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PREGLED 2013.
Zagreb, 2014.
ISBN 978-953-6998-57-9
9 7 8 9 5 3 6 9 9 8 5 7 9
PR
EG
LED
2013. Stručni i znanstveni rad
ovi
Stručni i znanstveni radovi
PREGLED2013.
StručniiznanstveniradoviNastavni zavodzajavnozdravstvo
„Dr.AndrijaŠtampar“
REVIEW2013
ProfessionalandscientificarticlesAndrijaŠtampar
TeachingInstituteofPublicHealth
Zagreb,2014.
IzdavačSlužbazaznanostinastavu
Nastavnogzavodazajavnozdravstvo„Dr.AndrijaŠtampar“
Uredništvo:JosipČulig
MarcelLeppéeIvanaPrgaJankač
Grafičkapripremaitisak:
ISBN:978-953-6998-57-9
Naklada200primjeraka
Zagreb,2014.
MojUredd.o.o.
Predgovor
Temeljem istraživačkog rada u znanstvenom području biomedicina i zdravstvo,znanstvenompoljujavnozdravstvoizdravstvenazaštita,utadašnjemZavoduzajavnozdravstvo Grada Zagreba, osnovana je Znanstvena jedinica, koja je 2001. godineregistrirana u Ministarstvu znanosti, obrazovanja i sporta (MZOS), kao Znanstvenajedinica ZZJZGZ s istraživačkim djelokrugom u znanstvenom području biomedicina izdravstvoteznanstvenompoljujavnozdravstvoizdravstvenazaštita.ZnanstvenapostignućadjelatnikaZavodaseredovitopublicirajuudomaćimiinozemnimčasopisima i knjigama. Znanstvenici i sveučilišni nastavnici zaposleni u ZavoduevidentiranisuuUpisnikuznanstvenikapriMinistarstvuznanosti,obrazovanjaisportaRepublike Hrvatske. Znanstveno istražuju u različitim područjima (javno zdravstvo izdravstvena zaštita, temeljna i kliničkamedicina, farmacija,prehrambena tehnologija,kemija,biologijaidrugo).ZahvaljujućiintenzivnimznanstvenimpostignućimaZavodjepostaosuradnaustanovamedicinskih fakulteta u Zagrebu, Osijeku i Rijeci, farmaceutskog fakulteta u Zagrebu,Zdravstvenog veleučilišta te drugih učilišta i znanstvenih instituta, zbog čega jepromijenioimeuNastavnizavod.UPregledustručnihiznanstvenihradovakojegredovitotiskamo,najednomsumjestuprikupljeneosnovneinformacijeopublikacijamaznanstvenikazaposlenihuNastavnomzavoduza javnozdravstvo„Dr.AndrijaŠtampar“.Znanstvenom,nastavnomistručnomraduseposvećujeznačajannaporuzizvršavanjeosnovnezdravstvenedjelatnostiZavoda.U2013.godinitojerezultiralouspješnimzavršetkomrazličitihznanstvenihprojekataštoseočitujeučak17radovaobjavljenihucijelosti(inextenso)učasopisimakojisecitirajuuCurrentContents(CC)bazipodataka,aukojimasudjelatniciZavodaimaliautorskuilikoautorskuulogu.Jošje6radovaobjavljenihudrugimindeksiranimčasopisima(PubMed,Medline)ucijelosti(inextenso)te10sažetakaradovaobjavljenihiprikazanihnaraznimmeđunarodnimkongresima,simpozijimaitiskanihurazličitimpublikacijama.Znanstvena djelatnost Nastavnog zavoda za javno zdravstvo „Dr. Andrija Štampar“ jeuspješno umrežena u međunarodne projekte, što je pretpostavka daljnjeg razvoja inapretka,unatočsloženimfinancijskimuvjetimazaovukomponentusvakodnevnograda.Bezznanstvenognapredovanjanemaukupnograzvojapajeznanostvažandiostrategijenašeustanove,aovamalapublikacijadokazjedaitekakoimasmislapoticatizaposlenikenadodatnenapore.
ZvonimirŠostar,dr.med.,ravnatelj
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SADRŽAJ
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1) RADOVIOBJAVLJENIUCURRENTCONTENTS-U(CC)U CIJELOSTI(INEXTENSO)
Broj1.DETERMINATIONOFCYANURICACIDINWHEYPOWDERUSINGHILIC-MS/MSIvešićM,BabićS,KrivohlavekA,ŠmitZ.
Broj2.ORGANOCHLORINEPESTICIDESINMURAENAHELENAL.1758FROMTHEEASTERNADRIATICSEA.DikicD,Mojsovic-CuicA,JurakG,LasicD,SkaramucaD,Matic-SkokoD,TutmanP,BosnirJ,FranjevicD,FranicZ,FuchsR,SkaramucaB.
Broj3.EFFECTSOFTEMPERATURE,LENGTHOFSTORAGEANDTECHNOLOGICALPROCESSESONTHEFORMATIONOFN-NITROSAMINESINLIVERPÂTÉJurak G Bo nir J Puntari D Pavlini Prokurica I mit Z Medi H Puntari I , š , ć , ć- ,Š , ć , ć ,Puntari E.ć
Broj4.NATURALOCCURRENCEOFAFLATOXINB1,OCHRATOXINAANDCITRINININCROATIANFERMENTEDMEATPRODUCTSMarkovK,PleadinJ,BevardiM,VahčićN,Sokolić-MihalakD,FreceJ.
Broj5.EFFECTSOFMAGNESIUM,CHROMIUM,IRONANDZINCFROMFOODSUPPLEMENTSONSELECTEDAQUATICORGANISMSBosnirJ,PuntaricD,CvetkovicZ,PollakL,BarusicL,KlaricI,MiskulinM,PuntaricI,PuntaricE,MilosevicM.
Broj6.HEAVYMETALSANDMETALLOIDCONTENTINVEGETABLESANDSOILCOLLECTEDFROMTHEGARDENSOFZAGREB,CROATIAPuntaricD,VidosavljevićD,GvozdićV,PuntarićE,PuntarićI,MayerD,BošnirJ,LasićD,JergovićM,KlarićI,VidosavljevićM,KrivdićI.
Broj7.FIGHTINGRABIESINEASTERNEUROPE,THEMIDDLEEASTANDCENTRALASIA-EXPERTSCALLFORAREGIONALINITIATIVEFORRABIESELIMINATIONAikimbayevA,BriggsD,ColtanG,DodetB,FarahtajF,ImnadzeP,KorejwoJ,MoiseievaA,TordoN,UsluerG,VodopijaR,VranješN.
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Broj8.MAMMOGRAPHICDENSITYANDESTIMATIONOFBREASTCANCERRISKININTERMEDIATERISKPOPULATIONTešićV,KolarićB,ZnaorA,KusacicKunaS,BrkljačićB.
Broj9.RISKFACTORSFORPULMONARYTUBERCULOSISINCROATIA:AMATCHEDCASE-CONTROLSTUDYJurcev-SavicevicA,MulicR,BanB,KozulK,Bacun-IvcekL,ValicJ,Popijac-CesarG,Marinovic-DunatovS,GotovacM,SimunovicA.
Broj10.HEALTHSYSTEMDELAYINPULMONARYTUBERCULOSISTREATMENTINACOUNTRYWITHANINTERMEDIATEBURDENOFTUBERCULOSIS:ACROSS-SECTIONALSTUDYJurcev-SavicevicA,MulicR,KozulK,BanB,ValicJ,Bacun-IvcekLj,GudeljI,Popijac-CesarG,Marinovic-DunatovS,SimunovicAetal.
Broj11.ASIXDECADESLONGFOLLOW-UPONBODYSIZEINADOLESCENTSFROMZAGREB,CROATIA(1951-2010)Zajc-PetranovićM,TomasZ,Smolej-NarancicN,Skaric-JuricT,VecekA,MilicicJ.
Broj12.INEQUALITIESINCROATIANPUPILS'RISKBEHAVIORSASSOCIATEDTOSOCIOECONOMICENVIRONMENTATSCHOOLANDAREALEVEL:AMULTILEVELAPPROACHPavic-SimetinI,KernJ,KuzmanM,PfoertnerTK.
Broj13.ESTIMATINGGLOBALANDREGIONALMORBIDITYFROMACUTEBACTERIALMENINGITISINCHILDREN:ASSESSMENTOFTHEEVIDENCELuksicI,MulicR,FalconerR,OrbanM,SidhuS,RudanI.
Broj14.EFFECTIVENESSOFSEASONALINFLUENZAVACCINESINCHILDREN-ASYSTEMATICREVIEWANDMETA-ANALYSISLukšićI,ClayS,FalconerR,PulanicD,RudanI,CampbellH,NairH.
Broj15.VIRALETIOLOGYOFHOSPITALIZEDACUTELOWERRESPIRATORYINFECTIONSINCHILDRENUNDER5YEARSOFAGE-ASYSTEMATICREVIEWANDMETA-ANALYSISLukšićI,KearnsPK,ScottF,RudanI,CampbellH,NairH.
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Broj16.PATIENTSELF-REPORTEDADHERENCEFORTHEMOSTCOMMONCHRONICMEDICATIONTHERAPYBoskovicJ,LeppéeM,CuligJ,EricM.
Broj17.SOILCONTAMINATIONASAPOSSIBLELONG-TERMCONSEQUENCEOFWARINCROATIAVidosavljevicD,PuntaricD,GvozdicV,JergovicM,MiskulinM,PuntaricI,PuntaricE,SijanovicS.
2) RADOVIOBJAVLJENIUCURRENTCONTENTS-U(CC)U OBLIKUSAŽETKA
Broj1.ADHERENCETOMEDICATIONINTHEMOSTCOMMONCHRONICDISEASESLeppéeM,CuligJ,MandicK,SkesM,Maric-BajsM.
Broj2.CONSUMPTIONOFANTIDEPRESSANTSINCROATIA:TRENDSINTHERATEOFHOSPITALIZATIONFORDEPRESSIONANDSUICIDE(2001-2010)Polic-VizintinM,StimacD,TripkovicI.
3) RADOVIOBJAVLJENIUDRUGIMINDEKSIRANIM ČASOPISIMAUCIJELOSTI(INEXTENSO)
Broj1.DETERMINATIONOFBOTANICORIGINOFTHECROATIANBLACKLOCUSTHONEY(ISTRIAREGION)USINGMELISSOPALYNOLOGICALANALYSISUršulin-TrstenjakN,HrgaI,StjepanovićB,DragojlovićD,LevanićD.
Broj2.UDIOMIKROELEMENATAUPOČETNOJIPRIJELAZNOJHRANIZADOJENČADTEHRANINABAZIŽITARICABošnirJ,FilipovićVrhovacI,RaczA,AntolićS,PuntarićD.
Broj3.ANTIFUGALNAIANTIPATULINSKAAKTIVNOSTGLUCONOBACTEROXIDANSIZOLIRANESPOVRŠINEJABUKEBevardiM,FreceJ,MesarekD,BošnirJ,MrvčičJ,DelašF,MarkovK.
Broj4.EPIDEMIOLOGYANDETIOLOGYOFCHILDHOODPNEUMONIAIN2010:ESTIMATESOFINCIDENCE,SEVEREMORBIDITY,MORTALITY,UNDERLYINGRISKFACTORSANDCAUSATIVEPATHOGENSFOR192COUNTRIESRudanI,O'BrienKL,NairH,LiuL,TheodoratouE,QaziS,LukšićI,FischerWalkerCL,BlackRE,CampbellH;ChildHealthEpidemiologyReferenceGroup(CHERG).
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Broj5.GERONTOLOGYPUBLICHEALTHMANAGEMENTINCROATIATomek-RoksandićS,TomasovićMrčelaN,SmolejNarančićN,ŠostarZ,LukićM,DurakovićZ,LjubičićM.
Broj6.PROGRAMOFPRIMARY,SECONDARYANDTERTIARYPREVENTIONFORTHEELDERLYTomek-RoksandićS,TomasovićMrčelaN,SmolejNarančićN,ŠostarZ,LukićM,DurakovićZ,LjubičićM,VučevacV.
