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8/11/2019 GNIPST Bulletin 36.4
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22nd
August, 2014 Volume No.: 36 Issue No.: 04
Vision
TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BAS
LEARNING AND PRACTICE
ontentsMessage from PRINCIPAL
Editorial board
Historical article
News Update
Knowledge based Article
Disease Related Breaking
News
Upcoming Events
Drugs Update
Campus NewsStudents Section
Editors Note
Archive
GNIPST Photo Gallery
or your comments/contribution
For ack-Issues,
ailto:gnipstbulletin@gmail.com
GURU NANAK INSTITUTE OF PHARMACEUTICAL
SCIENCE AND TECHNOLOGY
Website: http://gnipst.ac.in
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MESSAGE FROM PRINCIPAL
"It can happen. It does happen.
But it can't happen if you quit." Lauren Dane.
We are what we repeatedly do.
Excellence then is not an act, but a habit. Aristotle
It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank t
last years editors and congratulate the newly selected editors for the current year.
Our first consideration is always in the best interest of the students. Our goal is to promote academexcellence and continuous improvement.
I believe that excellence in education is aided by creating a learning environment in which all learners a
supported in maximizing their potential and talents. Education needs to focus on personalized learni
and instruction, while promoting an education system that is impartial, universally accessible, and meetin
the needs of all students.
It is of paramount importance that our learners have sufficient motivation and encouragement in order
achieve their aims. We are all very proud of you, our students, and your accomplishments and lo
forward to watching as you put your mark on the profession in the years ahead.
The call of the time is to progress, not merely to move ahead. Our progressive Management is looki
forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken
this direction and fruits of these efforts will be received by our students in the near future. Our Teache
are committed and dedicated for the development of the institution by imparting their knowledge and pl
the role of facilitator as well as role model to our students.
The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positi
challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holis
needs of our students.
I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of th
opportunities and meet the challenges with purpose and determination.
Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us
this path.
My best wishes to all.
Dr. A. Sengupta
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EDITORIAL BOARD
CHIEF EDITOR DR. ABHIJIT SENGUPTA
EDITOR MS. JEENATARA BEGUM
ASSOCIATE EDITOR MR. DIPANJAN MANDAL
HISTORICAL ARTICLE
Terra Sigillata An Early Trademarked DrugMan learned early of the prestigious advantage of trademarks as a
means of identification of source and of gaining customers'
confidence. One of the first therapeutic agents to bear such a mark
was Terra Sigillata (Sealed Earth), a clay tablet originating on theMediterranean island of Lemnos before 500 B.C. One day each year
clay was dug from a pit on a Lemnian hillside in the presence of
governmental and religious dignitaries. Washed, refined, rolled to
a mass of proper thickness, the clay was formed into pastilles and
impressed with an official seal by priestesses, then sun-dried. The
tablets were then widely distributed commercially.
NEWS UPDATE
Experimental Ebola drugs must be fairly
distributed, tested ethically in clinical trials:
(21stAugust, 2014)Critical ethical principles need to be adhered to if experimental
drugs are to be deployed in the Ebola outbreak, bioethicists say,stating that the patients selected to receive such drugs must not be
limited to well-off or well-connected patients - including health
care professionals. These experts also point out that, given the
limited supply of experimental drugs and their low probability of
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success, containment of the epidemic and strengthening health
systems in affected regions should be a priority.
Models to study polyelectrolytes developed,including DNA, RNA: (21stAugust, 2014)A novel and versatile modeling strategy has been developed to
simulate polyelectrolyte systems. The model has applications for
creating new materials as well as for studying polyelectrolytes,
including DNA and RNA. Polyelectrolytes are chains of molecules
that are positively or negatively charged when placed in water.
Because they are sensitive to changes in their environment,polyelectrolytes hold promise for use in applications such as drug
delivery mechanisms.
Adherence to diet can be measured from blood:
(21stAugust, 2014)New results show that it's possible to assess dietary compliance
from a blood sample. This is especially useful in controlled dietary
intervention studies investigating the health benefits of specific
diets. So far, such studies have mainly relied on the participants'
self-reported dietary intake, which is often biased, making it more
difficult to assess the real health benefits.
Missing Protein Restored in Patients with
Muscular Dystrophy: (20thAugust, 2014)
A research team has succeeded in restoring a missing repairprotein in skeletal muscle of patients with muscular dystrophy, a
scientific first. The team has offered a proof-of-principle study and
restored the missing protein in skeletal muscle of patients with
muscular dystrophy. Three patients carrying a dysferlin mutation
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received a single systemic dose of a proteasome inhibitor. After
only a few days the patients musculature produced the missing
dysferlin protein at levels that could be therapeutically effective.
