Supporting Information

A potent cytotoxic metabolite from terrestrial Actinomycete,

Streptomyces collinus

S. A. Rather ∙ Sunil Kumar ∙ Bilal Rah ∙ Mohammad Arif ∙ Asif Ali ∙ Parvaiz Qazi

Sunil Kumar () ∙ Mohammad Arif ∙ Asif Ali

Natural Products Chemistry Division, Indian institute of Integrative Medicine,

Canal Road -180001, Jammu, India

Bilal Rah

Cancer Pharmacology Division, Indian institute of Integrative Medicine,

Canal Road -180001, Jammu, India

S. A. Rather ∙ Parvaiz Qazi ()

Microbial Biotechnology Division, Indian institute of Integrative Medicine,

Sanat Nagar, Srinagar - 190005, Srinagar, India

Table of Contents Page

S1: 1H-NMR SPECTRUM OF COMPOUND 1 2

S2: 13C-NMR SPECTRUM OF COMPOUND 1 3

S3: 13C-NMR (DEPT-135) SPECTRUM OF COMPOUND 1 4

S4: 2D-NMR (COSY) SPECTRUM OF COMPOUND 1 5

S5: 2D-NMR (HSQC) SPECTRUM OF COMPOUND 1 6

S6: 2D-NMR (HMBC) SPECTRUM OF COMPOUND 1 7

S7: HRMS SPECTRUM OF COMPOUND 1 8

S8: HPLC CHROMATOGRAM OF COMPOUND 1 WITH UV SPECTRUM 9

S9: CHIRAL HPLC CHROMATOGRAM OF COMPOUND 1 10