Post on 22-Dec-2015
transcript
Mapping Science and Technologywith Heterogeneous Data Analysis
Tools for strategic management of innovation – Biotech.Obs
Andrei Mogoutov | AGUIDELParis - Montreal
www.aguidel.com
Tools for strategic management of innovation
• Data collection and management « Biotech » actors using online questionnaires, publications, patents, existing databases, institutional contacts, company websites, news and press releases
• Services/applications– Positioning of companies, projects, products, patents, publications, research fields– Startup support– Early warning– Partnership network building– Advice on local promotion – Advice on foundation and management of « clusters »– Evaluation of projects– Market and technological studies– Benchmarking, competitiveness– Consultancy for valorization actors– Communication strategy development– Academic research
• Software solutions: On-line applications, off-line applications, customized solutions, integration of customers data, analytical tools
• Data analysis: Custom methods for the analysis of complex & heterogeneous datasets, text and data mining, relational analysis, GIS, scientometrics
Projects & partners• CEA (French Nuclear Energy Commission): Nano/Bio - clusters -
Dynamics of Nano-bio-technology field. • Biotech Clusters - Genopole Evry – research labs, startups & big
pharma• Public Health Canada: Clusters of Nanotechnologies in Canada,
Obesity issues and research, • Regional innovation agencies – “Technopole” Angers• INSERM: Evaluation of research laboratories, strategic analysis of
neurosciences research, • INRA/CNRS: Mapping of controversies and research fields in
genetically modified food safety• McGill University: Anticancer drugs clinical trials, Microarray R&D,
Cancer research worldwide, Cancer and genetics, Standardisation and Migraine research,
• University of Vienna: Scientometrics of Social Studies of Science Field
• Big International Foundations: Open Society Institute, WWF Ford foundation, McArthur's foundation, Govcom.org foundation various political, ecological and technological issues
• Private companies: industry, big pharma, telecoms, medical imaging• Investors, business angels
../ANALYTICAL DIMENSIONS
ANALYTICAL DIMENSIONS/DATA/METHODS/TOOLS
SPACE TIME CONTENT ACTORS & NETWORKS
X USERS Client side Apps
News RSS Feeds Client side Apps News
Client side Apps News, Web search, Blogs
SUBSCRIBED UDERS
Client/Server Apps RSS Feeds archives
Client/Server Apps News RSS Feeds archives
Client/Server Apps Client side Apps News archives, Web search, Blogs
Client/Server side Apps RSS Feeds archives + Scientometrix
SPECIAL CONTRACT
Client/Server side Apps + offline apps archives + Scientometrix + third party tools + specific GIS analysis
Client/Server side Apps + offline apps archives + Scientometrix + third party tools + specific time analysis
Client/Server side Apps + offline apps archives + Scientometrix + third party tools + specific content analysis
Client/Server side Apps + offlina apps archives + Scientometrix + third party tools + specific analysis
DEVICES SERVICES
DIAGNOSTICS
GENOMICS
DRUG DELIVERY
LARGE MOLECULE
SMALL MOLECULE
PROTEOMICS
RECOMBINANT DNA
ANTIBODY
MOLECULAR DIVERSITYSCREENING
GENE THERAPY
SYNTHESIS
VACCINES
GENE EXPRESSION
GENERICS OTC
CELL THERAPY
AVENTIS
GLAXO
BIOINFORMATICS
J OHNSON
ROCHE
APPLERA
PFIZER
AHP
BMS
NOVARTIS
GENE SEQUENCING
GENZYME
AMERSHAM
ABBOTT
INCYTEG
MERCK_CO
PHMACIA
CHIRON
TRANSGENICS