Exercise may protect older women from irregularheartbeat: (20thAugust, 2014)Increasing the amount or intensity of physical activity can cut the
chances of older women developing a life-threatening irregular
heartbeat, according to new research. Researchers found that post-
menopausal women who were the most physically active had a 10
percent lower risk of developing atrial fibrillation (AF), compared
to women with low levels of physical activity, even if they wereobese. Obesity is an important risk factor for atrial fibrillation.
Severing nerves may shrink stomach cancers:
Botox injections slow growth of stomach tumors
in mice: (20thAugust, 2014)Nerves may play a critical role in stomach cancer growth and that
blocking nerve signals using surgery or Botox(onabotulinumtoxinA) could be an effective treatment for the
disease. Stomach cancer is the fourth-leading type of cancer and
the second-highest contributor to cancer mortality worldwide,
with a 5-year survival rate of less than 25 percent.
Seals and sea lions likely spread tuberculosis to
humans: (20thAugust, 2014)Scientists who study tuberculosis have long debated its origins.
New research shows that tuberculosis likely spread from humans
in Africa to seals and sea lions that brought the disease to South
America and transmitted it to Native people there before
Europeans landed on the continent.
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Scientists learn more about rare skin cancer
that killed Bob Marley: (20thAugust, 2014)Acral melanomas, the rare type of skin cancer that caused musician
Bob Marleys death, are genetically distinct from other types of
skin cancer. Acral melanoma most often affects the palms of the
hands, soles of the feet, nail-beds and other hairless parts of the
skin. Unlike other more common types of melanoma, it's not
caused by UV damage from the sun.
Teen sleeplessness piles on risk for obesity:
(20th
August, 2014)Teenagers who don't get enough sleep may wake up to worseconsequences than nodding off during chemistry class. According
to new research, risk of being obese by age 21 was 20 percent
higher among 16-year-olds who got less than six hours of sleep a
night, compared with their peers who slumbered more than eight
hours.
Severe infections with hospitalization afterprostate biopsy rising in Sweden: (20thAugust,
2014)Transrectal ultrasound guided biopsy is the gold standard for
detecting prostate cancer, but international reports have suggested
that the number of risks associated with the procedure is
increasing. In a new nationwide population-based study, Swedish
researchers found that six percent of men filled a prescription for
antibiotics for a urinary tract infection within 30 days after having
a prostate biopsy, with a twofold increase in hospital admissions
over five years.
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Novel gene predicts both breast cancer relapse,
response to chemotherapy: (20thAugust, 2014)Scientists have made it easier to predict both breast cancer
relapses and responses to chemotherapy, through the
identification of a unique gene. The newly found marker could help
doctors classify each breast cancer patient and customize a
treatment regimen that is more effective.
Gene therapy protects mice from lethal heart
condition, researchers find: (20thAugust, 2014)
A new gene therapy has been shown to protect mice from a life-threatening heart condition caused by muscular dystrophy. About
one in 3,500 children, mostly boys, are born with Duchenne
muscular dystrophy (DMD). They experience a progressive
wasting away of muscles, starting in the legs and pelvis. Children
with DMD have difficulty walking, and most need wheelchairs by
age 12.
Coronary arteries hold heart-regenerating cells:(20thAugust, 2014)Endothelial cells residing in the coronary arteries can function as
cardiac stem cells to produce new heart muscle tissue,
investigators have discovered. The heart has long been considered
to be an organ without regenerative potential, said one expert.
Recent findings, however, have demonstrated that new heart
muscle cells are generated at a low rate, suggesting the presence ofcardiac stem cells. The source of these cells was unknown.
For detail mail toeditor
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KNOWLEDGE BASED ARTICLE
Amyotrophic Lateral Sclerosis (ALS)A-myo-trophic comes from the Greek language. "A" means no or
negative. "Myo" refers to muscle, and "Trophic" meansnourishment"No muscle nourishment." When a muscle has no
nourishment, it "atrophies" or wastes away. "Lateral" identifies the
areas in a person's spinal cord where portions of the nerve cells
that signal and control the muscles are located. As this area
degenerates it leads to scarring or hardening ("sclerosis") in the
region.
It is characterised by musclespasticity,rapidly progressiveweakness due tomuscle atrophy,difficulty in speaking
(dysarthria), swallowing (dysphagia), and breathing (dyspnea).
ALS is the most common of the fivemotor neuron diseases.
