Post on 09-Sep-2018
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Introduction
July 27, 2014
Dear Laureates,
Honorable Guests,
Dear Friends of Bionorica,
I initiated the Global Research Initiative (GRI) to mark the 80th
anniversary of Bionorica. Starting in the fall of last year, we invited
scientists from all over the world to submit their research projects to the
competition, which we aptly named 'Phytoneering – one Step ahead in
Thinking and Research'. We were pleased with what we consider an
overwhelming response of over 130 entries. The members of the
esteemed jury were greatly impressed with the quality and density of
research that they were presented with.
With the GRI, I wanted to give young researchers the necessary space
to carry out their research ideas in plant medicine without financial
pressure. But we also expect new impulses for advanced innovation in
plant medicine. This involves, in particular, identifying specific starting
points for the development of new herbal preparations that improve
patients’ quality of life and sustainably protects their health.
What has always fascinated me is the correlation of the healing power of
nature and the opportunities advanced methods of science and
technology provide. Therefore, I want to congratulate each and every
one of our 20 laureates for his or her outstanding effort – I am looking
forward to read and consider the results of your ambitious works. It is
your courage and curiosity that we need in modern phytomedicine to
offer ever more cutting-edge and breakthrough healthcare solutions.
Yours sincerely,
Prof. Dr. Michael A. Popp
CEO Bionorica SE
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Content
Bergonzi, C.: Innovative formulations to enhance oral bioavailability of herbal extracts. ....... 4
Brandner, J. M.: Effects of Arnebia euchroma extracts on different stages of wound healing in
wounds with normal and impaired healing ...................................................................... 5
Clarke, R.: A novel human in vitro model to study the modulatory properties of plant-based
medicines on physical and chemical irritant activation of airway sensory nerves .................. 6
Dansranjavin, T.: Characterization of epigenetic regulation in prostatitis and prostate cancer
by a herbal preparation ................................................................................................ 7
Kalinina, S: Verbascum nigrum extract as a new complex phytotherapeutic agent ............... 8
Katarbayev, A.: New indications for a herbal preparation - “acute intestinal infections of
bacterial etiology” ........................................................................................................ 9
Koeberle, A.: Bioactive lipid networks in phytomedicine.................................................. 10
Kraus, B.: Correlating the structure of differently substituted chalcones with transcriptome
data and bioactivity in liver cells .................................................................................. 11
Krohn, M.: St John’s Wort extracts – ways to treat Alzheimer’s disease? .......................... 12
Quave, C.: Phytoneering Cosmeceuticals for Acne Vulgaris ............................................. 13
Margină, D.: Studies of some of the biological effects of encapsulated vegetal extracts from
plants with known positive cardiovascular actions .......................................................... 14
Pérez Novo, C. A.: Molecular targets mediating the effect of a specific herbal preparation on
chronic rhinosinusitis ................................................................................................. 15
Sadofsky, L.: How natural plant extracts modulate airway irritant receptor hypersensitivity 16
Savilova, A.: Investigation of the effects of a herbal preparation on endometrial mesenchymal
stromal cells ............................................................................................................. 17
Schwaiger, S.: Natural products with effects on the Neuropeptide S system...................... 18
Stute, P.: Impact of black cohosh on brain after menopause ........................................... 19
Szczepanski, M. J.: Anti-cancer effect of a herbal preparation in head and neck squamous cell
carcinoma................................................................................................................. 20
Wild, J.: Bactericidal/permeability-increasing protein (BPI) as a potential new target for the
antimicrobial and immunomodulatory activities of herbal extracts.................................... 21
Zabolotna, D.: Study of the adjuvant effects of phytoproducts on the formation of antibodies
against influenza virus antigens in the mucous membranes of the upper airways ............... 22
Zierau, O./Keiler, A: Effects of a hops extract on bone in a rat model of estrogen deficiency-
induced osteoporosis.................................................................................................. 23
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Bergonzi, C.: Innovative formulations to enhance oral bioavailability of herbal extracts.
Dr Maria Camilla Bergonzi, Researcher, Department of Chemistry,
University of Florence, Italy.
Title of Study
Innovative formulations to enhance oral bioavailability of herbal extracts
Biography
Graduated with Full Honors Degree (cum laude) in Pharmaceutical
Chemistry and Technology from the University of Pisa in 1997. She gained
her PhD in Science and Technology of Medicinal Plants in 2002.
Since 2005 she has held a tenured position of Assistant Professor at the Faculty of Pharmacy,
University of Florence. She has received several contracts from the University of Pisa and from
Consorzio Ferrara Ricerche for research on thalassemia. She was awarded a two-year fellowship and
a post-doctoral grant from the University of Florence in 2002 and 2003. She is author of over 45
scientific papers, a number of congress communications, one patent, and a chapter in a book. Since
2010 she has led the Course of Pharmaceutical Technology for ungraduated students of the Faculty
of Pharmacy. In 2011 she received a Research Incentivization Award from the University of Florence
for intense teaching activity in the academic year 2010-2011.
Major Target of Study
The project aims to assess the potential for preparation and easy industrial-scale production of new
and innovative oral formulations able to overcome the limited oral bioavailability of herbal drugs
and herbal extracts to increase their therapeutic efficacy.
Major Benefit of Study
The study should lead to increases in the solubility, bioavailability, activity, and stability of extracts,
allowing their pharmacokinetics and biodistribution to be modified. By applying these approaches,
the project aims to improve patients’ quality of life and protect human health.
Abstract
The project will study a phytopharmaceutical product well established from the point of view of its
effectiveness and safety and to seek ways of making it more effective and safer by using
technological strategies to overcome the disadvantages associated with conventional formulations.
New drug delivery systems which are technologically simple, allowing rapid industrial scale-up, will
be evaluated. In particular, the proposed strategies will include formulation of microemulsions,
complexation with cyclodextrin, solid-state simultaneous mechanochemical activation, and co-
crystallization and amorphization complexation.
My quote after learning about being a laureate:
I appreciate receiving the award because it gives me the chance to pursue my research on the
formulation of herbal extracts and to realize pharmaceutical preparations of industrial interest. I
think the GRI is a great idea because it provides an excellent opportunity for young researchers to
carry out their projects and in this way to increase the knowledge in the field of phytomedicines.
E-mail: mc.bergonzi@unifi.it
Phone: +39-0554573678
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Brandner, J. M.: Effects of Arnebia euchroma extracts on different stages of wound healing in wounds with normal and impaired healing
Prof. Johanna M. Brandner, Researcher, Department of
Dermatology and Venereology, Hamburg-Eppendorf University
Medical Center, Hamburg, Germany.