NIH
ELAN
BAYER
ELILILLY
AFFYMET
NUTRACEUTICALS
ASTRAZEN
GENENTEC
SCHER_AG
CELLTECH
SCHERING
MILL_PHA
PERKIN
BAXTER
NANOTECHNOLOGY
PCOP
AMGEN
MEDAREX
RATIONAL DRUG DESIGN
MERCK
BOEHRING
LEXICON
VERTEX
SEQUENOM
APP_BIOS
UN_CAL
E.I. DU
CORIXA
VALENTIS
BD MONSANTO
ARQULE
NATURAL PRODUCTS
DYAX
ABGENIX
NOVO NOR
HU_GE_SC
LION_BIO
ISIS
GENE_LOG
MDS
OXFGLYCO
CYTOGEN
MEDIMMUN
UNIV_TEX
ORCHID
INDEVUS
TREGA
BASF
GENOME
HARV_UNI
TGEN
EXELIXIS
J H_UNIV
AKZO
CARBOHYDRATE
CELL_PAT
BIOGEN
SUSM
MYRIAD
DPI
HMS
EVOTEC
TYCO_INT
SANOF_S
CAMBTECH
SANGAMO
BIOVAIL
QIAGEN
GENSET
BECKMAN
MIT
INVITROG
CHUGAI_B
OSI
MITSUB
IMMUNEX
TRIPOS
LIGAND
IMCLONE
ACAMBIS
P & G
CANC_RC
NEXSTAR
OXFBIOM
AURORA
XOMA
XENOVA
ENZON
AVANT
LYNX_USA
WATSON
E-HEALTH
MEDTRONI
MORPHOSY
THIRD_WA
GILEAD
SCIOS
DOUBLETW
HYSEQ
CURAGEN
SHIRE
SEPRACOR
CRUCELL
AMERNYCO
SKYEPH
MSKC_CEN
ANTIGENI
VICAL
THERMO_E
GENELABS
IVAX
DELTAGEN
GPC_BIOT
TULARIK
DOW_CHEM
GENVEC
PDL
NEORX
STEMCELL
CORNING
EPIMMUNE
HITACHI
BIO_TG
BAY_C_M
ALEXION
YAMANOUC
DUHS
IDEC
CUBIST
NEXELL
CEPHALON
FUJ ISAWA
TAKARA
LUDWIG_I
LIFE_TEC
GERON
NEOPROBE
PPD
ALLIANCE
SERONO
PROTSYS
TEVA
VARIAGEN
SOLVAY
CHRYSALI
DAIICHIP
DECODE
REPLIGEN
QUIDEL
SCHWARZ
TAKEDA
BIOSITE
YALE_U
UCSF
CELGENE
IMMUNOME
BIOMIRA
ROBERTS
ALLERGAN
PROGENIC
NPS
KIRIN
IMMUNOGE
ONCOR
AMRAD
DIVERSA
SCRIPPS
ICOS
ALKERMES
PITTSB_U
CURIS
POWDERJ
MYLAN
ID_BIOME
NANOGEN
BTG_PHAR
MEDIGENE
NEUR_BIO
UCSD
J TOBACCOKING
SANKYO
PEREGRIN
SUMITOM
MAXIGEN
IMMUNE
SOMATIX
SICOR
ONCORMED
BIOMERIE
HYBRIDON
UCLA
RIBOZYME
AD_POLY
NABI
AMYLIN
SUPERGEN
ICN_PHAR
IGEN
TAISHOPH
NYU
ACACIA
MGH
BIOCHEMP
U_WASH
SEQUUS
CAM_BIO
CELL_GEN
CYTRX
INHALE
RECORDAT
WASH_U
ANADYS
KYOWA
INSITE
BIO_RAD
3M
DEGUSSA
AASTROM
MAR_UN
GENTA
PROTHER
MCGILL_U
ALBANYMR
BBIOTECH
SYNCOR
AVANIR
ANTARES THERATEC
DSM_GIST
EISAI
CARDINAL
AMARINPHARMASC
PENEDERM
ALTANA
BIOGLAN
BOSTON_S
CENES
UNIV_COL
COLUMBIA
MAYO_FOU
MARTEK
COLLAGEN
LIPOSOME
IBM
MAX_PLAN
DUPONT_M
CORTECS
ADVMAG
DAINIPP
CYGNUS
MILLENN
ABSC
GENENCOR
ATRIX
UNIV_TR
BERLEX
UCB_GROU
BAUSCH
ENTREMED
OXFORD_U
CONNETIC
MGI
FISHER_S
MAYNE
ILEX
TRIANGLE
DRAXIS
VIRAGEN
TEIJ IN
MERI_BIO
ACCESS
DADEBE
GEN_EL
FOREST
TANABESE
MEDICIS
Pasteur
PHOTOTHERAPY
FRESENIU
ONO_PHAR
STERL_DR
PH_RES
QUESTCOR
AJ INOMO
MUNDIPHA
MICHIG_U
MEIJ I
DYNAGEN
SYNBIOTI
SENETEK
QUINTILE
MASS_GEN
PIERRE
NRC_CAN
NESTLE
COLLAGEX
CHIESI
AMERISB
XENOGEN
HESKA
CHEMTRAK
PHARMAS
BARR_LAB
OTSUKA
BENTLEY
PROVALIS
BTG
ASAHI
NYCOMED
SUNY
MERCKLE
GUILFORD
BEAUFOUR
ELF_AQUI
INTEG_LS
AD_TS
US_BIOSC
LUNDBECK
HSC
EPITOPE
WELLCOME
COCENSYS
SYNSORB
ALPHARMA
MEDCO_R
ORION
SMITH
KISSEI
AXCAN
AMARILLO
UNITED_T
SHIONOGI
SPECTRAL
CORNELLU
SUNTORY
AMBI
BCU
MYCOGEN
GELTEX
NCI
FERRER
BOOTS CO
PAREXEL
Information « Spaces »
• News Streams• Blog Sphere• Web Sites• E-Communication (Mailing Lists, Forums)• Scientific Information Data Bases (Publications, Patents)• Offline “Literature”• Press archives• Surveys/ Interviews• Traditional Media (TV, Radio) archives• Specific Data Bases• Etc ?
Traditions/Methods/Solutions
• Statistics / Data Mining• Textual Analysis Tools / Text Mining• Web Cartography• Scientometrics• Tools for Qualitative Data Analysis• Social / Socio-Technical Networks• GIS• Etc.
Heterogeneous Data Sets: Back Office
“Offline” Questionnaires
Sci publications
Existing Databases
Press archives
Online Data Collection
Tools
ActorLocation
ActorIdentity
ContentsClassification
Schema
Parsing & Matching System
J ohnson & J ohnson
Glaxo SmithKline plc
Aventis
Wyeth
Merck & Co. Inc.
