Post on 25-Feb-2018
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Diamond Nanoparticles
Raihaan Khan
University of Illinois atChicago
October 22 201
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Nanodiamonds
!ave e"cellent mechanical and optical properties
!igh s#rface areas
$i%e & nm
Optical properties and '#orescence Non to"ic
(iocompatibility
!igh thermal cond#ctivity and electric resistivity
Chemical stability $everal applications & tribology) dr#g delivery)
bioimaging) and tiss#e engineering) *ller materialfor nano composites+
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!istory
Initially ,ere prod#ced by detonation inthe 1-.0s+/1
In the 1-0s) these diamond started
getting pop#lar to the rest of the ,orld+ any brea3thro#ghs in the 1--0s+
Colloidal s#spension of individ#al particles
4l#orescent NDs #sed for biomedical imaging
Nano scale magnetic sensors #sing NDs
4o#nd to be less to"ic then other carbonnanopaticles
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4ormation
NDs are prod#ced from e"plosives ordetonation+
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Dr#g Delivery
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Dr#g Delivery
D#e to e"cellent biocompatibility) the NDs are being called)5(iomaterial of the 21stcent#ry6
edical diamond coatings are being heavily researched forimplants and prostheses+
ND7embedded device is c#rrently being made to deliver
chemotherapy dr#gs locally to sites ,here cancero#s t#mor hasbeen removed+
Dr+ Dean !o tells Nano,er36 8he nanodiamonds are comple"ed,ith a chemotherape#tic) and s#bse9#ently enable s#stained:slo,release of the dr#g for a minim#m of one month) ,ith a signi*cant
amo#nt of dr#g in reserve+ 8his opens #p the potential for highlylocali%ed dr#g release as a complementary and potent form oftreatment ,ith systemic in;ection to,ards the red#ction ofcontin#o#s dosing) and as s#ch) atten#ation of the often po,erf#lside e
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Dr#g Delivery Design
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=rotein imics
Nds can be #sed to mimic glob#lar proteins+
$mall si%e
$table core
>bility to self assemble ?o, cytoto"icity
Can be #sed to transport other molec#les li3egenetic material across cell#lar membranes+
Use NDs to ma3e arti*cial n#cleosomes) byattaching the s#rface ,ith covalent aminogro#ps) and ,rapping it in DN>+
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Nanocomposites
NDs are e"cellent *ller materials) d#eto it@s great mechanical and thermalproperties) and the rich s#rface
chemistry of the the ND particle+
Chemical stability of the diamondcore) ma3e it s#itable for biomedical
applications+ 5Nanocomposites are a rapidly
gro,ing area in nanodiamond
research+6/1
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Dental *llings
ND have recently been fo#nd tostrengthen dental *llings+ echanically rob#st *lling material
Combined ,ith an antibiotic the *lling cancombat infection that develops in the rootcanal+ >ltho#gh the *ller didn@t *ll the
complete region it needed to be *lled) ithad lo,er rate of infection+ UC?> dentistryteam are doing more research onto thiscomposite to ma3e it an ideal dental
*lling+
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Cancer
A"tensive research is goinginto NDs) and ho, they are#sed to treat cancer+
5(y binding m#ltiple
molec#les of a commonle#3emia dr#g ,ithnanodiamonds) scientistsfrom the NationalUniversity of $ingapore
BNU$ and University ofCalifornia) ?os >ngelesBUC?> managed to boostthe delivery of the dr#g tole#3emic cells and retain
the dr#g ,ithin the cells tocombat the cancer+6
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Refrences
1+ ochalin) adym N+ PUBLISHED ONLINE: 18 DECEMBER2011 | DOI: 10.1038/NNANO.2011.209 The Proer!"e# $%&
A'"($!"o%# o) N$%o&"$*o%Bn+d+E n+ pag+ Feb+
2+ Danilen3o) + + On the history of the discovery of
nanodiamond synthesis+ =hys+ $olid $tate H.) -&--B200H+
+ Jreiner) N+ R+) =hillips) D+ $+) ohnson) + D+ L ol3) 4+Diamonds in detonation soot+ Nat#re ) HH0&HH2 B1-+
H+ (ehler) K+ D+ et al+ Nanodiamond&polymer composite
*bers and coatings+ >C$ Nano ) .&.- B200-+ + Chang) M+ R+ et al+ ass prod#ction and dynamic imaging
of '#orescent nanodiamonds+ Nat#re Nanotech+ ) 2H&2B200+