Title of Study
Effects of Arnebia euchroma extracts on different stages of wound
healing in wounds with normal and impaired healing
Biography
Johanna Brandner is a PI in the Department of Dermatology and
Venereology at the Hamburg-Eppendorf University Medical Center.
She obtained her diploma in Biochemistry at the University of
Regensburg and earned her PhD supervised by Prof. Werner W.
Franke at the German Cancer Research Center Heidelberg, focusing on structure-
associated nuclear proteins. In 1998 she started research on skin barrier function and
wound healing, and since 2013 a collaboration with the Hanse-Merkur-Zentrum for
Traditional Chinese Medicine led to her interest in Arnebia euchroma.
With the outcome of the study, she plans to develop new wound healing treatment
strategies.
Major Target of Study
This study is expected to provide us with knowledge as to whether two extracts of A.
euchroma used alone or in combination at different time points can improve various
aspects of wound healing.
Major Benefit of Study
Based on this study – if the outcome is positive - we hope to generate patient-tailored
wound treatment by combining two extracts from a traditional herb.
Abstract
Wounding of the skin impairs the protective barrier of the body and facilitates the entry of
harmful substances and pathogens. Thus, timely regeneration of acute wounds is
essential and acceleration of wound healing is therefore desirable to avoid the formation
of chronic wounds. Chronic wounds are a substantial and global healthcare problem.
Traditional Chinese Medicine (TCM) is based on thousands of years of experience in the
field of treatment of wounds with medicinal plants and shows convincing results. However,
molecular understanding of the effects is often incomplete. In this project, we want to use
two extracts from a Chinese herb (A. euchroma) known from TCM and elucidate their
effects on various phases/aspects of wound healing with the aim finding a time- and
patient dependent combination of the two extracts for optimal wound healing.
My quote after learning about being a laureate:
I appreciate receiving the award because it gives us the opportunity to contribute to the
science-based acceptance of phytomedicine.
E-mail: brandner@uke.de
Phone: +49-40-7410-55819
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Clarke, R.: A novel human in vitro model to study the modulatory properties of plant-based medicines on physical and chemical irritant activation of airway sensory nerves
Ms Rebecca Clarke, PhD Student, Centre for Infection & Immunity,
Queen’s University Belfast, Northern Ireland.
Title of Study
A novel human in vitro model to study the modulatory properties of
plant-based medicines on physical and chemical irritant activation of
airway sensory nerves
Biography
Rebecca is a PhD student at Queen’s University Belfast. She obtained
a Bachelor’s degree in Biochemistry with Immunology at Trinity
College Dublin and began her PhD under the supervision of Dr Fionnuala Lundy and Dr Lorcan
McGarvey, focusing on the development of an in vitro model of human sensory neurons from
neural crest stem cells obtained from human dental pulp and validation of the model for the
study of human neuronal ion channels capable of sensing nociceptive stimuli. Rebecca will
complete her PhD in September 2014 and continue her work with the neuronal model as a
Postdoctoral Researcher in Queen’s University Belfast Rebecca is also a recipient of the John
Widdicombe award and Postgraduate IADR Hatton Award Irish Division.
Major Target of Study
An in vitro model of whole functional human sensory neurons will be used for a detailed study
of transient receptor potential (TRP) channels, an important family of nociceptors responsible
for pain sensation and irritant airway reflexes such as cough.
Major Benefit of Study
Examination of the effects of environmental irritants such as low temperature, acid pH and
chemicals in cigarette smoke on the activation of neuronal TRP channels will be used to
assess the potential of plant-based medicines to modulate irritant responses.
Abstract
Airway sensory nerves control protective reflexes but in asthma and following respiratory
viral infections these reflexes become hyperactive, causing troublesome cough and wheeze.
These abnormal responses, typically triggered by environmental irritants such as cigarette
smoke and cold air, are what disturb patients most about their condition. Discovering new
treatments for excessive coughing is made harder because human airway nerves are
extremely difficult to study. To overcome this we use novel techniques to differentiate human
dental pulp stem cells into peripheral neuron equivalents. Using this model we can examine
the effects of environmental irritants on sensory nerve activation and its potential modulation
with plant based medicines.
My quote after learning about being a laureate:
I am aware that many important medicines are plant-based and this award gives me the
opportunity to understand how they work and explore the possibility of developing new
treatments in the future.
E-mail: rclarke313@qub.ac.uk
Phone: +44-28-9097-2418
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Dansranjavin, T.: Characterization of epigenetic regulation in prostatitis and prostate cancer by a herbal preparation
Dr Temuujin Dansranjavin, Dept. of Molecular Urology and
Andrology, Justus-Liebig-Universität Gießen, Germany.
Title of Study
Characterization of epigenetic regulation in prostatitis and
prostate cancer by a herbal preparation
Biography
Temuujin Dansranjavin is a research fellow in the Department of
Molecular Urology and Andrology at Justus Liebig University,
Gießen. He studied biology (diploma 1996) at the Martin Luther
University, Halle, and subsequently obtained his doctorate (Drrer.nat.) in 2000 with a thesis
on the regulation of apoptosis in germ cell tumors. Since 2008 he has been working on
epigenetic regulation of tumor-associated genes in prostate cancer (PCa). His current project,
dealing with the characterization of metastasis-associated CpG-methylation in PCa, is funded
by a Research Grant from the University Medical Center Gießen and Marburg (UKGM). Dr
Dansranjavin is an elected member of the Working Group on Urological Research (AuF) of the
German Society of Urology (DGU).
Study
Development of chronic prostatic diseases such as BPH and PCa are significantly linked to
prostatic inflammation. One specific herbal preparation is widely used as an anti-
inflammatory treatment; however, little is known about molecular mechanisms and pathways
in prostate diseases. Epigenetic deregulation of tumor suppressor genes and oncogenes plays
a fundamental role in malignant tumor progression. We want to characterize the genes
affected by a specific treatment and evaluate the role of the epigenetic regulation of these
genes. This approach will provide novel insights into the molecular mechanisms underlying
the actions of the study medication and will contribute to the development of new molecular
markers for refining the treatment of prostate diseases.
E-mail: Temuujin.Dansranjavin@chiru.med.uni-giessen.de
Phone: +49-641-9939753
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Kalinina, S: Verbascum nigrum extract as a new complex phytotherapeutic agent
Dr Svetlana A. Kalinina, Researcher, Perm State Pharmaceutical
Academy, Russia.
