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UNIMIX - Vacuum processing units

Scale-up Basics

Rainer Liebig

Project Manager Sales EKATO SYSTEMS GmbH

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Agenda

Vacuum Processing Plant UNIMIX – Features Design Aspects Parameters for Scale-up

Tip speed of PARAVISC Mixing time of PARAVISC Tip speed of Homogeniser BTO – Batch Turn Over

Summary

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Vacuum Processing Plant EKATO UNIMIX

Features: Vacuum processing Heating/cooling Agitation with PARAVISC High Sheer Homogenizer S-Jet Raw material charging into

homogenizer Internal/external homogenisation

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sInnovation for your process

Professional scale-up calculation of Newtonian and non-Newtonian fluids.

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sScale-up calculation

EKATO SYSTEMS is unique with the possibility to calculate the scale-up parameters to maximize the quality and

quantity for our customer!

Important Design Aspects

Tip speed of Homogenizer – 27 m/s

Tip speed of PARAVISC agitator – 2.5 m/s

Vessel design: ratio H / Ø = 1 : 1

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sScale up calculation - Parameters

Tip speed of PARAVISC agitator

Mixing time PARAVISC

Tip speed of Homogenizer

BTO’s (Batch Turn Over’s) at homogeniser

Product transfer in case of pre-phase vessels

Tip speedRotor (homogenisator)

Tip speed PARAVISC

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Scale up calculation – Tip Speed PARAVISC

C = π * n/s * ddSRT25 = 0,284 m dSRC1000 = 0,976 m

nSRT25 = 120 rpm nSRC1000 = ? rpm

CSRT25 = 3,14* 120/60s * 0,284 = 1,78 m/sec

CSRC1000= 3,14 * X /60s * 0,401 = 1,78 m/secA

BX =2* 0,284 / 0,976 = 0,581 * 60 = 34,8 rpm

3,14 * 120/60s * 0,284 = 3,14 * X/60s * 0,976 = 34,8 rpm

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Scale up calculation – Mixing Time PARAVISC

tSRC1000 = (nSRT25 * tSRT25) / nSRC1000

tSRT25 = 2 min tSRC1000 = ? min

nSRT25 = 120 rpm nSRC1000 = 34,8 rpm

tip speed = 1,78 m/s tip speed = 1,78 m/s

tSRT1000 = (120SRT25 * 2SRT25) / 34,8SRC1000 = 6:53 min

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Scale up calculation – Tip Speed Homogeniser

C = π * n/s * ddSRT25 = 0,060 m dSRC1000 = 0,166 m

nSRT25 = 6000 rpm nSRC1000 = ? rpm

CSRT25 = 3,14 * 6000/60s * 0,060 = 18,8 m/sec

CSRC1000= 3,14 * x /60s * 0,166 = 18,8 m/secA

B 3,14 * 6000/60s* 0,060 = 3,14 * X/60s * 0,166 = 2164 rpm

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sScale up calculation – BTO (Batch Turn Over) at Homogeniser

25 L

1000 L

S-jet 100

S-jet 1000

= 100 L/min H2O

= 1000 L/min H2O

100 / 25 * 2:00 = 8 BTO‘s

* = all with same tip speed of 18,8 m/sec

tSRT25 = 2:00 min = 8 BTO’s tSRC1000 = ? min = 8 BTO’s

1000/1000

* 8 BTO‘s = 8:00

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sSummary

REMEMBER

In order to succeed in the scale-up calculation, the following information need to be established:

Tip speed of PARAVISC agitator

Mixing time PARAVISC

Tip speed of Homogenizer

BTO’s (Batch Turn Over’s) at homogeniser

Thank you for your attention!

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