Roche
Bristol-Myers Squibb Co.
Schering-Plough Corp.
Pfizer
Novartis
Pharmacia
Eli Lilly and Co.
Bayer AG
AstraZeneca
Abbott
NETWORK ORIENTED DATABASE
Web CrawlerPatents
Design of Analytical Solution
Back Office
- data tables- web crawler- matching tools- tools for textual analysis- tools for data update and control
Front Office
Middle Office
- a layer of analytical queries - pre-defined queries for multilevel -data aggregationand synthetic analysis and indicators
- graphical/analytical interfaces (GIS, Relational Mappings, Statistical Charts)- statistical tables, indicators and textual synthesis- integrated querying tools
ON-LINEOFF-LINE
DATA UPDATE FEED-BACK
Front Office “Desktop”
0
50
100
150
200
250
300
350
cancer familyhistory
risk factors hormonal-contraception
personalmedicalhistory
family relatives environment-tobacco
cancer genes
/Scientometrics/results (ReseauLu Sci_Metrix)
1
10
100
1000
1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003
20Proceedings of the National Academy of
Sciences of the United States of America
22Environmental Entomology
23Biofutur
23Current Science
26Euphytica
27Science
28Molecular Breeding
30OCL - Oleagineux, Corps Gras, Lipides
32Nature Biotechnology
32Transgenic Research
33Molecular Ecology
33Nature
37Biotechnology and Development Monitor
41Theoretical and Applied Genetics
98Journal of Economic Entomology
N. Art.Top Journals
20Proceedings of the National Academy of
Sciences of the United States of America
22Environmental Entomology
23Biofutur
23Current Science
26Euphytica
27Science
28Molecular Breeding
30OCL - Oleagineux, Corps Gras, Lipides
32Nature Biotechnology
32Transgenic Research
33Molecular Ecology
33Nature
37Biotechnology and Development Monitor
41Theoretical and Applied Genetics
98Journal of Economic Entomology
N. Art.Top Journals
selectable markers
biosafetyOil plants
rape
weeds
herbicides
herbicide resistance
gene flow
Insect pests
pest resistancegenes
gene expression
agricultural entomology
risk assessment
release
control
plant pests
glufosinate
maize
Pest control
transgenics
potatoes
reviews
resistance
interspecific hybridization
plant pathogensplant pathology
food safety
w ild relatives
polymerase chain reaction
plant diseases
tobacco
foods
DNA
stimulant plants
plant breeding
hybridization
risk
disease resistance
molecular genetics
soyabeans
Biology
pollen
entomopathogenic bacteria
root crops
genetics
toxins
glyphosate
nontarget effects
legislation
natural enemies
environmental impact
sugarbeet
Pathogenstomatoes
cereals
intergeneric hybridization
enzymes
regulations
bacterial insecticidescultivars
toxicity
rice
entomopathogensvegetables
tolerance
chemical control
pesticides
gene transfer
insect control
public opinion
coat proteins
plant genetic resources
biological control agents
dispersal
biological control
seed production
survival
genetic markers backcrossing
larvae
detection
sugar crops
weed control
phosphinothricin acetyltransferase
microbial pesticides
swede rape
pollination
parasitoids
lectins
insecticides
nucleotide sequences
trypsin inhibitors
ecology
analytical methods
volunteer plants
introgression
proteinase inhibitors
European Union
Herbicide resistant weedscrop plants as weeds
reporter genes
methodology
plant pathogenic fungi
labelling
nontarget organisms
allergens
flowering
plant parasitic nematodes
invasion
lines
evolution
food allergies safety
oilseed plants
growth
effects
promoters
plant pathogenic bacteria
agglutinins
genomes
fruitsfood products
models
leaves
consumer attitudes
contamination
marker genes
population dynamics
beta-glucuronidase
population genetics
Potyvirus
proteins
food legislation
Mol. Biol. and Virol.