Title of Study
Verbascum nigrum extract as a new complex
phytotherapeutic agent: Our pharmaceutical studies include
preparation of dried ethanolic and aqueous extracts of herbs, roots,
flowers, leaves and stems, as well as extraction of fractions
containing various classes of compounds (flavonoids, iridoids,
phenolic acids) from V. nigrum. The biological activities of these
extracts and fractions are evaluated. Overall, all extracts other
than the root extract were found to demonstrate anticoagulant,
hypotensive and diuretic activities.
Biography
Svetlana Kalinina is a research fellow at Perm State Pharmaceutical Academy. She obtained
her Diploma with honors in Pharmacy in 2009. As one of the leading PhD students she was
awarded a “Training Abroad” grant under the President of the Russian Federation Program.
As part of a research team at the School of Pharmacy, Curtin University of Technology,
Australia, she took part in research on the synthesis of new purine derivatives. In 2013 she
finished her PhD in medicinal chemistry and pharmacognosy. She continued her research on
plant materials and extracts and the separation of biologically active natural compounds.
Major Target of Study
This study will provide the first demonstration of the hypotensive, anticoagulant and diuretic
effects of V. nigrum extracts. The experiments reveal links between the pharmacological
activities and quantitative contents of biologically active compounds.
Major Benefit of Study
The detailed pharmacological study of the extract should lead to a significant expansion of
knowledge in the field of herbal medicine, in turn opening up an avenue for the creation of
new promising and safe natural drugs.
Abstract
An extract of the aerial part of V. nigrum has been shown to have significant antihypertensive
and diuretic activities, which were attributed mainly to the actions of flavonoids. Taking
phytochemical and pharmacological results and economic data into consideration, the optimal
technology for producing dry extract from V. nigrum herb has been developed and studied in
an experimental industrial environment.
My quote after learning about being a laureate:
I appreciate receiving the award, as I believe that it will support a crucial step in the
development of V. nigrum extract as a future remedy in the combined treatment of blood
clotting disorders, hypertension and renal diseases.
E-mail: phatpharm@rambler.ru
Phone: +7-9194630863
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Katarbayev, A.: New indications for a herbal preparation - “acute intestinal infections of bacterial etiology”
Dr Adyl Katarbayev, Director of the Pediatrics Teaching
Department and Head of the Department of Pediatric Infectious
Diseases, S. D. Asfendiyarov Kazakh National Medical University,
Almaty, Kazakhstan.
Title of Study
Preclinical studies of a herbal preparation in acute intestinal
infection.
Biography
In 1996 – PhD dissertation entitled "Particularities of the clinical
course of acute mixed enteric infections in small children". In 2010
–doctoral dissertation entitled “Correlation of medical-demographic
indicators with contagious diseases in children and development of
preventive measures”. Senior Doctor. Member of Research Council, Chairman of Scientific
Task Group for Pediatric Problems, member of Ethical Council, internal auditor of Quality
Management System at Kazakh National Medical University. Author of 88 scientific articles,
22 abstracts, 2 monographs (co-author), 5 guidance manuals (co-author), 1 certificate of
authorship and 1 patent.
Major Target of Study
This will be the first preclinical study (laboratory and histomorphological data) to suggest new
indications for a specific herbal preparation – “acute intestinal infections of bacterial etiology”
Major Benefit of Study
Based on this study, it will be possible to correct the quantitative and qualitative composition
of the drug. It will identify the conditions for the formation of new drugs with direct actions
treating and preventing acute intestinal infections.
Abstract
The efficacy of a specific herbal preparation in acute intestinal infection in laboratory animals
will be addressed by:
1. Assessing the sensitivity of different strains of pathogenic enterobacteria (genera
Salmonella, Shigella, Escherichia).
2. Conducting laboratory and histomorphological evaluations of the efficacies of different
doses and formulations in acute intestinal infection in laboratory animals.
My quote after learning about being a laureate:
This award will help me translate my own research ideas into medical practice (initially in the
treatment of infectious diseases in children).
E-Mail: adil.02.10.62@mail.ru
Phone: +7-777-681-09-19
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Koeberle, A.: Bioactive lipid networks in phytomedicine
Dr Andreas Koeberle, Junior research group leader, Professorial
Department of Pharmaceutical/Medicinal Chemistry, Institute of
Pharmacy, University of Jena, Germany.
Title of Study
Targeting of bioactive lipid networks: a novel pharmacological
strategy for anti-inflammatory phytomedicine
Biography
Andreas Koeberle is junior research group leader at the Chair of
Medicinal/Pharmaceutical Chemistry, University of Jena, Germany,
with a research focus on bioactive lipid profiling and molecular
pharmacology. After studying biochemistry, Koeberle completed his PhD studies at the
University of Tübingen, Germany, in 2009 and spent two years as postdoctoral fellow at the
University of Tokyo, Japan. His research is funded by grants from the Deutsche
Forschungsgemeinschaft, Takeda Science Foundation, the University of Jena, and the
Phospholipid Research Center, Heidelberg, and he is recipient of the Klaus-Grohe-Award for
Medicinal Chemistry.
With the outcome of the study, he plans to evaluate the potential of novel identified anti-
inflammatory mechanisms for (phyto)pharmacotherapy.
Major Target of Study
The study will extend our understanding of how some of the most prominent plant-derived
drugs modulate bioactive lipid networks and whether this might be relevant for their anti-
inflammatory features.
Major Benefit of Study
By providing insights into the anti-inflammatory principle of phytopharmaceuticals, the study
will help to estimate their pharmacological potential and provide a mechanistic basis for their
optimization.
Abstract
Emerging evidence shows that the interplay of multiple bioactive lipids shapes their biological
response. Koeberle speculates that distinct phytopharmaceuticals may exert anti-
inflammatory activity by modulating the bioactive lipid network of immune cells. His study
will employ a comprehensive lipidomics approach to determine how this network is affected
by selected phytopharmaceuticals and to address whether changes observed in the lipid
pattern impact immune cell function.
My quote after learning about being a laureate:
I highly appreciate receiving support for my efforts in unraveling the molecular mechanisms
of phytomedicine – a research field that has been neglected for a long time despite its
indispensable importance to exploiting the full power of nature for human health.