4) OSTALIRADOVI
4.1)INOZEMNI
Broj1.VALIDATIONOFAMETHODFORDETERMINATIONOFPHTHALATESINCOMMONUSEOBJECTS(TOYSANDCHILDCAREARTICLES)BYGASCHROMA-TOGRAPHYMASSSPECTROMETRY(GCMS)MandićAndačićI,RanogajecA,SmitZ.
Broj2.COMPARASIONOFFINEPARTICULATECONCENTRATIONSINURBANAREATRAFFICEXPOSEDAREAANDLANDFILLINTHEZAGREBCITY.MajićI,KrivohlavekA,ŠikićS,ŠostarZ.
Broj3.OXIDATIVESTRESSRESPONSEINTOBACCOEXPERIMENTALLYEXPOSEDTOCADMIUMANDZINCCvjetkoP,ŠikićS,Peharec-ŠtefanićP,TolićS,PavlicaM,BalenB.
Broj4.REGIONALDIFFERENCIESINDRINKINGHABITSAMONGCROATIANADOLESCENTSKuzmanM,Pavic-SimetinI,MarkelicM,Pejnovic-FranelicI.
Broj5.QUALITYLIFEIMPROVEMENTOFPEOPLEWITHINTELLEC-TUALDISABILITIESTHROUGHOUTARTTHERAPYANDMOVEMENTREHABILITATIONTHERAPYPROGRAMSŠ , č , č .kes M Lukave ki V Kli ek M
Broj6.THERELIABILITYOFADHERENCETOMEDICATIONSELF-REPORTINGSCALESCuligJ,LeppéeM,CuligB.
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Broj7.IMPACTOFP ' ATIENTS ADHERENCE TO MEDICATION ANDPHARMACOECONOMIC ANALYSISCuligJ,LeppéeM,CuligB.
Broj8.SELF-REPORTEDADHERENCEFORTHECHRONICMEDICATIONTHERAPYLeppéeM,CuligJ,Maric-BajsM.
4.2)DOMAĆI
Broj1.MELISOPALINOLOŠKEKARAKTERISTIKENAJVAŽNIJIHVRSTAMEDAUREPUBLICIHRVATSKOJHrgaI,StjepanovićB.
Broj2.ODREĐIVANJEBOTANIČKOGIGEOGRAFSKOGPODRIJETLAKONTINENTALNIHMEDOVAHRVATSKEHudinaT,MitićB,HrgaI,B.Stjepanović,D.Lasić,I.Nemet,S.Rončević.
Broj3.USPOREDBA KONCENTRACIJA SO U GRADSKOJ ZONI I ODLAGALI TU 2 Š OTPADAGRADAZAGREBAMajićI,KrivohlavekA,ŠikićS.
Broj4.ODREĐIVANJEADSORBILNIHORGANSKIVEZANIHHALOGENA(AOX)UVODIJukićM,SimonM,LazićV,KrivohlavekA,ŠikićS,OžićS.
Broj5.DESETGODINAAKREDITACIJEZAVODAZAJAVNOZDRAVSTVO„DR.ANDRIJAŠTAMPAR“;NormaHRNENISO/IEC17025:2007KrivohlavekA,Devčić-JerasA,ŠikićS.
Broj6.INSTITUCIONALNOPRAĆENJEUPORABEANTIBIOTIKAUPČELINJIMPROIZVODIMAKrivohlavekA.
Broj7.VAŽNOSTPRAĆENJACITRININAUŽITARICAMANAPODRUČJUREPUBLIKEHRVATSKE.BevardiM,OžićS,BošnirJ,BudečM.
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Broj8.OTPUŠTANJEFTALATAIZAMBALAŽEURAZNEVRSTEPIĆAGalićA,BarušićL,MandićI,JurkovićZ, ž D.Stra anac
Broj9.PRIKAZREZULTATAMONITORINGAISLUŽBENIHKONTROLAHRANENAPRISUTNOSTANALIZIRANIHMIKOTOKSINALasićD,BudečM,IvešićM,RanogajecA,BlagojevićK,KnezićK.
Broj10.KONTROLE MIKOTOKSINA U HRANI I HRANI ZA ŽIVOTINJE S NAGLASKOM NA UZORKOVANJEBošnirJ,PrskaloI,PavlekŽ,NovakA.
Broj11.ODREĐIVANJEBIOGENOGAMINA,HISTAMINA,UUZORCIMAKONZERVIRANERIBETEKUĆINSKOMKROMATOGRAFIJOMVISOKEDJELOTVORNOSTIBevardiM,BošnirJ,HorvatG,SerdarS,BrkićD.
Broj12.MIKROBIOLOŠKEIMIKOTOKSIKOLOŠKEOPASNOSTIZAZDRAVSTVENUISPRAVNOSTIKARAKTERIZACIJADOMAĆIHKOBASICAODMESADIVLJAČIMarkovK,PleadinJ,HorvatM,BevardiM,BošnirJ,Sokolić-MihalakD,DelašF,FreceJ.
Broj13.UGRIZI I UBODI KUKACA PAU NJAKA ZA TITA I OBRANA ( Č ), Š VodopijaI,VodopijaR,KrajcarD.
Broj14.MOGUĆATROVANJAANTIKOAGULANTIMATIJEKOMSUSTAVNEDERATIZACIJE–NEUOBIČAJENIKONTAKTISGLODAVCIMAVodopijaR.
Broj15.HUMANAANTIRABIČNAZAŠTITANAPODRUČJUKOPRIVNIČKO-KRIŽEVAČKEŽUPANIJEURAZDOBLJUOD2009.DO2011.GODINEPinterD,VodopijaR.
Broj16.INFEKCIJEUPUTNIKA:EPIDEMIOLOGIJA,KLINIČKASLIKA,DIJAGNOSTIKA,TERAPIJAIPREVENCIJAKosanovićML.
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Broj17.NADZORIPRAĆENJETIGRASTOGKOMARCA(AEDESALBOPICTUS)NANAJČEŠĆIMMJESTIMAUNOSAUKONTINENTALNOJHRVATSKOJKlobučarA,BenićN,KrajcarD,VrućinaI,VignjevićG,MerdićE.
Broj18.SUVREMENAPRIMJENAINFORMACIJSKO-KOMUNIKACIJSKETEHNOLOGIJE-GLODAVCIIKOMARCIUDIGITALNOMSVIJETUPuhaloD,KlobučarA,BenićN.
Broj19.EPIDEMIOLOGIJAGROZNICEZAPADNOGNILABenićN.
Broj20.KONTROVERZE I INJENICE O PRIMARNOJ PREVENCIJI SPOLNO PRENOSIVIH Č INFEKCIJAKuzman M.
Broj21.KAKO UNAPRIJEDITI ZA TITU REPRODUKTIVNOG ZDRAVLJA MLADIH Š ?KuzmanM.
Broj22.DIJAGNOSTIKA I PREVALENCIJA HPV INFEKCIJE U ENA ZAGREBA KE REGIJE Ž Č MarijanT.
Broj23.ZNAČENJESTALNEEDUKACIJEOOSNOVAMAIZGERONTOLOGIJEIGERIJATRIJEZARAZVOJHRVATSKOGGOSPODARSTVATomek-RoksandićS,TomasovićMrčelaN,SmolejNarančićN,DurakovićZ,LjubičićM,ŠostarZ,FortunaV,LukićM,PerkoG,ŠimunecD,HlatkiMatijevićS,JurišićS.
Broj24.ISKUSTVAISTAVOVIOKOCKANJUIKLAĐENJUPACIJENATAIKLIJENATASLUŽBEZAMENTALNOZDRAVLJEIPREVENCIJUOVISNOSTIZAVODAZAJAVNOZDRAVSTVO„DRANDRIJAŠTAMPAR”ŠalamonS,SabljićL,BekićM.
Broj25.PROFESIONALNIDJELOKRUGRADASOCIJALNOGRADNIKAUZDRAVSTVUINEPROFITNOMSEKTORURadicA,Devcic-MajericK,KovacevicN.
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Broj26.„PLESNARUBU“-VIŠEGODIŠNJEIZVANBOLNIČKOLIJEČENJEHEROINSKOGOVISNIKASKOMORBIDNIMPOREMEĆAJIMAGracinB,ĆavarZ,RomacD,BorovečkiŠimurinaA.
Broj27.KARAKTERISTIKEŽENA-OVISNICAOPSIHOAKTIVNIMSREDSTVIMABorovečkiŠimurinaA,Cahunek-ŽunecM,RomacD,GracinB,ĆavarZ.
Broj28.POSTAVLJANJEUPITAOPREZENTACIJSKOMEMEDIJUUCSS-KODURESPONZIVNEWEB-STRANICEPeterK.
Broj29.HRVATSKIZDRAVSTVENITURIZAMZASTRANEIDOMAĆESTARIJETURISTETomek-RoksandićS,Tomasović-MrčelaN,Smolej-NarančićN,LjubičićM,SmoljanovićM,StrnadM,DrakulićV,PredavecS,LukićM,MravakS,PerkoG,LeppéeM,BaklaićŽ,FortunaV,ŠostarZ,VlašićV.
Broj30.PATIENTS'ADHERENCETOMEDICATIONRATEANDPHARMACOECONOMICANALYSISCuligJ,LeppéeM,SkaronN,MalovicM,BilusicM.
Broj31.THEMOSTCOMMONCHRONICDISEASESANDADHERENCETODRUGSCuligJ,LeppéeM,BoskovicJ,MalovicM.
Broj32.ESTIMATESOFRELIABILITYADHERENCESELF-REPORTINGSCALESBYTHECOEFFICIENTOFINTERNALCONSISTENCYRELIABILITY(CRONBACH'S )αLeppéeM,Vracan-MravakS,MalovicM,CuligB.
Broj33.USPOREDBAOPĆEUSTRAJNOSTIPREMATERAPIJISUSTRAJNOŠĆUKODOBOLJELIHODARTERIJSKEHIPERTENZIJELeppéeM,CuligJ,Marić-BajsM,CuligB.
5) NAPREDOVANJA
6) DOKTORIZNANOSTI,MAGISTRIZNANOSTIISTRUČNIMAGISTRI
7) INDEKSAUTORA
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UVOD
Stručniiznanstveniradovipodijeljenisuučetirikategorije,sukladnokriterijimakojehrvatskasveučilištaprimjenjujuprilikomprocesanapredovanjaznanstvenikauvišiznanstvenistupanj:
1) RADOVIOBJAVLJENIUCURRENTCONTENTS(CC)ČASOPISIMAUCIJELOSTI (INEXTENSO) 2) RADOVI OBJAVLJENI U CURRENT CONTENTS (CC) ČASOPISIMA U OBLIKU SAŽETKA 3) RADOVIOBJAVLJENIUDRUGIMINDEKSIRANIMČASOPISIMA(PUBMED, MEDLINEIOSTALI)UCIJELOSTI(INEXTENSO) 4) OSTALIRADOVI
CurrentContents(ThomsonReuters)najpopularnijajebazapodataka,ahrvatskimjeznanstvenicimadostupnaprekoOvidsučelja.Razlozipopularnostisurelativnovisokikriterijodabiračasopisa,pokrivenostsvihpodručjaznanosti,učestalostažuriranja,citiranje autorskog sažetka, adrese autora, nazivi i adrese izdavača, mogućnostpregledasadržajapojedinogbrojačasopisatedodatneključneriječikojeunapređujupretraživanje.PremanavodimauređivačaCurrentContents citiraju se svi radovi izuključenihčasopisa,odkoricadokorica,tj.neradisenikakavodabir,kaokodnekihdrugihbaza.CCbazapodatakasastojiseod:
1. sadržajabrojevačasopisa 2. bibliografskihzapisaradovaiz9,500vodećihsvjetskihčasopisaizsvih područjaznanosti,višetisućaknjigaizbornihskupova.
