Membrane Transport

Chapter 11

Transcellular transport of glucose

The Na+ - K+ pump is an ATPase

Response of red blood cells to changes in osmolarity of extra cellular fluids

Distribution of phospholipids and glycolipids in the lipid bilayer of human red blood cells

Few Ions are required to cause a large change in membrane potential

Electrochemical gradient vs. membrane potential

Can work additively or against each other

Selectivity of a K+ channel

Ion Channels fluctuate between closed and open conformations

Gating of K+ channel

Gating of Ion Channels

A Typical Vertebrate Neuron

Ball and Chain Model of Rapid inactivation of ion channel

Changes in Na+ channels and the action potential

Changes in Na+ channels and the action potential

Myelination

Schwann cells and myelination of axons

Patch Clamp Recording

Patch Clamp Recording

Patch Clamp Measurements of single voltage gated Na+ channel

3 experiments on the same patch

cumulative of 144 experiments

Resting Chemical Synapse

Active Chemical Synapse

Neuromuscular Junction in a Frog

Three Conformations of Acetyl Choline receptor at the neuromuscular junction

DVD Clip 49

Ion Channels at Neuromuscular Junction

Motor Neuron Cell body in the Spinal Chord

Motor Neuron Cell body in the Spinal Chord

thousands of axon terminals are stained red by antibody that recognizes a protein in synaptic vesicles