Post on 12-Aug-2015
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Assessment of retinal arteriolar walls in hypertension using the rtx1
E. Koch, D. Rosenbaum, X. Girerd and M. Paques Clinical Investigation Center 503, INSERM,
Quinze-Vingts National Eye Hospital, Paris, FranceICAN E3M Institute, Cardiovascular Prevention Unit,
Pitié-Salpêtrière University Hospital, Paris, France
rtx1 adaptive optics retinal cameraCase reportArterial hypertension
Imagine Eyes rtx1 case report -- hypertension
Imaging retinal arterioles with the rtx1
Color fundus camera (zoom in)
Imagine Eyes rtx1
Resolution 3-4 µm
Resolution 15-20 µm
Comparison with a conventional color fundus camera
Color fundus camera
Resolution 15-20 µm
The microscopic structure of arterioles has become visible
Healthy 36 y.o. male subject
Imagine Eyes rtx1 case report -- hypertension
Arteriolar microscopic structure
wall
lumen
Imagine Eyes rtx1 case report -- hypertension
Wall-to-lumen ratio in hypertension• Aged matched healthy subject and patient with
untreated arterial hypertension• Assessment at 4 deg away from the papillary disc
WLR = 0.21 WLR = 0.37
Healthy Hypertension
Imagine Eyes rtx1 case report -- dry AMD
Conclusion
• Adaptive optics retinal imaging the first non-invasive technique that enables examining the microscopic structure of arterioles, including vessel walls
• Measurements with the rtx1 revealed elevated wall-to-lumen ratio (WLR) in patients with untreated arterial hypertension
• See also: E. Koch, D. Rosenbaum, A. Brolly, J.-A. Sahel, P. Chaumet-Riffaud, X. Girerd, F. Rossant, and M. Paques, “Morphometric analysis of small arteries in the human retina using adaptive optics imaging,” Journal of Hypertension, vol. 32, no. 4, pp. 890–898, Apr. 2014.