Presentation on Training Performed at Dwarkesh Pharmaceuticals Pvt

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8/7/2019 Presentation on Training Performed at Dwarkesh Pharmaceuticals Pvt

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INTRODUCTIONy DWARKESH PHARMACEUTICALS PRIVATE LIMITED

(DPPL) , AHMEDABAD

y LOCATION :- 4801/5, GIDC, Phase IV, Vatva ,Ahmedabad,382445

y Mfg. Lic. No:- G/1404

y Overall Area:- 1900 sq. m

y Built up area:- 2600 sq. m

ORGANISATIONCompany has its organization in the following sequence

y Director :- Mr. Rajesh R. Gupta

y Associate director :- Mr. Rajat Gupta

y Chief Manufacturing Chemist :- Mr. Rakesh G. Patel

y Chief Analysis chemist :- Mrs. Clara Joseph

Organization at section level

y Manager

ySenior Operator

y Helper

y Maintainer

y Security

MANUFACTURING UNIT

TABLETING SECTION

STEPS INVOLVED INPROCESSING OF TABLET

Raw Material

Testing of raw material

Issue of raw material

Sifting of raw material

Compression into tablet

In process testing of tablet

Coating of tablets

Visual inspection of tablets

Stripping & packaging of tablets

TABLET FORMULATION SECTION

IS DIVIDED FURTHER INTO:yW

eighing Section

y Mixing Section

y Granulation Section

y Drying Section

y Compression Section

In-process QualityC

ontrol

y Coating Section

y Packaging Section

Weighing Sectiony In the weighing section all the weighing is done

in accordance with the Master Formulation

record.yWeighing is done by :

y Electronic balance

y Physical balance

Mixing Section� All the materials received

from Weighing Section are

passed through sieves or sifters and mixed using mass

mixers.

� From here the mixed mass issent to Granulating section.

Granulating Sectiony Here granulation of the

material received from

the Mixing Section isdone using multi mill .

y Multi mill·s screen no.

varies from 0.5, 1, 1.5,2, 6 & 7 ( in increasing

order of mesh size).

Drying Sectiony Granules prepared in

the Granulating Section

are dried in FluidizedBed Dryer .

y Over drying should be

prevented.

For e.g. Paracetamol-20%-30% optimum

Compression Sectiony Rotary Punching

Machines are used for

fast production oftablets.

y 16 station-15,000

tabs/hr

y Upto 23 stations single

hopper

y Punch shape

Deep face-: sugarcoated tablets

Flat face-:uncoated

tablets

Punch size Weight of tablet(mg)

9/32 180-200

10/32 210-230

12/32 340-360

16/32 600-650

Oval 700-750

D.S. 800-1100

In-Process Quality Controly Parameters noted:

Weight

Disintegration time

Friability

Hardness

y Type of coating:

Sugar coating - sugar solution

Film coating ² Iso propyl alcohol

Enteric coating-Iso propyl alcohol + Acetone

Packaging Sectiony Two types of packing:

y Blister pack

y Strip pack

y Temperature of roles:

y Forming role :-160°-

y Sealing role :-170° -

190 °

THANK YOU

Presentation on Training Performed at Dwarkesh Pharmaceuticals Pvt

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