E-mail: andreas.koeberle@uni-jena.de
Phone: +49-3641-949815
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Kraus, B.: Correlating the structure of differently substituted chalcones with transcriptome data and bioactivity in liver cells
Dr Birgit Kraus, Pharmaceutical Biology, Institute of Pharmacy,
University of Regensburg, Germany.
Title of Study
Correlating the structure of differently substituted chalcones with
transcriptome data and bioactivity in liver cells.
Biography
Birgit Kraus is a research fellow at the Institute of Pharmacy at the
University of Regensburg, Germany. She obtained a degree in
Biology at the Technical University, Munich (TUM), and earned her
PhD under Prof. Elstner at the Center of Life and Food Sciences,
Weihenstephan (TUM), focusing on the influence of St John`s Wort (Hypericum perforatum)
extract on the immunological functions of microglial cells. In 2007, she moved as a
postdoctoral fellow to the group of Prof. Heilmann at the Institute of Pharmacy at the
University of Regensburg. Since 2010, she has been Assistant Professor (Habilitandin). Her
main research interests are hepatotoxicity, hepatoprotection, and chemoprevention by
natural products and their metabolites.
Major Target of Study
This will be the first study addressing correlations between results from cellular assays and
transcriptome data and the molecular structures of compounds. This will give new insights
into the cellular mechanisms of action of chalcones.
Major Benefit of Study
The outcome of the study will lead to a better understanding of how chalcones act on the
liver (in a positive or negative manner). It could further reveal entirely new applications and
indications for chalcones and chalcone metabolites.
Abstract
Chalcones possess a wide range of biological activities. Moreover, they offer an interesting
basic structure that allows investigation of structure-activity relationships and creation of
derivatives with altered and enhanced pharmacological properties. We have previously
analyzed the impact of different chalcones on cellular structures and functions of liver cells.
In this study, we will perform an in-depth data analysis with the aim of correlating our
previously obtained results from multi-parametric cellular assays with the structural
characteristics of chalcones. Furthermore, the results from the cellular assays will be
complemented with data from ultra-high-throughput mRNA sequencing of the transcriptome
of chalcone-treated liver cells.
My quote after learning about being a laureate:
I appreciate receiving the award because this award is exactly what is needed to foster
research in the current times of reduced government funding and tight budgets at academic
institutions.
E-mail: birgit1.kraus@chemie.uni-regensburg.de
Phone: +49-941-943-4494
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Krohn, M.: St John’s Wort extracts – ways to treat Alzheimer’s disease?
Dr Markus Krohn, Researcher, Neurodegeneration Research Lab
(NRL), Department of Neurology, University of Magdeburg, Germany
Title of Study
Defining specific extracts from St John’s Wort for the treatment of
Alzheimer’s disease
Biography
Markus Krohn is a research fellow at the Neurodegeneration
Research Lab in Magdeburg. He obtained a diploma in animal
physiology at the University of Greifswald and earned his PhD under
Prof. Jens Pahnke at the University of Rostock, focusing on ABC transporter function in
Alzheimer’s disease. In 2005 he started research on Alzheimer’s disease and soon focused on
the role of transport proteins in the development of this disease. After elucidating the
importance of the transporters ABCC1 and ABCB1, the NRL started searching for activators.
During the following years phytopharmaceuticals became one focus of his research.
Major Target of Study
This study will provide the first assessment of St John’s Wort extracts to identify the
components responsible for ABCC1 transporter activation. It will also raise awareness of the
usefulness of phytomedicines for human diseases.
Major Benefit of Study
This study will not only be the first step tin defining extraction methods that can be used to
produce phytopharmaceuticals from St John’s Wort with the potential to treat Alzheimer’s
disease, but it is also a first step in shedding light on its other mechanisms of action.
Abstract
Alzheimer’s disease (AD) is thought to be triggered by pathological aggregation of the protein
amyloid-beta (Aβ) in the brain. Most current treatment approaches therefore aim to reduce
the amounts of Aβ present. Our previous studies found that a defect in transport protein
ABCC1 can lead to a more-than-12-fold increase in brain Aβ concentrations in a mouse model
of AD (PMID: 21881209). To exploit this mechanism to develop a treatment, we tested
different extracts of various medicinal plants to test their capabilities to activate ABCC1. An
extract of St John’s Wort was effective independently of the hyperforin and hypericin
concentrations, which are historically regarded as the main active substances in this herb
(PMID: 24156265). This study now aims to further define a method for producing an extract
which is effective in activating ABCC1 transport function and potential as an effective
treatment option for AD.
My quote after learning about being a laureate:
Yeah, that’s great! Finally a research award esteeming the value of phytomedicine.
E-mail: markuskrohn@gmail.com
Phone: +49-391-6725003
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Quave, C.: Phytoneering Cosmeceuticals for Acne Vulgaris
Dr Cassandra Quave, Assistant Professor, Department of
Dermatology and Center for the Study of Human Health, Emory
University, USA
Title of Study
Botanical natural product inhibitors of acne biofilms
Biography
Cassandra L. Quave, PhD holds a joint appointment as Assistant
Professor of Dermatology in the Emory University School of
Medicine and Center for the Study of Human Health in the Emory
College of Arts and Sciences, where she leads drug discovery research initiatives and teaches
undergraduate courses on medicinal plants, food and health. She is also the Curator of the
Emory University Herbarium and is currently leading a revitalization effort for the collection.
Trained as a medical ethnobotanist, her research is focused on the documentation and
analysis of botanical remedies used in the treatment of infectious disease, with special
interest in natural product inhibitors of pathogenic bacterial cell signaling pathways.
Major Target of Study
For the first time, this study will assess the anti-acne biofilm activity of medicinal plants used
in traditional medicine for the treatment of skin and soft tissue infections in the
Mediterranean.
Major Benefit of Study
This study has the potential to lead to the discovery of novel botanical products for use in
future acne formulations.
Abstract
Acne vulgaris is a common skin disorder, which affects >85% of teenagers.
Propionibacterium acnes is implicated in its pathogenesis and biofilm formation within the
skin follicles plays a critical role in this process. Like many other bacteria, P. acnes is also
subject to emerging antibiotic resistance and novel therapies are in high demand. Medicinal
plants may represent a unique source of new therapeutic options. Our lab has already
demonstrated interesting anti-staphylococcal activity in a library of medicinal plant extracts.
However, these extracts have never been evaluated for their efficacy in targeting P. acnes
biofilms. The overall aim of this study is to evaluate these extracts and identify potential
leads for the development of new topical acne therapies.
