Post on 25-Dec-2014
description
transcript
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
Plasma Lipid TransportRole of HDL
Philip Barter, MBBS, FRACP, PhD Professor and Director
The Heart Research Institute, Sydney, Australia
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECEFCFC
Plasma Lipid TransportPlasma Lipid Transport
TGTG
Liver
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsTG: triglycerides
Adipose tissue
FFA
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECEFCFC
Plasma Lipid TransportPlasma Lipid Transport
TGTG
Liver VLDL
TGTG
Adipose tissue
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsTG: triglycerides
FFA
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECE
FFA LPLLPL
FCFC
Plasma Lipid TransportPlasma Lipid Transport
Liver
TGTG
TGTG
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
VLDL
Adipose and other tissues
Adipose tissue
FFA
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECEFCFC
TGTG
Plasma Lipid TransportPlasma Lipid Transport
CECE
TGTG
Liver
LDL
TGTG
TGTG
VLDLFFA LPLLPL
Adipose tissue
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
Adipose and other tissues
FFA
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECEFCFC
TGTG
Plasma Lipid TransportPlasma Lipid Transport
CECE
LDL LDL receptorreceptor
LDL receptorLDL receptor
Liver
LDL
Liver
Cell in peripheral tissue
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
Adipose tissue
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
Adipose and other tissues
FFA
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECEFCFC
TGTG
Newsynthesis
Plasma Lipid TransportPlasma Lipid Transport
FCFC
LDL LDL receptorreceptor
LDL receptorLDL receptor
Liver
LDL
Liver
Cell in peripheral tissue
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
Adipose tissue
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLPL: lipoprotein lipaseTG: triglycerides
Adipose and other tissues
FFA
CECE
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECEFCFC
TGTG
TGTG Newsynthesis
Plasma Lipid TransportPlasma Lipid Transport
LDL LDL receptorreceptor
LDL receptorLDL receptor
CECE
TGTG
Liver
HDL
LDL
Liver
Cell in peripheral tissue
TGTG
TGTG
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
TGTG
VLDLFFA LPLLPL
LCATLCAT
Adipose tissue
Adipose and other tissues
FFA
CECE
CECE
CECE
FCFC
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
Plasma Lipid TransportPlasma Lipid Transport
LDL LDL receptorreceptor
LDL receptorLDL receptor
Liver
LDL
Liver
Cell in peripheral tissue
TGTG
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
Adipose tissue
LCATLCAT
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
Adipose and other tissues
HDL
FFA
CECE
CECE
CECE
FCFCCECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
Plasma Lipid TransportPlasma Lipid Transport
LDL LDL receptorreceptor
LDL receptorLDL receptor
Liver
LDL
Liver
Cell in peripheral tissue
TGTG
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
Adipose tissue
LCATLCAT
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
Adipose and other tissues
HDL
FFA
CECE
CECE
CECE
FCFCCECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
Bile
Plasma Lipid TransportPlasma Lipid Transport
LDL LDL receptorreceptor
LDL receptorLDL receptor
Liver
LDL
Liver
Cell in peripheral tissue
TGTG
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
Adipose tissue
FCFC
LCATLCAT
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
Adipose and other tissues
HDL
FFA
CECE
CECE
CECE
FCFCCECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
Plasma Lipid TransportPlasma Lipid Transport
LDL LDL receptorreceptor
LDL receptorLDL receptor
Liver
LDL
Liver
Cell in peripheral tissue
Adipose tissue
TGTG
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
LCATLCAT
Adipose and other tissues
HDL
FFA
CETPCETP
Bile
FCFC
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CECE
CECE
CECE
FCFCCECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
Dyslipidemia in Diabetes and the Metabolic SyndromeDyslipidemia in Diabetes and the Metabolic Syndrome
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
CECE
FCFC
LDL LDL receptorreceptor
LDL receptorLDL receptor
CECE
Liver
LDL
Liver
Cell in peripheral tissue
Adipose tissue
TGTG
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
LCATLCAT
Adipose and other tissues
HDL
FFA
CETPCETP
Bile
FCFC
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
Dyslipidemia in Diabetes and the Metabolic SyndromeDyslipidemia in Diabetes and the Metabolic Syndrome
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
CECE
FCFC
LDL LDL receptorreceptor
LDL receptorLDL receptor
CECE
Liver
LDL
Liver
Cell in peripheral tissue
Adipose tissue
TGTG
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
LCATLCAT
Adipose and other tissues
HDL
FFA
CETPCETP
Bile
FCFC
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
Dyslipidemia in Diabetes and the Metabolic SyndromeDyslipidemia in Diabetes and the Metabolic Syndrome
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
CECE
FCFC
LDL LDL receptorreceptor
LDL receptorLDL receptor
CECE
Liver
LDL
Liver
Cell in peripheral tissue
Adipose tissue
TGTG
TGTG
TGTG
TGTG
VLDLFFA LPLLPL
LCATLCAT
Adipose and other tissues
HDL
FFA
CETPCETP
Bile
FCFC
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
Dyslipidemia in Diabetes and the Metabolic SyndromeDyslipidemia in Diabetes and the Metabolic Syndrome
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
CECE
FCFC
LDL LDL receptorreceptor
LDL receptorLDL receptor
CECE
Liver
LDL
Liver
Cell in peripheral tissue
Adipose tissue
TGTG
TGTG
TGTG
TGTG
FFA
LCATLCAT
Adipose and other tissues
LPLLPL
HDL
FFA
VLDL
CETPCETP
Bile
FCFC
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
Dyslipidemia in Diabetes and the Metabolic SyndromeDyslipidemia in Diabetes and the Metabolic Syndrome
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
CECE
FCFC
LDL LDL receptorreceptor
LDL receptorLDL receptor
CECE
Liver
LDL
Liver
Cell in peripheral tissue
Adipose tissue
TGTG
TGTG
TGTG
TGTG
FFA
Adipose and other tissues
LCATLCAT
HDL
FFA
VLDL LPLLPL
CETPCETP
Bile
FCFC
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
Dyslipidemia in Diabetes and the Metabolic SyndromeDyslipidemia in Diabetes and the Metabolic Syndrome
CECE
CECEFCFC
TGTG
TGTG Newsynthesis
CECE
FCFC
LDL LDL receptorreceptor
LDL receptorLDL receptor
CECE
Liver
LDL
Liver
Cell in peripheral tissue
Adipose tissue
TGTG
TGTG
TGTG
TGTG
FFA
Adipose and other tissues
FFA
VLDL LPLLPL
LCATLCAT
HDL
CETPCETP
Bile
FCFC
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CE: cholesteryl esterCETP: cholesteryl ester
transfer proteinFC: free cholesterolFFA: free fatty acidsLCAT: lecithin cholesterol
acytransferase LPL: lipoprotein lipaseTG: triglycerides
CECE
CECE
Source: International Chair on Cardiometabolic Riskwww.cardiometabolic-risk.org
www.cardiometabolic-risk.org