Post on 26-Mar-2015
transcript
Elias A. Zerhouni, M.D.February 27, 2004
The NIH Roadmapfor Medical Research
Questions, questions and more questions
How and why was the NIH Roadmap developed?
How is it being implemented?
What are the initiatives?
How will the Roadmap benefit my research area?
Challenges for NIH
Revolutionary and rapid changes in Science
Increasing breadth of mission and growth
Complex organization with many units(27 institutes and centers, multiple program offices, e.g., OWHR, OAR, ORD, ...)
Structured by Disease, Organ, Life stage, Disciplines ….
Rapid Convergence of Science
Acute to chronic conditions
Evolving Public Health Challenges
Health Disparities
Emerging Diseases
Aging Population
Biodefense
U.S. Health Expenditures(Percentage of GDP)
18
16
14
12
101985 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 2007 2009 2011
Year
Per
cen
t
ActualProjected
Imperatives for NIH
Accelerate pace of discoveries in life sciences
Translate research more rapidly from laboratories to patients and back
Explore novel approaches orders of magnitude more effective than current
Develop new strategies: NIH Roadmap
How was the Roadmap developed?
Extensive consultations with stakeholders, scientists, health care providers– What are today’s scientific challenges?– What are the roadblocks to progress?– What do we need to do to overcome
roadblocks?
What is the NIH Roadmap?
A framework of priorities the NIH as a whole must address in order to optimize its entire research portfolio.
A vision for a more efficient, innovative and productive system of biomedical and behavioral research.
A set of initiatives that are central to extending the quality of healthy life for people in this country and around the world.
NIH Roadmap for Medical Research
New Pathwaysto Discovery
Re-engineering theClinical Research Enterprise
Research Teamsof the Future
NIH
Emerging Complexity of Biology
Need to understand biological systems
Brent Cell, 2000
The Biological Data of the Future
Destructive
Qualitative
Uni-dimensional
Low temporal resolution
Low data density
Variable standards
Non cumulative
Non-destructive
Quantitative
Multi-dimensional and spatially resolved
High Temporal resolution
High data density
Stricter standards
Cumulative
Multi- and Interdisciplinary Research will be Required to Solve the “Puzzle” of Complex Diseases and Conditions
GenesBehaviorDiet/NutritionInfectious agentsEnvironment Society???
NIH Roadmap Research Teams of the Future
Scale and complexity of 21st C research requirenew organizational models for scientific teams
Multi-disciplinary and Inter-disciplinary TeamsLarger, coordinated, resource sharing
TeamsPreserve the investigator(s)-initiated
strategy
Translational ResearchFor historical reasons, clinical research has evolved haphazardly– Started as cottage industry and select centers– Now has more complex requirements: regulation,
technology, speed, efficiency– Greater links to basic science
Need transformation to move into the 21st Century– Individual apprenticeship discipline of clinical research– Uniform gauge harmonize rules, build infrastructure
and create networks– Focus on mentoring multidisciplinary teams
The key value is access to well characterized cohorts of patients and biological samples
Bench Bedside Practice
Building Blocks PathwaysMolecular LibrariesBioinformatics and Computational BiologyStructural BiologyNanomedicine
TranslationalResearchInitiatives
Clinical ResearchInformatics
Integrated ResearchNetworksClinical outcomes
TrainingNational Clinical Research Associates
Interdisciplinary ResearchPioneer Award Nanomedicine
Public PrivatePartnerships
NIH Roadmap Strategy
Re-engineering the Clinical Research
Enterprise
Public-PrivatePartnerships
High-riskResearch
Interdisciplinary Research Nanomedicine
Bioinformatics and Computational Biology
StructuralBiology
Building Blocks, Biological Pathways
and Networks
Molecular Libraries
and Imaging
ImplementationImplementationGroupsGroups
New Pathways to DiscoveryResearch Teams
ClinicalEnterprise
Key elements of Roadmap funding and management
All Institutes:– Participate with their scientific community in defining all components of the
Roadmap
– Contribute equally and proportionately
– Participate directly in decision making and have a direct liaison to the Roadmap
All Roadmap initiatives are offered for competition to researchers from all fields
All research communities can compete for all initiatives
The peer-review process will ensure appropriate expertise
Roadmap Funding dollars in millions
New Pathwaysto Discovery
Re-engineering the Clinical Research Enterprise
Research Teamsof the Future
NIH
$64.1
$26.6 $37.6
FY 2004 Funding = $128.3 (dollars in millions)
Roadmap Fundingdollars in millions
FY04 FY05 FY06 FY07 FY08 FY09 Total
Pathways to
Discovery
64 137 169 182 209 188 948
Research
Teams
27 39 44 92 96 93 390
Clinical
Research
38 61 120 174 214 227 833
Total 128 237 332 448 520 507 2,172
To be competed for in a common pool of initiatives by all researchers from every discipline
0.34% 0.63% ~0.9%
NIH Roadmap Goal
Accelerate basic research discoveries and speed translation of those discoveries into clinical practice
Explicitly address roadblocks that slow the pace of medical research in improving the health of the American people
“How does the NIH Roadmap benefit my research area?”
Speeding removal of major and fundamental roadblocks common to all diseases
No Institute can solve these issues alone
THIS IS A COMMON TRANS-NIH POOL OF TRANSFORMING INVESTMENTS OPEN TO ALL DISEASE AREAS FOR COMPETITION
“Yes, but we’re already doing those things. What’s new?”
THE NIH ROADMAP POOLS RESOURCES FOR SPECIFIC ENABLING INVESTMENTS THAT INDIVIDUAL INSTITUTES COULD NOT UNDERTAKE
Expanding molecular probe libraries publicly available to researchers by a factor of 7Increasing the number of publicly available molecular probes from less than 100,000 to over 500,000Developing a common national research informatics platform allowing interoperability for data for all patients whether seen at a research hospital or in their own community (NECTAR)Improving the implementation of Breakthrough research trials through the creation of INTEGRATED research partnerships
MORE RAPID DIFFUSION OF BEST PRACTICES TO PATIENTS
There is no wrong time to do the right thing.
IdeasPeople
ResourcesLeadership
NIH