student 2016

INTRODUCTION

Cellular cycle is part of every cell, it the growth, devolpement and even dead of the cell

This area of studying help us understad and investigate lots of desease associated at the process

OPEN CHROMATIN PROFILING KEY TO IDENTIFY LEUKEMIA CELLS OF ORIGIN

Jacksons Laboratory(2016, July 11).

OPEN CHROMATIN PROFILING KEY TO IDENTIFY LEUKEMIA CELLS OF ORIGIN

They identify the cell of origin in a case of leukemia thanks for certain experiment with mouses with MLL-AF2 expression

OPEN CHROMATIN PROFILING KEY TO IDENTIFY LEUKEMIA CELLS OF ORIGIN

They use differents states of cells to analyzed in the mouses and comparing them with a control group.

OPEN CHROMATIN PROFILING KEY TO IDENTIFY LEUKEMIA CELLS OF ORIGIN

After the discover, the researchers said that they’ll be more studies about it, but this discover leads to a bran new future in oncologic treatmens and even in the early pragnosis.

OPEN CHROMATIN PROFILING KEY TO IDENTIFY LEUKEMIA CELLS OF ORIGIN

STUDENT OBSERVATION:

I think that by analazying the bulk tumor, it open a brench where cancer biomarkers showing the impact in the clinical progression in cancers early steps, and to detect their regions to a more focus treatment and more infromation of the illness itself. 

NEW TYPE OF RARE BRITTLE-BONE DISEASE DISCOVERED

University of Zurich. (2016, July 6).

NEW TYPE OF RARE BRITTLE-BONE DISEASE DISCOVERED

The osteogenesis imperfecta is a desease in wich the bones can easily break, and has deformities cause of it and very stunted growth.

It can be acompany with some other tissues problems in witch the connective tissue malfunction.

NEW TYPE OF RARE BRITTLE-BONE DISEASE DISCOVERED

They were studied in two families with same characteristics, with a total of 8 patients in each family.

In both families the brittle bone disease was caused by a mutation of the same gen MBTPS2 that encode a protease.

NEW TYPE OF RARE BRITTLE-BONE DISEASE DISCOVERED

They were surprised because the mutation of the same gene also leads to a variety of diferente desease, not only the brittle bone disease.

This was all discovered by a simple test in the urine at measuring metabolites.

NEW TYPE OF RARE BRITTLE-BONE DISEASE DISCOVERED

STUDENT OBSERVATIONThis research is very important, cause it shows that even thought we already know about some of the desease in one gene, the mutation of itself can make other desease in exposure, the uncertainly remainds unknown in so many aspects, but this leads many other investigations helping to understad how it Works and how is done a lot of things in our body 

Even thought, lots of experiment may help us understand known desease, it also help to recognize the unkown ones, this is an example of how far is the human knowledge of the humans itself.The first reserchr is a clear example of how technology is an usefull tool on desease, such as cancer, in how to prevent and deal with the illness.The sencond let us known that we just know a small kind of desease, that our world and knowledge is growing and changing, but it also make us notice that our experience and our progress leads our path to prevent and stunt among them. 

Medical Utility

Both researchers may cause an impact on how diferentes studies are progressing, showing not only a tratment or cure, so as well as different kind of desease that remainds unkown.

Medical Utility

This can help not only in the knowledge, but as well in the health of our patients and bring hope on those that is still uncertain.

Medical Utility

We might be far of know it all, but with this kind of research, it brings a whole new area of studies that can bring a new chance and more understanding in our deseases.

Bibliografy Jackson Laboratory. (2016, July 11). Open chromatin profiling key to

identifying leukemia cells of origin. ScienceDaily. Retrieved July 16, 2016 from www.sciencedaily.com/releases/2016/07/160711092306.htm

University of Zurich. (2016, July 6). New type of rare brittle-bone disease discovered. ScienceDaily. Retrieved July 30, 2016 from www.sciencedaily.com/releases/2016/07/160706091737.htm

Martinez Sanchez, Lina Maria. Biologia molecular.8.ed.Medellin: UPB. Fac.Medicina.