Post on 14-Mar-2020
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RENAL FUNCTION TEST
DR. MD. MAHBUBUR RAHMAN
MBBS, M. Phil , MBT (New Delhi)
DEPT. OF BIOCHEMISTRY
RAJSHAHI MEDICAL COLLEGE
Definition of Renal Function test
the group of test by which we can assess the function of kidney is known as Renal Function Test.
Function of kidney
Formation of urine
Maintenance of water balance
Maintenance of electrolyte balance
Maintenance of acid base balance
Excreation of waste product e.g. Urea., uric acid
Endocrine function e.g. Erythropoietin, vit –D3
Maintenance of osmotic balance
FUNCTION OF
KIDNEY
Regulation of water, electrolyte & acid-base balance.
Excretion of the products of protein and nucleic acid metabolism e.g. urea,
creatinin, creatin ,uric acid, sulphate, and phosphate.
RENAL FUNCTION TEST
It is convenient to discuss renal function in terms of the assessment of glomerular and tubular function
TEST OF GLOMERULAR
FUNCTION
Clearence : This is the volume of plasma which would be completely ‘cleared’ of the substance in the time specified to give the amount seen in urine.
U X V
volume of plasma=
P
U =Urine concentration of creatinine P =Serum or Plasma concentration of creatinine V = Volume of urine
Serum creatinine & urea
mesurment
Normal value of serum creatinine
male: 60-130µmol/L(0.7-1.4 mg/dl)
Female: 40-60µmol/L(0.4-1.2mg/dl)
Normal value of serum urea
Adults: 3.3-7.7mmol/L(20-50mg/dl)
Infants: 1.3-5.8mmol/L(8-35mg/dl)
serum creatinine is better
than serum urea because----
Creatinine is derived from
muscle creatine
serum urea level is altered
by dietary protein, tissue
breakdown, hemorrhage,
dehydration.
Cause of proteinuria
Nephritic syndrom
Chronic glomerulonephritis
Toxaemia of pregnancy
Severe lower urinary tract infection
Pyogenic or tuberculous pyelonephritis
Diabetic nephropathy
Hypertension
Test of tubular function
Osmolarity mesurments in the plasma and urine & there ratio.[Normal1-3]
Specific proteinuria: β2 microglobulin α2 microglobulin