IAN Test Drive

Baylor• Principal Investigator: Dr. Robin Goin-Kochel• Study Title: Autism Treatment Network• Location: Baylor College of Medicine/Texas Children's Hospital• Inclusion: 1. Children between the ages of 3.0 –17.9; the subject will be

expected to complete the protocol by his/her eighteenth birthday. 2. Parent/Caregiver fluent in written and spoken English/ English spoken in the home with the child at least 75% of the time (because most assessment questionnaires are validated in English only). (Additional inclusion criteria, such as having an ADI-R/ADOS confirmed ASD diagnosis, will be done at the ATN site.)

• Exclusion: 1. Blindness precluding valid testing. 2. Deafness precluding valid testing. 3. Ongoing or planned participation in another research protocol that would either prevent successful completion of planned study testing or invalidate the results of study testing.

Baylor

Baylor

300 Subjects

Baylor

University of Iowa• Principal Investigator: Dr. Karla McGregor• Study Title: The Development of Word Meaning• Location: University of Iowa • Catchment area: Iowa or 100 miles of Iowa City• Inclusion: chronological age = 8 to 13 years; verbal; high-

functioning (not mentally retarded); normal hearing acuity• Exclusion: none• Sample size: 30

Iowa

Iowa

Multi-Center Baby Sibs Study• Principal Investigator: Dr. Joe Piven et al• Study Title: Brain Development in Infants at High Risk for Autism• Location: (Multi-center) University of North Carolina at Chapel Hill,

Washington University, University of Washington, Yale University• Inclusion: under 12 months of age; at least one older sibling with a

documented diagnosis of autism• Exclusion:• * Certain medical and genetic conditions • * MRI contraindication• * Non-English speaking

Baby Sibs (ACE Study, Joe Piven et al)0

1020

3040

Freq

uenc

y

0 2 4 6 8 10age_in_months

N=160

Exploring the Treatment Data

Treatments0

100

200

300

400

Num

ber o

f chi

ldre

n

0 5 10 15 20 25 30 35 40Number of Treatments

updated 18 Jun 2007

Number of Treatments per Child

Top Twelve Treatments Nationwide1. Speech and Language Therapy2. Occupational Therapy 3. Applied behavior analysis (ABA)4. Social Skills Group 5. Picture Exchange Communication System (PECS)6. Physical Therapy7. Visual Schedules8. Sensory Integration Therapy9. Social Stories10.Risperdal11.Casein-free diet12.Melatonin

Intervention Improvement Expected Improvement

ExpectedRisk

ExpectedBurden

N

Keppra 2.8 3.7 2.6 2.1 15

Ritalin 2.7 3.4 2.6 2.1 32

Feingold diet 2.7 2.8 1.1 3.4 15

Homeopathy 2.5 2.5 1.6 2.4 23

Melatonin 2.5 2.9 1.7 1.5 179

Clonidine 2.5 3.2 2.2 1.9 135

DTT 2.4 3.5 1.4 2.6 115

Prayer 2.4 2.9 1.1 1.2 133

Remeron 2.4 3.3 2.5 1.9 11

Parental Age

Parental Age0

200

400

600

800

Freq

uenc

y

20 25 30 35 40 45 50 55 60 65FathersAge

Moternal Age0

200

400

600

800

1000

Freq

uenc

y

20 25 30 35 40 45 50 55 60 65MothersAge

020

040

060

0

20 25 30 35 40 45 50 55 60 65 20 25 30 35 40 45 50 55 60 65

1 2

Freq

uenc

y

FathersAgeGraphs by gender_id

32.8

33.0

P=0.5

MaleFemale

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