Post on 07-Dec-2014
description
transcript
Characterizing disease resistance in native oysters
that have experienced disease pressure
Steven Roberts, Roxanna Smolowitz, Rick Karney
Northeastern Regional Aquaculture Center
MVineyardflickr | cpurrin1
Disease Resistance ?
Roxannna SmolowitzRick Karney
Market size
apoptosis
protease
Without Pressure
n.d.
n.d.
High Mobility Group Protein
Apoptosis – BCL-X
• Resistant oyster strains could downregulate apoptosis suppression
• Allowing for increased apoptosis
• Decreasing number of cells available for Perkinsus proliferation
Schematic
Resistant Wild-type
BCL-X BCL-X
Text
Parasite
Hemocytes
causative or associative?
Markers ?Does it matter?
Summary
• Offspring of survivors of heavy disease pressure are more tolerant to disease
• Mechanisms involved in host responses to P. marinus include proteases, apoptosis, and molecule signaling
• Careful selection of broodstock (potentially aided by markers) can benefit aquaculture and conservation efforts
Future
• Increased analysis on current data set
• Analyze gene expression patterns in different locations under different diseased pressure
• Application of markers
• Could assignment be made via gene expression?