Post on 16-Jul-2015
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The gastric mucosal barrier is the
property of the stomach that allows it to
contain acid
If the barrier is broken , then the acid
diffuses back into the mucosa and
damage the stomach wall
The gastric mucosal barrier is made up of
3 components
compact epithelial cell lining with tight
junctions
Gastric mucus covering(gel like coating )
Bicarbonate ions, secreted by the
surface epithelial cells. The bicarbonate
ions act to neutralize harsh acids
Mucus is secreted by mucus cells
Present allover the GIT
Acts as a protectant and lubricant of
wall of gut
Mucus is a viscous gel which contains
mucin, phospholipids, electrolytes
(mainly HCO3 )and water
Separates the epithelial cells from acid
of stomach
This maintains the Ph of epithelial cells
alkaline despite gastric acid
Mucus is strongly resistant to digestion by
gastric enzymes
Has buffering properties( neutralize acid )
Helps in propulsive movement by
lubrication
Easy slippage of food
Ulcer :- An Ulcer is a discontinuity or
break in a bodily membrane ,or breach
in the epithelium
Ulcer and occur anywhere in the body
When it occurs in stomach its gastric
ulcer
In duodenum its duodenal ulcer
Ulcer occurring in either of these two
sites is called peptic ulcer
Its also known as acid peptic disease
If the secretion of mucus is impaired
Or bicarbonate production is impaired
Such damage is caused by drugs like
asprin, NSAID
Chronic stress conditions (stress ulcer )
Chronic anxiety
Common in people with busy life style
Hurry , worry , curry
Intake of spicy food –leads to
hyperchlorhydria
Conditions with hyperchlorhydria
(Zollinger ellison syndrome ) gastrin
secreting tumor
Major cause of peptic ulcer
This bacterial infection causes
Damage to the mucosal barrier
Increase in gastrin secretion from G cells
Reduce somatostatin from D cells
Initially causes gastritis which later on
leads to peptic ulcer
Upper abdominal pain
Pain usually by empty stomach relieved
by food or antacid
Vomiting
Blood vomiting and perforation in severe
cases
Avoid stress
Adequate sleep
Regulation of diet
Avoid spicy foods , alcohol
Withdrawal of drugs like aspirin, NSAIDS