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Emerging Oncogenic Viruses Programme
Wednesday 30 May 2012
Arrival of participants
Accommodation at the Hotel dei Bizantini and Registration
19:00-24:00
Opening ceremony and Dinner at Cantina Produttori Vini-Museo della Civiltà del Vino Primitivo (transport by bus)
19:00-19:15 Welcome Address
Dr Christopher Wild, IARC Director
19:15-19:45 Opening lecture “History and Perspectives of Tumor Virology”
Professor Harald zur Hausen, Nobel Prize in Medicine 2008
20:00-24:00 Dinner
Thursday 31 May 2012
08:00-09:00 Registration
Session 1
09:00-13:00
Epidemiology I
Chaired by Ethel-Michele De Villiers and Robert Garcea
09:00-09:25
[O1]
Risk of cancers in HIV-infected people and organ transplant-recipients
Silvia FRANCESCHI
(France)
09:25-9:50
[O2]
HPV markers in cancers of the upper aerodigestive tract
Michael PAWLITA
(Germany)
09:50-10:15
[O3]
Cutaneous HPV Type Distribution in Pathologically Confirmed External Genital Lesions (EGLs): The HIM Study
Anna GIULIANO
(USA)
10:15-10:30
[O4]
Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors
Mauro TOGNON
(Italy)
10:30-10:45
[O5]
Merkel Cell polyomavirus in gastro-intestinal neuroendocrine tumors
Massimo BARBERIS
(Italy)
10:45-11:00
[O6]
Prospective serological study of the new cutaneous polyomaviruses in immuno-suppressed renal transplant recipients
Els VAN DER MEIJDEN
(The Netherlands)
11:00-11:30 Coffee break
11:30-11:55
[O7]
Neutralization serotyping of BK polyoma-virus infection in kidney transplant recipients
Christopher BUCK
(USA)
11:55-12:20
[O8]
Epidemiology of MCPyV, HPyV6, HPyV7, HPyV9 and TSPyV polyomaviruses in humans and identification of cross-reactivity
Pierre COURSAGET
(France)
12:20-12:45
[O9]
A prospective study of the natural history of cutaneous human papillomaviruses and polyomaviruses in healthy men
Dana ROLLISON
(USA)
12:45-13:00
[O10]
Prognostic value of antibodies against MCPyV VLPs and MCPyV T-antigen, and vitamin D levels in Merkel cell carcinoma patients
Antoine TOUZÉ
(France)
13:00-14:30 Lunch
Session 2
14:30-18:10
Immunology
Chaired by Martin Kast and Raphael Viscidi
14:30-14:55
[O11]
Reversal of HPV-mediated suppression of Langerhans cell function with the TLR3 agonist Poly-ICR
W Martin KAST
(USA)
14:55-15:20
[O12]
Oncoviruses and innate immunity: the inflammasome response in the human liver and its role against HBV infection
Uzma HASAN
(France)
15:20-15:35
[O13]
The Large T antigen of Merkel Cell Polyoma virus down regulates human Toll-Like Receptor 9 Promoter
Naveed SHAHZAD
(France)
15:35-15:50
[O14]
MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome
Torbjörn RAMQVIST
(Sweden)
15:50-16:05
[O15]
New perspectives of immunotherapy in HPV-associated head and neck cancers
Aldo VENUTI
(Italy)
16:05-16:35 Coffee Break
16:35-17:00
[O16]
Antibody dependent cellular cytotoxicity (ADCC) epitopes in human papilloma-virus type 16 E2 protein
Raphael VISCIDI
(USA)
17:00-17:25
[O17]
Passive protection of mice against gential HPV infection independently of FcRn using L2-specific monoclonal antibody
Richard RODEN
(USA)
17:25-17:40
[O18]
Efficacy of a second-generation broad-spectrum RG1-VLP HPV vaccine
Christina SCHELLENBACHER
(Austria)
17:40-17-55
[O19]
Development of AAV vectors for vaccination against HPV
Anna SACHER
(Germany)
17:55-18:10
[O20]
Natural variants in the major neutralizing epitope of human papillomavirus minor capsid protein L2
Hanna SEITZ
(Germany)
18:15-19:15 Poster Session
20:00 Dinner at Ristorante Reggia Domizia
(transport by bus)
Friday 1 June 2012
Session 3
08:30-13:05
Virus-host interaction I
Chaired by Alison McBride and Paul Lambert
08:30-08:55
[O21]
Distinct contributions of ATM and ATR to BK polyomavirus infection
Michael IMPERIALE
(USA)
08:55-09:20
[O22]
Nuclear virus factories in polyomavirus-infected cells
Robert GARCEA
(USA)
09:20-09:45
[O23]
Structural biology of polyomavirus host-cell attachment strategies
Thilo STEHLE
(Germany)
09:45-10:00
[O24]