As motor neurons degenerate, they can no longer send impulses to
the muscle fibers that normally result in muscle movement. Early
symptoms of ALS often include increasing muscle weakness,
especially involving the arms and legs, speech, swallowing orbreathing. When muscles no longer receive the messages from the
motor neurons that they require to function, the muscles begin to
atrophy (become smaller). Limbs begin to look "thinner" as muscle
tissue atrophies.
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The body has many kinds of nerves. There are those involved in the
process of thinking, memory, and of detecting sensations (such as
hot/cold, sharp/dull), and others for vision, hearing, and other
bodily functions. The nerves that are affected when you have ALS
are the motor neurons that provide voluntary
movementsand muscle power. Examples of voluntary movements
are your making the effort to reach for the phone or step off a curb;
these actions are controlled by the muscles in the arms and legs.
The heart and the digestive system are also made of muscle but adifferent kind, and their movements are not under voluntary
control. When your heart beats or a meal is digested, it all happens
automatically. Therefore, the heart and digestive system are not
involved in ALS. Breathing also may seem to be involuntary.
Remember, though, while you cannot stop your heart, you can
hold your breath - so be aware that ALS may eventually have an
impact on breathing.
Although the cause of ALS is not completely understood, the
recent years have brought a wealth of new scientific understanding
regarding the physiology of this disease.
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Causes:
Genetics:
There is a known hereditary factor in familial ALS, where the
condition is known to run in families. A defect onchromosome 21,
which codes forsuperoxide dismutase,is associated with
approximately 20% of familial cases of ALS, or about 2% of ALS
cases overall. This mutation is believed to be transmitted in
anautosomal dominantmanner, and has over a hundred different
forms of mutation. The most common ALS-causing mutation is a
mutant SOD1 gene, seen in North American patients; this is
characterized by an exceptionally rapid progression from onset todeath. The most common mutation found in Scandinavian
countries,D90A-SOD1,is more slowly progressive than typical ALS
and patients with this form of the disease survive for an average of
11 years.
Another very common cause of ALS is alesion to the motor system
in areas such as the frontotemporal lobes. Lesions in these areas
often show signs of early deficit, which can be used to predict theloss ofmotor function,and result in the spread of ALS.
Pathophysiology:
The defining feature of ALS is the death of both upper and lower
motor neurons in the motor cortex of the brain, the brain stem, and
the spinal cord. Prior to their destruction, motor neurons develop
protein-richinclusionsin their cell bodies andaxons.This may be
partly due to defects in protein degradation. These inclusions oftencontainubiquitin,and generally incorporate one of the ALS-
associated proteins:SOD1,TAR DNA binding protein (TDP-43, or
TARDBP), orFUS.
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Diagnosis:
No test can provide a definite diagnosis of ALS, although the
presence of upper and lower motor neuron signs in a single limb is
strongly suggestive. Instead, the diagnosis of ALS is primarilybased on the symptoms and signs thephysicianobserves in the
patient and a series of tests to rule out other diseases. Physicians
obtain the patient's full medical history and usually conduct a
neurologic examination at regular intervals to assess whether
symptoms such as muscle weakness, atrophy of muscles,
hyperreflexia, and spasticity are getting progressively worse.
Certainelectromyography(EMG) findings can support thediagnosis of ALS. Another common test measuresnerve conduction
velocity(NCV).
Management:
Riluzole(Rilutek) is the only treatment that has been found to
improve survival but only to a modest extent. It lengthens survival
by several months, and may have a greater survival benefit for
those with a bulbar onset. It also extends the time before a person
needs ventilation support. Riluzole does not reverse the damage
already done to motor neurons, and people taking it must be
monitored for liver damage (occurring in ~10% of people taking the
drug). It is approved byFood and Drug Administration (FDA) and
recommended by theNational Institute for Clinical
Excellence(NICE).
Ice Bucket Challenge:
TheIce Bucket Challenge, sometimes called the ALS Ice Bucket
Challenge, is an activity involving dumping a bucket of ice water
on one's head or donating to theALS Associationin the United
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States. It went viral throughoutsocial mediaduring theNorthern
Hemispheresummer of 2014.The challenge dares nominated
participants to have a bucket of ice water poured on their head.
One common stipulation gives 24 hours from the time they are
nominated to complete the dare; otherwise, the participant is
asked to donate money to charity.
How Has Stephen Hawking Lived to 70 with ALS?
One thing that is highlighted by this man's course is that this is an
incredibly variable disorder in many ways. On average people live
two to three years after diagnosis. But that means that half thepeople live longer, and there are people who live for a long, long
time.
