JOUNRAL CLUB PRESENTATION

DR MOHD SHAHID DEPARTMENT OF MOLAJAT

NIUM, BANGALORE

BMC Complementary and Alternative Medicine is an open access, peer-reviewed journal that considers articles on interventions and resources that complement or replace conventional therapies, with a specific emphasis on research that explores the biological mechanisms of action, as well as their efficacy, safety, costs, patterns of use and/or implementation

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Received: 16 Nov 2012 Accepted: 01 Nov 2013Published: 13 Nov 2013

Article information

A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia

Title of the Research article

Informative ?

Self Explanatory ? Variables are Specific ?

Critics

Daniel W O’Connor* Barbara Eppingstall John Taffe Eva S van der Ploeg

*Correspondence: Daniel.OConnor@monash.edu School of Psychology and Psychiatry, Monash University, Kingston Centre, Warrigal Road, Cheltenham, Victoria 3192, Australia

Authors

Competent ?

Degree and Designations ?

E mail is mentioned

Critics

A progressive, irreversible decline in mental function, marked by memory impairment and, often, deficits in reasoning, judgment, abstract thought, registration, comprehension, learning, task execution, and use of language

In the U.S., 4.5 million people are afflicted by dementia. The prevalence is esp. high in the very elderly: about 20% to 40% of those over 85 are demented

Dementia is somewhat more common in women than in men

Definition of Dementia

Synonym L. officinalis Chaix. L. spica Linn.

Family Labiatae; Lamiaceae.

Habitat Native to Mediterranean region; cultivated in Jammu and Kashmir

English name: Lavender

Lavandula angustifolia (C P Khare)

Action Herb—mildly sedative, antiflatulent and cholagogue. Essential oil—antiseptic, antibacterial, antispasmodic.

Major constituents of the essential oil are linalool and linalyl acetate.

Family Papilionaceae; Fabaceae.

Habitat Mediterranean region and Asia Minor. Dried plant and flowers are imported into Mumbai from Persian Gulf

English Arabian or French: Lavender

Unani: Ustukhuddus, Alfaajan

Folk: Dhaaru

Lavandula stoechas Linn.

Action Flowers—antidepressive, sedative, anticonvulsant, carminative, antispasmodic, antibacterial, antiseptic. Used in depression, nervous headache, sluggish circulation, physical and mental exhaustion, insomnia, epilepsy, neuralgia and rheumatic affections

Plant—used for the treatment of epilepsy and chronic sinusitis in Unani medicine.

Cont...

BACKGROUND clearly mentioned Objective is clearly stated (want to know efficacy of

test drug ) It is a Randomized, single blind cross-over trial,

mentioned in abstract Study design is also given in abstract Hypothesis is declare Results also mentioned clearly that test drug is not

significant against the conrol drug Trial registration also stated (ACTRN)

Abstract

Conclusion is comprehensible

Within the word limit

Purpose of study is well defined

Cont...

Within word limits

Appropriate

Key words

Prevalence missing of dementia More emphasis on Lavender Wonderfully describe why they choose test drug

with proper references. One study quted, that describe the efficacy is

equal to lorazepam0.5 mg Literature review provided Aim of study is mentioned Astonishingly discussed about previous study

INTRODUCTION

Need of study is mentioned

Purpose of study is mentioned but why they choose fore arm massage instead of head or any other part of the body, not declared

Cont...

Palace of study point out, and also from where the participants enrolled (8 specialist Psychogeriatric nursing home and 3 private nursing home in Melbourne)

Diagnostic criteria is declare, with REFERENCE (CLINICAL DEMENTIA RATING SCALE)

Inclusion & Exclusion criteria Stated Test drug & dosage are mentioned properly, WHY

THIS DRUG---- REFERENCES given Duration of study mentioned between 2009 and 2011)

Methodology

Study protocol approved by IEC Test drug choose after electrophysical analysis in

Department of Pharmacology and Toxicology, Otago University, New Zealand

Not describe the control drug (just stated neutral control oil)

Follow up & total number of patient screened declared Drop outs declared, with REASONS Randomization done through

Exel random number generator

Cont...

Duration of protocol is also declared, that is both intervention comprised 3 exposures over a one week with 4 days washout period and the trial was limited to 2 week

Sample size declared Group A: total allocated patients 38, number of patients

complete the intervention are 37 Group B ; total allocated patients 28, number of patients

complete the intervention are 27 Written consent was taken from the next of Kin or legal

guardians Study design mentioned

Cont...

Subjective and Objective criteria point out

Tables are clearly defined, with Graphical representation

Analysis are made through 1. Two sided hypothesis test with Type I error rate 0.05

and power set to 902. Binomial regression test

Results

Discussion about the result are justified Mention the limitation of study1. Product varialbility2. Limited knowledge base of lavender’s

pharmacological properties3. Dosing strategies are based largely on traditional

practice

Discussion

Unambiguously declare that Studies of essential oils are constrained by their variable formulations and uncertain pharmacokinetics and so optimal dosing and delivery regimens remain speculative.

However this, topically delivered, high strength, pure lavender oil had no discernible effect on affect and behaviour in a well-defined clinical sample.

Conclusion

Acknowledgements are declare

Funding: By National Health and Medical Research Council and the Dementia Collaborative Reasearch Centre administered through the University of New South Wales. Neither funding body, nor the supplier of materials, played any part in analysing data and preparing this report.

Reference according to the journal guidelines

This is wonderful example that how to done and write a standard paper

For me, this is the way to approach a study before going to conduct it

They have given every answers before you raise any question

Wonderful paper

Take home message

Always welcome at drshahidkhan2005@gmail.com

Thanks for your patience

Open For Discussion