Pseudoviruses and VP1 pentamers as surrogates to study infectious entry of human polyomaviruses
Walter ATWOOD
(USA)
10:00-10:25
[O25]
Human papillomavirus entry into host cells depends on delivery of the viral genome into the nucleus by nuclear envelope breakdown
Mario SCHELHAAS
(Germany)
10:25-10:55 Coffee Break
10:55-11:20
[O26]
Sequential engagement of multiple heparan sulfate binding sites during infectious entry of human papilloma-virus type 16
Martin SAPP
(USA)
11:20-11:45
[O27]
Potential papillomavirus virion/host-species specific interactions
Patricia DAY
(USA)
11:45-12:10
[O28]
Human papillomaviruses use a novel Trojan Horse approach for gaining entrance to human keratinocytes to initiate infection
Michelle OZBUN
(USA)
12:10-12:35
[O29]
A sequence-specific interaction with sulfated polysaccharides triggers a structural change in Human Papilloma-virus type 16 independently of a glycosaminoglycan protein
Carla CERQUEIRA
(Germany)
12:35-12:50
[O30]
The effect of HIV protease inhibitors on HPV16 titers and infectivity: comparison of cervical and oral tissue
Craig MEYERS
(USA)
12:50-13:05
[O31]
Beta papillomavirus replication in hair follicles provides a model for their reactivation in EV patients and organ transplant recipients
Cinzia BORGOGNA
(Italy)
13: 05-14:30 Lunch
Session 4
14:30-18:30
Cellular transformation I
Chaired by Denise Galloway and Mike Imperiale
14:30-14:55
[O32]
Interpreting cancer genomes using systematic host perturbations by tumor virus proteins
James DECAPRIO
(USA)
14:55-15:20
[O33]
Beta Human Papillomavirus 5 and 8 E6 Expression Attenuates UV Damage Signaling by Impairing ATR Activation
Denise GALLOWAY
(USA)
15:20-15:45
[O34]
HPV8-E6 inhibits transcription of the PDZ-protein Syntenin-2
Herbert PFISTER
(Germany)
15:45-16:10
[O35]
Tranforming properties of E6 and E7 oncoproteins from the genus beta human papillomavirus types
Rosita ACCARDI
(France)
16:10-16:25
[O36]
Effect of HPV16 E6 and E7 expression on multipotent epithelial progenitors
Katerina STRATI
(Cyprus)
16:25-16:55 Coffee Break
16:55-17:20
[O37]
Mechanisms regulating differentiation-dependent HPV genome amplification and late gene expression
Laimonis LAIMINS
(USA)
17:20-17:45
[O38]
HPV-associated cancers: who is the driver and how does she/he act?
Paul LAMBERT
(USA)
17:45-18:00
[O39]
Regulation of cellular microRNAs by the human papillomavirus Type 16 E6 oncogene
Saleem KHAN
(USA)
18:00-18:15
[O40]
MicroRNA profiling in E6/E7 HPV-transformed human keratinocytes
Vincenza CHIANTORE
(Italy)
18:15-18:30
[O41]
Elucidating the transforming potential of MCPyV T-Antigens
Nicole FISCHER
(Germany)
18:30-19:30 Poster Session
20:30 Dinner
Saturday 2 June 2012
Session 5
08:30-12:00
Epidemiology II
Chaired by Anna Giuliano and Michael Pawlita
08:30-08:55
[O42]
Further clues to the mystery of TT viruses
Ethel-Michele DE VILLIERS
(Germany)
08:55-09:20
[O43]
The trichodysplasia spinulosa-associated polyomavirus (TSPyV); epidemiology and pathogenicity
Mariet FELTKAMP
(The Netherlands)
09:20-09:45
[O44]
Oral HPV prevalence in young men and women is similar, yet higher in women with genital HPV, but less abundant than in patients with oropharynx cancer
Tina DALIANIS
(Sweden)
09:45-10:00
[O45]
Human papillomaviruses and TP53 mutation status in oropharyngeal squamous cell carcinoma
Maria Lina TORNESELLO
(Italy)
10:00-10:15
[O46]
Molecular evidence for transforming activity of established and probable/ possible high-risk human papillomavirus types in cervical cancer
Gordana HALEC
(Germany)
10:15-10:30
[O47]
Case-control study of genus-beta human papillomaviruses in plucked eyebrow hairs and squamous cell carcinoma of the skin
Michelle IANNACONE
(France)
10:30-11:00 Coffee Break
11:00-11:15
[O48]
No Evidence of Human beta papilloma-
virus (HPV) infection in skin tumours from chronic lymphocytic leukemia patients
Alberto PERETTI
(Italy)
11:15-11:30
[O49]
Search for viruses causing human cancer: a new genomic approach
Vincent FERRETTI
(Canada)
11:30-11:45