PrekosvojihsedamsekcijaCurrentContentspokrivasvapodručjaznanosti:
1. Agriculture,BiologyandEnvironmentalSciences(AGRI)–citiravišeod 1040vodećihsvjetskihčasopisaizdisciplinakaoštosuagronomija, biotehnologija,botanika,ekologija,entomologija,hidrologija,nutricionizami veterinarskamedicina. 2. ClinicalMedicine(CLIN)–citiravišeod1120vodećihsvjetskihčasopisaiz kliničkemedicine,uključujućipodručjakaoštosuanatomija,anesteziologija, kirurgija,kliničkapsihijatrija,kliničkafarmakologija,nuklearnamedicina, onkologija,pedijatrijaiinternamedicina. 3. Engineering,TechnologyandAppliedSciences(TECH)–citiravišeod1120 vodećihsvjetskihčasopisaizinženjerstva,tehnologijaiprimijenjenihznanosti, uključujućiaeronautiku,automatizaciju,elektrotehniku,energetiku,optiku, računalneznanostiitehnologijuitelekomunikacije. 4. LifeSciences(LIFE)–citiravišeod1370vodećihsvjetskihčasopisaizbio-
znanosti,uključujućipodručjakaoštosubiokemija,biofizika,farmakologija, fiziologijaitoksikologija. 5. Physical,ChemicalandEarthSciences(PHYS)–citiravišeod1050vodećih svjetskihčasopisaizprirodnihznanostiuključujućipodručjakaoštosu astronomija,fizika,kemija,matematika,meteorologija,paleontologija, statistikaivjerojatnost. 6. SocialandBehavioralSciences(BEHA)–citiravišeod1620vodećih svjetskihčasopisaizdruštvenihznanostiuključujućipodručjakaoštosu antropologija,ekonomija,informacijskeznanosti,knjižničarstvo, komunikacije,lingvistika,međunarodniodnosi,obrazovanje,planiranjei razvoj,političkeznanosti,poslovanje,povijest,pravo,socijalnamedicina, sociologija,upravljanjetezemljopis. 7. ArtsandHumanities(ARTS)–pokrivaoko1120vodećihsvjetskihčasopisaiz humanističkihznanosti,uključujućipodručjakaoštosuarhitektura,izvedbena umjetnost,filozofija,lingvistika,književnost,povijest,religijaiteologijate vizualnaumjetnost.
KnjižnicaNastavnogzavodaza javnozdravstvo „Dr.AndrijaŠtampar“ senalazinadrugomkatuUpravnezgradeZavodaiotvorenajezaposlenicimaisuradnicimasvakogradnogdana.UKnjižnicijemogućekoristitiznanstveno-stručnuliteraturu.Ukupnojena raspolaganju 19 časopisa u tiskanom obliku (vidi priloženu tablicu), a prekoCARNETajeomogućenpristuprazličitimbazamapodataka,npr.PubMed.
PubMedjeslobodnodostupnabazapodatakaizprirodnihznanostiibiomedicine,kojasadrži citate, apstrakte i za određenbroj članaka cijeli tekst.AmeričkaNacionalnabibliotekazamedicinu(NLM)podpokroviteljstvomNacionalnoginstitutazazdravlje(NIH)održavaPubMedkaodioEntrezsustavazapretraguinformacija.
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TablicaPopisčasopisadostupnihuKnjižniciNastavnogzavodazajavnozdravstvo„Dr.AndrijaŠtampar“
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CollegiumAntropologicum
ClinicalMicrobiologyandInfection
ClinicalInfectiousDiseases
TheJournalofInfectiousDiseases
InternationalJournalofEpidemiology
FoodMicrobiology
PharmacoEconomics
Liječničkenovine
Farmaceutskiglasnik
ActaPharmaceutica
NeurologiaCroatica
PaediatriaCroatica
GynaecologiaetPerinatologia
Hrvatskimeteorološkičasopis
Librioncologici
Pharmaca
Liječničkivjesnik
Alcoholism
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Pregled2013.
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Pregled2013.
1)RADOVIOBJAVLJENIUCURRENTCONTENTS(CC)UCIJELOSTI(INEXTENSO)
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Pregled2013.
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Pregled2013.
Broj1.
Anal.Methods,2013,5,5188–94.
DETERMINATIONOFCYANURICACIDINWHEYPOWDERUSINGHILIC-MS/MS
1 2 1 1IvešićM ,BabićS ,KrivohlavekA ,ŠmitZ .1AndrijaStamparInstituteofPublicHealth2FacultyofChemicalEngineeringandTechnology,Zagreb,Croatiamartina.ivesic@stampar.hr
Ahydrophilicliquidchromatography-tandemmassspectrometrymethodwasdevelopedfordeterminationofcyanuricacidinwheypowdersamplesinthemassfractionrange
-1from1.00to100.0mgkg .Thecyanuricacidwasextractedfromwheypowderwithanacetonitrile: water (60:40, v/v) extraction solution. Separation was performed on aXBridgeAmidecolumn3.5µmusingacetonitrile:water(90:10,v/v)asthemobilephaseat
-1a flow rate of 0.2 mL min . Detection was achieved by triple quadrupole massspectrometryusingheatedelectrosprayionizationinterface.TheanalysiswasperformedinthenegativeionizationmodeusingtheSRMtransitionscombinationsofm/z128→42andm/z128→85forquantitativeandqualitativedetectionofcyanuricacid,respectively
13 15andm/z134→44andm/z134→89forisotope-labelledcyanuricacid( C , N –CYA)3 3detection,usedtocorrectformatrixeffects.Thedevelopedandoptimizedmethodwasvalidatedbydetermingfollowingvalidationparameters:selectivity,linearity,precision,accuracy,recovery,limitsofdetectionandquantificationandstabilityofcyanuricacidinwheypowderextract.Therecoveriesofcyanuricacidfromwheypowderspikedat1.00,
-12.50, 7.00, 50.0 and 100.0 mg kg were within the range of 96.7-107.2%, intra-dayprecisionwas≤6.45%,inter-dayprecisionwas≤9.13%andaccuracywasbelow10%.Matrixeffectsinvestigatedwiththreedifferentmatriceswerelessthan15%.Thelimitof
-1 -1detectionandquantificationwas0.30mgkg and1.00mgkg respectively.Thesuitabilityofthedevelopedmethodforuseinroutinedeterminationwasconfirmedthroughanalysisofwheypowdersamplesfromdairyindustryandsupermarkets.
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Pregled2013.
Broj2.
JournalofAppliedIchthyol2013;:1–6
ORGANOCHLORINEPESTICIDESINMURAENAHELENAL.1758FROMTHEEASTERNADRIATICSEA.
1 2 3 3 1 4DikicD ,Mojsovic-CuicA ,JurakG ,LasicD ,SkaramucaD ,Matic-SkokoD ,
4 3 1 5 5 5,6TutmanP ,BosnirJ ,FranjevicD ,FranicZ ,FuchsR ,SkaramucaB .1FacultyofScience,DepartmentofAnimalPhysiology,UniversityofZagreb,Zagreb,Croatia2UniversityofAppliedHealthStudies,Zagreb,Croatia3AndrijaStamparInstituteofPublicHealth4InstituteofOceanographyandFisheries,Split,Croatia5InstituteofMedicalResearch,Zagreb,Croatia6DepartmentofAquaculture,UniversityofDubrovnik,Dubrovnik,Croatiagordana.jurak@stampar.hr
ThisworkexaminesthebioaccumulatedorganochlorinecompoundsinMuraenahelenatodrawattentiontothisspeciesasapotentialbioindicatororganism.ThemorayswerecaughtintheEastAdriaticSea,ElaphiteIslands,nearDubrovnik,Croatia(lat:42°45′38.8″;long:17°45′53.6″)atthesamelocationinsummer(August,2009)andwinter(January,2010),atdepthsfrom5to10m.Ninefishwerecaughtbylonglinehookspereachfieldtrip(totalinsummerandwinter,N=18).Nosinglefishwasfreeoforganochlorines(OC),butnotallpesticideswerepresentineveryfish.Theconcentrationlevelwas:Endrin>ppDDE> Heptachlor epoxide > Heptachlor > Aldrine > Lindane > bHCH > dHCH > Endrinaldehyde). Endrin was the only pesticide approaching the maximum concentrations
-1proposedbytheEuropeanUnionandCroatia(summermax.concentration=14.75lgkg ;-1 -1
wintermax.concentration=8.35lgkg ).Allotherpesticidesrangedfrom0.1to0.7lgkg .Heptachlor was absent in winter and d-HCH and Endrin aldehyde in summer, whileLindaneandpp-DDEhadhigher(P≤0.05)concentrationsinsummer.Otherresidueshadsimilarseasonalconcentrationlevels.Thep-DDTwassimilarasinotherbiotafromtheAdriatic or Mediterranean. HCH concentrations corresponded to those found inorganisms from the Italian area of the Adriatic. The endocrine and reproductivedisruptingpotentialofthedetectedOCsarebasesforfuturestudies.Resultsshowthatmoraysareagoodbioindicatormodel,withslightinterspeciesandseasonalvariabilityinOCbioaccumulationasaconsequenceofdiversefoodconsumption.
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Pregled2013.
Broj3.
ActaAlimentaria2013;42:481–94
EFFECTSOFTEMPERATURE,LENGTHOFSTORAGEANDTECHNOLOGICALPROCESSESONTHEFORMATION
OFN-NITROSAMINESINLIVERPÂTÉ
Jurak G Bo nir J Puntari D Pavlini Prokurica I mit Z Medi H Puntari I , š , ć , ć- ,Š , ć , ć ,Puntari Eć .AndrijaStamparInstituteofPublicHealthgordana.jurak@stampar.hr
TheaimofthestudywastodeterminethepossiblepresenceofN-nitrosaminesinliverpâtésavailableontheCroatianmarketandtocomparethemwithaliverpâtéfromEUmarket.Inaddition,theeffectsoftemperature,andlengthofstorageonN-nitrosamineconcentrationswere assessed. A total of 630 sampleswere randomly chosen. Thirtysamplesofeachwereanalyzedimmediatelyuponsampling,whereasanother30sampleswerestoredfor5and10daysat4ºC,22ºCand37ºC,respectively.Inthesamplesstoredat4ºC,themeantotalN-nitrosaminelevelwas1.3-6.8 g/kgonday5and1.0-5.0 g/kgonμ μday10.Inthesamplesstoredat22ºC,themeantotalN-nitrosaminelevelwas3.6-9.3μ μ μg/kg(day0),11.9-24.5 g/kgonday5,and22.7-32.3 g/kgonday10.Inthesamplesstoredat37ºC,themeantotalN-nitrosaminelevelwas104.9-231.1 g/kg(day5)andμ801.3-1329.0 g/kg (day 10). Temperature and length of storage were found to beμassociatedwiththeformationofN-nitrosaminesinmeatproducts,butcarciongenicdiEtinparticular,accidentlyornot,wasnotpresentatallintheproductsoriginatingfromEU.
Keywords:N-nitrosamines,diet,meatproducts,liverpâté,temperature,storage
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Pregled2013.
Broj4.
FoodControl34,312-7
NATURALOCCURRENCEOFAFLATOXINB1,OCHRATOXINAANDCITRINININCROATIAN
FERMENTEDMEATPRODUCTS2 2 1 2 2 2
MarkovK ,PleadinJ ,BevardiM ,VahčićN ,Sokolić-MihalakD ,FreceJ .1AndrijaStamparInstituteofPublicHealth2Prehrambeno-biotehnološkifakultet,Zagreb,Hrvatskakmarko@pbf.hr
Whendomesticanimalsareexposedtomycotoxins,significantamountsofthelattershallbecarriedoverintoanimalproductssuchasmilk,eggsandmeat.ThisstudywascarriedoutinordertodeterminethepossiblepresenceofaflatoxinB1(AFB1),ochratoxinA(OTA)andcitrinin(CIT)ingamesausages(nĽ15),semi-drysausages(nĽ25)andfermenteddry-meatproducts(nĽ50),randomlytakenfromindividualproducersandtheCroatianmarket.AFB1andOTAwerequantifiedusingELISA,whileCITwasquantifiedusingHPLC-fluorescencedetector.Outof90samples, thefungimostfrequently isolatedfromdry-curedmeatproductswereofPenicilliumspecies,whileAspergilluswasisolatedfromonlyonesample.Asmuchas68.88%ofthesampleswerepositiveformycotoxins.Finally,theanalysisofdifferenttypesofmeatproductsresultedinOTAidentificationin64.44%,CITidentificationin4.44%andAFB1identificationin10%ofthesamples.ThemaximumOTAconcentrationsestablishedinthecommercialsausagesamplesequalledto7.83mg/kg,whilethatofAFB1amountedto3.0mg/kg.Generally,althoughOTAwasdetectedinallthree types of products in different percentage shares, mutual differences were notstatisticallysignificant(P>0.05).