Detection
Agr. entomology
Weed management - geneflow
GM Food safety
../Stem Cells - Counts
0
1000
2000
3000
4000
5000
6000
1960 1965 1970 1975 1980 1985 1990 1995 2000 2005 2010
STEM CELLS - AUTHORS
Name Nb Pub
WEISSMAN, IL 45
ZSEBO, KM 26
ORKIN, SH 26
OGAWA, M 25
GAGE, FH 24
JAENISCH, R 22
BRADLEY, A 22
ROSSANT, J 22
MOORE, MAS 21
EAVES, CJ 21
WILLIAMS, DA 19
LANSDORP, PM 19
NISHIKAWA, S 18
MULLIGAN, RC 18
SMITHIES, O 18
HUMPHRIES, RK 16
ALT, FW 16
DICK, JE 16
MAK, TW 15
DEXTER, TM 15
ARMITAGE, JO 15
RAJEWSKY, K 14
MORRISON, SJ 14
MoyenneDePositionName NbCit NbCitPos0,87 WEISSMAN, IL 10455 89710,83 BRADLEY, A 8217 74350,76 ROSSANT, J 7859 53980,86 MULLIGAN, RC 7029 64510,62 ZSEBO, KM 7016 5119,750,82 MAK, TW 6275 56660,95 JAENISCH, R 5798 5588,50,71 RAJEWSKY, K 5729 3963,50,84 ORKIN, SH 5471 44720,83 OGAWA, M 5368 4483,750,94 GAGE, FH 5244 4905,50,54 LANSDORP, PM 5197 2774,250,27 WAKEHAM, A 4889 1277,50,86 SMITHIES, O 4850 40740,38 GERTSENSTEIN, M 4611 1503,75
1 CAPECCHI, MR 4519 45190,65 REYNOLDS, BA 4487 31490,84 WILLIAMS, DA 4429 3444,5
0,7 MOORE, MAS 4301 2947,750,88 DEXTER, TM 4025 38060,91 WEISS, S 3985 3598,50,81 LI, E 3957 3335,50,47 LANGLEY, KE 3893 1782,25
0,3 BRONSON, RT 3850 1298,50,44 NISHIKAWA, S 3831 16690,78 SORIANO, P 3766 3296,5
Stem Cells Co-CitationBRAIN RES
BLOOD P NATL ACAD SCI USA
NATURE
CELL
J IMMUNOL
SCIENCE
J EXP MED
J BIOL CHEM
DEVELOPMENT
MOL CELL BIOL
EMBO J
GENE DEV
EXP HEMATOL
J CLIN INVEST
DEV BIOL
EUR J IMMUNOL
CANCER RES
J CELL BIOL
NEURONJ NEUROSCI
NEW ENGL J MED
J INVEST DERMATOL
ONCOGENE
NAT GENET
NUCLEIC ACIDS RES
BRIT J HAEMATOL
BONE MARROW TRANSPL
BIOCHEM BIOPH RES CO
IMMUNOL TODAY
LEUKEMIA
LANCET
J VIROL
J CELL PHYSIOL
ANNU REV IMMUNOL
J CLIN ONCOL
NAT MED
AM J PATHOL
IMMUNITY
EXP CELL RES
HUM GENE THER
J COMP NEUROL
ANN NY ACAD SCITRENDS GENET
J EMBRYOL EXP MORPH
MECH DEVELOP
CURR BIOL
TRANSPLANTATION
ENDOCRINOLOGY
J NATL CANCER I
USA-GLAXO INC
USA-Harvard Univ
USA-Univ Washington
USA-UNIV TEXAS
CANADA.-UNIV TORONTO
USA-Mem Sloan Kettering Canc Ctr
USA-BAYLOR COLL MED
FRANCE.-Serv Hematol
USA-UNIV CALIF LOS ANGELES
USA-FRED HUTCHINSON CANC RES CTR
USA-Stanford Univ
USA-Univ Michigan
USA-Indiana Univ
USA-Univ Penn
FRANCE.-DEPT HEMATOL
USA-J OHNS HOPKINS UNIV
USA-Duke UnivUSA-Univ Minnesota
CANADA.-UNIV BRITISH COLUMBIAUSA-UNIV CALIF SAN FRANCISCO
USA-BRIGHAM & WOMENS HOSPJ APAN.-OSAKA UNIV
USA-NCI
USA-DANA FARBER CANC INST
USA-UNIV CHICAGO
USA-Northwestern Univ
USA-UNIV NEBRASKA
USA-MED COLL WISCONSIN
FRANCE.-Hop Necker Enfants Malad
USA-Yale Univ
USA-MIT
USA-UNIV COLORADO
USA-Univ Wisconsin
USA-City Hope Natl Med Ctr
USA-CASE WESTERN RESERVE UNIV
USA-GENENTECH INC
USA-CHILDRENS HOSP
FRANCE.-HOP ST LOUIS
USA-Univ Pittsburgh
NETHERLANDS.-LEIDEN UNIV
GERMANY.-Univ Tubingen
USA-WASHINGTON UNIVJ APAN.-Univ Tokyo
USA-NHLBI
USA-NYU
USA-St J ude Childrens Hosp
USA-Univ Florida
CANADA.-HOSP SICK CHILDREN
USA-Univ Illinois
CANADA.-BRITISH COLUMBIA CANC AGCY
USA-CORNELL UNIV
USA-YESHIVA UNIV ALBERT EINSTEIN COLL MED
USA-UNIV SO CALIF
J APAN.-KYOTO UNIV
USA-AMGEN INC
USA-St J ude Childrens Res Hosp
GERMANY.-Univ Freiburg
SWEDEN.-KAROLINSKA INST
USA-VANDERBILT UNIV
CANADA.-MCGILL UNIV
ENGLAND.-UNIV CAMBRIDGE
ISRAEL.-Weizmann Inst Sci
USA-MAYO CLIN & MAYO FDN
USA-Univ Calif San Diego
FRANCE.-INST GUSTAVE ROUSSY
FRANCE.-INST J PAOLI I CALMETTES
CANADA.-Mt Sinai Hosp
USA-Univ Tennessee
ITALY.-Univ Turin
SCOTLAND.-UNIV EDINBURGH
ISRAEL.-HADASSAH UNIV HOSP
GERMANY.-UNIV HAMBURG
USA-BETH ISRAEL HOSP
GERMANY.-Univ Ulm
USA-UNIV MASSACHUSETTS
USA-NIAID
CANADA.-UNIV CALGARY
FRANCE.-HOP HENRI MONDOR
USA-Oregon Hlth Sci Univ
USA-Salk Inst Biol Studies
USA-VET ADM MED CTR
FRANCE.-Inst Pasteur
USA-MED UNIV S CAROLINA USA-COLUMBIA UNIV COLL PHYS & SURG
USA-VIRGINIA COMMONWEALTH UNIV
USA-CHILDRENS HOSP MED CTR
ITALY.-UNIV MILAN
USA-New York Med Coll
ENGLAND.-IMPERIAL CANC RES FUND
ENGLAND.-UNIV MANCHESTER
GERMANY.-UNIV COLOGNE
ENGLAND.-MRC
ISRAEL.-Technion Israel Inst Technol
NETHERLANDS.-Erasmus Univ
USA-DNAX RES INST MOLEC & CELLULAR BIOL INC
ENGLAND.-UNIV OXFORD
USA-NINDS
USA-GENET INST
AUSTRALIA.-ROYAL ADELAIDE HOSP
USA-NHGRI
STEM CELLS – Collaboration networks
Morocco.
