Charge:• Your task is to develop core ideas/projects for an $8-10M

($1.25-1.5M per year for 5 years) NIH Center proposal.

• Specifically, you should consider the following questions

Molecular Imaging• Group MembersPeter A. DowbenYuri L, LyubchenkoXiao Cheng ZengRon CernyStephen DiMagnoMichael Boska

Briefly describe the core projects your group would design for the Center. Please dream big.• We envision a comprehensive center that spans molecular biology,

target identification, whole cell studies, small animal, large animal, human imaging.

• Key new components of the facility include: centralized cell culture facility, an adjacent animal facility, cyclotron, preclinical PET/CT scanner, whole body MRI, small animal fluorescence scanner, imaging mass spectrometer.

• Magnetic and electric dipolar molecules with functionalities not only as MRI agents BUT also magnetocaloric and inductive heating and cooling; nanoimaging characterization of the MRI agents; imaging liqand-protected metal nanoparticles, PET, radiochemistry facility (cyclotron).

• “Donor’s Name” Institute for Translational Molecular Imaging

Identify the key faculty from from both campuses to involve in these projects. Include their strengths. (UNMC on next slide)• UNL Faculty StrengthsA. Gruverman ferroelectricsWai-Ning Mei (UNO) electronic structure theoryR. Sabirianov (UNO) electronic structure theoryL. Parkhurst, UNL Chemistry, fluoresenceD. Sellmyer, UNL Physics, metal nanoparticles

synthesisJ. Shield, UNL Mech. Eng., nanoparticle

characterizationStephen DiMagno 18F Radiotracer synthesisChemistry (UNL)Electrical Engineering (UNL)Biomedical Engineering (UNL)

Identify the key faculty from from both campuses to involve in these projects. Include their strengths.

• UNMC Faculty StrengthsLiu, Yutong MRI applications, Image processingBoska, Michael MRI applicationsSajja, Bala Image processingEppley Cancer Institute (UNMC) Molecular Biology/target IDNeurosciences (UNMC) Moleuclar/histology/animal

modelsCardiology (UNMC) EtcRadiology (UNMC)College of Pharmacy (UNMC)

Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects.Dana Farber Cancer InstituteU. Missouri Medical CenterFree University of Berlin (Institute for Inorganic Chemistry, Physical

Chemistry, FU Medical Center)University of Minnesota

List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested.

Thermo Fischer Scienticfic Health Care GE Health CareSigma AldrichEpichemLuna NovaCardinal HealthSiemens

Describe how you would link the Center to other campus resources.• MRI facilities• Nanoimaging core facility, UNMC• Nanoscience facility, UNL• Mass Spectrometry facility, UNL