04/19/23 1

Commitment & Efforts Toward Translational Science

Subtitle Placeholder

04/19/23 2

To improve the health of our patients & community through innovation &

excellence in care, education, research & service.

Clarian’s Mission- 1997

04/19/23 3

To improve the health of our patients & community through innovation &

excellence in care, education, research & service.

Clarian’s Mission- 1997

IU Health Research Support

• Annual support to IUSM for program development and strategic development

• Hospital partner in CTSI development and operation

• Alignment of Methodist Research Institute clinical trial unit within CTSI

• IU Health Values Grants for Research & Education ($1.2 million/year) - focus on young investigators and pilot studies

• IU-IRB infrastructure/operational support

04/19/23

IUH Research Support, cont’d

• IU Health Annual Research Pillar Goal

04/19/23

04/19/23 6

Preeminence Framework

04/19/23 7

Preeminence Framework

04/19/23 8

04/19/23 9

Total admissions: 135,701

Total OP visits: 2,094,533

Total physicians: 3,707

Transformational & Pillar Goals

• 2014 Transformational Goal: IU Health will be recognized as one of the nation’s leaders in hosting and supporting translational research, and in the development of personalized medicine, & clinical trials/participants across the system.

• A key requirement will be a robust infrastructure, including IT.

• 2011 Pillar Goal: Develop & implement system-wide IRB & biobank programs (target: 5375)

04/19/23

Clinical Trials: IT Support

• For investigators: identification of potential trial candidates.

• For patients: usable information about available clinical trials

• For physicians: point-of-service information about potential patient-specific clinical trials

04/19/23 11

Biorepository patients

• Mechanism established to allow IU Health submissions prior to completion of system-wide IU IRB (current total 1221)

• System IU IRB project initial focus on Bloomington, Arnett, Ball. Target to be operational: July 2011.

• Other IU Health facilities to be engaged on staggered basis.

04/19/23

IUSM-IU Health Joint Strategic Research Planning

• Enterprise-wide research retreats (2010)

• Establishment of broad-based Strategic Research Council

• Development of a major Joint Aligned Strategic Plan for research (2011)

• Aligned with key strategic service lines

• Under leadership of David Wilkes, MD, Executive Associate Dean for Research, IUSM

04/19/23 13

Joint Strategic Research Proposal

• Cancer

• Center of Excellence in Cardiovascular Research

• Neuroscience Research

• Horizontal programs: IU Health Translational Postdoctoral Scholar Program; Faculty Retention Program.

• Includes benchmarks, outcomes measures

04/19/23 14

Cancer

• Pilot projects

• Strategic recruitment

• Statewide Clinical Research Office

• Center for Chemical Biology and Drug Discovery

04/19/23 15

Cardiovascular Research

• Basic and translational research in heart failure

• Pharmacogenomics to promote drug efficacy and safety

• Data Coordinating Center for Cardiovascular Outcomes Research

04/19/23 16

Neuroscience Research

• Comprehensive Brain Injuries and Insults Research

• Neurodegenerative Disorders Research

• Neurodevelopmental Disorders Research

04/19/23 17

04/19/23

Joint Strategic Research Proposal

Current Status

So...Why is IUH Committed to Enhancing Research?

• It is a core component of our mission, and aligned with IUSM

• It is a requisite for providing preeminent quality care for our patients

• It extends the benefits beyond individuals, to also include the community and the next generation of our citizens and investigators

04/19/23

Thank youThank you