My quote after learning about being a laureate:
With this award, Bionorica is supporting my growth and career development as a phyto-
scientist. I am deeply appreciative of their generous support and will use these funds to
undertake the important first steps in identifying novel therapies for an important medical
condition.
E-mail: cquave@emory.edu
Phone: +1-404- 727 7065
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Margină, D.: Studies of some of the biological effects of encapsulated vegetal extracts from plants with known positive cardiovascular actions
Dr Denisa Margină, Carol Davila University of Medicine and Pharmacy,
Faculty of Pharmacy, Bucharest, Romania
Title of Study:
Studies of some of the biological effects of encapsulated vegetal extracts
from plants with known positive cardiovascular actions.
Biography
Dr Denisa Margină is an Associate Professor with habilitation at the
Department of Biochemistry, Faculty of Pharmacy, Bucharest, Romania. She
earned her PhD in 2006 with the thesis “Studies of the biochemical and
immunological implications of endothelial dysfunction”. Between 2010 and
2012 she was a post-doctoral fellow and conducted research on the positive effects induced by certain
polyphenols on cellular mechanisms involved in the development of complications of chronic
hyperglycemia. As a result, she published a number of papers in high-impact-factor journals: Food and
Chemical Toxicology, Journal of Proteomics, Aging Clinical and Experimental Research, International
Journal of Molecular Sciences, General Physiology and Biophysics.
Major Target of Study
The study aims to assess some of the biological properties of vegetal extracts (Aesculus Hippocastanum
semen, Vitis vinifera L. folium and Curcuma Longa rhizoma) known for their positive cardiovascular
actions, in encapsulated forms.
Major Benefit of Study
The results from this study should show whether or not encapsulated forms have effects similar to those
observed for plant extracts and whether encapsulation has potential to be used either for preparing
nutraceuticals or in the manufacture of functional foods.
Abstract
The major drawbacks in using polyphenols as medicines include low bioavailability and instability at the
pH levels reached in the digestive tract. The use of encapsulated polyphenols could efficiently alleviate
these deficiencies. The plants identified above were chosen for evaluation of their potential antioxidant
and anti-inflammatory properties. The effects will be assessed in vitro and in vivo and compared to their
non-encapsulated forms and to other substances known to have antioxidant and vasoprotective effects:
quercetin, curcumin, and vitamin C. The project will evaluate the quality of the extracts and their
biological effects in a standardized cell culture model and in vivo using invertebrates such as Daphnia
magna.
My quote after learning about being a laureate:
It is a great honor for me to be a GRI Bionorica laureate, and I consider this prize not only an award, but
also an exceptional opportunity. This will be a good starting point for more elaborate studies of vegetal
extracts with potential beneficial cardiovascular actions. I am working in a young research team and this
GRI Bionorica project could be a challenge not only for me, but also for other young researchers to
approach and deepen pharmaceutical research in the field of natural compounds.
E-mail: denisa.margina@gmail.com
Phone: +4-0744-339-630
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Pérez Novo, C. A.: Molecular targets mediating the effect of a specific herbal preparation on chronic rhinosinusitis
Dr Claudina Angela Pérez Novo, post-doctoral
Researcher at the Upper Airways Research Laboratory,
Ghent University, Belgium.
Title of Study: Genome-wide transcriptome analysis for
the elucidation of the molecular mechanisms involved in
the anti-inflammatory action of a specific herbal
preparation in chronic rhinosinusitis
Biography
Claudina Pérez Novo obtained her PhD in Medical
Sciences in 2006 under the supervision of Prof. Claus
Bachert and Prof. Paul Van Cauwenberge at the
University of Ghent, Belgium. Her research work is focused in the role of lipid mediators/eicosanoids in
the pathogenesis of chronic rhinosinusitis and aspirin-exacerbated respiratory disease. At present she is
a senior post-doctoral researcher in the same department. Her research topic has currently been
extended to the role of epigenetic events in the initiation and persistence of inflammation in chronic
airway diseases. The data obtained in this study will provide an extensive gene expression/regulatory
targets database linked to the pharmacological action of a specific herbal preparation that will be the
start point for further mechanistic studies of the drug.
Major Target of Study
This study intends to elucidate the signaling pathways mediating the anti-inflammatory action of a
specific herbal preparation in chronic rhinosinusitis by comparing the entire transcriptome expressed in
inflamed nasal tissue before and after drug interference.
Major Benefit of Study
This study will provide the first gene reference database containing molecular targets, pathways and
regulatory networks linked to the pharmaco-molecular mechanisms of a specific herbal preparation in
chronic rhinosinusitis.
Abstract
Chronic rhinosinusitis (CRS) is one of the most common healthcare problems worldwide. One specific
herbal preparation has been proven to alleviate clinical symptoms of this disease in both children and
adults. However, very little is known about the signaling mechanisms and molecular targets mediating
its action. This study intends to elucidate the signaling pathways mediating the anti-inflammatory action
of a specific herbal preparation in CRS. To achieve our goal, sinunasal tissue from patients suffering
from CRS will be collected and incubated with the specific herbal preparation and then used for
genome-wide analysis of expression. This approach will identify differentially expressed gene targets
and regulatory networks involved in the mechanism of action of this compound.
My quote after learning about being a laureate
For me is a great honor to be selected as one of the laureates of the Bionorica Global Research Initiative.
This prize will not only allow me to contribute to consolidating and extending our knowledge of the
molecular mechanisms of a specific herbal preparation in chronic rhinosinusitis, but will also enrich my
knowledge in the field of phytomedicine in the management of inflammatory airways disease.
E-mail: Claudina.Pereznovo@UGent.be
Phone: +32-332-96422
- 16 -
Sadofsky, L.: How natural plant extracts modulate airway irritant receptor hypersensitivity
Dr Laura Sadofsky, Lecturer, Hull York Medical School, University
of Hull, UK.
Title of Study
In vitro effects of natural agonists and antagonists of airway irritant
receptors
Biography
Laura Sadofsky is a lecturer at Hull York Medical School, University
of Hull. She gained a BSc in Biochemistry and an MSc in Toxicology
from the University of Birmingham and then moved to Hull to study
for a PhD in medicine under Prof. Morice, focusing on the molecular pharmacology of the
capsaicin receptor. On completing her PhD she worked as a post-doctoral researcher in
respiratory medicine at the University of Hull before becoming a lecturer in 2011. Her
research focuses on the molecular pharmacology of thermo-transient receptor potential
channels in cough and airways inflammation. She plans to publish the outcome of the study
and to provide an assay platform to verify the modulation of irritant receptors by
phytopharmaceuticals.
