Property of Retectix, LLC. Confidential. © 2013.

Matthew MacEwan, MD, PhD* Founder / President

A COMMON PROBLEM

1 of 4

THE CLINICAL PAIN

>40% FAIL

OUTDATED TECHNOLOGY

Woven Surgical Mesh

OUTDATED TECHNOLOGY

≠  Macroscopic Nanoscopic

Woven Mesh Human Tissue

A BETTER SOLUTION?

≠  Nanoscopic Nanoscopic

Synthetic, Non-Woven Material? Human Tissue

?

Man

ufac

turin

g P

roce

ss: B.) Collector:A.) Instrumentation: C.) Resulting Fibers

Radial

Random

+

-

+

-

Planar Collector

Circular Collector +Central Point Electrode

Nanofiber Deposition Nanofiber Monolayers Surgical MeshLayer AssemblyAPPLIED NANOTECHNOLOGY

=  Nanoscopic Nanoscopic

RETECTIX Nanofibers Human Tissue

?

BIO-INSPIRED DESIGN

AlignedRandom

NOVEL BIOLOGICAL PROPERTIES

CELLULAR MODULATION

THE NEXT STEP?

BENCHTOP TO BUSINESS

2.3  B  market  

>$2 Billion Market / ASP $500

(1)  Millennium Research Report, (2)  IMS 2010/2011

SCALING UP PRODUCTION

B.) Collector:A.) Instrumentation: C.) Resulting Fibers

Radial

Random

+

-

+

-

Planar Collector

Circular Collector +Central Point Electrode

Nanofiber Deposition Nanofiber Monolayers Surgical Mesh Layer Assembly

• Proprietary method • Proprietary equipment • Proprietary process

• Proprietary patterns • Proprietary designs • Proprietary materials

• Proprietary methods • Proprietary features

• Proprietary devices • Proprietary uses and applications

INNOVATIVE SOLUTION

A new class of surgical mesh…

RAPID WOUND HEALING

Novel Method Nanomaterial Regeneration Unoperative Dura Dura  Repaired  with  Radial  Nanofiber  Mesh

(Cortical  view) (Cortical  view) (Cortical  view)

Dura  Repaired  with  Collagen  Matrix

Animal Tissue No Ingrowth Unoperative Dura Dura  Repaired  with  Radial  Nanofiber  Mesh

(Cortical  view) (Cortical  view) (Cortical  view)

Dura  Repaired  with  Collagen  Matrix

Cell Ingrowth

Manu

factur

ing Pr

oces

s: B.) Collector:A.) Instrumentation: C.) Resulting Fibers

Radial

Random

+

-

+

-

Planar Collector

Circular Collector +Central Point Electrode

Nanofiber Deposition Nanofiber Monolayers Surgical MeshLayer Assembly

Poor Healing Treated Collagen

Resistant to tears /suture pullout

0

2

4

6

8

10

12

14

16

18

DuraGen™ DuraMatrix™ DuraPatch™ Cerafix™

Su

ture

Pu

llo

ut

Str

eng

th (

N)

UNIQUE HANDLING & STRENGTH

DuraStar™

OEM Manufacturing

Research & Development Regulatory / Legal

Finished Device Manufacturer

POISED FOR GROWTH

BREAKING BOUNDARIES

Est. clinical release: Q2 2014

ERA OF MICROBIOLOGY…

… TO ERA OF NANOTECHNOLOGY

Property of Retectix, LLC. Confidential. © 2013.

RETECTIX, LLC 4633 World Parkway Circle

St. Louis, MO 63134 info@retectix.com www.retectix.com