Post on 02-Mar-2016
transcript
Slide 1
ABSORPTION OF DRUGSShaik. Vaheeda rehmanDept of pharmacology
Welcome
Introduction of absorption.
Structure of the Cell Membrane.
Gastro intestinal absorption of drugs.
Mechanism of Drug absorption.CONTENTS
introduction
Introduction of AbsorptionDefinition :-The process of movement of unchanged drug from the site of administration to systemic circulation.
Anatomy and physiologyOf stomach
Anatomy and physiologyOf stomachWall of the stomach:-Muscle layerOuter layer(longitudinal fibres)Middle layer(circular fibres)Inner layer(oblique fibres)mucosa
Lumen of stomach
Nerve supplyPara sympathetic supply:Contraction of smooth muscleSecretion of digestive juicesSympathetic supply:Reduces smooth muscle contraction vagus nerve Reduces the glandular secretion
Blood supplyArterial supply:-Stomach- coeliac arterySmall intestine- superior mesenteric arteryLarge intestine- inferior mesenteric arteryVenous drainage:-Portal veinStomach- right gastroepiploic veinSmall intestine- superior mesenteric veinLarge intestine- inferior mesenteric vein
Cell membrane
Gastro intestinal absorption of drugs
Mechanism of drug absorption
Mechanism of action
Trans cellular absorptionPara cellular absorptionTransport in vesicles
Transcellular absorption:Passive diffusionCarrier mediated transportactive transportFaciliated transportCarrier mediated intestinal transportIonic/electrochemical diffusionIon pair transport
Paracellular transport:Pore transportTransport in vesiclesEndocytosis(phagocytosis, penocytosis)Exocytosistranscytosis
Difference between passive and active transport
Ion pair transport
Transport in vesicles
Pore transport
Thank you