Major Target of Study
This study will provide the first demonstration of whether chronic exposure to a range of
naturally occurring compounds affects irritant (TRP) channel expression or sensitivity and the
mechanism involved.
Major Benefit of Study
The study will identify changes in irritant channel expression/sensitivity in airways after
chronic exposure to plant products and show how these can be used to treat chronic cough or
other conditions involving these channels.
Abstract
Herbal remedies have been used for many years to treat cough. We wish to explore the
mechanism of modulation of irritant receptor (thermo-TRP) hypersensitivity by plant extracts
to understand the therapeutic basis for such remedies. We hypothesize that the
expression/sensitivity of TRP channels can be influenced by chronic exposure to their agonists
via the LTB4 pathway. To this end, qPCR, western blotting and calcium signaling studies using
primary cells and cell lines will be employed to obtain pharmacological and biochemical
evidence of modulation of TRP channels altering responses to tussive agents. We will show
how natural compounds can be used to treat chronic cough and conditions where TRP
channels are important, such as itch and pain.
My quote after learning about being a laureate:
This award will help me establish myself as an independent researcher and allow me to
pursue my interest in the pharmacology of natural plant-derived products.
E-mail: L.R.Sadofsky@Hull.ac.uk
Phone: +44-1482-465008
- 17 -
Savilova, A.: Investigation of the effects of a herbal preparation on endometrial mesenchymal stromal cells
Dr Anastasia Savilova, Head of Cell Technology Laboratory, FSBI
"Research Center for Obstetrics, Gynecology and Perinatology,"
Ministry of Health of the Russian Federation, Moscow, Russia.
Title of Study
Investigation of the mechanism of action of a specific herbal
medicine on eutopic and ectopic endometrial mesenchymal stromal
cells.
Biography
Anastasia Savilova is head of the Cell Technology Laboratory at
"Research Center for Obstetrics, Gynecology and Perinatology". She obtained a Specialist
degree in Biochemistry in 1998 at Moscow State University, and earned her PhD under
supervision of prof. V. M. Stepanov in 2001, focusing on the study of proteinase precursors of
microorganisms. In 2010, she started research for eutopic and ectopic endometrial
mesenchymal stromal cells at the Cell Technology Laboratory. With the outcome of the study,
she plans to continue the work using endometrial mesenchymal stromal cells as a model for
studies of the effects of various substances on normal and ectopic human endometrium.
Major Target of Study
This study for the first time looks into the interaction of a specific herbal preparation and
human endometrium by investigating its effects on eutopic and ectopic endometrial
mesenchymal stromal cells, comparing its action with estradiol.
Major Benefit of Study
This study will allow the mechanisms of action of a specific herbal preparation on human
normal and ectopic endometrial mesenchymal stromal cells to be proposed.
Abstract
The aims of the project are to study the effect of a specific herbal preparation on endometrial
cells from healthy women and to compare its action to that of estradiol, as well as to evaluate
the effect of a specific herbal preparation on ectopic endometrial cells from endometriotic
lesions. The possible effects on endometrial MSCs will be studied using different
concentrations of Vitex agnus castus extract, followed by evaluation of changes in cell
phenotype (by flow cytometry) and gene and protein expression (by real-time PCR and
ELISA), followed by comparison with gene/protein expression in cells exposed to estradiol
and unexposed cells/vehicle control cells.
My quote after learning about being a laureate:
I appreciate receiving the award because it is a great opportunity for our laboratory to begin
investigations of endometrial cells as a model for studying the effects of various substances
on normal and ectopic human endometrium.
E-mail: bushueva@gmail.com
Phone: +7-917-561-05-36
- 18 -
Schwaiger, S.: Natural products with effects on the Neuropeptide S system
Dr Stefan Schwaiger, senior-postdoc, Institute of Pharmacy/
Pharmacognosy, University of Innsbruck, Austria.
Title of Study
Natural products with effects on the NPS/NPSR system
Biography
Stefan Schwaiger is a senior-postdoc at the University of Innsbruck/Institute of Pharmacy/Pharmacognosy. He obtained his master's degree in pharmacy at 2001 and earned his PhD under the supervision of Univ. Prof. Dr Hermann Stuppner in 2005, focusing on phytochemical studies of edelweiss (Leontopodium nivale ssp.
alpinum). Afterwards, he continued his work at the same department, isolating and elucidating the structures of secondary metabolites from higher plants with anti-inflammatory and other pharmacological activities, resulting in contributions to 40 publications.
Major Target of Study
This proposal is the first attempt to use a ligand-based pharmacophore model of the NPS
receptor for the discovery of natural products interfering with this target.
Major Benefit of Study
Natural products with effects on the NPS/NPSR system will be of paramount importance for
understanding which biological functions are controlled by the NPS/NPSR system and for
defining the therapeutic potential of selective non-peptidic NPSR ligands.
Abstract
Exploration of the neuropeptide S (NPS)/NPS receptor (NPSR) system, including as a
therapeutic target, is limited due to the lack of non-peptidic ligands (agonists). Thus, there is
a strong need to identify small, non-peptide molecules interacting with this system. Since the
3D structure of the NPSR is unknown, a ligand-based pharmacophore model has been
generated based on known NPSR ligands. This model was used for virtual screening of
natural product (NP) libraries, resulting in a hit list of more than 250 potentially active NPs.
The planned experiments will include the isolation of virtually predicted NPs and evaluation of
their ability to interact with the NPS/NPSR-system. The most promising compounds will be
analyzed in vivo.
My quote after learning about being a laureate:
This initiative is a great idea to support upcoming researchers in their careers.
E-mail: stefan.schwaiger@uibk.ac.at
Phone: +43-512-507-58409
- 19 -
Stute, P.: Impact of black cohosh on brain after menopause
Dr Petra Stute, Head of Menopause Clinic and Gynecological Endocrinology,
Deputy Head of Gynecological Endocrinology and Reproductive Medicine
Section, Department of Obstetrics and Gynecology, Inselspital Bern,
Switzerland.
Title of Study
Impact of black cohosh on hippocampal and hypothalamic gene expression
profiles in ovariectomized rats.
