Post on 03-Jan-2016
description
transcript
Review of muscle cell structure and phenotype plasticity.
LEARNING OBJECTIVES
1. Review the structure of skeletal muscle.
BS277 Biology of Muscle
Review of muscle structure.Organism to cell.
1
2
3
4 56
7
8
86
79
8
4
10
6
10
10
12
14
11
13
15
16
18
10
17
1. Brachium2. Tendon3. Skeletal muscle / biceps4. Epimysium5. Blood vessels and nerves6. Perimysium7. Muscle fascicle8. Muscle fibre / myocyte/muscle cell9. Blood vessels10. Endomysium11. Capillary12. Sarcolemma13. Sarcoplasm14. Nucleus15. Mitochondria16. Nerve17. Satellite cell
Overview of Muscle Development.
Review of muscle structure. Cell to organelle. 1
1
2
2
3
4
4
67
1
8
910
11
5
1. Sarcolemma2. Sarcoplasm3. Nucleus4. Myofibril5. Sarcoplasmic reticulum6. Terminal cisterna7. Mitochondrion8. T-tubule9. Triad10.Thick myofilament11.Thin myofilament
Review of muscle structure. Cell to organelle.
Review of muscle structure. Myofibril banding pattern.
Sarcomere
A bandI band
H zone
M line
Z line
Zone of overlap
Thin myofilament
Thick myofilament
Titin
Review of muscle structure. Myofibril banding pattern.
The molecular basis of the sarcomere banding pattern
Sarcomere
Thin myofilamentThick
myofilamentα-actinin
Titin
Titin
The molecular basis of myofilament structure
The molecular basis of myofilament structure
Sliding filaments and muscle contraction
Overview of the regulation of muscle contraction
The active state. Initiation of cross bridge cycling.
The cross bridge cycle. Step 1.