USA
FRANCE.
GERMANY.
ITALY.
ENGLAND.
J APAN.
CANADA.
NETHERLANDS.
SPAIN.
SWEDEN.
AUSTRALIA.
SWITZERLAND.BELGIUM.
ISRAEL.
SCOTLAND.
South Korea.AUSTRIA.
FINLAND.
DENMARK.
NORWAY.
PEOPLES R CHINA.
GREECE.
Brazil.
Poland.
Czech Republic.Taiwan.
ARGENTINA.
Hungary.
Portugal.
New Zealand.
Croatia.
RUSSIA.
Singapore.
Wales.
SOUTH AFRICA.
Ireland.
North Ireland.
Turkey.
Mexico.
Saudi Arabia.
Thailand.
YUGOSLAVIA.
KUWAIT.
Luxembourg.
Egypt.
Iceland.
STEM CELLS – International Collaboration
19902000
1995
Humans
Research Support, Non-U.S. Gov't
Animal
2005
Hematopoietic
Cells, Cultured
Fibroblasts
Research Support, U.S. Gov't
Cell Differentiation
Female
Cell Division
Male
Bone Marrow
Antigens
Cell Line
Comparative Study
Adult
Gene Expression
RNA, Messenger
DNA
Middle Aged
Embryo
Polymerase Chain Reaction
Time Factors
Flow Cytometry
Neurons
Interleukin
Immunohistochemistry
Colony-Forming Units Assay
Signal Transduction
Molecular Sequence Data
Tumor Cells, Cultured
Granulocyte Colony-Stimulating Factor
Transfection
Transcription Factors
Recombinant Proteins
Base Sequence
Cell Movement
Dose-Response Relationship, Drug
Cell Separation
Aged
Skin
Cell Adhesion
Cell Count
Phenotype
Fetal Blood
Cytokines
Tumor Stem Cells
Collagen
Erythroid Progenitor Cells
Biological Markers
Transforming Growth Factor beta
Adolescent
Stem Cell Factor
Cell Cycle
Child
Proto-Oncogene Proteins
Liver
Genetic Vectors
Immunophenotyping
Culture
Membrane Proteins
Clone
Phosphorylation
Blotting, Western
T-Lymphocytes
B-Lymphocytes
In Vitro
Stem Cell Transplantation
Antibodies, Monoclonal
Pregnancy
Kinetics
Macrophages
Fetus
Amino Acid Sequence
Tumor Necrosis Factor-alpha
Retroviridae
Bone Marrow Transplantation
Trans-Activators
Transcription, Genetic
Growth Substances
Enzyme Inhibitors
Models, Biological
Extracellular Matrix
Proteins
Cell Nucleus
Spleen
Endothelium, Vascular
Mesoderm
Epithelial CellsEnzyme Activation
Actins
Lung
Neoplasm Proteins
Mutation
Granulocytes
Infant, Newborn
Erythropoietin
Microscopy, Electron
Neoplasms
Antineoplastic Agents
Fibronectins
Fluorescent Antibody Technique
Thymus Gland
Cell Transformation, Neoplastic
Monocytes
Leukemia
Cell Membrane
Chick Embryo
Lymphocytes
Erythropoiesis
Erythrocytes
Thymidine
Tritium
Colony-Stimulating Factors
Cell Lineage
Cell Culture Techniques
Apoptosis
Stromal Cells
Coculture Techniques
STEM CELLS – Emerging themes
Scientometrix: Early Warning: Strategic Diagrams of Research Scientometrix: Early Warning: Strategic Diagrams of Research Community Evolution: biosafety researchCommunity Evolution: biosafety research
MALONE LA - 35
LEFOL E - 35
MICHAUD D - 36
J EFFERSON RA - 36
WILLIAMSON M - 37
RIESEBERG LH - 37
MACINTOSH SC - 37
HILDER VA - 37
CAPRIO MA - 37
LINDER CR - 40
SNOW AA - 41
SCHUBBERT R - 41