Biography
Petra Stute is a specialist in gynecological endocrinology and reproductive
medicine. She completed her medical training in Germany and became
Deputy Head of the Gynecological Endocrinology and Reproductive Medicine
Section, Department of Obstetrics and Gynecology, Inselspital Bern, Switzerland, in 2009. She started
her scientific training as a postdoc at the Department of Comparative Medicine, Wake Forest University
School of Medicine, Winston-Salem, USA. Since then her research activities have focused on the
menopause. The study will lead to deeper insight into gene regulation in the brain before and after
menopause, with and without medical intervention.
Major Target of Study
Cognitive decline is a major concern in postmenopausal women. However, although estrogens have
shown some promising effects on cognitive function, they are neither approved for this indication nor
recommended for long-term use, due to potential major health risks such as thromboembolism. Thus, a
drug with positive impact on cognition but without increasing health risks would be ideal.
Major Benefit of Study
This study may demonstrate that black cohosh has a positive impact on the brain after menopause.
Abstract
Menopause-related estrogen decline affects the aging process of the female brain and is accompanied
by progressive decline in cognition and memory. Furthermore, estrogen decline also leads to
dysfunction of temperature-sensitive neurons in the hypothalamic preoptic area and other hypothalamic
nuclei areas, which may explain the reduced ability to adapt to changes in ambient temperature
resulting in hot flushes, the most common menopausal symptom. The hippocampus plays a major role
in learning and memory. However, it also contributes to attention, arousal, and emotional states,
including stress, as well as to adaptive and reproductive behavior. Hippocampal outputs are
predominantly inhibitory on downstream neuroendocrine activity. During the peri- and postmenopausal
periods, estrogens or herbs such as black cohosh are often used to treat hot flushes. One explanation
may be that estrogens and black cohosh increase the density of cells in the hypothalamic nuclei
expressing c-fos protein (a marker of neuronal activity). Furthermore, black cohosh also interacts with
the hypothalamic-pituitary-adrenal axis such that it alleviates the acute stress response in rats. Its
neuroprotective effect was recently studied using Sprague-Dawley rats, with comparison of the impact
of estradiol and black cohosh on the hypothalamic nuclei in ovariectomized and intact rats.
My quote after learning about being a laureate:
I think the GRI is a great idea providing the opportunity to focus on research in phytomedicine.
E-Mail: petra.stute@insel.ch
Phone: +41-31-632-1303
- 20 -
Szczepanski, M. J.: Anti-cancer effect of a herbal preparation in head and neck squamous cell carcinoma
Dr Miroslaw J. Szczepanski, MD, PhD, assistant professor,
Department of Otorhinolaryngology, Faculty of Medicine and
Dentistry, Medical University of Warsaw, Poland.
Title of Study
Anti-cancer effect of a herbal preparation in head and neck squamous
cell carcinoma
Biography
Dr Miroslaw J. Szczepanski is an Otolaryngologist certified by the
Polish Board. He received his MD from Poznan University of Medical
Sciences (Poland). He completed his Residency in Otorhinolaryngology
at the Department of Otorhinolaryngology (Warsaw, Poland). He
received his PhD in tumor immunology in 2010 under Professor Grzegorz Dworacki. He spent
a 3.5-year postdoctoral fellowship at the University of Pittsburgh Cancer Institute, Pittsburgh,
PA, USA in Dr Theresa Whiteside's laboratory (2006-2009). He has authored a number of
publications on tumor immunology. Recent honors include the Polish Ministry of Health Award
and the Professor Miodonski Research Award for young laryngologist-scientists. In addition to
work, his passion is scuba diving.
Major Target of Study
This study is the first investigation of the possible in vitro anti-cancer effects of a specific
herbal preparation.
Major Benefit of Study
The information derived from these studies will allow the possible usefulness of a specific
herbal preparation in the chemoprevention or adjuvant treatment of HNSCC to be evaluated.
Abstract
Head and neck squamous cell cancers (HNSCC) are a group of upper respiratory/digestive
tract neoplasms with a substantial clinical and socio-economic relevance. An association
between the development of cancer and inflammation has long-been appreciated. Recently,
attention has been paid to herbal medicines in the treatment of various disorders including
chronic inflammation and cancers. The study focuses on a frequently used herbal medicine
that possesses anti-inflammatory effects. We hypothesize that this medicinal product might
inhibit in vitro tumor development/progression via inhibition of proliferation and induction of
apoptosis in HNSCC cell lines.
My quote after learning about being a laureate:
I think the GRI is a great idea because it will help young scientists to start their own research
projects and translate their research ideas to practical reality.
E-mail: mirski1975@gmail.com
Phone: +48-669-757-552
- 21 -
Wild, J.: Bactericidal/permeability-increasing protein (BPI) as a potential new target for the antimicrobial and immunomodulatory activities of herbal extracts.
Dr Jens Wild, Scientist, Institute of Medical Microbiology & Hygiene,
University of Regensburg, Regensburg, Germany.
Title of Study
Bactericidal/permeability-increasing protein (BPI) as a potential new
target for the antimicrobial and immunomodulatory activities of herbal
extracts.
Biography
Jens Wild obtained a diploma in biology at the Saarland University,
Saarbrücken, and earned his PhD at the University of Ulm. In 2000, he
started working on the development and improvement of innovative
HIV-specific vaccine candidates at the Institute of Medical Microbiology & Hygiene at the
University of Regensburg, where he received habilitation in 2012. In recent years he has
focused on characterizing the in vitro and in vivo functions of bactericidal/permeability-
increasing protein (BPI) as well as T-cell regulation in infectious diseases in mouse models.
Major Target of Study
The study will evaluate the effects of herbal extracts in regulating the production, release,
and biological function of bactericidal/permeability-increasing protein (BPI), one of the most
potent substances of the body’s antimicrobial defense.
Major Benefit of Study
The study will provide an understanding of a possible novel mode of action among the
documented antimicrobial activities of plant compounds, as well as the opportunity to
evaluate effects in vitro and in vivo in well-defined models.
Abstract
The respiratory tract is permanently exposed to inhaled airborne particles, including
potentially harmful pathogens. The first line of host defense is built by innate immune
responses, e.g., infiltrating polymorphonuclear leukocytes (PMNs) which contain a broad
range of pre-stored antimicrobial proteins and peptides, including BPI, which is one of the
body's most potent defense substances. This project will systematically test if and how
various herbal extracts are able to stimulate the degranulation of BPI from PMNs. For in vitro
experiments, human whole blood samples, as well as stem cell-derived murine granulocytes,
will be evaluated; promising extracts will then be tested in vivo in transgenic mouse models.
