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Mo-99 Topical MeetingMontreal, September 2017
Jayne Senior
Reliable & Timely Mo-99 Supply Globally
Agenda
1. ANM Project Background
2. ANM Design & Capacity
3. ANM Construction & Commissioning Status
ANM Project Background
ANSTO Nuclear Medicine – ANM
ANSTO Nuclear Medicine
Operated as a subsidiary of
ANSTO
One product-Mo-99
Scalable domestic and worldwide
supply
Full lifecycle consideration
Mo-99 Facility ANM
Synroc Waste PlantSyMo
TWO PARTS
ANSTO Nuclear Medicine Project
Synroc Waste Plant“SyMo”
Mo-99 Plant“ANM”
OPAL
Lucas Heights Location
ANM Design & Capacity
Mo-99 PlantANM
Synroc Waste PlantSyMo
TWO PARTS
3,500 6 day Ci per week
LEU fuel & LEU targets
Base Digestion process
Proven, reliable technology
Low emissions (Xe-133)
Integrated preparation and testing labs
Hot Isostatic Press technology
320 cans produced per year
Integrated with Mo-99 facility
Treats Intermediate Level Liquid Waste
Waste volume reduction by 90%
Immobilised waste form
ANSTO Nuclear Medicine Project
Integrated Mo-99 Production Cycle
OPAL Irradiation Plate TransportPlate Target
Generator Production Chemical Separation ANM
ANM Mo-99 production process
Plates DissolutionFiltering
and separation
Purification Conditioning Mo-99 Patient
Waste streams
World best safety features
New production efficiencies throughout
State of art hot cell design
Separate hot cells for each process step
Radiation shielding
In-cell equipment back-up
Best practice hot cell transfer system
Extensive emission control
systems
ANM – Capacity and Flexibility
0
10
20
30
40
50
60
70
80
90
weekend rest of week
World Demand Profile9000 6-Day Ci
% Demand
0
10
20
30
40
50
60
70
80
90
weekend rest of week
ANM Supply Profile3500 6-Day Ci
% Supply
Capacity Increase TimingProjection of 6-Day Ci Production/Week
2016 2017 2018
0
500
1000
1500
2000
2500
3000
3500
4000
Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2
Current Facility4 Runs x 8 Plates
Current Facility5 Runs x 12 Plates
ANM10 Runs x 12 Plates
Construction & Comissioning Status
16
Before
After……
Front Entrance
Ramp to Front Entrance
Side Access
Production Cell Face
Hydrogen Cell face
Dissolution Cell Control Panel
Waste Handling Cells
Rear of Hot Cells
Rear of Hot Cells
Basement Gas Tanks
Basement Iodine Filters
Plant Room
QC Intermediate Sample Test Lab
QC Intermediate Sample Test Lab
Process Preparation Room
Mo-99 Facility MilestonesOperation licence submission to ARPANSA
Public consultation
Construction complete
Commissioningunderway
Activecommissioning and operation
APRIL2017
JUNE2017
JULY2017
November2017
Subject toARPANSA licence
COMMISSIONING ACTIVECOMMISSIONING
ANM Commissioning MilestonesDesign
Qualification(DQ)
TGA /ARPANSA Licences
Instrumentation Qualification
(IQ)
Low & High Activity Runs
Finish 18 November
Product Qualification
(PQ)
Facility Services Complete
In Cell Process
Equipment Finish 26 October
Operational Qualification
(OQ)
AuditsEnd
October/Early
November
Facility Services Complete
In Cell Process
Equipment Commenced
Complete
Product Validation
Supply Customer Validation SamplesStart 20
November
Current Operations and ANM Transition
0
2
4
6
8
10
54
32
10
0
1
2
3
4
5
6
7
8
9
10
0 + (5) 2 + (4) 4 + (3) 6 + (2) 8 + (1) 10 + (0)
Planned Scale up of ANM + Reduction in Current Operations
Number of runs per week in ANM + (Number of runs per week in B54)
Current FacilityFull Capacity (Now)
Current FacilityShut-Down (Q3 2018)
Mo-99 Topical MeetingMontreal, September 2017
Jayne Senior
Reliable & Timely Mo-99 Supply Globally