Case Report.Cutaneous

LeukocytoclasticVasculitis associated with Dexibuprofen

F. Peral Rubio, M.D.Department of Dermatology Complejo Hospitalario Universitario, Badajoz, Spain.

www.dermatoblog.com

Cutaneous LeukocytoclasticVasculitis associated with

Dexibuprofen

A 65-year-old female Palpable purpura of the trunk and extremities. He had been diagnosed with polyarthrosis 2 months earlier, initiating treatment with non steroidal anti inflammatory (dexibuprofen).

Cutaneous LeukocytoclasticVasculitis associated with

Dexibuprofen

A purpuric appeared on the lower and upper extremities. The skin lesions spread progressively over the entire body, and several lesions coalesced, resulting in blisters and ulcers.

Cutaneous LeukocytoclasticVasculitis associated with

DexibuprofenBlood investigations showed increased levels of acute phase reactants .Investigations done to exclude other causes of this rash include hepatitis B surface antigen, hepatitis C IgG antibody, presence of cryoglobulin and anti-neutrophil cytoplasmic antibody (ANCA) and Anti-nuclear antibody; all were negative. There was no evidence of microscopic haematuria or casts on microscopic examination of the urine.Skin biopsy showed that small vessels in the dermis were surrounded by neutrophils and nuclear debris. Red cell extravasate was present. There were no eosinophils and few lymphocytes were seen.Immunofluorescence was negative for antibodies or immune-complexes.

Cutaneous LeukocytoclasticVasculitis associated with

Dexibuprofen

The patient was treated with prednisona (60 mg) the dose was reduced on progressive improvement of the vasculitis lesions.

Case Report.Cutaneous

LeukocytoclasticVasculitis associated with Dexibuprofen

F. Peral Rubio, M.D.Department of Dermatology Complejo Hospitalario Universitario, Badajoz, Spain.

www.dermatoblog.com