My quote after learning about being a laureate:
We are very happy about receiving the award because this allows us to provide further
insights into the function of BPI and novel modes of action of herbal extracts.
E-mail: jens.wild@klinik.uni-regensburg.de
Phone: +49-941-9446472
- 22 -
Zabolotna, D.: Study of the adjuvant effects of phytoproducts on the formation of antibodies against influenza virus antigens in the mucous membranes of the upper airways
Dr Diana Zabolotna, Senior Research Fellow, Department of Clinical Allergology,
State Institution “O. S. Kolomiychenko Institute of Otolaryngology, Ukrainian
National Academy of Medical Sciences”, Kiev, Ukraine.
Title of Study
Study of the adjuvant effects of phytoproducts on the formation of antibodies
against influenza virus antigens in the mucous membrane of the upper airways (a
clinical-experimental study).
Biography
Education: graduated from the medical faculty of Bogomolets National Medical
University in 1997 (with honors, number 001011, July 4 1997)
• Specialty - medicine, with 16 years' experience.
• Graduate Education: Internship in Otorhinolaryngology at Bogomolets National Medical University,
1999
• Academic degree and title: PhD in Medicine (2002), Doctor of Medicine ("Clinical and experimental
justification for the use of probiotics in the treatment of chronic nonspecific inflammatory and
allergic diseases of the upper respiratory tract") in 2010
• She plans to continue medical research on the efficacy of phytoproducts
Major Target of Study
This study will explore local monovaccination in the upper airways area against infections entering via the
upper airways and will address the use of immunomodulators for augmenting the effects of vaccination.
Major Benefit of Study
Our data confirm the activating effects of phytoproducts on immune reactions and their anti-inflammatory
and adaptogenic properties; the study will identify whether the concomitant use of phytoproducts and
mucosal vaccines against influenza promotes effective prevention and treatment of viral infections.
Abstract
Study goal and tasks:
- to identify a suitable vector and the extent of immunomodulation of protective antibody formation against
influenza virus by phytoproducts in patients with inflammatory airway diseases and in experimental animals,
both normal and immunodeficient
- to determine the efficacy of immunomodulation (with phytoproducts) of the response to influenza virus
antigens depending on administration time (before or after antigenic stimulation).
- to study a mucosal vaccination method in an optimized regimen (topical only, parenteral only, combined)
in combination with phytoproducts.
- to assess the intensity of antibody formation against influenza virus in patients suffering from chronic
inflammatory diseases undergoing topical or systemic vaccination and using phytoproducts.
My quote after learning about being a laureate:
My laboratory and I appreciate receiving this honorable award because it represents serious recognition of
the work of our scientific group.
E-Mail: dianazab@ukr.net
Phone: +380505068004
- 23 -
Zierau, O./Keiler, A: Effects of a hops extract on bone in a rat model of estrogen deficiency-induced osteoporosis
Dr Oliver Zierau, Researcher, Department of Biology,
Faculty of Science, Institute of Zoology, Technische
Universität Dresden, Germany
Biography
Dr Zierau graduated from the School of Veterinary
Medicine, Hanover, in 1996, did his thesis work at the
Institute for Molecular Medicine at the Medical University
in Lübeck. His doctoral thesis (1999) was: “Influence of
antiestrogens on the expression of estradiol-regulated genes in the endometrial
adenocarcinoma cell line RUCA-I” and his habilitation thesis (2012) at the TU Dresden, was
“Endocrine effects of plant-derived secondary metabolites and synthetic derivatives of
naringenin”. His main research topics at the Department of Molecular Cell Physiology and
Endocrinology at the TU Dresden are the characterization of the cellular and molecular effects
of phytoestrogens in vitro and in vivo as well as the role of estrogens in carcinogenesis and
development. The study will determine whether a hops extract possesses bone sparing
effects in a situation of estrogen deficiency.
My quote after learning about being a laureate:
This award will help us to find and test an alternative to the classical hormone replacement
therapy and to test the efficacy and safety of a hops extract in this situation.
E-mail: oliver.zierau@tu-dresden.de
Phone: + 49-351-463-378-41
Annekathrin Keiler, Researcher, Department of Biology,
Faculty of Science, Institute of Zoology, Technische Universität
Dresden, Germany
Biography
Annekathrin Keiler graduated from the Technical University of
Dresden in 2009. At the moment, she is finishing her PhD
thesis at the Department of Molecular Cell Physiology and
Endocrinology at the TU Dresden. Her main research topics are further characterization of a
preclinical model of postmenopausal osteoporosis and the bone-sparing effects of plant
secondary metabolites using the ovariectomized rat. The study will determine whether a hops
extract possesses bone sparing effects in a situation of estrogen deficiency.
My quote after learning about being a laureate:
I appreciate receiving the Global Research Initiative Award because it might help us find
alternatives for classical hormone replacement therapy.
E-mail: annekathrin.keiler@tu-dresden.de
Phone: +49-351-463-347-33
- 24 -
Title of Study
Effects of a hops extract on bone in a rat model of estrogen deficiency-induced osteoporosis.
Major Target of Study
This study represents the first investigation of the potential of a hops extract in the
prophylaxis and treatment of estrogen deficiency-induced bone loss.
Major Benefit of Study
This study will evaluate hops extracts as an alternative to classical HRT in terms of the
efficacy and safety of potential bone-sparing effects in an animal model of estrogen
deficiency-induced osteoporosis.
Abstract
From the health perspective, the most important results of menopause are osteoporosis and
its consequences. Unfortunately, hormone replacement therapy is associated with increases
in the incidence of breast cancer and cardiovascular diseases. This has led to rising interest in
plant-derived treatment alternatives. Humulus lupulus L. (hops) has a long history as a
medicinal plant e.g., in alleviating gynecological disorders. We plan to use a small-animal
model of osteoporosis to test the potential of a hops extract in estrogen deficiency-induced
bone loss. We also plan to analyze the cancerogenic potential of the hops extract. These
studies should therefore allow us to evaluate the potential of the hops extract as a herbal
remedy for preventing postmenopausal osteoporosis, as well as its safety.
- 25 -
MEDIA CONTACT BIONORICA GLOBAL RESEARCH INITIATIVE
Regina Körner
Head of Global Corporate Communications
Tel.: +49-9181-231-7289
regina.koerner@bionorica.de
For more information please visit:
www.bionorica.de/research.initiative2013
DISCLAIMER
English:
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winners. Bionorica assumes no responsibility for the accuracy, completeness, timeliness or
quality of the information provided. All contents are non-binding.
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