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Pregled2013.
Broj5.
CollAntropol2103;37(3):965-71
EFFECTSOFMAGNESIUM,CHROMIUM,IRONANDZINCFROMFOODSUPPLEMENTSONSELECTEDAQUATIC
ORGANISMS
BosnirJ,PuntaricD,CvetkovicZ,PollakL,BarusicL,KlaricI,MiskulinM,PuntaricI,PuntaricE,MilosevicM.AndrijaStamparInstituteofPublicHealthjasna.bosnir@stampar.hr
Theaimofthisstudywastodeterminetheeffectofuncontrolledenvironmentaldisposaloffoodsupplementscontainingmagnesium(Mg),chromium(Cr),iron(Fe)andzinc(Zn)onselectedaquaticorganismsincludingfreshwateralgaeScenedesmussubspicatusandRaphidocelissubcapitata,waterfleaDaphniamagnaandduckweedLemnaminor.Thirtydifferent foodsupplements containingMg,Cr,FeandZnwereanalyzed.Resultswereexpressedaseffectiveconcentration50(EC ), i.e.growth inhibitingMg,Cr,FeandZn50(mg/L) concentration immobilizing 50%of treated organisms. Particularmetal EC50differedsignificantly(p
Broj6.
CollAntropol2013;37(3):957-64
HEAVYMETALSANDMETALLOIDCONTENTINVEGETABLESANDSOILCOLLECTEDFROMTHE
GARDENSOFZAGREB,CROATIA1 1,2 3 4 5 6
PuntarićD ,VidosavljevićD ,GvozdićV ,PuntarićE ,PuntarićI ,MayerD ,7 8 7 8 9 10BošnirJ ,LasićD ,JergovićM ,KlarićI ,VidosavljevićM ,KrivdićI .
1„JosipJurajStrossmayer“UniversityOsijek,SchoolofMedicine,DepartmentofPublicHealth,Osijek,Croatia2VukovarGeneralHospital,Vukovar,Croatia3„JosipJurajStrossmayer“UniversityOsijek,DepartmentofChemistry,Osijek,Croatia4UniversityofZagreb,FacultyofScience,BiologyDepartment,EnvironmentalSciencesDirection,Zagreb,Croatia5ZagrebCountyInstituteforEmergencyMedicine,Zagreb,Croatia6CroatianNationalInstituteofPublicHealth,Zagreb,Croatia7ZagrebPublicHealthInstitute,DepartmentodHealthEcology,Zagreb,Croatia8„JosipJurajStrossmayer“UniversityOsijek,FacultyofAgriculture,Osijek,Croatia9VinkovciGeneralHospital,DepartmentforInternalMedicine,Vinkovci,Croatia10SINACOLtd.,Zagreb,Croatiajasna.bosnir@stampar.hr
Aimof this studywas todetermineconcentrationofPb,Cd,AsandHg ingreen leafyvegetablesandsoil in theurbanareaofZagreb,Croatiaandtodetermine if there isaconnectionbetweenthecontaminationofsoilandvegetables.Greenleafyvegetablesandsoil samples were taken from the gardens located in the outskirts of the city.ConcentrationsofPb,Cd,AsandHgweredeterminedbyatomicabsorptionspectrometry;showingthataverageconcentrationsofmetalsandmetalloidsinvegetablesandinsoil,regardlessofthelocationofsamplingwerebelowthemaximumallowedconcentration(MAC).Theanalysisdeterminedthatmetalconcentrationsinonlyninevegetablesamples(9%) were above maximum allowed values prescribed by national and Europeanlegislation(threewithhigherconcentrationsofPb,onewithahigherconcentrationofCdandfivewithhigherconcentrationsofHg).Concentrationsofcontaminantspresentintheanalysedsamples,ingeneral,arelowerthantheonespublishedinsimilarstudies.Thefinal distribution and concentration of contaminants in vegetables of Zagreb, besidesindustryandtraffic,isaffectedbythedominantwinddirection.Keywords:atomicabsorptionspectroscopy,metals,metalloids,soil,vegetables,Zagreb
24
Pregled2013.
25
Pregled2013.
Broj7.
ZoonosesPublicHealth.2013Jun19.doi:10.1111/zph.12060.[Epubaheadofprint]
FIGHTINGRABIESINEASTERNEUROPE,THEMIDDLEEASTANDCENTRALASIA-EXPERTSCALLFORAREGIONALINITIATIVEFORRABIESELIMINATION
AikimbayevA,BriggsD,ColtanG,DodetB,FarahtajF,ImnadzeP,KorejwoJ,MoiseievaA,TordoN,UsluerG,VodopijaR,VranješN.AndrijaStamparInstituteofPublicHealthradovan.vodopija@stampar.hr
RabiesexpertsfromeightMiddleEastandEasternEuropeancountries(Croatia,Georgia,Iran,Kazakhstan,Romania,Serbia,TurkeyandUkraine)metinParisonJune5-8,2012.These experts constitute an informal network of 'local champions' dedicated to theeliminationofhumanrabies.During the three day meeting, these champions met with experts from the PasteurInstituteandtheGlobalAllianceforRabiesControl(GARC)todiscusstherabiessituationintheirrespectivecountriesandidentifiedstrategiestopreventandcontrolthediseaseintheirregionalcontext.SuccessstoriesinCroatiaandSerbiaprovethateliminationofhumanrabiesisachievableintheMEEREBregion.Itrequirespoliticalwillingnessandcooperationofallstakeholders,includingMinistriesofHealthandofAgriculture;adequatemanagementofanimalbitesthroughPEPusingappropriaterabiesimmunobiologicals;pre-exposureprophylaxisforpopulationsathighriskofrabiesexposure;animalvaccination;andhumanecontrolofstraydogpopulations.MEEREBmemberscallforaregionalinitiativeforrabieseliminationinEasternEuropeandMiddleEast.Theyareconfidentthattheeliminationofhumanrabiesofcanineorigincan be achieved in the region through intersectorial cooperation and a One Healthapproach,andthatcampaignsforrabieseliminationwillhavesignificantbenefitforpublichealth,includingstrengtheningthestructureforcontrolofotherzoonoses.
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Pregled2013.
Broj8.
TheBreastJournal2013;19:71-8.
MAMMOGRAPHICDENSITYANDESTIMATIONOFBREASTCANCERRISKININTERMEDIATERISK
POPULATION1 2,3 4 5 6
TešićV ,KolarićB ,ZnaorA ,KusacicKunaS ,BrkljačićB .1AndrijaStamparInstituteofPublicHealth2SchoolofMedicine,UniversityofRijeka,Rijeka,Croatia3ZagrebCountyInstituteofPublicHealth,Zagreb,Croatia4CroatianInstituteofPublicHealth,Zagreb,Croatia5ClinicalHospitalCentre,Zagreb,Croatia6UniversityHospital„Dubrava“,MedicalSchool,UniversityofZagreb,Zagreb,Croatiavanja.tesic@stampar.hr
Itisnotcleartowhatextentmammographicdensityrepresentsariskfactorforbreastcanceramongwomenwithmoderateriskfordisease.Weconductedapopulation-basedstudytoestimatetheindependenteffectofbreastdensityonbreastcancerriskandtoevaluate the potential of breast density as a marker of risk in an intermediate riskpopulation.FromNovember2006toApril2009,datathatincludedAmericanCollegeofRadiologyBreastImagingReportingandDataSystem(BI-RADS)breastdensitycategoriesand risk information were collected on 52,752 women aged 50-69 years withoutpreviously diagnosed breast cancer who underwent screening mammographyexamination. A total of 257 screen-detected breast cancers were identified. Logisticregressionwasusedtoassesstheeffectofbreastdensityonbreastcarcinomariskandtocontrolforotherriskfactors.Theriskincreasedwithdensityandtheoddsratioforbreastcanceramongwomenwithdensebreast(heterogeneouslyandextremelydensebreast),was1.9(95%confidenceinterval,1.3-2.8)comparedwithwomenwithalmostentirelyfatbreasts,afteradjustmentforage,bodymassindex,ageatmenarche,ageatmenopause,ageatfirstchildbirth,numberoflivebirths,useoforalcontraceptive,familyhistoryofbreastcancer,priorbreastprocedures,andhormonereplacementtherapyusethatwereallsignificantlyrelatedtobreastdensity(p<0.001).Inmultivariatemodel,breastcancerrisk increasedwithage,bodymass index, familyhistoryofbreastcancer,priorbreastprocedureandbreastdensityanddecreasedwithnumberoflivebirths.Ourfindingthatmammographic density is an independent risk factor for breast cancer indicates theimportanceofbreastdensitymeasurements forbreastcancerriskassessmentalso inmoderateriskpopulations.
27
Pregled2013.
Broj9.
BMCPublicHealth.2013Oct21;13(1):991.doi:10.1186/1471-2458-13-991.
RISKFACTORSFORPULMONARYTUBERCULOSISINCROATIA:AMATCHEDCASE-CONTROLSTUDY
1 2 3 4 3 5Jurcev-SavicevicA ,MulicR ,BanB ,KozulK ,Bacun-IvcekL ,ValicJ ,
6 7 1 8Popijac-CesarG ,Marinovic-DunatovS ,GotovacM ,SimunovicA .1TeachingPublicHealthInstituteofSplitandDalmatiaCounty,Split,Croatia2SchoolofMedicine,UniversityofSplit,Split,Croatia3AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia4PublicHealthInstituteofOsječko-BaranjskaCounty,Osijek,Croatia5PublicHealthInstituteofIstarskaCounty,Pula,Croatia6PublicHealthInstituteofKrapinsko-ZagorskaCounty,Zlatar,Croatia7PublicHealthInstituteofZadarskaCounty,Zadar,Croatia8CroatianNationalInstituteofPublicHealth,Zagreb,Croatiabozica.ban@stampar.hr
Background
Mycobacteriumtuberculosis isanecessary,butnotsufficient,causeof tuberculosis.Anumberofstudieshaveaddressedtheissueofriskfactorsfortuberculosisdevelopment.Croatia is a European countrywith an incidence rate of 14/100000which is slowlydecreasing.Theaimofthisstudyistoevaluatethepotentialdemographic,socioeconomic,behaviouralandbiologicalriskfactorsfortuberculosisinCroatiaincomparisontootherhigh-income,low-incidenceEuropeancountries.
Methods
Atotalof300tuberculosispatientswerematchedforage,sexandcountyofresidenceto300 controls randomly selected from general practitioners' registers. They wereinterviewedandtheirmedicalrecordswereevaluatedforvariablesbroadlydescribedaspotentialriskfactors.
Results
Inmultiplelogisticregression,thefollowingfactorsweresignificant:parentsborninaparticularneighbouringcounty(BosniaandHerzegovina)(OR = 3.90,95%CI2.01-7.58),thelowestlevelofeducation(OR = 3.44,95%CI1.39-8.50),poorhouseholdequipment(OR = 4.72,95%CI1.51-14.76),unemployment(OR = 2.69,95%CI1.18-6.16),contactwithtuberculosis(OR = 2.19,95%CI1.27-3.77),former(OR = 2.27,95%CI1.19-4.33)andcurrentsmokinghabits(OR = 2.35,95%CI1.27-4.36),diabetes(OR = 2.38,95%CI1.05-5.38), amalignant disease (OR = 5.79, 95% CI 1.49-22.42), being underweight in thepreviousyear(OR = 13.57,95%CI1.21-152.38).
Conclusion
In our study, the identified risk groups for tuberculosis reflect a complex interaction
28
Pregled2013.
between socioeconomic conditions, lifestyle and non-communicable diseases.Interventions focused on poverty will undoubtedly be useful, but not sufficient.Tuberculosiscontrolwouldbenefitfromacombinationofbroadpublichealthactivitiesaimedatthepreventionandcontrolofriskylifestylesandnon-communicablediseases,interventionsoutsidethehealthsector,andeffortstoconstantlyimprovetheCroatiannationaltuberculosisprogramme.
29
Pregled2013.
Broj10.
