Post on 18-Jan-2017
transcript
EGF
0 Human EGF is a 6045-Da protein with 53 amino acid
residues and three intramolecular disulfide bonds.
0 EGF acts by binding with
high affinity to EGFR on the
cell surface and stimulating
the intrinsic protein-tyrosine
kinase activity of the receptor.
0 Accelerate epidermal regeneration
of partial and full thickness skin wounds.
Background
But, the clinical use of rhEGF
in case of patients have generated some controversy in advantage.
Purposes
0 In this study,
0 Twelve patients had partial thickness wounds because of
burn and skin graft donor site were treated with rhEGF
0 We investigated the clinical effect of rhEGF on partial
thickness wounds of patients
Materials
0 Periods: Feb’08~Oct’08
0 Patients:
0 Patients that have second degree burn wounds (n=5)
0 Patients that have donor site wounds after skin graft (n=7)
0 Sex: all male
0 Age: 33.5
0 Exclusion: patients that have comorbidities,
such as DM or vascular diseases
Methods
0 Each wound was divided two areas (group A and B)
0 Marking 2 x 2 cm2 sized square shape
0 Treatment twice daily
0 Group A (experimental): foam dressing with rhEGF
0 Group B (control): foam dressing without rhEGF
Analysis
0 The extent of reepithelialized area was recorded by
percentage ratio
0 The statistical analysis was conducted about the
difference of the number of days between two area until
total wound was reepithelialized
Results
Patient Etiology of wound Group A
(days)
Group B
(days)
Difference
(A-B, days)
1 Second-degree burn 10 13 -3
2 Skin graft donor site 11 11 0
3 Skin graft donor site 8 10 -2
4 Second-degree burn 11 9 2
5 Skin graft donor site 8 10 -2
6 Skin graft donor site 9 12 -3
7 Second-degree burn 12 11 1
8 Skin graft donor site 8 9 -1
9 Second-degree burn 10 12 -2
10 Skin graft donor site 9 10 -1
11 Second-degree burn 11 14 -3
12 Skin graft donor site 10 12 -2
Results
0 Healing time
0 Group A: 9.75 days (8-10 days)
0 Group B: 11.08 days (9-14 days)
0 Statistically significant difference between two groups (P < 0.05)
Conclusion
0 The topical application of rhEGF
0 Accelerated the re-epithelialization
0 Healing of partial-thickness wound clinically