Experimental surgery: Surgical techniques

Alper Toker, MD

Istanbul Medical School Department of Thoracic Surgery

Rat Hilusu

Perikardial window

Diafragmatic repair

Technical experiences Lung transplantation on dogs Five dogs in 1994 To establish the surgical techniques

Apneic oxygenation on Rabbits (2001)

Not Successfull,

Fragile tissues,

Difficulties on feeding the animals.

Effects of ventilation on lung function after normorthermic ischemia

3 groups of rat Ischemia of 1 hour

Lung is expanded during ischemia, Atelectatic, Sham operation

Complians, PvaCO2, PvaO2 Pathology

Toker, A., K. Bostancı, D.Yılmazbayhan, E. Dayıoğlu ve E. Onursal, “Effects of ventilation on lung function after normorthermic ischemia”, Asian Cardiovasc Thorac Ann , 7,309-312 (1999).

Dose related effects of theophylline added to modified Euro-Collins solution used for hypothermic preservation of lung

3 groups of rats An bloc removal of the both lungs of the

rat Different preservation solutions with different

teophillen concentrations

MDA and lipid metobolites in lung paranchym.

Bostancı, K., A. Toker, Y. Bayrak, Ş. Dilege, M. Şentürk ve M. Tuğrul, “Dose related effects of theophylline added to modified Euro-Collins solution used for hypothermic preservation of lung”, J Thoracic and Cardiovasc Anesth 2004;17(6):721-4.

Isolated lung perfusion with paclitaxel and docetaxel: the comparison of the early effects on pulmonary physiology.

Three groups (n:5), 1st group:Docetaxel 2nd group:Paclitaxel 3rd group: Control group (İzotonik)

Ventilation parameters Blood Gas Analyses Pathological researches

Tanju S, Akpolat B, Şentürk E, Ziyade S, Toker A, Yılmazbayhan D, Aydıner A, Dilege Ş. Isolated lung perfusion with paclitaxel anmd docetaxel: the comparison of the early effects on pulmonary physiology. Thorac Cardiovasc Surg, 2007

A new greft for tracheal reconstruction: Cyanoacrylate coated trachea

Closure and reconstruction of the rat tracheal defects. Cyanoacrylate.

Erdik, O., T. Işıtmangil, A. Toker, H. Çermik ve Ö.Y. Öztürk, “Trakea rekonstrüksiyonunda yeni bir greft yöntemi: Cyanoacrylate kaplanmış trakea”. İst Tıp Fak Mecmuası,2002; 65: 255-263.