HEALTHSYSTEMDELAYINPULMONARYTUBERCULOSISTREATMENTINACOUNTRY
WITHANINTERMEDIATEBURDENOFTUBERCULOSIS:ACROSS-SECTIONALSTUDY
1 2 3 4 5 4 6Jurcev-SavicevicA ,MulicR ,KozulK ,BanB ,ValicJ ,Bacun-IvcekLj ,GudeljI ,
7 8 9Popijac-CesarG ,Marinovic-DunatovS ,SimunovicA etal.1TeachingPublicHealthInstituteofSplitandDalmatiaCounty,Split,Croatia2SchoolofMedicine,UniversityofSplit,Split,Croatia3PublicHealthInstituteofOsječko-BaranjskaCounty,Osijek,Croatia4AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia5PublicHealthInstituteofIstarskaCounty,Pula,Croatia6DepartmentofpulmonaryDiseases,SplitUniversityHospital,Split,Croatia7PublicHealthInstituteofKrapinsko-ZagorskaCounty,Zlatar,Croatia8PublicHealthInstituteofZadarskaCounty,Zadar,Croatia9CroatianNationalInstituteofPublicHealth,Zagreb,Croatiabozica.ban@stampar.hr
Background
Delayeddiagnosisandtreatmentoftuberculosisincreaseboththeseverityofthediseaseandthedurationofinfectivity.Anumberofstudieshaveaddressedtheissueofhealthsystemdelaysinthetreatmentoftuberculosis,butmostlyincountrieswithahighorlowincidenceofthedisease.Ourunderstandingofdelayisquitelimitedinsettingswithanintermediateburdenoftuberculosis.WeexplorethedurationandfactorsassociatedwithdelaysintheCroatianhealthsystemwhichhasfreehealthcareandasufficientnetworkofhealthservicesprovidingtuberculosisdiagnosisandcare.
Methods
Atotalof241consecutiveadultswithculture-confirmedpulmonarytuberculosiswereinterviewedinsevenrandomlyselectedCroatiancountiesandtheirmedicalrecordswereevaluated. A health system delay was defined as the number of days from the firstconsultationwithaphysiciantotheinitiationofanti-tuberculosistreatment.Alongdelaywas defined as a period exceeding the median delay, while an extreme delay wasconsideredtobeabovethe75thpercentiledelay.
Results
Themedianhealthsystemdelaywas15dayswhilethe75thpercentilewas42days(the5thand95thpercentilebeing1and105daysrespectively).Almost30%oftuberculosispatientsremainedundiagnosedformorethan30daysaftertheinitialhealthcarevisit.Female patients (p = 0.005), patients with a negative sputum smear (p = 0.002) and patients having symptoms other than the usual ones (0.027) were found to be insignificantcorrelationwithalongdelay.Inamultivariatemodel,alongdelayremainedassociatedwiththesamevariables(p = 0.008,p = 0.003,andp = 0.037,respectively).
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Pregled2013.
Asignificantassociationwasdemonstratedbetweenboththefemalegender(p = 0.042) andanegativesputumsmear(p < 0.001)andextremedelay,whileonlyanegativesputum smear(p < 0.001)remainedsignificantinthemultivariateanalysis.
Conclusions
Our findings suggest that some groups of tuberculosis patients experienced a healthsystemdelay.Insuchasettingwheretuberculosisincidenceisdecreasing,whichleadstoalack of physician experience and expertise, training in tuberculosis is required. Suchmeasuremaybeusefulinreducingthenumberofmissedopportunitiesfortuberculosisdiagnosis.
31
Pregled2013.
Broj11.
ASIXDECADESLONGFOLLOW-UPONBODYSIZEINADOLESCENTSFROMZAGREB,CROATIA(1951-2010)
EconomicsandHumanBiology2013;xxx:xxx.Articleinpress
1 1 1 1 2Zajc-PetranovićM ,TomasZ ,Smolej-NarancicN ,Skaric-JuricT ,VecekA ,
1MilicicJ .1InstituteforAnthropologicalResearch,Zagreb,Croatia2AndrijaStamparInstituteofPublicHealthandrea.vecek@stampar.hr
Moststudiesanalysingtheinfluenceofsocioeconomicdeterirationonbodysizefocusontheimpactoffoodshortagesanddiseasesongrowthinearlychildhood.Toevaluatehowsocioeconomicconditionsinfluencethegrowthduringtheadolescence,wetrackedthebody sizeof15-19year-olds the last sixtyyears covering the socijalistperiod (1951-1990), thewar (1991-1995) and the transition to capitalistic economy. This study ofZagreb, Croatia, adolescent population provides information on the secular trend inheight,weightandBodyMassIndeks(BMI)andexaminestheirrelationwithRealGrossDomesticProduct.From1951to2010thegirlsᶦheightapproximatelyincreasedby6.2cmandweightby6,8kgwhiletheboysᶦheightincreasedby12.2cmandweightby17,3kg.Prior to 1991 mean BMI in girls was higher than in boys, but from 1991 on, theinterrelationbetweenthesexeshasbeenopposite,possiblymirroringtheculturaltrendsthatstartedinmid-1970sandreflectinghighersensitivityofboystothesocioeconomicchanges.Inconclusion,theseculartrendinbodysizeovertheinvestigatedperiodreflectsthe positive economic trends interrupted by the war. The recent increase in BMIcorrespondstothecountryᶦseconomicrecoveryandindicatesthe„nutritiontransition̋.
32
Pregled2013.
Broj12.
SocialScience&Medicine2013;98:154-61.
INEQUALITIESINCROATIANPUPILS'RISKBEHAVIORSASSOCIATEDTOSOCIOECONOMICENVIRONMENT
ATSCHOOLANDAREALEVEL:AMULTILEVELAPPROACH
1 2 1 3Pavic-SimetinI ,KernJ ,KuzmanM ,PfoertnerTK .1YouthHealthCareandDrugAddictionPreventionDepartment,CroatianNationalInstituteofPublicHealth,Zagreb,Croatia2DepartmentofMedicalStatistics,EpidemiologyandMedicalInformatics,UniversityofZagreb,SchoolofMedicine,AndrijaStamparSchoolofPublicHealth,Zagreb,Croatia3InstituteofMedicalSociology,MedicalFaculty,Martin-LutherUniversityofHalle-Wittenberg,Halle,Saale,Germanyiva.pavic-simetin@hzjz.hr
Thesocioeconomicinequalityinpupils'riskbehaviorshasbeenthetopicofmanystudieswithquitecontradictoryfindings.Furthermore,theroleofsocioeconomicenvironmenthasbeenanalyzedmuchlessoftenthantheroleofindividualsocioeconomicstatus(SES).This study examined the association between school/area-level socioeconomicenvironmentandCroatianpupils' riskbehaviors (tobaccouse,drunkenness, cannabisuse, early sexual initiation and fighting). Data from the WHO-Collaborative 'HealthBehaviorinSchool-agedChildren'studyconductedinCroatiain2006(1601secondaryschools' pupils, aged 15) and census data were used. Multilevel logistic regressionanalyses,adjustedbygender,wereperformed.TheindividuallevelofSESexplainedthemajorityofdifferencesinallriskbehaviorsamongadolescents.Differencesintobaccouse,earlysexualinitiationandfightingweremorecloselyattributedtoschoollevelthanarealevel,whichwasmorecloselyassociatedwithdifferencesinadolescentdrunkennessandcannabis use. At the individual level, high individual SESwas associatedwith higherprobability for tobacco use and drunkenness compared to low individual SES.Furthermore, school heterogeneity (compared to school homogeneity) and mediumschool-level SES (compared to low school-level SES) were associated with higherprobability for cannabis use. Compared to themost advanced schools (gymnasiums),attendingtheleastadvancedschools(industrialandcraftsschools)wasassociatedwithhigherprobabilityforfighting.Comparedtolowarea-levelSES,mediumarea-levelSESwasassociatedwithhigherprobabilityforcannabisuseandfighting.Conclusively,itwasfoundthatlowSESatindividual,schoolandarealevels,schoolhomogeneityandadvancedschoolattendanceplayaprotectiveroleagainstriskbehaviours.Toreduceinequalitiesinpupils'riskbehaviors,thereisaneedforcommunityandschool-basedprogramsthattake
intoconsiderationnotonlyindividualSESbutalsoschool-andarea-levelsocioeconomiccircumstances.
Keywords: socioeconomic environment; Croatia; school; tobacco use; drunkenness;sannabisuse;earlysexualinitiation;fighting
33
Pregled2013.
Broj13.
CroatMedJ.2013Dec28;54(6):510-8.
ESTIMATINGGLOBALANDREGIONALMORBIDITYFROMACUTEBACTERIALMENINGITISINCHILDREN:
ASSESSMENTOFTHEEVIDENCE1 2 3 1 3 3
LuksicI ,MulicR ,FalconerR ,OrbanM ,SidhuS ,RudanI .1AndrijaStamparInstituteofPublicHealth2DepartmentofPublicHealth,UniversityofSplit,MedicalSchool,Croatia3CentreforPopulationHealthSciences,UniversityofEdinburgh,MedicalSchool,Edinburgh,Scotland,UKivana.luksic@stampar.hr
AimToestimateglobalmorbidityfromacutebacterialmeningitisinchildren.MethodsWeconductedasystematicreviewofthePubMedandScopusdatabasestoidentifybothcommunity-basedandhospitalregistry-basedstudiesthatcouldbeusefulinestimationof the global morbidity from bacterial meningitis in children. We were primarilyinterestedintheavailabilityandqualityoftheinformationonincidenceratesandcase-fatalityrates.Weassessedtheimpactoftheyearofstudy,studydesign,studysetting,thedurationofstudy,andsamplesizeonreportedincidencevalues,andalsoanyassociationbetween incidence and case-fatality rate.We also categorized the studies by6WorldHealthOrganizationregionsandanalyzedtheplausibilityofestimatesderivedfromthecurrentevidenceusingmedianandinter-quartilerangeoftheavailablereportsineachregion.ResultsWefound71studiesthatmettheinclusioncriteria.Theonlytwosignificantassociationsbetween the reported incidence and studied covariateswere thenegative correlationbetween the incidence and sample size (P
Broj14.
CroatMedJ.2013;54:135-45.
EFFECTIVENESSOFSEASONALINFLUENZAVACCINESINCHILDREN-ASYSTEMATICREVIEW
ANDMETA-ANALYSIS1 2 2 3,4 2 2 2,5
LukšićI ,ClayS ,FalconerR ,PulanicD ,RudanI ,CampbellH ,NairH .1AndrijaStamparInstituteofPublicHealth2CentreforPopulationHealthSciences,UniversityofEdinburgh,MedicalSchool,Edinburgh,Scotland,UK3ClinicalHospitalCentreZagreb,Zagreb,Croatia4J.J.StrossmayerUniversityofOsijek,MedicalSchool,Osijek,Croatia5PublicHealthFoundationofIndia,NewDelhi,Indiaivana.luksic@stampar.hr
Aim
Toassesstheefficacyandeffectivenessofseasonalinfluenzavaccinesinhealthychildrenuptotheageof18years.
Methods
MedLine,EMBASE,CENTRAL,CINAHL,WHOLIS,LILACS,andGlobalHealthweresearchedforrandomizedcontrolledtrialsandcohortandcase-controlstudies investigatingtheefficacyoreffectivenessofinfluenzavaccinesinhealthychildrenuptotheageof18years.Thestudieswereassessedfortheirqualityanddataontheoutcomesofinfluenza-likeillness,laboratory-confirmedinfluenza,andhospitalizationswereextracted.Sevenmeta-analyseswereperformedfordifferentvaccinesanddifferentstudyoutcomes.
Results
Vaccine efficacy for live vaccines, using random effectsmodel,was as follows: (i) forsimilar antigen, using per-protocol analysis: 83.4% (78.3%-88.8%); (ii) for similarantigen,usingintentiontotreatanalysis:82.5(76.7%-88.6%);(iii)foranyantigen,usingperprotocolanalysis:76.4%(68.7%-85.0%);(iv)foranyantigen,usingintentiontotreatanalysis: 76.7% (68.8%-85.6%). Vaccine efficacy for inactivated vaccines, for similarantigen,usingrandomeffectsmodel,was67.3%(58.2%-77.9%).Vaccineeffectivenessagainst influenza-like illnessfor livevaccines,usingrandomeffectsmodel,was31.4%(24.8%-39.6%)andusingfixed-effectmodel44.3%(42.6%-45.9%).Vaccineeffectivenessagainstinfluenza-likeillnessforinactivatedvaccines,usingrandomeffectsmodel,was32.5%(20.0%-52.9%)andusingfixed-effectmodel42.6%(38.3%-47.5%).
