Latin American Section of the American Nuclear Society Symposium 2005

Post on 02-Jan-2016

34 views 1 download

description

Latin American Section of the American Nuclear Society Symposium 2005 FDG Production at IEN/ CNEN - Rio de Janeiro, Brazil J.C.Suita. Instituto de Engenharia Nuclear. Foundation: 1962 280 employees today. /CNEN. - PowerPoint PPT Presentation

transcript

Latin American Section of the American Nuclear Society

Symposium 2005

FDG Production at IEN/ CNEN - Rio de Janeiro, Brazil

J.C.Suita

Instituto de Engenharia Instituto de Engenharia NuclearNuclear

Foundation: 1962Foundation: 1962280 employees today280 employees today

/CNEN

It occupies an area of 146.000m2, in the Campus of the UFRJ, being 18.028m2 of constructed area.

Main Activities Areas: ReactorsCornerstone of the Institute, the research reactor Argonauta is nowadays one of IEN's installations designed for experimental activities in physics and reactor engineering. Together with the nuclear and thermohydraulic measurement laboratories, it is used for the development of new applications in nuclear techniques; in supporting technical studies for the project, license and operation of nuclear installations, in the irradiation and sample analysis, as well as in personnel training, with post-graduate and specialization courses.

Instrumentation and Human Reliability

IEN has developed more that 20 prototypes of spectrometry, radiation protection and nuclear medicine equipment during this period. The activities related to human reliability started with the Laboratório de Interfaces Homem/Sistema - LABIHS (Human/System Interface Laboratory), an installation that simulates the processes and the working environment in a nuclear plant control room.

Chemistry and Nuclear MaterialsThe research, development and services related to chemistry conducted by IEN include the following activities: chemical and metallurgical processes, environmental technology, chemical analysis and material tests. The development of methodologies that use ultrasound techniques to evaluate residual tension in structures/components of nuclear reactors and others, as well as the efficiency of the measures taken to decrease tension, is an example of how advanced IEN is in the material characterization field.

Radiopharmaceutical Radiopharmaceutical ProductionProduction

CV 28 Cyclotron - 1974 RDS-111 Cyclotron - 2002

Radiopharmaceutical Radiopharmaceutical Production at IENProduction at IEN

123123I-NaII-NaI

123123I-MIBGI-MIBG

1818 F-FDG F-FDG

DIRA/SERADDIRA/SERAD

Routine ProductionRoutine ProductionWeekly ScheduleWeekly Schedule

Irradiation:Irradiation:SundaySunday 04:00 - 07:00 pm Iodide 04:00 - 07:00 pm Iodide MondayMonday 08:00 am - 02:00 pm MIGB 08:00 am - 02:00 pm MIGBTuesday Tuesday 01:00 - 04:00 pm 01:00 - 04:00 pm IodideIodide

Chemical Process:Chemical Process:

MondayMonday 07:30 am - 10:00 am Iodide 07:30 am - 10:00 am Iodide Tuesday Tuesday 07:30 am - 11:30 am 07:30 am - 11:30 am MIGBMIGBWednesdayWednesday 07:30 am - 10:00 am 07:30 am - 10:00 amIodideIodide

FDG Production: DailyFDG Production: Daily

Quality ControlQuality Control

GCAcetonitrile

andEthanol

--Chemical Purity

7.07.07.5-8.0pH

Limulus Testand

Sterility

Limulus Testand Sterility

Limulus Test andSterility

Biological Purity

Half LifeGammaSpectrocopy:

> 99%

GammaSpectrocopy:

> 99%

Radionuclide Purity

HPLCF-/FDG> 96%

HPLCI-/MIBG

> 95%

HPLCI-/IO3

- > 97%Radiochemical Purity

18F-FDG123I-MIBGNa123I

GCAcetonitrile

andEthanol

--Chemical Purity

7.07.07.5-8.0pH

Limulus Testand

Sterility

Limulus Testand Sterility

Limulus Test andSterility

Biological Purity

Half LifeGammaSpectrocopy:

> 99%

GammaSpectrocopy:

> 99%

Radionuclide Purity

HPLCF-/FDG> 96%

HPLCI-/MIBG

> 95%

HPLCI-/IO3

- > 97%Radiochemical Purity

18F-FDG123I-MIBGNa123I

Positron Emission Tomography - PET

Number Installed in the world

0

200

400

600

800

1000

1200

1400

1600

81 86 87 88 89 90 91 92 93 94 95 96 97 98 99 2000 2001 2002

New Instalations for FDG ProductionNew Instalations for FDG Production 18O(p,n)18F

Ep = 11 MeV

T1/2 = 109 m

Current: 40 µA

FDG Production SystemFDG Production System

Establishing a PET Radiopharmaceuticals Establishing a PET Radiopharmaceuticals Production Facility in colaboration with IAEAProduction Facility in colaboration with IAEA

Double Hot Cells

Automated Vial Dispenser

Osmometer

HPLC

Gas Chromatography

Leak Detector

Dose Calibration

Spare Parts from CTI

Production of Production of 1818FF-- WITH WITH CV-28 CYCLOTRONCV-28 CYCLOTRON

M.C.M.R.

FDG Production in Brazil

S.Paulo - 2000 Rio - 2003

Recife - 2007

BH - 2007

Thank youThank you

I-123 UltrapureI-123 Ultrapure

1996 - IAEA-FZK-IEN : Instalation of KIPROS system

Xe(p,2n) Cs Xe I124 123123 123

Ep = 24 MeV

T1/2 = 13,6 h

Current: 20 µA

Yield: 3,5 mCi/µAh