Life expectancy turns on two things: the motor neurons running
the diaphragmthe breathing muscles. So the common way
people die is of respiratory failure. And the other thing is the
deterioration of swallowing muscles, and that can lead to
malnutrition and dehydration. If you don't have these two things,
you could potentially live for a long timeeven though you're
getting worse. What's happened to him is just astounding. He's
certainly an outlier.
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ALS still doesn't have a cure. What have we learned about the
disease recently that might help us find oneor at leastbetter
treatments?
Beginning in 2006 it became clear that like a lot of otherneurodegenerative diseases, ALS was determined by the
accumulation of abnormal proteins in the brain. Ten percent of
ALS is genetic and based on a gene mutation. There are also at-risk
genes for ALS, but there are now multiple genes that have been
identified as potentially causing the disease. Each one of them are
interesting in that they lead to the accumulation of different
proteins in the brain. Knowing specific genes gives us particular
mechanisms in the brain, and would potentially give us targets fortherapies. But none of this has given us any robust therapies yet.
Anurag Chanda
Student (B.Pharm, 4thYear)
DISEASE RELATED BREAKING NEWS
Ebola virus disease, West Africa (20thAugust,
2014)Between 17 and 18 August 2014, a total of 221 new cases of Ebola
virus disease (laboratory-confirmed, probable, and suspect
cases) as well as 106 deaths were reported from Guinea, Liberia,
Nigeria, and Sierra Leone.Read more
UPCOMING EVENTS
5thInternational Conference on Stem Cells and Cancer 2014, JNU
Convention Centre, New Delhi, India from 8-10 November, 2014
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http://www.scientificamerican.com/article.cfm?id=playing-defense-against-lhttp://www.scientificamerican.com/article.cfm?id=playing-defense-against-lhttp://www.scientificamerican.com/article.cfm?id=playing-defense-against-lhttp://www.who.int/csr/don/2014_08_20_ebola/en/http://www.who.int/csr/don/2014_08_20_ebola/en/http://www.who.int/csr/don/2014_08_20_ebola/en/http://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://www.who.int/csr/don/2014_08_20_ebola/en/http://www.scientificamerican.com/article.cfm?id=playing-defense-against-lhttp://www.scientificamerican.com/article.cfm?id=playing-defense-against-l8/11/2019 GNIPST Bulletin 36.4
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DRUGS UPDATES
FDA allows marketing of first ZnT8Ab autoantibody
test to help diagnose type 1 diabetes: (20thAugust, 2014)
U.S. Food and Drug Administration allowed marketing of the first
zinc transporter 8 autoantibody (ZnT8Ab) test that can help
determine if a person has type 1 diabetes and not another type of
diabetes. When used with other tests and patient clinical
information, the test may help some people with type 1 diabetesreceive timely diagnosis and treatment for their disease.Read more
CAMPUS NEWS
The Freshers welcome programme was held on 14thAugust, 2014.Welcome 1styear students.
We congratulate the following M.Pharm. final year students who
have made their positions in different pharmaceutical companies.Anirban Banerjee (Emami Ltd.)
Mahender Roy (Stadmed private Ltd.)
We congratulate the following B.Pharm. final year students fortheir success.
Samadrita Mukherjee (Abbott India Ltd.)
Suman Sarkar (Tata Medical Centre-Apollo Pharmacy)
Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition)Avishek Naskar (Glaxo SmithKline-Marketing)
Bappaditya Manik (USV Limited)
Sarbani Das (Nutri Synapzz-Marketing)
Ankita Roy (Nutri Synapzz-Marketing)
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Rahul Mitra (B M Pharmaceuticals-Production)
The following B.Pharm. final year students have qualified, GPAT-2014. We congratulate them all.
Utsha SinhaSatarupa Bhattacharya
Sandipan Sarkar
Purbali Chakraborty
Reminiscence, 2014(GNIPST Reunion) was held in Collegecampus on 2ndFebruary,2014.
1st Annual Sports of GNIPST was held on 3rd February,2014 in
College campus ground.An industrial tour and biodiversity tour was conducted in Sikkim
for B.Pharm and B.Sc. students under the supervision of Mr. Asis
Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.
B.Pharm 3rd year won the GNIPST Football Champions trophy,2013. B.Pharm 3rdyear won the final match 1-0 against B.Pharm 2nd
year. Deep Chakrabortywas the only scorer of the final.
STUDENTS SECTION
WHO CAN ANSWER FIRST????
Richard Martin Willstatter first
chemically synthesized which
compound?
In 1981 US dept of defense adopted
which technique for selling good?