Conclusions
Influenza vaccines showed high efficacy in children, particularly live vaccines.Effectivenesswaslowerandthedataonhospitalizationswereverylimited.
35
Pregled2013.
Broj15.
CroatMedJ.2013Apr;54(2):122-34.
VIRALETIOLOGYOFHOSPITALIZEDACUTELOWERRESPIRATORYINFECTIONSINCHILDRENUNDER5
YEARSOFAGE-ASYSTEMATICREVIEWANDMETA-ANALYSIS
1 2 2 2 2 2,3LukšićI ,KearnsPK ,ScottF ,RudanI ,CampbellH ,NairH .1AndrijaStamparInstituteofPublicHealth2CentreforPopulationHealthSciences,UniversityofEdinburgh,MedicalSchool,Edinburgh,Scotland,UK3PublicHealthFoundationofIndia,NewDelhi,Indiaivana.luksic@stampar.hr
Aim
Toestimatetheproportionalcontributionofinfluenzaviruses(IV),parainfluenzaviruses(PIV),adenoviruses(AV),andcoronaviruses(CV)totheburdenofsevereacute lowerrespiratoryinfections(ALRI).
Methods
The review of the literature followed PRISMA guidelines. We included studies ofhospitalizedchildrenaged0-4yearswithconfirmedALRIpublishedbetween1995and2011. A total of 51 studies were included in the final review, comprising 56091hospitalizedALRIepisodes.
Results
IVwasdetectedin3.0%(2.2%-4.0%)ofallhospitalizedALRIcases,PIVin2.7%(1.9%-3.7%),andAVin5.8%(3.4%-9.1%).CVaretechnicallydifficulttoculture,andtheyweredetectedin4.8%ofallhospitalizedALRIpatientsinonestudy.Whenrespiratorysyncytialvirus(RSV)andlesscommonviruseswereincluded,atleastoneviruswasdetectedin50.4%(40.0%-60.7%)ofallhospitalizedsevereALRIepisodes.Moreover,21.9%(17.7%-26.4%)oftheseviralALRIweremixed,includingmorethanoneviralpathogen.AmongallsevereALRIwithconfirmedviraletiology,IVaccountedfor7.0%(5.5%-8.7%),PIVfor5.8% (4.1%-7.7%), andAV for 8.8% (5.3%-13.0%). CVwas found in 10.6%of virus-positivepneumoniapatientsinonestudy.
Conclusions
Thisarticleprovidesthemostcomprehensiveanalysisofthecontributionoffourviralcauses to severe ALRI to date. Our results can be used in further cost-effectivenessanalysesofvaccinedevelopmentandimplementationforanumberofrespiratoryviruses.
36
Pregled2013.
Broj16.
ScandJPublicHealth2013;41(4):333–335.doi:10.1177/1403494812471447
PATIENTSELF-REPORTEDADHERENCEFORTHEMOSTCOMMONCHRONICMEDICATIONTHERAPY1 2 2,3 4
BoskovicJ ,LeppéeM ,CuligJ ,EricM .1SchoolofPharmacyandBiochemistry,UniversityofZagreb,Zagreb,Croatia2AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia3SchoolofMedicine,JosipJurajStrossmayerUniversity,Osijek,Croatia4SchoolofMedicine,UniversityofNoviSad,NoviSad,Serbiajelboskovic@gmail.com
Aims
To determine adherence to chronic disease medication measured by self-reportedquestionnaire.
Methods
Thesurveywasconductedat106Zagrebpharmacies,andthequestionnairewasfilledoutbythestudysubjects.
Results
A total 1.357 diagnoseswere reported by survey respondents (i.e., an average of 2.1diagnosesperrespondent).Themostcommondiagnoseswerediseasesofthecirculatorysystem(n=500;36.8%).Thegreatmajorityofstudysubjectsreportedforgetfulness(“Ijustforgot”)asthemainreasonforskippingdrugdoses.
Conclusions
Amongthemanyreasonspeoplegivefornotadheringtodrugtreatment,forgetfulnesswasthemostcommon.Commonbarrierstoadherenceareunderthepatient'scontrol,sothatattentiontothemisanecessaryandimportantstepinimprovingadherence.Theexistenceofmorethanonecauseofriskconsiderablyincreasesthenonadherenceriskofapatient.
Keywords:adherence;chronictherapy;self-report;Zagreb.
37
Pregled2013.
Broj17.
ActaAgriculturaeScandinavicaSectionB-SoilandPlantScience,2013http://dx.doi.org/10.1080/09064710.2013.777093
SOILCONTAMINATIONASAPOSSIBLELONG-TERMCONSEQUENCEOFWARINCROATIA1,2 2 3 4 2,5 6
VidosavljevicD ,PuntaricD ,GvozdicV ,JergovicM ,MiskulinM ,PuntaricI ,7 2
PuntaricE ,SijanovicS .1VukovarGeneralHospital,Vukovar,Croatia2DepartmentofPublicHealth,SchoolofMedicine,JosipJurajStrossmayerUniversityofOsijek,Osijek,Croatia3DepartmentofChemistry,JosipJurajStrossmayerUniversityofOsijek,Osijek,Croatia4DepartmentofHealthEcology,ZagrebPublicHealthInstitute,Zagreb,Croatia5DepartmentofHealthEcology,PublicHealthInstituteofOsijek-BaranjaCounty,Osijek,Croatia6SchoolofMedicine,UniversityofZagreb,Zagreb,Croatia7DepartmentofBiology,EnvironmentalSciencesDirection,FacultyofScience,ZagrebUniversity,Zagreb,Croatiadinko.puntaric@stampar.hr
WarinCroatiaresultedinasignificantreleaseofcontaminantsintotheenvironmentasaresultoftheuseofcombatassets,mainlyconventional,mostlyaimedatciviliantargets.TheaimofthestudywastoinvestigatetheconcentrationofmetalsandmetalloidsinthesoilsofeasternCroatia.Comparedwithsoilsamplesfromareasexposedtolowintensitycombat activity soil samples from areas exposed to heavy fighting had higherconcentrationsofAs,HgandPbthanallowedbynationallegislationforecologicfarmingas well as even higher concentrations of Hg than the maximum allowed values foragricultureingeneral.DescriptivestatisticsshowsthatmeanvaluesofCu,Zn,Ni,Pb,PandBaareallhigherinsamplescollectedattheareasofhighcombatactivitycomparedwiththeonescollectedfromthelowcombatactivityareas.Sbconcentrationwaselevatedinonelocation,whichcanalsobecorrelatedwithpopulationexposure.Theresultsoftheprincipalcomponentanalysissuggestpossiblecorrelationbetweenthewaractivityandthedegreeofcontaminationbythemetalsfoundinammunition.
Keywords:ammunition,environment,metals,metalloids,traceelements.
38
Pregled2013.
2)RADOVIOBJAVLJENIUCURRENTCONTENTS-U(CC)UOBLIKUSAŽETKA
39
Pregled2013.
40
Pregled2013.
Broj1.
EurJPubHealth2013;AbstractBook
ADHERENCETOMEDICATIONINTHEMOSTCOMMONCHRONICDISEASES
1 1,2 3 1 1LeppéeM ,CuligJ ,MandicK ,SkesM ,Maric-BajsM .1AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia2SchoolofMedicine,JosipJurajStrossmayerUniversity,Osijek,Croatia3UniversityHospitalCenter,Zagreb,Croatiamarcel.leppee@stampar.hr
Background
Priorresearchhasshownthatadherencetomedicationislow,whichisasignificantpublichealthproblem.
Aims
Theaimwastodetermineeventuallydifferencetomedicationadherencebetweenthemostchronicdiseases.
Methods
Weconductedacross-sectionalsurveyusinga33-itemself-administeredquestionnairethat includedaconveniencesampleof635 individualswhowerecollectingorbuyingdrugs for thetreatmentofchronicdiseases.Thesurveywasconductedat106Zagrebpharmaciesandthequestionnairewasfilledoutbythestudysubjectswithinstructionsandhelpprovidedbythepharmacist,whoadministeredthequestionnaire.Studysubjectsweredividedintotwogroups,withadherentdefinedasa“yes”responsetothestatementthatthey“neverfailtotaketheirmedicationontime.”
Results
Thesurveyquestionnairelistedthe16mostcommonreasonsfornon-adherenceandthestudysubjectshadtoanswerthequestionforeachofthesereasonsreportingitasthepossible cause of his non-adherence. In our study population (n=635), non-adherentsubjectsprevailedoveradherentsubjects(n=370;58.3%vs.n=265;41.7%).Atotal1357diagnoseswere reportedbysurveyrespondents (i.e., anaverageof2.1diagnosesperrespondent). The most common diagnoses were diseases of the circulatory system(n=500;36.8%)andendocrine,nutritionalandmetabolicdiseases(n=285;21.0%).Eachpatientwasclassifiedintooneprimarychronicdiagnosis.Therewasnodifferenceintheproportionofself-reportedadherenceacrossthedistributionofnineprimarydiagnoses.Thegreatmajorityofstudysubjectsreportedforgetfulness(“Ijustforgot”)asthemainreasonforskippingdrugdoses,followedbybeingawayfromhomeandshortageofthedrug(havingconsumeditall).Onlyinpatientswithdepressivedisorderthereasonsweresomewhatdifferent.
Conclusions
Researchonadherencehastypicallyfocusedonthebarrierspatientsfaceintakingtheirmedications. Common barriers to adherence are under the patient's control(forgetfulness was the most common, so that attention to them is a necessary andimportantstepinimprovingadherence).Theexistenceofmorethanonecauseofriskconsiderablyincreasesthenon-adherenceriskofapatient.
41
Pregled2013.
Broj2.
EurJPubHealth2013;(Suppl).6thEuropeanPublicHealthConference,EUPHA,Brussels,Belgium,13-16November2013.
CONSUMPTIONOFANTIDEPRESSANTSINCROATIA:TRENDSINTHERATEOFHOSPITALIZATIONFOR
DEPRESSIONANDSUICIDE(2001-2010)1 1 2Polic-VizintinM ,StimacD ,TripkovicI .
1AndrijaStamparInstituteofPublicHealth2PublicHealthInstituteofSplit-DalmatiaCounty,Split,Croatiamarina.polic-vizintin@stampar.hr
Aims
To assess the effect of antidepressant consumption on the rate of hospitalization fordepressionandsuicide.
Methods
Theepidemiologicalmethodofdescriptiveandanalyticalobservationwasusedin10-yearstudy.Hospitalizationdatawerecollectedforeverypatient hospitalizedfordepression.Suicidedatawereobtainedfrommortalitystatistics.DataondrugutilizationfromZagrebMunicipalPharmacywereusedtocalculatethenumberofdefineddailydoses(DDD)andDDDper1000inhabitantsperday(DDD/TID)usingtheWHOAnatomical-Therapeutic-Chemicalmethodology.OnDDD/TIDcalculation,datafromthe2001censuswereused,accordingtowhichthepopulationofZagrebwas770058.
Results
From 2001 to 2010, the rate of hospitalization for depression was reduced from17.3/10,000to15.4/10,000.Themeanlengthofhospitalstaywasreducedfrom34.9to31.2days.Therateofsuicidedecreasedfrom19.9/100,000to14/100,00.From2001to2010,consumptionofantidepressantsincreasedby89,8%(from10.8to20.5DDD/TID)inoutpatienthealthcare.ThehighestrisewasrecordedintheoutpatientconsumptionofSSRI by 106% (from 6.9 to 14.2 DDD/TID). Outpatient consumption of nonselectiveinhibitorsofmonoaminereuptakedecreasedby46%(from3.9to2.1DDD/TID).Theanxiolytic/antidepressantratiodecreasedfrom6,45to2.55.
