Control theory and homeostasis

Control theory

That branch of mathematics and engineering which deals with thedesign, identification and analysis of systems with a view towardscontrolling them, i.e., to make them perform specific tasks or to behave in a desired way

Homeostasis

The ability and tendency of certain systems to maintain a relativelyconstant internal state in spite of changes in external conditions

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Human designed control systems

Human designed control systems

Cornelis Drebbel 1620

Human designed control systems

satellite attitude control

controller processactuator

sensor

inputfilter

+controlsignalreference

disturbance

_output

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block diagram of a basic feedback control

Calcium homeostasis

TumbleCW

10µm

RunCCW

Increasing Chemical Gradient

Bacterial chemotaxis

biased random walk:

increase concentration -> decreased tumbling frequency

Tethering Analysis

Agonist changes rotational bias Kirby et al (JBC, 1999)

perfect adaptation of tumbling frequency

Zn

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intracellular nutrient homeostasis

a simplified model for Zinc homeostasis

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“homeostasis” 126408 hits

“control theory” 432

“homeostasis” AND “control theory” 27