Post on 01-Jan-2016
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Randomized Fellow-Eye Controlled Study of Posterior
Capsule Opacification with Acrylic Asphereic and Spherical IOL
Models
Mayank A. Nanavaty, DO, MRCOphth, MRCS(Ed)
David J. Spalton, FRCP, FRCS, FRCOphth
James Boyce. PhD St. Thomas’ Hospital,
London
MAN: Travel funded by Bausch & Lomb. DJS, JM: No financial interest
DJS & JB were consultants to Alcon Laboratories, Texas, USA. MAN: No financial interests in any product or procedure.This project was supported by grant from Alcon Laboratories
Optic sphericity Aspheric Spheric
Design Single piece, posterior aspheric surface
Single piece
Optic diameter 6 mm 6 mm
Over all size 13 mm 13 mm
Material Hydrophobic acrylic Hydrophobic acrylic
AcrySof IQ AcrySof Natural
The posterior aspheric design of this IOL makes it interesting to study it’s influence on PCO
Background
To compare post-operative
• Visual acuity
• Posterior capsular opacification (PCO)
• Rhexis area
after implantation of AcrySof IQ and AcrySof Natural IOLs
Aims
Methods
• Prospective randomised fellow eye comparison
• Normal eyes with bilateral cataracts
• Single Surgeon, standardised phaco technique
• Follow-up at 1m, 3m, 6m, 1yr, 2yrs
Follow-up data
At each visit:
• 100% & 9% LogMAR BCVA
• PCO and rhexis area measured with
retroillumination images and POCO software
Results
• 94 eyes of 47 patients were enrolled
• Average age 76 yrs +/- 7.7 (60-91yrs)• Follow-up at 1m = 94 eyes of 47 patients
3m & 6m = 88 eyes of 44 patients
12m = 84 eyes of 42 patients
24m = 82 eyes of 41 patients
• There was no significant difference in capsulorhexis area at any follow up visits between the two groups (p = ns)
9% BCVA
Best corrected visual acuity
P=0.03
1 63
Months
*
100% BCVA
p = ns p = ns
AcrySof IQ AcrySof Natural
Mean PCO score
1 63 12 24
Months
P < 0.05 at all time points
* **
**
AcrySof IQ
AcrySof Natural
p = ns
OS AcrySof IQ
OD AcrySof Natural
1 m 3 m 6 m 1 y
Pt OSP
2 y
OS AcrySof IQ
OD AcrySof Natural
1 m 3 m 6 m 1 y
Pt ILA
2 y
Optic edge thickness
197.7 198.7
AcrySof IQ AcrySof Natural
Not a very big difference in edge thickness!Nanavaty MA, Spalton DJ, et al. J Cataract Refract Surg 2008
Conclusion
• Best corrected 100% and 9% LogMAR visual acuity is not
different between AcrySof IQ and AcrySof Natural
• PCO is not significantly different between the two IOLs at 2
years
• Posterior asphericity of AcrySof IQ does not influence the
PCO outcomes