Scott Anthony Designing a Curious Organization

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Designing an Innovative Company

Scott D. Anthony

March 2014

@ScottDAnthony

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Genius is 1 percent

inspiration and 99

percent perspiration

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“Something can be a real failure until it’s not. It’s just an absolute dud

until it’s a hit.

Leadership has to really lean in and not let

things die on the vine. ”

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UK-92480

Pfizer was investigating a drug named “UK-92480″ that they had

discovered by rational drug design. It caused smooth muscle

relaxation through inhibition of the phosphodiesterase

(specifically PDE5), which is responsible for hydrolysis of cyclic

GMP. It was hoped that inhibition of PDE5 would cause smooth

muscle relaxation via the pathway above, and lower blood

pressure in patients. Unfortunately, results were modest.

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An interesting side-effect of the drug was noticed by male patients

however, and the drug was surprisingly popular among the study

participants despite the poor control of blood-pressure.

Pfizer, not being idiots, realized they had hit gold. Finally, a

treatment for erectile dysfunction in pill form had arrived.

Source: The Road to Sildenafil – A history of artificial erections, by Mark Hoofnagle

http://scienceblogs.com/denialism/2007/10/15/the-road-to-sildenafil-a-histo/

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“You learn far more from your failures than you do from your

successes – far more from your failures.

What we’re trying to do now is fail a lot faster, fail a lot cheaper,

so we can fail more and get on to the next idea or the next

innovation that may become a commercial success.”

AG Lafley, Procter & Gamble Chairman and CEO

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@ScottDAnthony

www.innosight.com

Scott Anthony Designing a Curious Organization

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