Post on 18-Nov-2014
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R E A X Y SReaxys is a web-based system for searching organic, inorganic, and organometallic data. Vendor-Elsevier.
The interface searches: Beilstein (Organic Chemistry from 1700's) Gmelin (Inorganic Chemistry from 1800's) Patent Chemistry Database (Patents from 1975)
ACCESSING REAXYS
Access from the Library Website -
Article Databases & GALILEO Link Chemistry Research Guide
SUPPORTED CHEMICAL EDITORS
- MarvinSketch (ChemAxon)- ISIS/Draw (Symyx)- Symyx Draw (Symyx)- CrossFire Structure Editor (Elsevier)- ChemDraw (CambridgeSoft)
Reaxys defaults to MarvinSketch (requires current Java and JRE (Java Runtime Environment)
PLATFORMS FOR REAXYS
Windows PC Macintosh PC Linux Reaxys is supported on browsers Internet
Explorer, Safari, and Mozilla Firefox
THINK THREE WORDS! Physical Reactions Spectra
BACKGROUND
Beilstein - Handbook of Organic Chemistry
(1st Ed. 1881)
Gmelin - Handbook of Inorganic & Organometallic Chemistry (1st Ed. 1817)
Organic Chemistry and Life Science Patents - (USA-since 1976; World/Europe-since 1978)
HANDBOOK OF ORGANIC CHEMISTRY (1ST Ed. 1881)
BEILSTEIN HISTORY 1881 - 1st Ed. Handbook of Organic Chemistry
By Friedrich Konrad Beilstein (Russian chemist) 1885 - 2nd Edition 1906 - 3rd Ed. and death of Beilstein 1918 - 4th Ed. by German Chemical Society 1984-1998 - Print 5th Supple./4th Ed. (covers 1960-1979)
Only v. 17-27 (Heterocycles) published (English). Ceased publication in 1998
1994 - Beilstein Client ‘CrossFire’ introduced!
(Handbuch migrated to a database in 1980’s) 2009 - Reaxys - web-based platform introduced!
BEILSTEIN LITERATURE COVERAGE
1771-1959 - Comprehensive organic journal coverage
1869-1959 - Comprehensive patent coverage
1960-1979 - Patents & 2,000 journals selectively reviewed
BEILSTEIN LITERATURE COVERAGE
1980-1994 - Cut back to 80 prime journals increasing over time to 120 journals (no patents)
1980+ - Abstracts included
1995 - Increased to 180 journals, adding ecotox & pharmacology coverage
Currently ~220 journals covered
BEILSTEIN TODAY
Today, "Beilstein" represents the Handbook, Beilstein Online, CrossFire, CrossFire plus
Reactions, and CrossFire Gmelin, Autonom, Current Facts, and more.
BEILSTEIN NEWS
2007 Elsevier acquired Beilstein database from frankfurt-based Beilstein Institute (Full Ownership)
1st major open access chemistry journal – Beilstein J. of Organic Chemistry
BEILSTEIN SEARCH NOTE Only about 50% of the compounds have CAS
Registry Numbers
Name searching is unreliable since Beilstein has relatively few synonyms
Only sure search is a “Structure Search”
GMELIN- 1817 (3 vols.) Handbuch der Theoretischen
Chemie (Leopold Gmelin)
- 1852 5th edition Handbuch der Theoretischen Chemie (organic chemistry was seperated and covered by Beilstein)
- 1922 8th edition (last edition). Supplements to the books continued to be issued.
- 1887to 1981 published as: Gmelins Handbuch der anorganischen Chemie (i.e., "Gmelin's handbook on inorganic chemistry")
-1981 to September 1990 published as: Gmelin Handbook of Inorganic Chemistry (Since 1982 in English )
GMELIN
-1996 - Gmelin CrossFire introduced!
-1997 - Gmelin Inst. closed. Print version ceased
-1995-1999 - Data gap: minimal coverage in online database
-2000+ Gmelin CrossFire produced by Gesellschaft Deutscher Chemiker and supplied by MDL
-2009 - Reaxys - web-based platform introduced!
BEILSTEIN COMPOUND COVERAGE
Organics (<255 “heavy” atoms) Organometallics with Li, Na, K, Rb, Cs, Mg, Ca, Sr,
and Ba central atoms Organometallic carbides, cyanides, cyanates, and
thiocyanates with C-metal bonds
Since 2002 Biomolecules e.g., hormones, enzymes, &
carbohydrates Mixtures & Polymers
BEILSTEIN/ GEMLIN SEARCHES 3 DATABASES
GMELIN COMPOUND COVERAGE Inorganics Switched to English in ~1982
Since 1971 Organometallics
except Li, Na, K, Rb, Cs, Mg, Ca, Sr, & Ba central atoms
Incl. metal-carbon bonds except carbides, cyanides, cyanates, and thiocyanates
BEILSTEIN STATISTICS ~10 million compounds and ~425 properties ~36 million “facts” ~18 million properties & spectra ~9 million eco-toxicological/pharmacology ~9 million reaction details (e.g., temperature,
pressure, solvent, yield, etc.,) ~10 million reactions ~2 million literature references
Current data is indexed from over 175 journals
GMELIN STATISTICS
2.2 million compounds with up to ~500 properties (Fields)
1.6 million reactions 1.1 million literature references
Current data is indexed from over 62 journals
PATENT CHEMISTRY DATABASE CONTENT
Patent documents from World, European, US patents (US, WO, EP) since 1976
English language patents Historical patent coverage from Beilstein and Gmelin
files (1869-1980)
(Note - SciFinder Scholar has a more complete patent coverage)
BEILSTEIN USER STATISTICS AT GSU
BEILSTEIN VS. CHEMICAL ABSTRACTSBeilstein
1. Beilstein covers primarily the chemical literature focused on organic chemistry dating back as far as 1771
2. Beilstein covers the chemical literature in which scientific data is presented, providing all the data presented in each published article as given by the original authors.
3. Even though Beilstein has covered "classical" chemistry for most of the 19th and 20th centuries, as it moves into the 21st century it has responded to the needs of the chemical community and expanded its coverage of the literature to include toxicological and physiological effects of chemicals.
Chemical Abstracts (CA) 1. CA covers virtually all of the chemical
literature - organic, inorganic, physical, analytical, polymer, materials part of the ACS back to1907
2. CA covers the literature primarily from a very different and valuable perspective by providing an abstract and a summary that is a synopsis of each article.
BEILSTEIN/GMELIN VS SCIFINDER SCHOLAR
Beilstein & Gmelin SciFinder ScholarPurely chemistry
(inorg./org./orgmetal.)Chemistry very broadly
defined1771+ 1900+
Strength older literature & properties Strength currency & scope
Richly featured, high learning curve
Very intuitive, functionality slightly limited
1 record per compound 1 record per citation
Updated monthly Updated daily
Full-text to catalog ChemPort for full-text
ENDNOTEYes - When you open the Output tool, select "Literature Management Systems" and then import your hits or range of hits into EndNote or other bibliographic management software.
HOW TO SEARCH?
By structure, sub-structure
(note - can generate structure from name!) By numerical values of properties By text, author(s) e.g., Bibliographic information Advanced searching for entering complex
property/combination queries following the general rule "<field code> <operator> <field value(s)>"
ALERTS Need to register (Free) and then you can
create alerts for your searches as well as customize your settings (e.g., colors of structure and text, hits per page, and searching options).
HISTORY SETS
History sets can be combined using AND, OR, NOT Boolean Operators.
HOW DO DATABASES SEARCH?
BooleanOperators