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2020

I II

I.

ATP14S 14S

KCla e

A E

b ) 8 C A A 2 01

K 4 (

Abs280

1~2

Abs280

280 nm

pH

pH pH

d D CC D

(i)

2~3 (ii) 1

II. F ATP

(a)

FF

AATP

A

F

ATP

AATP B

ATPC D

(b)ATP CD

S 4

[ ] Z

α-

A D Li+

(a) F

(b) (i) ATP

(ii) (i) (b)

(a) RNA

(b) 60S 40S80S

RNA IRNA rRNA 45S

rRNA 28S 5.8S 18S rRNA 28S rRNA 5.8S rRNA 60S 18S rRNA 40S

60S (c) RNA III5S rRNA

80S

(a) A C

RNAA B

A RNADNA C B mRNA

(b) 60S 40S100S 1 2

(c) 5S rRNA RNA IIIRNA 1 RNA

mRNA

X RNA

X RNA2 3

X RNA

1 2 3

X RNA

3 4

I V

(a) (b)

(c)

(d)

(e)

DNA I (a) 1 5

1.

90% 2. CpG CpG

3. DNA 4. 2 3 5. N

1/(4N)

II (b) 1 4

4

2

1

III (c)

3 5

IV (d)

22 3

���

V (e)

DNADNA

2 DNA DNADNA

DNA ]

DNA DNA

2′ 3′ 3′ 2′ 2′ 5′ 5′ 2′ 3′ 5′ 5′ 3′ DNA RNA DNA DNA DNA

[

I II

)

RGCRGC )

RGC )

180 )

) a RGC )

)

)RGC )

b ) )

�� C

G C

( a ) )RGC

)( 1

RGC ●RGC ○

( b ) 1 2) )

) X) )

A B

A

)RGC )

)

) PI-PLCC )

) c ) )

�

B)

X )d )

��� C �

�

( c ) X 1

A ) X RGC

( d ) ) X )

( d ) ) X ) RGC)

)2 3

I III

I. i) ii)

8 Lewis

H2SO3

i) CH3NO ii) HNO3

i)ii)

i) 4-(1- ) ii) (E)-3- -2- -2- -1- II. i) v) AF

III. 1 5 1 2 1. C4H8Cl2 6 2. (1S,2S)-1- -2- E2 1-

3. 2

4.

pKa

5. Michael

CO2CH2CH3

CO2CH2CH3

CH3

O

マロン酸ジエチル メチルビニルケトン

I III I. 10

A D

[ ]

CrO3 KMnO4 H2, Pd/C Na2SO4 Na2CO3, H2O

HNO3, H2SO4

NaH HO(CH2)2OH CH3NO2

1 2 2 1H NMR

Ha δ (ppm) (0 ppm)

1~3 3~5 5~7 7~9 9~11 11~13 3 4 7 2

1 2 6 Hb 7 Hc 1H NMR

δ (ppm) 1 2

OHC CH

O

II. [ A ] [ B ] [ A ]

[ C ] [ B ] s [ D ] %[ C ] s [ E ]% s

[ F ] [ G ] 44 [ G ] 25

[ H ]

( RO- ) ( ROH )

ROH [ G ] [ G ] [ I ]

[ A ] [ I ]

[ ] ΔG0 ΔH0 Kd Ka Kb pKa pKb pH sd sd2 sd3 sp sp2 sp3

20 25 33 40 50 60 67 75

( ROH )

III. 11 6 5

5 3

I V

25

25 (s) (l)

(g)

2

I. 1.0×10 V 7.0 A 5.0×102 s

5.0 K

q J kJ

C

II. 1.0×10−2 mol

1.4 K 1 mol

ΔU

III.

NH2CH2COOH (s) + O2 (g) CO2 (g) + H2O (l) + N2 (g)

(g)

- Δνgas Δνgas =

IV. 1 mol ΔH

R T ΔH ΔU Δνgas

V.

ΔU ΔH

ΔU ΔH

pa

Va na T T

pa

Vb Va Vb / Va

p V V + dV

w p

pa q

Va Vb

.

x px 0 h

ℎ = 6.626 × 10!!" �x

�px

− ℏ!/2! !!!"! + ! ! ! ! = !" !

! ! m

ℏ = ℎ/2! ! ! E

0

! ! = 0 0 ≤ ! ≤ ! , ! ! = ∞ (! < 0, ! > !) ! 0 = ! ! =

! n

! = ! ! = !×N !" !!!"

!! !!

1 ! ! ! =

7 L ! = 0 ≤ ! ≤ ! ! ! = 0E ! = !!/2! = L

! = 1 E

1

[ ]

J s Js Js–1 ∆!!∆! ≥ ℎ/2! ∆!!∆! ≤ ℎ/2! ∆!!∆! ≥ ℎ/4! ∆!!∆! ≤ ℎ/4!0 1 h ° nL L/n

2nL 2L/n�sin !"#/! cos !"#/! tan !"#/!! ℎ! ℎ/! !/ℎ nh/L n/hL nh/2L n/2hL nh/8mL2 n2h2/8mL n2h/8mL2

n2h2/8mL n2h2/8mL2

MO MO

. MO ����������� HOMO

. MO LUMO

MO

.

1