Energy, Catalysis and Biosynthesis

Metabolism*catabolism *anabolism

Complexity of metabolism

Review of Energy:Energy

*kinetic energy*potential energy

Free energy, stability, work capacity and changeFree energy

Change in free energy =DG

Gravitational Motion

Diffusion Chemical Reaction

Free energy, stability, work capacity and changeEquilibrium

*chemical equilibrium

DG = 0, no net change in the system

Chemical reactions with free energy changes:

*energetically favorable *energetically unfavorable

Metabolic Disequilibrium

*Multistep open hydroelectric system

EnzymesEnzymes speed up metabolic reactions:

Enzymes

Enzymes are catalytic proteinsEnzymes lower the barrier of EA

EnzymesInduced Fit

Enzymes: How they work

EnzymesPhysical and chemical properties affect enzyme activity:

*inhibitor

*cofactor

*coenzyme

*activators

ATPMain types of (cellular) work:

*mechanical*transport*chemical

ATP