Conclusions
Therateofhospitalizationfordepressiondecreased,themeanlengthofhospitalstaywasreduced,therateofsuicidedecreased,whileconsumptionofantidepressants,especiallySSRI increased. The anxiolytic/antidepressant ratio as quality indicator decreasedsignificantly.Thesetrendsreflectanimprovedpsychiatricmanagementthroughintensiveprograms,outpatientfollow-up,andtreatmentwithspecificantidepressants.Respectiveeducationoffamilyphysiciansinclinicalpsychopharmacologyisofutmostimportanceforearlyrecognitionandtreatmentofmildandmoderatedepressivedisorders.
42
Pregled2013.
3)RADOVIOBJAVLJENIUDRUGIMINDEKSIRANIMČASOPISIMAUCIJELOSTI(INEXTENSO)
43
Pregled2013.
44
Pregled2013.
45
Pregled2013.
Broj1.
JournalofHygienicEngineeringandDesign,inpress
DETERMINATIONOFBOTANICORIGINOFTHECROATIANBLACKLOCUSTHONEY(ISTRIAREGION)
USINGMELISSOPALYNOLOGICALANALYSIS1 2 2 3 1
Uršulin-TrstenjakN ,HrgaI ,StjepanovićB ,DragojlovićD ,LevanićD .1PolytechnicofVaraždin,Varaždin,Croatia2AndrijaStamparInstituteofPublicHealth3MeteorologicalandHydrologicalInstituteofCroatia,Zagreb,Croatianatalija.ursulin-trstenjak@velv.hr
InCroatia,thelargesthoneyproductionisrelatedtotheproductionofblacklocusthoney.For the purpose of proving botanical and geographical origin of honeymelissopalynologicalanalysisisused-itincludesquantitativeanalysisofpolleninhoney,i.e.thedeterminationoftherelativecontentofpolleninhoney.Theaimofthispaperistopresenttheresultsofmelissopalynologicalanalysisoffortysamplesofblacklocusthoneycollected by the Istria region beekeepers during two seasons. The analyses of honeysamplesconfirmedthebotanicaloriginofhoneydefinedbythemanufacturer.AllofthecollectedsamplesconformtothecriteriaofunifloralityaccordingtotherequirementsoftheCroatianregulations,whichprescribetheminimumof20%ofthepollengrainsofaplantRobiniapseudacacia.Conductingpollenanalysisonsamplesofblacklocusthoneyovertwoseasonshasledtoidentifyingpollengrainsof36plantspecies.ThemostcommononesarepollengrainsofgenusRobinia pseudacacia (family Fabaceae), rose family (Rosaceae), cabbage family(Brassicaceae)andbeanfamily(Fabaceae).
Keywords:Blacklocusthoney,Botanicoriginofhoney,Melissopalynologicalanalysi
46
Pregled2013.
Broj2.
MedJad2013;43(1-2):23-31
UDIOMIKROELEMENATAUPOČETNOJIPRIJELAZNOJHRANIZADOJENČADTE
HRANINABAZIŽITARICA1 1 2 2 1
BošnirJ ,FilipovićVrhovacI ,RaczA ,AntolićS ,PuntarićD .1Zavodzajavnozdravstvo„Dr.AndrijaŠtampar“2Zdravstvenoveleučilište,Zagrebjasna.bosnir@stampar.hr
Usprkospreporuci o dojenju kao optimalnomoblikuprehrane za dojenčaddo šestogmjesecaživota,višeod75%djeceuHrvatskojbivahranjenoizamjenskimindustrijskimproizvodima.CiljradajeispitatiudiomikroelemenataupočetnojiprijelaznojhranizadojenčadihraninabazižitaricadostupnimanatržištuHrvatske,usporeditiprikladnostproizvoda sobziromnapreporučenidnevniunos te sunosompriprehrani isključivomajčinim mlijekom. Drugi cilj rada je ispitati utjecaj različitih temperatura vode zarehidraciju pripravaka na mikroelementarni sastav. Za kvantifikaciju je korištenamultielementarna tehnikamasene spektrometrije s induktivno spregnutomplazmom.Količine željeza,mangana i selena znatno variraju, dok je udio bakra i cinka priličnoujednačen.Prijelaznoadaptiranomlijekosadržistatističkiznačajnovećekoličineželjezaod početnog adaptiranog mlijeka, dok prosječni dnevni unos adaptiranoga mlijeka ijednoga obroka hrane na bazi žitarica, osigurava 75%potreba dojenčadi za željezomtijekomdrugihšestmjeseciživota.Dnevniunoscinkapremašujeprihvatljivigornjidnevniunos,dokjednevniunosmanganakoddojenčadistarostitrimjesecaza40putavećiodadekvatnoga.Trećinaproizvodaneosiguravanitipolovinupreporučenogdnevnogunosaselena za dojenčad do 6 mjeseci. Statistički nije potvrđen utjecaj temperature nasmanjenjekoličinemikroelementa.
Ključneriječi:hranazadojenčad,mikroelementi,dnevniunos,ICP-MS
47
Pregled2013.
Broj3.
Arhivzahigijenuradaitoksikologiju,2013;64(2):93-8
ANTIFUGALNAIANTIPATULINSKAAKTIVNOSTGLUCONOBACTEROXIDANSIZOLIRANE
SPOVRŠINEJABUKE1 2 2 2 2 2 2
BevardiM ,FreceJ ,MesarekD ,BošnirJ ,MrvčičJ ,DelašF ,MarkovK .1Zavodzajavnozdravstvo„Dr.AndrijaŠtampar“2Prehrambeno-biotehnološkifakultet,Zagreb,Hrvatskamartina.bevardi@stampar.hr
Tretiranjevoća fungicidimanakonberbe,uobičajeni jenačinsuzbijanjaplaveplijesni.Međutim, propadanje voća može se spriječiti i upotrebom antagonističkihmikroorganizama,kaoštojebakterijaGluconobacteroxydans.SvrhaovogaradabilajeizoliratiprirodnumikrobnupopulacijuspovršinejabukaiistražitimogućeinhibitornodjelovanjeGluconobacteroxydans1Jnaplavuplijesan,Penicilliumexpansum,najvažnijeguzročnika kvarenja jabuka u skladištu. Najveća antifungalna aktivnost bakterijeprimijećenajeizmeđu3.i9.dana,kadanijezabilježenporastkolonija,anakon12.danapromjerkolonijeplijesnibiojemanjiza42,3%.IakoistraživanabakterijaGluconobacteroxydans1Jnijeupotpunostiinhibiralarastplijesniujabučnomsokupokazalajevisokurazinuučinkovitosti(od86%do95%).Gluconobacteroxydans1Jdjelomičnoinhibirarastplijesniiupotpunostibiosintezupatulina,ovisnoovremenuiuvjetimauzgoja.
Ključne riječi: antagonistički mikroorganizmi, nakupljanje toksina, Penicilliumexpansum,rastplijesni
48
Pregled2013.
Broj4.
JGlobHealth.2013;3:10401.doi:10.7189/jogh.03.010401.
EPIDEMIOLOGYANDETIOLOGYOFCHILDHOODPNEUMONIAIN2010:ESTIMATESOFINCIDENCE,SEVEREMORBIDITY,MORTALITY,UNDERLYINGRISKFACTORSANDCAUSATIVEPATHOGENS
FOR192COUNTRIES1 2 1 2 1 3 4RudanI ,O'BrienKL ,NairH ,LiuL ,TheodoratouE ,QaziS ,LukšićI ,
2 2 1FischerWalkerCL ,BlackRE ,CampbellH ;ChildHealthEpidemiologyReferenceGroup(CHERG).1CentreforPopulationHealthSciencesandGlobalHealthAcademy,UniversityofEdinburghMedicalSchool,Edinburgh,UK2DepartmentofInternationalHealth,JohnsHopkinsBloombergSchoolofPublicHealth,Baltimore,MD,USA3DepartmentofMaternal,Newborn,ChildandAdolescentHealth,WorldHealthOrganization,Geneva,Switzerland4AndrijaStamparInstituteofPublicHealthivana.luksic@stampar.hr
Background
TherecentseriesofreviewsconductedwithintheGlobalActionPlanforPneumoniaandDiarrhoea(GAPPD)addressedepidemiologyofthetwodeadlydiseasesattheglobalandregionallevel;italsoestimatedtheeffectivenessofinterventions,barrierstoachievinghighcoverageand themain implications forhealthpolicy.Theaimof thispaper is toprovidetheestimatesofchildhoodpneumoniaat thecountry level.Thisshouldallownationalpolicy-makersandstakeholderstoimplementproposedpoliciesintheWorldHealthOrganization(WHO)andUNICEFmembercountries.
Methods
Weconductedaseriesofsystematicreviewstoupdatepreviousestimatesoftheglobal,regional and national burden of childhood pneumonia incidence, severe morbidity,mortality, risk factors and specific contributions of the most common pathogens:streptococcus pneumoniae (sp), haemophilus influenzae type b (hib), respiratorysyncytialvirus(RSV)andinfluenzavirus(flu).Wedistributedtheglobalandregional-level estimates of the number of cases, severe cases and deaths from childhoodpneumonia in 2010-2011 by specific countries using an epidemiological model. Themodelwasbasedontheprevalenceofthefivemainriskfactorsforchildhoodpneumoniawithincountries(malnutrition,lowbirthweight,non-exclusivebreastfeedinginthefirstfourmonths, solid fueluseandcrowding)andriskeffect sizesestimatedusingmeta-analysis.
49
Pregled2013.
Findings
Theincidenceofcommunity-acquiredchildhoodpneumoniainlow-andmiddle-incomecountries (LMIC) in the year2010, usingWorldHealthOrganization's definition,wasabout 0.22 (interquartile range (IQR) 0.11-0.51) episodes per child-year (e/cy),with11.5%(IQR8.0-33.0%)ofcasesprogressingtosevereepisodes.This isareductionofnearly25%overthepastdecade,whichisconsistentwithobservedreductionsintheprevalenceof risk factors forpneumonia throughoutLMIC.At the levelofpneumoniaincidence, RSV is themost common pathogen, present in about 29% of all episodes,followed by influenza (17%). The contribution of different pathogens varies bypneumoniaseveritystrata,withviraletiologiesbecomingrelativelylessimportantandmostdeaths in2010causedby themainbacterialagents -SP (33%)andHib (16%),accountingforvaccineuseagainstthesetwopathogens.
Conclusions
Incomparisonto2000,theprimaryepidemiologicalevidencecontributingtothemodelsof childhood pneumonia burden has improved only slightly; all estimates have wideuncertaintybounds.Still,thereisevidenceofadecreasingtrendforallmeasuresoftheburden over the period 2000-2010. The estimates of pneumonia incidence, severemorbidity,mortalityandetiology,althougheachderivedfromdifferentandindependentdata,areinternallyconsistent-lendingcredibilitytothenewsetofestimates.Pneumoniacontinues tobe the leadingcauseofbothmorbidityandmortality foryoungchildrenbeyondtheneonatalperiodandrequiresongoingstrategiesandprogresstoreducetheburdenfurther.
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Pregled2013.
Broj5.
Periodicumbiologorum2013;115:469-74
GERONTOLOGYPUBLICHEALTHMANAGEMENTINCROATIA
1 1 2 1Tomek-RoksandićS ,TomasovićMrčelaN ,SmolejNarančićN ,ŠostarZ ,
1 2 3LukićM ,DurakovićZ ,LjubičićM .1AndrijaStamparInstituteofPublicHealth2InstituteforAnthropologicalResearch,Zagreb,Croatia,3CroatianInstituteofPublicHealth,Zagreb,Croatia.spomenka.tomek-roksandić@stampar.hr
The gerontologic-public health service provided at primary health care level by theCenters of Gerontology of the Public Health Institutes (PHI) in particular Croatiancounties,CityofZagrebandRepublicofCroatiaisbasedontheestablishedgerontologic-public health parameters of health care needs and functional ability of the elderly ininstitutional and non-institutional health care. Appropriate preventive gerontologicprogramofprimarypreventionfortheelderlyhasalsobeenperformedbyGerontologyCentersinlocalcommunity,providingimmediategerontologicnon-institutionalcarefortheelderly.Acomprehensiveapproachinhealthcareoftheelderly,withfamilymedicineplayingtheleadingrole,isensuredbyduecoordinationatthelevelofprimaryhealthcarefor the elderly as part of the gerontologic-public health service with a catchmentpopulationof30,000peopleolderthan65.Thepublichealthrelevanceofhealthmanagementfortheelderlyatthesethreelevels(superior,intermediaryandbasichealthmanagement)isbasedontheprimaryhealthcarefortheelderly.Thestrategicgoalsisbasedonthemonitoring,studying,evaluationandreporting,withcoordinationandsupervisionoftheimplementationofhealthcareneedsoftheelderlythroughmonitoringofhealthcareneeds.