ONSTAD DW - 41
MEYER R - 42
SHELTON AM - 43
PADGETTE SR - 43
DEBLOCK M - 43
ANDOW DA - 44
ALSTAD DN - 44TAYLOR SL - 45
J OHNSON MT - 45
BARTSCH D - 45
TANG J D - 47
SAXENA D - 47
CHEVRE AM - 48
STEWART CN - 49
PILCHER CD - 49
LIU YB - 49
J ORGENSEN RB - 49
SCHEFFLER J A - 50
NIELSEN KM - 50
MIKKELSEN TR - 54KLINGER T - 54
RAYBOULD AF - 57
SIMS SR - 59
LOSEY J E - 59SCHULER TH - 64
GATEHOUSE AMR - 71
KOZIEL MG - 72CRAWLEY MJ - 76
DALE PJ - 85
DANIELL H - 89
HILBECK A - 92
ROUSH RT - 96
PERLAK FJ - 98MCGAUGHEY WH - 98
ELLSTRAND NC - 114
TABASHNIK BE - 250
GOULD F - 258
0,001
0,01
0,1
0,0001 0,001 0,01 0,1
1984-1999
2000
-200
3
Scientometrix/ Adds Heterogeneous Networks Heterogeneous NetworksCompanies & TechnologiesCompanies & Technologies
DEVICES SERVICES
DIAGNOSTICS
GENOMICS
DRUG DELIVERY
LARGE MOLECULE
SMALL MOLECULE
PROTEOMICS
RECOMBINANT DNA
ANTIBODY
MOLECULAR DIVERSITYSCREENING
GENE THERAPY
SYNTHESIS
VACCINES
GENE EXPRESSION
GENERICS OTC
CELL THERAPY
AVENTIS
GLAXO
BIOINFORMATICS
J OHNSON
ROCHE
APPLERA
PFIZER
AHP
BMS
NOVARTIS
GENE SEQUENCING
GENZYME
AMERSHAM
ABBOTT
INCYTEG
MERCK_CO
PHMACIA
CHIRON
TRANSGENICS
NIH
ELAN
BAYER
ELILILLY
AFFYMET
NUTRACEUTICALS
ASTRAZEN
GENENTEC
SCHER_AG
CELLTECH
SCHERING
MILL_PHA
PERKIN
BAXTER
NANOTECHNOLOGY
PCOP
AMGEN
MEDAREX
RATIONAL DRUG DESIGN
MERCK
BOEHRING
LEXICON
VERTEX
SEQUENOM
APP_BIOS
UN_CAL
E.I. DU
CORIXA
VALENTIS
BD MONSANTO
ARQULE
NATURAL PRODUCTS
DYAX
ABGENIX
NOVO NOR
HU_GE_SC
LION_BIO
ISIS
GENE_LOG
MDS
OXFGLYCO
CYTOGEN
MEDIMMUN
UNIV_TEX
ORCHID
INDEVUS
TREGA
BASF
GENOME
HARV_UNI
TGEN
EXELIXIS
J H_UNIV
AKZO
CARBOHYDRATE
CELL_PAT
BIOGEN
SUSM
MYRIAD
DPI
HMS
EVOTEC
TYCO_INT
SANOF_S
CAMBTECH
SANGAMO
BIOVAIL
QIAGEN
GENSET
BECKMAN
MIT
INVITROG
CHUGAI_B
OSI
MITSUB
IMMUNEX
TRIPOS
LIGAND
IMCLONE
ACAMBIS
P & G
CANC_RC
NEXSTAR
OXFBIOM
AURORA
XOMA
XENOVA
ENZON
AVANT
LYNX_USA
WATSON
E-HEALTH
MEDTRONI
MORPHOSY
THIRD_WA
GILEAD
SCIOS
DOUBLETW
HYSEQ
CURAGEN
SHIRE
SEPRACOR
CRUCELL
AMERNYCO
SKYEPH
MSKC_CEN
ANTIGENI
VICAL
THERMO_E
GENELABS
IVAX
DELTAGEN
GPC_BIOT
TULARIK
DOW_CHEM
GENVEC
PDL
NEORX
STEMCELL
CORNING
EPIMMUNE
HITACHI
BIO_TG
BAY_C_M
ALEXION
YAMANOUC
DUHS
IDEC
CUBIST
NEXELL
CEPHALON
FUJ ISAWA
TAKARA
LUDWIG_I
LIFE_TEC
GERON
NEOPROBE
PPD
ALLIANCE
SERONO
PROTSYS
TEVA
VARIAGEN
SOLVAY
CHRYSALI
DAIICHIP
DECODE
REPLIGEN
QUIDEL
SCHWARZ
TAKEDA
BIOSITE
YALE_U
UCSF
CELGENE
IMMUNOME
BIOMIRA
ROBERTS
ALLERGAN
PROGENIC
NPS
KIRIN
IMMUNOGE
ONCOR
AMRAD
DIVERSA
SCRIPPS
ICOS
ALKERMES
PITTSB_U
CURIS
POWDERJ
MYLAN
ID_BIOME
NANOGEN
BTG_PHAR
MEDIGENE
NEUR_BIO
UCSD
J TOBACCOKING
SANKYO
PEREGRIN
SUMITOM
MAXIGEN
IMMUNE
SOMATIX
SICOR
ONCORMED
BIOMERIE
HYBRIDON
UCLA
RIBOZYME
AD_POLY
NABI
AMYLIN
SUPERGEN
ICN_PHAR
IGEN
TAISHOPH
NYU
ACACIA
MGH
BIOCHEMP
U_WASH
SEQUUS
CAM_BIO
CELL_GEN
CYTRX
INHALE