[O50]
EBV, HPV and MMTV as multiple viruses in breast cancer
Noel WHITAKER
(Australia)
11:45-12:00
[O51]
Epstein-Barr Virus, Human Polyoma-viruses and Non-Hodgkin Lymphoid Neoplasms
Lauren R TERAS
(USA)
12:00-13:30 Lunch
Session 6
13:30-16:35
Virus-host interaction II
Chaired by Susanna Chiocca and Thomas Schulz
13:30-13:55
[O52]
Regulation of the human papillomavirus life cycle by host cell protein kinases
Sally ROBERTS
(UK)
13:55-14:20
[O53]
Replication and persistence of papillomavirus genomes by association with host chromatin
Alison MCBRIDE
(USA)
14:20-14:45
[O54]
Discovery and function of microRNAs in small DNA Viruses
Christopher SULLIVAN
(USA)
14:45-15:10
[O55]
Mutations in the GM1 binding site of SV40 VP1 alter receptor usage and cell tropism
Daniel DIMAIO
(USA)
15:10-15-25
[O56]
How structures of papillomavirus E6 and E7 oncoproteins improve our under-standing of their evolution
Sebastian CHARBONNIER
(France)
15:25-15:55 Coffee Break
15:55-16:20
[O57]
Infectious canine papillomavirus production and tropism
Hang YUAN
(USA)
16:20-16:35
[O58]
Examining the viral and cellular micro-RNA targetome during EBV infection
Rebecca SKALSKY
(USA)
Session 7
16:40-18:20
Cellular transformation II
Chaired by Sally Roberts and Daniel DiMaio
16:40-17:05
[O59]
Oncogene-induced Senescence and the pRB signaling network
Karl MUNGER
(USA)
17:05-17:30
[O60]
Cellular targets of cutaneous HPV types and their role in skin cancer
Ingo NINDL
(Germany)
17:30-17:55
[O61]
How does SV40 DNA replication exploit host DNA damage signaling?
Ellen FANNING
(USA)
17:55-18:20
[O62]
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression
Thomas SCHULZ
(Germany)
20:00 Social Dinner at Masseria Li Surìì
(transport by bus)
Sunday 3 June 2012
Departure – Shuttles to airport
…/…
Poster Sessions
Thursday 31 May 2012, 18:15-19:15
Friday 1 June 2012, 18:30-19:30
P1 Antibodies in single-chain format against the E6 and E7 oncoproteins of Human Papilloma-viruses type 16: biological effects in vitro and in vivo
Luisa ACCARDI (Italy)
P2 Conservation and evolution of the E3 ubiquitin ligase assembled by the adenoviral proteins E4orf6 and E1B55K
Paola BLANCHETTE (Canada)
P3 Comparative analysis of transforming properties of E6 and E7 of different beta HPV types
Iris CORNET (France)
P4 Oxidative stress and cell adaptation to oxidative stress are two distinct features of HPV 16 carcinogenesis
Federico DE MARCO (Italy)
P5 hScrib contributes to the regulation of HPV-18 E6 expression
Christian KRANJEC (Italy)
P6 Role of IkappaB kinase beta in cutaneous human papillomavirus type 38–mediated transformation
Djamel SAIDJ (France)
P7 In vitro RT-PCR infectivity assays using native cutaneous and mucosal HPV virions
Saeed SHAFTI-KERAMAT (Austria)
P8 Regulation of tumour suppressor DOK1 expression in Burkitt’s lymphoma: role of Epstein Barr virus
Maha SIOUDA (France)
P9 Structural analysis of receptor engagement by the Trichodysplasia Spinulosa- associated Polyomavirus
Luisa J. STRÖH (Germany)
P10 HPV E6 oncoproteins from high and low risk types associate with the proteasome independently of E6AP
Vjekoslav TOMAIC (Italy)
P11 The role of HPV16 variants in the development of cervical cancer worldwide
Iris CORNET (France)
P12 Mucosal and cutaneous human papilloma-viruses detected in raw sewages collected throughout Italy
Luisa ACCARDI (Italy)
P13 Human papillomavirus prevalence and p16INK4a overexpression in Head and Neck squamous cell carcinoma
Maria BENEVOLO (Italy)
P14 The distribution of JC virus receptors in human tissue
Sheila HALEY (USA)
P15 Oncogenic viruses and cancers in southern Africa
Danuta KIELKOWSKI (South Africa)
P16 The detection of novel polyomaviruses HPyV6, HPyV7 and MCPyV in healthy and immuno-compromised individuals
Vojtech SROLLER (Czech Republic)
P17 HPVs manipulation of the SUMO pathway Domenico MATTOSCIO (Italy)
P18 Human papillomavirus type 38 E6 and E7 act as tumor promoter during skin chemical carcinogenesis
Daniele VIARISIO (Germany)