Post on 31-Dec-2015
transcript
Pathophysiology
Zhao Mingyao (Jasper)
Department of Pathophysiology
Medical College, Zhengzhou University
zmy66@zzu.edu.cn/67739263(o)
Top 10 China’s Universities for MBBS study with moderate tuition fees (Duration: 6 years, 2012 )
16/72 (22.2%)
University Tuition fee RMB( USD) per year
University Tuition fee RMB( USD) per year
1. Central South University
32000 (5160) 6. Jiangsu University 22000 (3500)
2. Zhengzhou University*****
26000 (4195) 7. Dalian Medical University
42000 (6774)
3. Southeast University 30000 (4840) 8. Wuhan University 32000 (5160)
4. Huazhong University of Science and Technology
40000 (6452) 9. Capital Medical University
35000 (5500)
5. Tianjin Medical University
41000 (6620) 10. Xi’an Jiaotong University
40000 (6600)
*****
about 5 , 10, 20y later
A true doctor
could not find a position in society
?Consist of every day and every class
In ZZU now
Study hard for good future
How many attend class? Total 72.
2012-031-28
Data analyse
• 16/72 (22.2%) international students from ZZU passed Medical License Exams in India , 2012 46 failed
• In India, More than 6000 students from the world participated in the Medical License Exams in 2011 ， 800 passed it. 60 graduates from TMU attended the exams and 39 of them passed(65%).
• Among 800 passman, Mr. Aurabh Suman came second in the exams.
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Roll No 11275357
Name GAURAV JOSHI
Course FMGE
Result PASS
Session SEPTEMER 2011
Date Of Birth 30/07/88
Marks Obtained : 182 (Maximum Marks : 300)
The above displayed results are for internet based information only. Result letters are sent to all candidates by post. Candidates may verify their results from signed copy of result placed at the reception office of the National Board of examinations, Ansari Nagar, New Delhi.
Run fast to get worm Run fast to get gold medal
You pass Medical License Exams as soon as possible, can get ideal job earlier
How to do?
I only hear; I forget
I see, write down and repeat; I remember
I do and think; I understand
1. What is Pathophysiology ？2. Why to study it ？3. How to study it ？4. What is it consisted of in our textbook?
Preface to Pathophysiology
1.What is pathophysiology?
Pathophysiology ?
=
• Clinical Physiology
• Medical Physiology
• Physiology of Disease
• Physiology of Disordered Function
Pathophysiology ?
= abnormal physiology
+ abnormal biochemistry
Pathophysiology =
Explore the rule of origin and evolution of disease processes (the underlying mechanisms).
Basing on physiology and biochemistry
The Methodologies Used in Pathophysiology
Experiments studyClinical observationEpidemiological study
?
Basic medicine Clinical
medicine
2. Why to study Pathophysiology ？
explain “Why and How” of diseases
Why Is Pathophysiology Important? An essential introduction to clinical medicine
A bridge: basic medicine and diseases
Enables us to understand why and how diseases develop
Various clinical manifestations appear, which are the underlying mechanisms In so doing devise rational therapeutics
3. How to study pathophysiology ？
Success comes with industry, but diligence …?
Major Points in Learning Pathophysiology
The general concepts The etiology and pathogenesis The alterations of metabolism and function The principles for prevention and therapies
4.Content of pathophysiology in this textbook
Pathological process
General introduction on disease
Systemic and organic ~
Cellular and molecular ~
Conspectus of Disease
Chapter 1
1.Concept of Disease
Aberrant manifestation of deregulated homeostasis caused by harmful agents
The development of a disease is a pathologic process with a characteristic set of signs and symptoms involved in the whole body or any of its parts
Concept of Health
Without any evidence of disease, and a state of complete well-being physically, socially and psychologically
-----WHO
health diseasesubhealth
transition stage
2.Etiology of Disease
Study the causative agents Answer the question why disease happens
complete well-beingphysically socially psychologically
Extrinsic Factors Intrinsic Factors
Predisposing factors
Precipitating factors
3. Pathogenesis of diseases
General rules for pathogenesis of diseases
(1) Disruption of homeostasis
(2) Process of damage and anti-damage
(3) Reversal role of cause and result
(4) Correlation between systemic and local regulations
furuncle
Eyewinker
Monocyte
Physic barrier
Stress
Immunoreaction
Inflammation
Coagulation
Detoxification
Radiation
Microbe
StressorPyrogen
Teratologic
Carcinogen
Trauma
Process of damage and anti-damage
Neural regulations Humoral regulations Cellular regulations Molecular regulations
Basic Mechanisms for Disease
4.Phases of Diseases
LatencyProdrome
RecoveryDisease
序曲前奏
高潮
尾声
Clinic symptoms
Outcome of Disease
Recovery
Death
Complete recovery
Incomplete recovery
Death
The body as a whole stops working forever
Brain death is the marker for the diagnosis
Brain Death (WHO criteria)
• Cessation of spontaneous respiration
• Irreversible coma
• Absence of cephalic reflexes
• Dilated or fixed pupils
• Absence of any electrical activity of the brain
• Absence of brain blood flow
Significance for diagnosis of brain death
In favor of recording the time of death
Define the time to terminate for the rescue
In favor of organ transplantation
How to do?
• I only hear; I forget
• I see, write down and repeat; I remember
• I do and think; I understand
Thank you!