RECORDAT
WASH_U
ANADYS
KYOWA
INSITE
BIO_RAD
3M
DEGUSSA
AASTROM
MAR_UN
GENTA
PROTHER
MCGILL_U
ALBANYMR
BBIOTECH
SYNCOR
AVANIR
ANTARES THERATEC
DSM_GIST
EISAI
CARDINAL
AMARINPHARMASC
PENEDERM
ALTANA
BIOGLAN
BOSTON_S
CENES
UNIV_COL
COLUMBIA
MAYO_FOU
MARTEK
COLLAGEN
LIPOSOME
IBM
MAX_PLAN
DUPONT_M
CORTECS
ADVMAG
DAINIPP
CYGNUS
MILLENN
ABSC
GENENCOR
ATRIX
UNIV_TR
BERLEX
UCB_GROU
BAUSCH
ENTREMED
OXFORD_U
CONNETIC
MGI
FISHER_S
MAYNE
ILEX
TRIANGLE
DRAXIS
VIRAGEN
TEIJ IN
MERI_BIO
ACCESS
DADEBE
GEN_EL
FOREST
TANABESE
MEDICIS
Pasteur
PHOTOTHERAPY
FRESENIU
ONO_PHAR
STERL_DR
PH_RES
QUESTCOR
AJ INOMO
MUNDIPHA
MICHIG_U
MEIJ I
DYNAGEN
SYNBIOTI
SENETEK
QUINTILE
MASS_GEN
PIERRE
NRC_CAN
NESTLE
COLLAGEX
CHIESI
AMERISB
XENOGEN
HESKA
CHEMTRAK
PHARMAS
BARR_LAB
OTSUKA
BENTLEY
PROVALIS
BTG
ASAHI
NYCOMED
SUNY
MERCKLE
GUILFORD
BEAUFOUR
ELF_AQUI
INTEG_LS
AD_TS
US_BIOSC
LUNDBECK
HSC
EPITOPE
WELLCOME
COCENSYS
SYNSORB
ALPHARMA
MEDCO_R
ORION
SMITH
KISSEI
AXCAN
AMARILLO
UNITED_T
SHIONOGI
SPECTRAL
CORNELLU
SUNTORY
AMBI
BCU
MYCOGEN
GELTEX
NCI
FERRER
BOOTS CO
PAREXEL
GENOMICS
PROTEOMICS
GENE EXPRESSION
BIOINFORMATICS
INCYTEG
MERCK_CO
AFFYMET
NANOTECHNOLOGY
LEXICON
SEQUENOM
APP_BIOS
HU_GE_SC
GENE_LOG
OXFGLYCO
ORCHID
GENOME
EXELIXIS
MYRIAD
GENSET
INVITROG
LYNX_USA
THIRD_WA
HYSEQ
CURAGEN
GPC_BIOTCORNINGHITACHI
VARIAGEN
DECODE
NANOGEN
WASH_U
MCGILL_U
IBM
MAX_PLAN
MILLENNUNIV_TR
SUNY
Scientometrix / Adds: Actor/Networks Actor/Networks
Aventis
Glaxo SmithKline plc
Johnson & Johnson
Roche
Pfizer
Novartis
Bristol-Myers Squibb Co.
Abbott
Pharmacia
Wyeth
National Institutes of Health
Eli Lilly and Co.
Genzyme Corp.
AstraZeneca
Merck & Co. Inc.Elan Corporation plc.
Applera Corporation
Chiron Corp.
Bayer AG
Amersham Pharmacia Biotech
Monsanto
Merck KGaABaxter International inc.
Schering AGSchering-Plough Corp.
Celltech Group plc
Genentech Inc.
Incyte Genomics
Boehringer Ingelheim EI DuPont de Nemours & Co. Inc.
Perkin Elmer
Amgen
Sanofi-SynthelaboBecton Dickinson and Co.
Novo NordiskShire Pharmaceuticals Group plc
Pharmacopeia Inc.
BASF
IVAX Corporation
Mitsubishi Group
Millennium Pharmaceuticals Inc.
University of California
Akzo Nobel NV
Medarex Inc.
Tyco International Ltd.
Affymetrix Inc.
Procter & Gamble Co.
Harvard University
MedImmune Inc.
Massachusetts Institute of Technology
Solvay Pharmaceuticals incChugai Biopharmaceuticals Inc.
Biogen Inc.
Mds Inc.
Johns Hopkins University
Biovail Corporation
Corixa Corp.
Stanford University School of MedicineMedtronic Inc.
Vertex Pharmaceuticals Incorporated
Watson Pharmaceuticals Inc
Harvard Medical School
Sequenom Inc.
University of Texas Interneuron
Fujisaw a Healthcare INCLigand Pharmaceuticals
ISIS Pharmaceuticals Inc.
Bio-Technology General Corp.
Lion Bioscience AG
Cytogen Corp.Schw arz Pharma AG
QUIDEL Corp.
