Gold Graphene Nano Composite Sensors for …...SCIO 1) Screen printed electrodes - SCI 2)...

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Gold Graphene Nano Composite Sensors for Biomolecule DetectionAITAustrianIns,tuteofTechnologyGmbHHealth&EnvironmentDepartmentMolecularDiagnos,csRudolfHeerwww.ait.ac.at/profile/detail/Heer-Rudolf

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Austriasbiggestnon-universityresearchins,tuteinnumbersOwners:50.46%RepublicofAustria

BMVITFederalMinistryforTransport,InnovaConandTechnology49.54%Federa,onofAustrianIndustries

Employees:1000plus200-250oncontractbasis,thereof95PhDstudentsFinancialGoal: 30%CooperaCveResearch

30%ContractResearch

40%BasicFundingTotalOpera,ngIncome:120Mio.€

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Diagnostic Biosensors Diagnostic Biosensors

BusinessUnitMolecularDiagnos,cs

Saliva Diagnostics

Biomarker Development

Assay Development

Systems Integration Point-of-Care

Bioinformatics

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Pep,des

(e.g.hormones)

Proteins(e.g.anCbodies,

enzymes,hormones)

Nucleicacids

(DNA,RNA,mRNA,miRNA)

Viruses,cells

Biologicaltargets

Waveguides

Surfaceplasmonresonance(SPR)

Fluorescence

Chemo-luminescenceWhitelightinterferometry

MagneCcnanoparCcles

Magneto-resistance(GMR,TMR)Micro-nuclearmagneCcresonance

Colorimetric(lateralflowdevices)

Quartzcrystalmicrobalance

SurfaceacousCcwaves

Amperometry

Voltammetry

Impedancespectroscopy CanClevers

Op,cal Magne,c Electro-chemical

Massbased

Sampleliquid

Signalreadout&processing

Transducer

Receptorsurface

Biosensor

Displayofresults

Waveguides Magne,cnanopar,cles

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Diagnostic biosensor development

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SCIO2013Trademission–NanotechnologyScien,fictalksandB2Bmee,ngsBeijing–ChineseAcademyOfSciencesShuzhou–Exhibi,onattheAustrianCHInano2013boothShanghai–ShanghaiUniversity

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1st Call for Austrian - Chinese Cooperative RTD Projects between FFG and SHANGHAI UNIVERSITY

NaCoS … Gold Graphene Nano Composite Sensors for Biomolecule Detection AIT Austrian Institute of Technology GmbH AIT Nanoscience & Technology Research Center SHU SCIO Holding GmbH SCI

Novel inkjet printing biofunctionalization

concept of screen printed electrodes

Diagnosis and treatment of cardiovascular disease to

demonstrate the feasibility CRP,BNP,Thrombin

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AIT

AIT SCI

SHU

The overall process flow bases on different semi-finished goods.

&

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SCIO2)Gold/grapheneoxidenano-composits-SHU1)Screenprintedelectrodes-SCI

5)Electrochemicalsensorwithamperometricreadout-AIT

3)Func,onaliza,onofGoldNPinavessel-AIT

„commercial“availableaptamers(withaaachedredoxlabel)

fordetec,onof:CRP,BNP,Thrombin

4)Prin,ngfunc,onalizedink-AIT

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Gold Graphene Nano Composites

Graphene-Oxide / Gold-nanoparticle composite Biofunctionalization of the gold nanoparticles

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RudolfHeerwww.ait.ac.at/profile/detail/Heer-Rudolf

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