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Answer of Previous Issues Questions
A) Fields Medal
B)PETA
Identify the person
Answer of Previous Issues Image
J.C.Field
Send your thoughts/
Quiz/Puzzles/games/write-ups or any other
contributions for Students Section
answ ers of this Section at gnipstbulletin@gmail.com
EDITORS NOTE
It is a great pleasure for me to publish the 4th
issue of 36th
Volume
of GNIPST BULLETIN. All the followers of GNIPST BULLETIN
are able to avail the bulletin through facebook account GNIPST
bulletin I am very much thankful to all the GNIPST members and
readers who are giving their valuable comments, encouragements
and supports. I am also thankful to Dr. Abhijit Sengupta, Director
of GNIPST for his valuable advice and encouragement. Special
thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar
and Mr. Soumya Bhattacharya for their kind co-operation and
technical supports. Thank you Mr. Soumya Bhattacharyafor the
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questionnaires of the student section. An important part of the
improvement of the bulletin is the contribution of the readers. You
are invited to send in your write ups, notes, critiques or any kind of
contribution for the forthcoming special and regular issue.
ARCHIVE
Students of GNIPST organized pre puja celebration programme,Saaranya on 7thOctober, 2013 in college Auditorium.
GNIPST organized a garment distribution programme on 28th
September, 2013 at Dakshineswar Kali Temple and Adyapith,Kolkata. On this remarkable event about hundred people have
received garments. More than hundred students and most of the
faculties participated on that day with lot of enthusiasm.
GNIPST celebrated World Heart Day (29th September) andPharmacists Day (25thSeptember)on 25thand 26thSeptember,
2013 in GNIPST Auditorium. A seminar on Violence againstwoman and female foeticide was held on GNIPST Auditorium on
25th September organized by JABALA Action Research
Organization. On 26thSeptember an intra-college Oral and Poster
presentation competition related to World Pharmacists day and
Heart day was held in GNIPST. Ms. Purbali Chakraborty of
B.Pharm 4th year won the first prize in Oral Presentation. The
winner of Poster presentation was the group of Ms. Utsa Sinha,
Mr. Koushik Saha and Mr. Niladri Banerjee(B.Pharm 4thyear).
A good number of students have participated in both the
competition with their valuable views.
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Teachers daywas celebrated on 5thSeptember, 2013 by the
students of GNIPST in GNIPST Auditorium.
A zalea exotic flower ) , the fresher welcome programme fornewcomers of GNIPST in the session 2013-14 was held on 8th
August in GNIPST Auditorium.
One day seminar cum teachers development programme forschool teachers on the theme of Recent Trends of Life Sciences
in Higher Education organized by GNIPST held on 29th June,
2013 at GNIPST auditorium. The programme was inaugurated by
Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, DyDirector of JIS Group and Dr. Abhijit Sengupta, Director cum
Principal of GNIPST with lamp lighting. The programme started
with an opening song performed by the B.Pharm students of this
institute. The seminar consists of a series of lectures, video
presentations and poster session. On the pre lunch session 4
lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata
Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty
respectively. On their presentation the speakers enlighten the
recent development of Pharmacy, Genetics and Microbiology and
their correlation with Life Sciences. On the post lunch session,
Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the
recent development and career opportunities in Biotechnology
and Hospital Management. The programme was concluded with
valedictory session and certificate distribution.
About 50 Higher secondary school teachers from differentschools of Kolkata and North& South 24 Parganas district of
West Bengal participated in this programme. A good interactive
session between participants and speakers was observed in the
seminar. The seminar was a great success with the effort of
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faculties, staffs and students of our Institute. It was a unique
discussion platform for school teachers and professional of the
emerging and newer branches of Life Science.
The general body meeting of APTI, Bengal Branch has beenconducted at GNIPST on 15th June, 2012. The program started
with a nice presentation by Dr. Pulok Kr. Mukherjee, School of
Natural Products, JU on the skill to write a good manuscript for
publication in impact journals. It was followed by nearly two hour
long discussion among more than thirty participants on different
aspects of pharmacy education. Five nonmember participants
applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm)
in P H A R M A C O L O G Y .The approved number of seat is 18.
The number of seats in B.Pharm. has been increased from 60 to
120.
AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-13to
GNIPST as per the details below:
a. Beneficiary Institution:Guru Nanak Institution of Pharmaceutical
Science & Technology.
b.Principal Investigator:Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d.Approved duration: 3 years
e. Title of the project: Screening and identification of potential
medicinal plant of Purulia & Bankura districts of West Bengal
with respect to diseases such as diabetes, rheumatism, Jaundice,
hypertension and developing biotechnological tools for enhancing
bioactive molecules in these plants.