Allergan INC.
Abgenix Inc.
Cardinal Health Inc.
Acambis plc
Teva Pharmaceutical Industries Ltd
Yamanouchi Pharmaceutical Co. Ltd.Lexicon Genetics Incorporated
Degussa AG
Cell Pathw ays Inc.
Corning Inc
Applied Biosystems Group
SankyoCephalon Inc.Takeda Chemical Industries Ltd
ICN Pharmaceuticals Inc.
Duke University Health SystemDyax Corporation
Xoma ltd.
SkyePharmaOSI Pharmaceuticals Inc.
Nycomed Amersham plc.
King Pharmaceuticals Inc
Xenova Group plc
ArQule Inc.
Genome Therapeutics Corp.
Aurora Biosciences Corp.
Valentis Inc.
0%
1%
2%
3%
4%
5%
6%
7%
8%
0% 2% 4% 6% 8% 10% Density
Cen
trality Pharma Group I
Central, Star-like hierarchical networks
Pharma Group IILess central, Less hierarchical
Platform Tech. CompaniesClique-like, complex networks
Scientometrix /GIS SpaceSpace
Biotech ClustersBiotech Clusters
01801
01801
02210
01730
01803
02451
02481
02132
02139
02118Boston
Boston Region
Scientometrix /GIS – Zooming InSub-clusters of the Montreal region, Note the Bio/medicine sub cluster in Laval.
Technology transfer: Industrial Partners of INSERM
0
50
100
150
200
250
300
350
400
450
1980 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003
0
100
200
300
400
500
600
GROUPE
PME
START-UP
Total
Industrial partners of INSERM: Emerging domains
1996-00
Biotechnologie/Médicament
2001-03
Chimie/Vaccins
1991-95
Technologie biomédicale
Diagnostic
1986-90
Epidémiologie Recherche clinique
1980-85
Nutrition
FRANCE
Médicament
Vaccins
Diagnostic
Technologie biomédicale
ETATS-UNIS
Epidemiologie
SUISSE
ROYAUME-UNI
Recherche clinique
ALLEMAGNE
BELGIQUE
ITALIE
JAPON
CANADA
Agroalimentaire
SUEDE
PAYS-BAS
DANEMARK
FINLANDE
ESPAGNE
IRAN
MONACO
LIBAN
IRLANDE
LUXEMBOURG
VENEZUELA
CHINE
ISRAEL
AUTRICHE
COREE DU SUD
ARGENTINE
AUSTRALIE
AFRIQUE DU SUD
INDE
POLOGNE
TCHECOSLOVAQUIE
CUBA
COREE DU NORD
ESTONIE
ISLANDE
R.D.A.
SINGAPOUR
HONGRIE
INSERM: international Collaboration
Technologies & Companies
Culture de cellules ou tissus
2
Génomique
Chimie combinatoire
17Zootechnie/Animalerie
11
13
Bioinformatique
5
22
14
15
21
6
Modélisation
Technologie Biomedicale
3
4
1
19
18
7
16
8
9
12
News
North Korea + Regime Change North Korea + Reunification
North Korea + Nuclear
North Korea + Axis of Evil
North Korea + Human Rights
North Korea + Famine
North Korea + War
MSNBC
Korea Times
New York Times
Asia Times Online
Korea Herald
Channel News Asia
Financial Times (subscription)
Frontpagemag.com
Voice of America
Washington Times
Daily Times
Taipei Times
Radio Free Asia
Reuters
San Francisco Chronicle
Chosun Ilbo
SpaceDailyFOX News
Donga
CNN Asia
Stuff.co.nz
Guardian
IranMania News
J apan Today
Minneapolis Star Tribune (subscription)
Arms Control Today
Louisville Courier J ournal
Atlanta J ournal Constitution
Washington Post
GoAsiaPacific.com
International Herald Tribune
Wired News
J apan Times
American Daily
eTaiwan News
CNN
Aljazeerah.info
Rocky Mount Telegram
Reuters AlertNet
Straits Times
Tech Central Station
CNN International
Whitehouse.gov (press release)
The Militant
Toronto Star
Newsweek
Newsday
New Zealand Herald
ABC Online
Telegraph.co.uk
The North Korean English News Space, Sept. 15 – Nov. 15, 2003.
Findings:Whitehouse.gov (press release) couches
North Korea in terms of regime change and human rights. The only other outlet that does so is Frontpagemag.org, a site which at the time of this map, extolled surfers to sign and e-petition and help “Stop the Left’s Anti-American Agenda… Help expose terrorists in our midst>”
Connecting regime change to war is done by Fox News, Newsweek, and Asia Times online. Thus it is clear that these media outlets are framing regime change in terms of military conflict.
Regime Change and Reunification are, basically, disconnected. Thus there is little talk of a German model achievement of Regime Change.
The Financial Times subscription service, a strong example of the corporate angle on the issue, presented North Korea only in terms of regime change, notably isolating the issue from conflict, reunification, famine and other issues.
Only CNN is able to connect famine and reunification, one of the more practical and meaningful associations between the issues of import in the peninsula. This finding defies conventional wisdom which would have CNN less informed by the stance of regionally located English media outlets.