Keywords:healthmanagementfortheelderly,CentersofGerontologyofthePublicHealthInstitutes, Gerontology Centers, gerontologic-public health team, the measures ofgerontologic-publichealthcare.
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Pregled2013.
Broj6.
Periodicumbiologorum2013;115:475-81
PROGRAMOFPRIMARY,SECONDARYANDTERTIARYPREVENTIONFORTHEELDERLY
1 1 2 1Tomek-RoksandićS ,Tomasović-MrčelaN ,Smolej-NarančićN ,ŠostarZ ,1 2 3
LukićM ,DurakovićZ ,LjubičićM ,VučevacV.1AndrijaStamparInstituteofPublicHealth2InstituteforAnthropologicalResearch,Zagreb,Croatia,3CroatianInstituteofPublicHealth,Zagreb,Croatia.spomenka.tomek-roksandić@stampar.hr
The aging process is very individual and normal physiological phenomenon. Thisindicates that the elderly are a heterogeneous group that requires individualgerontological approach.Thebasis for the implementationof theprogramof healthyagingrepresenttheirowndecisionsaboutpositivehealthbehaviors,thataremadeatayoungerageandinteractwithaneffectivehealthprogramsofpreventivehealthmeasuresfortheelderly.Aspartofevaluationoftheimplementationofthepreventiveprogramfortheelderlyisimportanttodefinenegativehealthbehaviouroftheelderlyanddeterminetheriskfactorsofpathologicalageing.Primarypreventionfortheelderlyensuresnotonlypreventionofdeathinearlyoldagebutalsopreservationoffunctionalabilityindeepoldagethroughhealthpromotioninoldage.Theimplementationofsecondarypreventioninhealthcareoftheelderlypeopleresultsintimelydiagnosisofdiseasewhichcanstopitsfurtherdevelopmentandhelpinitstreatment,nursingcareandrehabilitation.Tertiarypreventionincludesdifferenthealthproceduresthatpreventphysicalandmentaldeclineinadiseasedoldindividualanddevelopstheremainingfunctionalcapacity.TheProgramofHealthcareMeasuresofPrevention for theElderly isprimarilycarriedout throughactiveprimaryhealthcareinstitutionswithinlocal,regionalandnationalgerontologicalcentresoftheInstituteofPublicHealth.Implementationofpreventiveprogramsfortheelderly can avert thedevelopment of a number of preventable diseases; for instance,diabetesmellitus, obesity, hypertension, cerebrovascular and cardiovascular diseases,cancer of the breast, ovaries, prostate, lungs, osteoporosis/fractures, incontinence,mentaldisorders,respiratorydiseases.InCroatia,theprogrampromotesahealthyactiveaging,consistingofthe"Guideforactivehealthyaging“.
Keywords:active,healthyaging,gerontology,familymedicine,positivehealthbehaviour,Programofhealthpromotionfortheelderly,primaryprevention,secondaryprevention,tertiaryprevention,negativehealthbehaviour,Programofbasicpreventivehealthcaremeasuresforelderly.
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Pregled2013.
4)OSTALIRADOVI
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4.1)INOZEMNI
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Pregled2013.
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Pregled2013.
Broj1.
6thBlackSeaBasinconferenceonAnalyticalChemistry,Turkey,Trabzon,September2013,BookofAbstract2013:228
VALIDATIONOFAMETHODFORDETERMINATIONOFPHTHALATESINCOMMONUSEOBJECTS(TOYSANDCHILDCAREARTICLES)BYGASCHROMA-TOGRAPHYMASSSPECTROMETRY(GCMS)
MandićAndačićI,RanogajecA,SmitZ.AndrijaStamparInstituteofPublicHealthivana.mandic@stampar.hr
Phthalicacidesters (phthalates)are themost commonlyusedplasticizer inpolyvinylchloride(PVC)basedproductsduetotheircompatibilityandsofteningcapability.Theirprimarlyroleistosoftenpolyvinylchlorid(PVC),andthereforetheiruseiswidespreadinproductionof commonuseobject.Theneedfordeterminationofphthalatesintoysandchildcarearticles is related to the fact that theyarepotential cancerous.According todirective 2005/84/EC, phthalates (bis(2-ethylhexyl) phthalte, dibutyl phthalate andbenzylbuthylphthalate)mustnotbeusedassubstancesorasconstituentsofpreparationatconcentrationgreaterthan0,1%bymassoftheplasticmaterialintoysandchildcarearticles.Thesameconditionsareapplicablefordiisononylphthalate,diisodecylphthalteanddi-n-octylphthalateintoysandchildcarearticleswhichcanbeplacedinmouthbychildren.Method for determination of phthalates in toys and childcare articles is based onextraction of sample (1g), with dichloromethane on Soxtherm, followed by gaschromatographymass spectrometry analysesof resultig extracts.Method is validatedaccordingtoNormHRNEN14372:2004,withsomeimprovementsofextractiontime(4hinstead6h)andsamplequantity(1ginstead2g).Duringvalidationofmethodfollowingvalueshavebeenachived:recovery(83%-107%),limitofdetection(0,05%and0,01%),limitofquantification(0,01%and0,02%),linearityrange(0,015-0,15%).Obtainedresultssatisfygivencriteriaofacceptability.Method isaccredited in flexiblearea,andcanbeusedfordeterminationofphthalatesincommonuseobjects.
Keywords:phalates,GCMS,commonuseobjects
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Pregled2013.
Broj2.
2ndInternationalConferenceonEnvironment,ChemistryandBiology(ICECB2013)Stockholm,Sweden,13.-14.December2013.
COMPARASIONOFFINEPARTICULATECONCENTRATIONSINURBANAREATRAFFICEXPOSED
AREAANDLANDFILLINTHEZAGREBCITY
MajićI,KrivohlavekA,ŠikićS,ŠostarZ.AndrijaStamparInstituteofPublicHealthivona.majic@stampar.hr
ThispaperpresentstheresultsofmeasurementoffineparticulatePM10inZagrebair,atthreedifferentlocations,duringtheyearsof2011and2012.Air quality monitoring in Dr Andrija Stampar Institute of Public Health, began inDecemberof2003.Themonitorsarelocatedatsitescharacterizedbydifferentexposuretoemissionsources:residentialurbanarea,areamainlyexposedtotrafficemissions,andlandfillareaalsocharacterizedbyhightrafficdensity.Weeklybehaviorsofconcentrationlevelsareseparatelypresentedforthecoldandwarmseasonsof theyear.Thereductionofconcentration levels isalsoobservedduring theweekendscomparedtoworkingdays.Concentration levelsarequiteuniformover theentirecity,with the lowestvalues forresidentialareaofZagreb,highervaluesforsitewithhightrafficdensityandthehighestforlandfillsite.Workday behaviors generally show a progressive increase of the daily concentration,reachingamaximuminthemiddleoftheweekfollowedbyadownwardtrendtowardstheminimum always observed on weekends. The reduction in concentration level isconsistent with observed reductions of the traffic volume between weekends andworkdaysandsignificanttrafficdecreaseonthe1stofNovember.
Keywords: PM10, urban air pollution, descriptive statistics, traffic emission, weeklybehavior,trafficdecreasingeffect
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Pregled2013.
Broj3.
SEBValencia2013abstracts,Dempster,Talja(ed),Valencia,Spain.SocietyofExperimentalBiology2013:165.
OXIDATIVESTRESSRESPONSEINTOBACCOEXPERIMENTALLYEXPOSEDTOCADMIUMANDZINC
CvjetkoP,ŠikićS,Peharec-ŠtefanićP,TolićS,PavlicaM,BalenB.AndrijaStamparInstituteofPublicHealthsandra.sikic@stampar.hr
Abstract
Becauseoftheirpersistence,heavymetalsofeithernaturaloranthropogenicoriginareconsideredtobethemostcommonenvironmentalpollutants.Therefore,theeffectsof10and15μMcadmium(Cd),anonessentialtoxicelementand25and50μMzinc(Zn),anessentialmicronutrient,wasinvestigatedintobaccoplantsafterexposuretoeachmetalaloneortotheircombinations.TheassessmentofCdandZncontents,inbothshootsandrootoftobaccoplants,showedthatbothmetalsaccumulatewithtime,butwhenpresentincombination, they reduced uptake of each other. As result, leaves exhibited oxidativestress in all treatments except the one with individual Zn concentrations. In roots,increasedMDAandproteincarbonylcontentwasrecordedaftertreatmentwitheither10or15μMCd,althoughincombinedtreatments25and50μMZnsignificantlyreducedmeasuredvalues.Amongtheinvestigatedantioxidativeenzymes,activityofSOD,PPXandAPXwaselevated inboth leavesand roots after exposure to eitherCd concentration,whoseeffectwas substantially alleviatedbyadditionofZn. Interestingly,CATactivityfailedtoshowanydifferencebetweenappliedtreatmentsinleaves,whileinrootsCATactivitywassignificantlyreducedinalltreatmentscomparedtocontrol.Inconclusion,combinedtreatmentsshowedlowervaluesofoxidativestressparametersincomparisontotreatmentswitheithermetalalone,whichindicatesalleviatingeffectofZnonoxidativestressinCd-treatedplants.
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Pregled2013.
Broj4.
Congress:Breakingdownthebarriers,London27-29June2013.Abstractbook42.
REGIONALDIFFERENCIESINDRINKINGHABITSAMONGCROATIANADOLESCENTS
1 1 1KuzmanM1,Pavic-SimetinI ,MarkelicM ,Pejnovic-FranelicI .1CroatianNationalInstituteofPublicHealthmarina.kuzman@stampar.hr
Foryoungpeoplecontextualfactorsasbehaviourofadultsandpeersmakemodelsandinfluencemanyhabits,drinkinghabitsincluded.Especiallyvulnerableperiodisearlyandmiddleadolescence.DatafrominternationalsurveyESPAD1995-2011wereanalysed(studentsaged15-16,nationallyrepresentativesample).Variablesofdrinkinghabitsandselectedproblemsorconsequencesofriskydrinkingwereanalysed.The frequency of drinking among Croatian adolescents is increasing in the surveyedperiod,moreamong females than inmales.Selectedvariableswereanalysed forbothgendersregionally(northern,eastern,southern,western,middleregionandtheCityofZagreb).All drinking parameters were highest in the northern Croatian region, exceptdrunkennessinthepast12months(higherforbothgendersinthewesternregion-OR1,5,CI1,096-1,984fortheboys;OR1,3,CI1,004-1,754forthegirls)anddrunkennessinthepast30daysforthegirls(OR1,5;CI1,064-2,087).Adolescentsfromsouthernregionhadlessriskydrinkinghabitsforthegirlsaswellfortheboys.Thelowestprobabilityfortheyoungageofthefirstdrunkenness(13yrsorless)hadgirlsfromeasternregion.Boysformthe City of Zagreb had less probability for risky drinking for three, and girls for twovariables.Forthosewhohaddrunkalcoholtheconsequencesasproblemsinschoolwerelessprobableinthesouthernregion(OR0,58,CI0,443-0,752).Problemswiththepoliceweremoreprobableinthewesternregion(OR1,53,CI1,149-2,037)andnecessityofthehospital treatment more probable in the western region (OR 1,83, CI 1,072-3,121)Drinkinghabitsamongadolescentsareinfluencedbythepeergroupbutreflectedalsothecontextualenvironment.Preventiveprogramsshouldthereforebeencreatedaimingatallstakeholdersinvolvedinthebehaviouralprocess,includingeducation,availability,trafficmeasures,advertisementandpricingpolicy.
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Pregled2013.
Broj5.
IIndInternationalScientificandScienceConference„TrendsineducationandrehabilitationofPersonswithDisabilities”,Šabac,Serbia,25-27October2013.
QUALITYLIFEIMPROVEMENTOFPEOPLEWITHINTELLECTUALDISABILITIESTHROUGHOUTARTTHERAPYANDMOVEMENTREHABILITA